Publications from 2016

@article{RN15724,

title = {A Longitudinal Study of Association between Adiposity Markers and Intraocular Pressure: The Kangbuk Samsung Health Study},

author = {D Zhao and M H Kim and R Pastor-Barriuso and Y Chang and S Ryu and Y Zhang and S Rampal and H Shin and J M Kim and D S Friedman and E Guallar and J Cho},

doi = {10.1371/journal.pone.0146057},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {1},

pages = {e0146057},

abstract = {IMPORTANCE: Intraocular pressure (IOP) reduction or stabilization is the only proven method for glaucoma management. Identifying risk factors for IOP is crucial to understand the pathophysiology of glaucoma. OBJECTIVE: To examine the associations of change in body mass index (BMI), waist circumference, and percent fat mass with change in intraocular pressure (IOP) in a large sample of Korean adults. DESIGN, SETTING AND PARTICIPANTS: Cohort study of 274,064 young and middle age Korean adults with normal fundoscopic findings who attended annual or biennial health exams from January 1, 2002 to Feb 28, 2010 (577,981 screening visits). EXPOSURES: BMI, waist circumference, and percent fat mass. MAIN OUTCOME MEASURE(S): At each visit, IOP was measured in both eyes with automated noncontact tonometers. RESULTS: In multivariable-adjusted models, the average increase in IOP (95% confidence intervals) over time per interquartile increase in BMI (1.26 kg/m2), waist circumference (6.20 cm), and percent fat mass (3.40%) were 0.18 mmHg (0.17 to 0.19), 0.27 mmHg (0.26 to 0.29), and 0.10 mmHg (0.09 to 0.11), respectively (all P \< 0.001). The association was stronger in men compared to women (P \< 0.001) and it was only slightly attenuated after including diabetes and hypertension as potential mediators in the model. CONCLUSIONS AND RELEVANCE: Increases in adiposity were significantly associated with an increase in IOP in a large cohort of Korean adults attending health screening visits, an association that was stronger for central obesity. Further research is needed to understand better the underlying mechanisms of this association, and to establish the role of weight gain in increasing IOP and the risk of glaucoma and its complications.},

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pubstate = {published},

tppubtype = {article}

}

@article{RN15708,

title = {A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk},

author = {R C Travis and P N Appleby and R M Martin and J M P Holly and D Albanes and A Black and H B A Bueno-de-Mesquita and J M Chan and C Chen and M D Chirlaque and M B Cook and M Deschasaux and J L Donovan and L Ferrucci and P Galan and G G Giles and E L Giovannucci and M J Gunter and L A Habel and F C Hamdy and K J Helzlsouer and S Hercberg and R N Hoover and Jamjl Janssen and R Kaaks and T Kubo and L Le Marchand and E J Metter and K Mikami and J K Morris and D E Neal and M L Neuhouser and K Ozasa and D Palli and E A Platz and M Pollak and A J Price and M J Roobol and C Schaefer and J M Schenk and G Severi and M J Stampfer and P Stattin and A Tamakoshi and C M Tangen and M Touvier and N J Wald and N S Weiss and R G Ziegler and T J Key and N E Allen},

doi = {10.1158/0008-5472.Can-15-1551},

issn = {0008-5472},

year  = {2016},

date = {2016-01-01},

journal = {Cancer Res},

volume = {76},

number = {8},

pages = {2288-2300},

abstract = {The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all \</= 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15697,

title = {A Nested Case-Control Study of Metabolically Defined Body Size Phenotypes and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)},

author = {N Murphy and A J Cross and M Abubakar and M Jenab and K Aleksandrova and M C Boutron-Ruault and L Dossus and A Racine and T Kuhn and V A Katzke and A Tjonneland and K E Petersen and K Overvad and J R Quiros and P Jakszyn and E Molina-Montes and M Dorronsoro and J M Huerta and A Barricarte and K T Khaw and N Wareham and R C Travis and A Trichopoulou and P Lagiou and D Trichopoulos and G Masala and V Krogh and R Tumino and P Vineis and S Panico and H B Bueno-de-Mesquita and P D Siersema and P H Peeters and B Ohlsson and U Ericson and R Palmqvist and H Nystrom and E Weiderpass and G Skeie and H Freisling and S Y Kong and K Tsilidis and D C Muller and E Riboli and M J Gunter},

doi = {10.1371/journal.pmed.1001988},

issn = {1549-1277},

year  = {2016},

date = {2016-01-01},

journal = {PLoS Med},

volume = {13},

number = {4},

pages = {e1001988},

abstract = {BACKGROUND: Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterparts. Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown. METHODS AND FINDINGS: The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolic health/body size phenotypes were defined according to hyperinsulinaemia status using serum concentrations of C-peptide, a marker of insulin secretion. A total of 737 incident colorectal cancer cases and 737 matched controls were divided into tertiles based on the distribution of C-peptide concentration amongst the control population, and participants were classified as metabolically healthy if below the first tertile of C-peptide and metabolically unhealthy if above the first tertile. These metabolic health definitions were then combined with body mass index (BMI) measurements to create four metabolic health/body size phenotype categories: (1) metabolically healthy/normal weight (BMI \< 25 kg/m2), (2) metabolically healthy/overweight (BMI \>/= 25 kg/m2), (3) metabolically unhealthy/normal weight (BMI \< 25 kg/m2), and (4) metabolically unhealthy/overweight (BMI \>/= 25 kg/m2). Additionally, in separate models, waist circumference measurements (using the International Diabetes Federation cut-points [\>/=80 cm for women and \>/=94 cm for men]) were used (instead of BMI) to create the four metabolic health/body size phenotype categories. Statistical tests used in the analysis were all two-sided, and a p-value of \<0.05 was considered statistically significant. In multivariable-adjusted conditional logistic regression models with BMI used to define adiposity, compared with metabolically healthy/normal weight individuals, we observed a higher colorectal cancer risk among metabolically unhealthy/normal weight (odds ratio [OR] = 1.59, 95% CI 1.10-2.28) and metabolically unhealthy/overweight (OR = 1.40, 95% CI 1.01-1.94) participants, but not among metabolically healthy/overweight individuals (OR = 0.96, 95% CI 0.65-1.42). Among the overweight individuals, lower colorectal cancer risk was observed for metabolically healthy/overweight individuals compared with metabolically unhealthy/overweight individuals (OR = 0.69, 95% CI 0.49-0.96). These associations were generally consistent when waist circumference was used as the measure of adiposity. To our knowledge, there is no universally accepted clinical definition for using C-peptide level as an indication of hyperinsulinaemia. Therefore, a possible limitation of our analysis was that the classification of individuals as being hyperinsulinaemic-based on their C-peptide level-was arbitrary. However, when we used quartiles or the median of C-peptide, instead of tertiles, as the cut-point of hyperinsulinaemia, a similar pattern of associations was observed. CONCLUSIONS: These results support the idea that individuals with the metabolically healthy/overweight phenotype (with normal insulin levels) are at lower colorectal cancer risk than those with hyperinsulinaemia. The combination of anthropometric measures with metabolic parameters, such as C-peptide, may be useful for defining strata of the population at greater risk of colorectal cancer.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15750,

title = {Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in nonsmoking postmenopausal women from the EPIC cohort},

author = {M Obon-Santacana and H Freisling and P H Peeters and L Lujan-Barroso and P Ferrari and M C Boutron-Ruault and S Mesrine and L Baglietto and R Turzanski-Fortner and V A Katzke and H Boeing and J R Quiros and E Molina-Portillo and N Larranaga and M D Chirlaque and A Barricarte and K T Khaw and N Wareham and R C Travis and M A Merritt and M J Gunter and A Trichopoulou and P Lagiou and A Naska and D Palli and S Sieri and R Tumino and V Fiano and R Galassom and H B Bueno-de-Mesquita and N C Onland-Moret and A Idahl and E Lundin and E Weiderpass and H Vesper and E Riboli and E J Duell},

doi = {10.1002/ijc.29853},

issn = {0020-7136},

year  = {2016},

date = {2016-01-01},

journal = {Int J Cancer},

volume = {138},

number = {5},

pages = {1129-38},

abstract = {Acrylamide, classified in 1994 by IARC as "probably carcinogenic to humans," was discovered in 2002 in some heat-treated, carbohydrate-rich foods. Four prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The purpose of this nested case-control study, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, was to evaluate, for the first time, the association between hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA) and the risk of developing EC in non-smoking postmenopausal women. Hemoglobin adducts were measured in red blood cells by HPLC/MS/MS. Four exposure variables were evaluated: HbAA, HbGA, their sum (HbAA+HbGA), and their ratio (HbGA/HbAA). The association between hemoglobin adducts and EC was evaluated using unconditional multivariable logistic regression models, and included 383 EC cases (171 were type-I EC), and 385 controls. Exposure variables were analyzed in quintiles based on control distributions. None of the biomarker variables had an effect on overall EC (HRHbAA;Q5vsQ1 : 0.84, 95%CI: 0.49-1.48; HRHbGA;Q5vsQ1 : 0.94, 95%CI: 0.54-1.63) or type-I EC risk. Additionally, none of the subgroups investigated (BMI \< 25 vs. \>/=25 kg m(-2) , alcohol drinkers vs. never drinkers, oral contraceptive users vs. non-users) demonstrated effect measure modification. Hemoglobin adducts of acrylamide or glycidamide were not associated with EC or type-I EC risk in 768 nonsmoking postmenopausal women from the EPIC cohort.},

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pubstate = {published},

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@article{RN15764,

title = {Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study},

author = {M Stepien and T Duarte-Salles and V Fedirko and A Floegel and D K Barupal and S Rinaldi and D Achaintre and N Assi and A Tjonneland and K Overvad and N Bastide and M C Boutron-Ruault and G Severi and T Kuhn and R Kaaks and K Aleksandrova and H Boeing and A Trichopoulou and C Bamia and P Lagiou and C Saieva and C Agnoli and S Panico and R Tumino and A Naccarati and H B Bueno-de-Mesquita and P H Peeters and E Weiderpass and J R Quiros and A Agudo and M J Sanchez and M Dorronsoro and D Gavrila and A Barricarte and B Ohlsson and K Sjoberg and M Werner and M Sund and N Wareham and K T Khaw and R C Travis and J A Schmidt and M Gunter and A Cross and P Vineis and I Romieu and A Scalbert and M Jenab},

doi = {10.1002/ijc.29718},

issn = {0020-7136},

year  = {2016},

date = {2016-01-01},

journal = {Int J Cancer},

volume = {138},

number = {2},

pages = {348-60},

abstract = {Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log-transformed standardised (mean = 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15652,

title = {An overview of biological processes and their potential for CO2 capture},

author = {A Goli and A Shamiri and A Talaiekhozani and N Eshtiaghi and N Aghamohammadi and M K Aroua},

doi = {10.1016/j.jenvman.2016.08.054},

issn = {0301-4797},

year  = {2016},

date = {2016-01-01},

journal = {J Environ Manage},

volume = {183},

pages = {41-58},

abstract = {The extensive amount of available information on global warming suggests that this issue has become prevalent worldwide. Majority of countries have issued laws and policies in response to this concern by requiring their industrial sectors to reduce greenhouse gas emissions, such as CO2. Thus, introducing new and more effective treatment methods, such as biological techniques, is crucial to control the emission of greenhouse gases. Many studies have demonstrated CO2 fixation using photo-bioreactors and raceway ponds, but a comprehensive review is yet to be published on biological CO2 fixation. A comprehensive review of CO2 fixation through biological process is presented in this paper as biological processes are ideal to control both organic and inorganic pollutants. This process can also cover the classification of methods, functional mechanisms, designs, and their operational parameters, which are crucial for efficient CO2 fixation. This review also suggests the bio-trickling filter process as an appropriate approach in CO2 fixation to assist in creating a pollution-free environment. Finally, this paper introduces optimum designs, growth rate models, and CO2 fixation of microalgae, functions, and operations in biological CO2 fixation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15700,

title = {Antenatal Care Utilisation and Content between Low-Risk and High-Risk Pregnant Women},

author = {P L Yeoh and K Hornetz and M Dahlui},

doi = {10.1371/journal.pone.0152167},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {3},

pages = {e0152167},

abstract = {BACKGROUND: The purpose of antenatal care is to monitor and improve the wellbeing of the mother and foetus. The World Health Organization recommends risk-oriented strategy that includes: (i) routine care to all women, (ii) additional care for women with moderately severe diseases and complications, (iii) specialised obstetrical and neonatal care for women with severe diseases and complications. Antenatal care is concerned with adequate care in order to be effective. Measurement for adequacy of antenatal care often applies indexes that assess initiation of care and number of visits. In addition, adequacy of care content should also be assessed. Results of studies in developed settings demonstrate that women without risk factors use antenatal services more frequently than recommended. Such over-utilisation is problematic for low-resourced settings. Moreover, studies show that a substantial proportion of high-risk women had utilisation or content of care below the recommended standard. Yet studies in developing countries have seldom included a comparison between low-risk and high-risk women. The purpose of the study was therefore to assess adequacy of care and pregnancy outcomes for the different risk groups. METHODS: A retrospective study using a multistage sampling technique, at public-funded primary health care clinics was conducted. Antenatal utilisation level was assessed using a modified Adequacy of Prenatal Care Utilisation index that measures the timing for initiation of care and observed-to-expected visits ratio. Adequacy of antenatal care content assessed compliance to routine care based on the local guidelines. RESULTS: Intensive or "adequate-plus" antenatal care utilisation as defined by the modified index was noted in over half of the low-risk women. On the other hand, there were 26% of the high-risk women without the expected intensive utilisation. Primary- or non-educated high-risk women were less likely to have a higher antenatal care utilisation level compared with tertiary educated ones (OR = 0.20},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15744,

title = {Application of TOPSIS and VIKOR improved versions in a multi criteria decision analysis to develop an optimized municipal solid waste management model},

author = {M Aghajani Mir and P Taherei Ghazvinei and N M Sulaiman and N E Basri and S Saheri and N Z Mahmood and A Jahan and R A Begum and N Aghamohammadi},

doi = {10.1016/j.jenvman.2015.09.028},

issn = {0301-4797},

year  = {2016},

date = {2016-01-01},

journal = {J Environ Manage},

volume = {166},

pages = {109-15},

abstract = {Selecting a suitable Multi Criteria Decision Making (MCDM) method is a crucial stage to establish a Solid Waste Management (SWM) system. Main objective of the current study is to demonstrate and evaluate a proposed method using Multiple Criteria Decision Making methods (MCDM). An improved version of Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) applied to obtain the best municipal solid waste management method by comparing and ranking the scenarios. Applying this method in order to rank treatment methods is introduced as one contribution of the study. Besides, Viekriterijumsko Kompromisno Rangiranje (VIKOR) compromise solution method applied for sensitivity analyses. The proposed method can assist urban decision makers in prioritizing and selecting an optimized Municipal Solid Waste (MSW) treatment system. Besides, a logical and systematic scientific method was proposed to guide an appropriate decision-making. A modified TOPSIS methodology as a superior to existing methods for first time was applied for MSW problems. Applying this method in order to rank treatment methods is introduced as one contribution of the study. Next, 11 scenarios of MSW treatment methods are defined and compared environmentally and economically based on the waste management conditions. Results show that integrating a sanitary landfill (18.1%), RDF (3.1%), composting (2%), anaerobic digestion (40.4%), and recycling (36.4%) was an optimized model of integrated waste management. An applied decision-making structure provides the opportunity for optimum decision-making. Therefore, the mix of recycling and anaerobic digestion and a sanitary landfill with Electricity Production (EP) are the preferred options for MSW management.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15670,

title = {Are the Poor Dying Younger in Malaysia? An Examination of the Socioeconomic Gradient in Mortality},

author = {J Mariapun and N N Hairi and C W Ng},

doi = {10.1371/journal.pone.0158685},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {6},

pages = {e0158685},

abstract = {INTRODUCTION: Socioeconomic inequalities in health represent unfairness in the health distribution of a population. Efforts to produce information on mortality distributions in many low and middle income countries (LMICs) are mostly hampered by lack of data disaggregated by socioeconomic groups. In this paper we describe how mortality statistics obtained from multiple data sources were combined to provide an evaluation of the socioeconomic distribution of mortality in Malaysia, a LMIC located in the Asia Pacific region. METHODS: This study has an ecological design. As a measure of socioeconomic status, we used principal component analysis to construct a socioeconomic index using census data. Districts were ranked according to the standardised median index of households and assigned to each individual in the 5-year mortality data. The mortality indicators of interest were potential years of life lost (PYLL), standardised mortality ratio (SMR), infant mortality rate (IMR) and under-5 mortality rate (U5MR). Both socioeconomic status and mortality outcomes were used compute the concentration index which provided the summary measure of the magnitude of inequality. RESULTS: Socially disadvantaged districts were found to have worse mortality outcomes compared to more advantaged districts. The values of the concentration index for the overall population of the Peninsula are C = -0.1334 (95% CI: -0.1605 to -0.1063) for the PYLL},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15664,

title = {Assessment of Risk and Sero-Prevalence of Helicobacter pylori Colonization among Remote Orang Asli Tribes in Peninsula Malaysia},

author = {K Thevakumar and J R Chandren and G I Perez-Perez and E G Chua and L K Teh and M Z Salleh and J A Tan and A H Leow and K L Goh and A C Tay and B J Marshall and J Vadivelu and M F Loke and L P Wong},

doi = {10.1371/journal.pone.0159830},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {7},

pages = {e0159830},

abstract = {The epidemiology of Helicobacter pylori (H. pylori) infection is related to human poverty with marked differences between developing and developed countries. Socioeconomic factors and living standards are the main determinants of the age-dependent acquisition rate of H. pylori, and consequently its prevalence. The aim of this study was to assess the risk and sero-prevalence of H. pylori colonization among Orang Asli in Peninsula Malaysia. This cross-sectional study was conducted on Orang Asli subjects in seven isolated settlements spanning across all three major tribes (Negrito, Proto Malay and Senoi) in Malaysia. Socio-demographic characteristics of the subjects were obtained through interview. Subjects were tested for H. pylori colonization based on CagA and whole cell (WC) antigen serological assays. A total of 275 subjects participated in this study. Among these subjects, 115 (44.7%) were H. pylori sero-positive with highest sero-prevalence among Negrito (65.7%). Among subjects who were H. pylori sero-positive, CagA sero positivity was also significantly higher among Negrito. The highest proportion of respondents reported to be H. pylori sero-positive was from age group 30 years old and below (57.9%), males (56.2%), Negrito (48.6%) and live in bamboo house (92.3%). The highest proportion of respondents reported to be CagA sero-positive was from age group 30 years old and below (41.4%), males (35.6%) and Negrito (48.6%). The results of this study demonstrate that H. pylori colonization can be related to age, gender, tribes and house materials and CagA sero-positive stain closely associated with age, gender and tribes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15699,

title = {Association between pain catastrophising and musculoskeletal disorders is modified by past injuries in Malaysian military recruits},

author = {F H Mohd Din and S Rampal and M A Muslan and V C Hoe},

doi = {10.1136/oemed-2015-103140},

issn = {1351-0711},

year  = {2016},

date = {2016-01-01},

journal = {Occup Environ Med},

volume = {73},

number = {7},

pages = {429-34},

abstract = {OBJECTIVES: Pain catastrophising is de fi ned as exaggerated negative thoughts, which can occur during an actual or anticipated painful experience, such as musculoskeletal injuries (MSI) or disorders (MSD). The aims of this study are to examine the association between pain catastrophising and MSI and MSD in Malaysian Army male recruits, and evaluate the effects of past injury. METHODS: A cohort of 611 male Malaysian Army recruits were recruited and followed up at 3 and 6 months. Pain catastrophising, MSD, sociodemographic and work factors were measured using a self-administered questionnaire, and MSI incidence was retrieved from the medical records. Multivariable fixed effects regression was used to model the cumulative incidence of MSD and MSI. RESULTS: Approximately 12% of the recruits were diagnosed with incident MSI and 80% reported incident MSD. Higher pain catastrophising at baseline was associated with higher 6 month MSD risk (adjusted OR (aOR) 1.6 per 1 SD increase of Pain Catastrophising Scale (PCS) scores; 95% CI 1.2 to 2.0), and longitudinally associated with MSD incidence (aOR 1.2, 95% CI 1.1 to 1.4). Pain catastrophising was not associated with MSI incidence (aOR 1.0, 95% CI 0.8 to 1.3). The association between pain catastrophising and self-reported MSD was stronger among recruits with self-reported past injury (p for interaction \<0.001). CONCLUSIONS: Pain catastrophising was able to predict symptomatic MSD, and not physician-diagnosed MSI, and these findings are directly related to individual health beliefs. Pain catastrophising has a greater influence on how military recruits perceived their musculoskeletal conditions during training, and efforts to reduce pain catastrophising may be beneficial.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15657,

title = {Attitudes and factors affecting acceptability of self-administered cervicovaginal sampling for human papillomavirus (HPV) genotyping as an alternative to Pap testing among multiethnic Malaysian women},

author = {M Ma'som and N Bhoo-Pathy and N H Nasir and J Bellinson and S Subramaniam and Y Ma and S H Yap and P P Goh and P Gravitt and Y L Woo},

doi = {10.1136/bmjopen-2015-011022},

issn = {2044-6055},

year  = {2016},

date = {2016-01-01},

journal = {BMJ Open},

volume = {6},

number = {8},

pages = {e011022},

abstract = {OBJECTIVE: The objective of this study was to determine the attitudes and acceptability of self-administered cervicovaginal sampling compared with conventional physician-acquired Papanicolaou (Pap) smear among multiethnic Malaysian women. METHOD: A cross-sectional study was carried out via interviewer-administered surveys from August 2013 through August 2015 at five government-run, urban health clinics in the state of Selangor. Subjects were participants from an ongoing community-based human papillomavirus (HPV) prevalence study who answered a standard questionnaire before and after self-sampling. The cervicovaginal self-sampling for HPV genotyping was performed using a simple brush ('Just for Me'; Preventive Oncology International, Hong Kong). Detailed data on sociodemographics, previous Pap smear experience, and attitudes towards self-administered cervicovaginal sampling were collected and analysed. Acceptability was inferred using a five-item Likert scale that included six different subjective descriptives: experience, difficulty, convenience, embarrassment, discomfort or pain, and confidence in collecting one's own sample. RESULTS: Of the 839 participants, 47.9% were Malays, followed by 30.8% Indians, 18.8% Chinese and 2.5% from other ethnicities. The median age of the participants was 38 years (IQR 30-48). Some 68.2% of participants indicated a preference for self-sampling over the Pap test, with 95% indicating willingness to follow-up a positive result at the hospital. Age, ethnicity and previous Pap test experience were significant independent factors associated with preference for self-sampling. The older the individual, the less likely they were to prefer self-sampling (adjusted OR 0.94, 95% CI 0.90 to 0.98). The Chinese were less likely to prefer self-sampling (72.6%) than the Malays (85.1%) (adjusted OR 0.57, 95% CI 0.33 to 0.98},

keywords = {},

pubstate = {published},

tppubtype = {article}

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@article{RN15709,

title = {Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study},

author = {S C Chuang and H Boeing and S E Vollset and O Midttun and P M Ueland and B Bueno-de-Mesquita and M Lajous and G Fagherazzi and M C Boutron-Ruault and R Kaaks and T Kuehn and T Pischon and D Drogan and A Tjonneland and K Overvad and J R Quiros and A Agudo and E Molina-Montes and M Dorronsoro and J M Huerta and A Barricarte and K T Khaw and N J Wareham and R C Travis and A Trichopoulou and P Lagiou and D Trichopoulos and G Masala and C Agnoli and R Tumino and A Mattiello and P H Peeters and E Weiderpass and R Palmqvist and I Ljuslinder and M Gunter and Y Lu and A J Cross and E Riboli and P Vineis and K Aleksandrova},

doi = {10.1186/s12979-016-0059-y},

issn = {1742-4933 (Print) 

1742-4933},

year  = {2016},

date = {2016-01-01},

journal = {Immun Ageing},

volume = {13},

pages = {5},

abstract = {BACKGROUND: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). RESULTS: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p \< 0.01 for men and 9.2 %, p \< 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). CONCLUSIONS: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15695,

title = {Circulating Folate and Vitamin B12 and Risk of Prostate Cancer: A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls},

author = {A J Price and R C Travis and P N Appleby and D Albanes and A Barricarte Gurrea and T Bjorge and H B Bueno-de-Mesquita and C Chen and J Donovan and R Gislefoss and G Goodman and M Gunter and F C Hamdy and M Johansson and I B King and T Kuhn and S Mannisto and R M Martin and K Meyer and D E Neal and M L Neuhouser and O Nygard and P Stattin and G S Tell and A Trichopoulou and R Tumino and P M Ueland and A Ulvik and S Vogel and S E Vollset and S J Weinstein and T J Key and N E Allen},

doi = {10.1016/j.eururo.2016.03.029},

issn = {0302-2838},

year  = {2016},

date = {2016-01-01},

journal = {Eur Urol},

volume = {70},

number = {6},

pages = {941-951},

abstract = {BACKGROUND: Folate and vitamin B12 are essential for maintaining DNA integrity and may influence prostate cancer (PCa) risk, but the association with clinically relevant, advanced stage, and high-grade disease is unclear. OBJECTIVE: To investigate the associations between circulating folate and vitamin B12 concentrations and risk of PCa overall and by disease stage and grade. DESIGN, SETTING, AND PARTICIPANTS: A study was performed with a nested case-control design based on individual participant data from six cohort studies including 6875 cases and 8104 controls; blood collection from 1981 to 2008, and an average follow-up of 8.9 yr (standard deviation 7.3). Odds ratios (ORs) of incident PCa by study-specific fifths of circulating folate and vitamin B12 were calculated using multivariable adjusted conditional logistic regression. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Incident PCa and subtype by stage and grade. RESULTS AND LIMITATIONS: Higher folate and vitamin B12 concentrations were associated with a small increase in risk of PCa (ORs for the top vs bottom fifths were 1.13 [95% confidence interval (CI), 1.02-1.26]},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15675,

title = {Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population},

author = {T Duarte-Salles and S Misra and M Stepien and A Plymoth and D Muller and K Overvad and A Olsen and A Tjonneland and L Baglietto and G Severi and M C Boutron-Ruault and R Turzanski-Fortner and R Kaaks and H Boeing and K Aleksandrova and A Trichopoulou and P Lagiou and C Bamia and V Pala and D Palli and A Mattiello and R Tumino and A Naccarati and H B Bueno-de-Mesquita and P H Peeters and E Weiderpass and J R Quiros and A Agudo and E Sanchez-Cantalejo and E Ardanaz and D Gavrila and M Dorronsoro and M Werner and O Hemmingsson and B Ohlsson and K Sjoberg and N J Wareham and K T Khaw and K E Bradbury and M J Gunter and A J Cross and E Riboli and M Jenab and P Hainaut and L Beretta},

doi = {10.1158/1940-6207.Capr-15-0434},

issn = {1940-6215},

year  = {2016},

date = {2016-01-01},

journal = {Cancer Prev Res (Phila)},

volume = {9},

number = {9},

pages = {758-65},

abstract = {We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated the association between prediagnostic circulating OPN levels and HCC incidence in a large population-based cohort. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. During a mean follow-up of 4.8 years, 100 HCC cases were identified. Each case was matched to two controls and OPN levels were measured in baseline plasma samples. Viral hepatitis, liver function, and alpha-fetoprotein (AFP) tests were also conducted. Conditional logistic regression models were used to calculate multivariable odds ratio (OR) and 95% confidence intervals (95% CI) for OPN levels in relation to HCC. Receiver operating characteristics curves were constructed to determine the discriminatory accuracy of OPN alone or in combination with other liver biomarkers in the prediction of HCC. OPN levels were positively associated with HCC risk (per 10% increment},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15687,

title = {Combined effects of smoking and HPV16 in oropharyngeal cancer},

author = {D Anantharaman and D C Muller and P Lagiou and W Ahrens and I Holcatova and F Merletti and K Kjaerheim and J Polesel and L Simonato and C Canova and X Castellsague and T V Macfarlane and A Znaor and P Thomson and M Robinson and D I Conway and C M Healy and A Tjonneland and U Westin and J Ekstrom and J Chang-Claude and R Kaaks and K Overvad and D Drogan and G Hallmans and G Laurell and H B Bueno-de-Mesquita and P H Peeters and A Agudo and N Larranaga and R C Travis and D Palli and A Barricarte and A Trichopoulou and S George and D Trichopoulos and J R Quiros and S Grioni and C Sacerdote and C Navarro and M J Sanchez and R Tumino and G Severi and M C Boutron-Ruault and F Clavel-Chapelon and S Panico and E Weiderpass and E Lund and I T Gram and E Riboli and M Pawlita and T Waterboer and A R Kreimer and M Johansson and P Brennan},

doi = {10.1093/ije/dyw069},

issn = {0300-5771},

year  = {2016},

date = {2016-01-01},

journal = {Int J Epidemiol},

volume = {45},

number = {3},

pages = {752-61},

abstract = {BACKGROUND: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood. METHODS: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multi-centre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression. RESULTS: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer. CONCLUSIONS: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15654,

title = {Comparing effects of soybean oil- and palm olein-based mayonnaise consumption on the plasma lipid and lipoprotein profiles in human subjects: a double-blind randomized controlled trial with cross-over design},

author = {T Karupaiah and K A Chuah and K Chinna and R Matsuoka and Y Masuda and K Sundram and M Sugano},

doi = {10.1186/s12944-016-0301-9},

issn = {1476-511x},

year  = {2016},

date = {2016-01-01},

journal = {Lipids Health Dis},

volume = {15},

number = {1},

pages = {131},

abstract = {BACKGROUND: Mayonnaise is used widely in contemporary human diet with widespread use as a salad dressing or spread on breads. Vegetable oils used in its formulation may be a rich source of omega-6 PUFAs and the higher-PUFA content of mayonnaise may be beneficial in mediating a hypocholesterolemic effect. This study, therefore, evaluated the functionality of mayonnaise on cardiometabolic risk within a regular human consumption scenario. METHODS: Subjects underwent a randomized double-blind crossover trial, consuming diets supplemented with 20 g/day of either soybean oil-based mayonnaise (SB-mayo) or palm olein-based mayonnaise (PO-mayo) for 4 weeks each with a 2-week wash-out period. The magnitude of changes for metabolic outcomes between dietary treatments was compared with PO-mayo serving as the control. The data was analyzed by ANCOVA using the GLM model. Analysis was adjusted for weight changes. RESULTS: Treatments resulted in significant reductions in TC (diff = -0.25 mmol/L; P = 0.001), LDL-C (diff = -0.17 mmol/L; P = 0.016) and HDL-C (diff = -0.12 mmol/L; P \< 0.001) in SB-mayo compared to PO-mayo without affecting LDL-C:HDL-C ratio (P \> 0.05). Lipoprotein particle change was significant with large LDL particles increasing after PO-mayo (diff = +63.2 nmol/L; P = 0.007) compared to SB-mayo but small LDL particles remained unaffected. Plasma glucose, apolipoproteins and oxidative stress markers remained unchanged. CONCLUSIONS: Daily use with 20 g of linoleic acid-rich SB-mayo elicited reductions in TC and LDL-C concentrations without significantly changing LDL-C:HDL-C ratio or small LDL particle distributions compared to the PO-mayo diet. TRIAL REGISTRATION: This clinical trial was retrospectively registered with the National Medical Research Register, National Institute of Health, Ministry of Health Malaysia, (NMRR-15-40-24035; registered on 29/01/2015; https://www.nmrr.gov.my/fwbPage.jsp?fwbPageId=ResearchISRForm\&fwbAction=Update\&fw bStep=10\&pk.researchID=24035\&fwbVMenu=3\&fwbResearchAction=Update ). Ethical approval was obtained from the National University of Malaysia's Medical Ethics Committee (UKM 1.5.3.5/244/SPP/NN-054-2011, approved on 25/05/2011).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15650,

title = {Comparing the mechanical strength of hip spica cast between a conventional and a new method of application},

author = {K L Wan and R Shanmugam and K Y Lee and A Saw},

doi = {10.1007/s11832-016-0770-4},

issn = {1863-2521 (Print) 

1863-2521},

year  = {2016},

date = {2016-01-01},

journal = {J Child Orthop},

volume = {10},

number = {5},

pages = {387-94},

abstract = {PURPOSE: The current technique of hip spica application is mostly based on a publication by Kumar (J Pediatr Orthop 1(1):97-99, 1981). We modified the technique of hip spica application in order to reduce the rate of breakage across the hip joint and designed this study to compare the strength between hip spica applied according to Kumar's technique and the new technique. METHODS: We created 12 hip spica casts with 24 hips according to Kumar's technique, and another 12 casts according to a new technique. The two types of spica were tested with a mechanical testing machine (Instron 3365 series) by using compression loading to failure in flexion, extension, abduction and adduction. Data were analysed in SPSS version 20.0. Comparison of means was done with an independent T test for normally distributed data and the Mann-Whitney test for skewed data. RESULTS: The new technique involved the creation of three slabs, instead of 14 slabs as described by Kumar. The loads to failure for hip spica cast applied according to the new technique were higher than those applied according to Kumar's technique, and the differences were statistically significant. The stiffness was also higher in spica casts applied with the new technique; the difference was not statistically significant under extension force. CONCLUSION: Hip spica applied with the new technique was stronger than that applied according to Kumar's technique based on load to failure testing. The new technique of application would potentially reduce the risk of cast breakage during the management of developmental dysplasia of the hip (DDH) and femur fracture in children.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15680,

title = {Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort},

author = {Y Lu and A J Cross and N Murphy and H Freisling and R C Travis and P Ferrari and V A Katzke and R Kaaks and A Olsson and I Johansson and F Renstrom and S Panico and V Pala and D Palli and R Tumino and P H Peeters and P D Siersema and H B Bueno-de-Mesquita and A Trichopoulou and E Klinaki and C Tsironis and A Agudo and C Navarro and M J Sanchez and A Barricarte and M C Boutron-Ruault and G Fagherazzi and A Racine and E Weiderpass and M J Gunter and E Riboli},

doi = {10.1007/s10552-016-0772-z},

issn = {0957-5243},

year  = {2016},

date = {2016-01-01},

journal = {Cancer Causes Control},

volume = {27},

number = {7},

pages = {919-27},

abstract = {BACKGROUND: The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC. METHODS: We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and abdominal obesity were assessed by body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression modeling was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Stratified analyses were conducted by sex, BMI, and smoking status. RESULTS: During an average of 13.9 years of follow-up, 131 incident cases of SIC (including 41 adenocarcinomas, 44 malignant carcinoid tumors, 15 sarcomas and 10 lymphomas, and 21 unknown histology) were identified. WC was positively associated with SIC in a crude model that also included BMI (HR per 5-cm increase = 1.20, 95 % CI 1.04, 1.39), but this association attenuated in the multivariable model (HR 1.18, 95 % CI 0.98, 1.42). However, the association between WC and SIC was strengthened when the analysis was restricted to adenocarcinoma of the small intestine (multivariable HR adjusted for BMI = 1.56, 95 % CI 1.11, 2.17). There were no other significant associations. CONCLUSION: WC, rather than BMI, may be positively associated with adenocarcinomas but not carcinoid tumors of the small intestine. IMPACT: Abdominal obesity is a potential risk factor for adenocarcinoma in the small intestine.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15754,

title = {Cross-Cultural Adaptation and Psychometric Properties of the Malay Version of the Short Sensory Profile},

author = {S I Ee and S Y Loh and K Chinna and M J Marret},

doi = {10.3109/01942638.2015.1040574},

issn = {0194-2638},

year  = {2016},

date = {2016-01-01},

journal = {Phys Occup Ther Pediatr},

volume = {36},

number = {2},

pages = {117-30},

abstract = {AIMS: To translate, culturally adapt, and examine psychometric properties of the Malay version Short Sensory Profile (SSP-M). METHODS: Pretesting (n = 30) of the original English SSP established its applicability for use with Malaysian children aged 3-10 years. This was followed by the translation and cross-cultural adaptation of the SSP-M. Two forward and two back translations were compared and reviewed by a committee of 10 experts who validated the content of the SSP-M, before pilot testing (n = 30). The final SSP-M questionnaire was completed by 419 parents of typically developing children aged 3-10 years. RESULTS: Cronbach's alpha of each section of the SSP-M ranged from 0.73 to 0.93 and the intraclass correlation coefficient (ICC) indicated good reliability (0.62-0.93). The seven factor model of the SSP-M had an adequate fit with evidence of convergent and discriminant validity. CONCLUSIONS: We conclude that the SSP-M is a valid and reliable screening tool for use in Malaysia with Malay-speaking parents of children aged 3-10 years. The SSP-M enables Malay-speaking parents to answer the questionnaire with better reliability, and provides occupational therapists with a valid tool to screen for sensory processing difficulties.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15701,

title = {Cyclical Patterns of Hand, Foot and Mouth Disease Caused by Enterovirus A71 in Malaysia},

author = {N NikNadia and I C Sam and S Rampal and W WanNorAmalina and G NurAtifah and K Verasahib and C C Ong and M MohdAdib and Y F Chan},

doi = {10.1371/journal.pntd.0004562},

issn = {1935-2727},

year  = {2016},

date = {2016-01-01},

journal = {PLoS Negl Trop Dis},

volume = {10},

number = {3},

pages = {e0004562},

abstract = {Enterovirus A71 (EV-A71) is an important emerging pathogen causing large epidemics of hand, foot and mouth disease (HFMD) in children. In Malaysia, since the first EV-A71 epidemic in 1997, recurrent cyclical epidemics have occurred every 2-3 years for reasons that remain unclear. We hypothesize that this cyclical pattern is due to changes in population immunity in children (measured as seroprevalence). Neutralizing antibody titers against EV-A71 were measured in 2,141 residual serum samples collected from children \</=12 years old between 1995 and 2012 to determine the seroprevalence of EV-A71. Reported national HFMD incidence was highest in children \<2 years, and decreased with age; in support of this, EV-A71 seroprevalence was significantly associated with age, indicating greater susceptibility in younger children. EV-A71 epidemics are also characterized by peaks of increased genetic diversity, often with genotype changes. Cross-sectional time series analysis was used to model the association between EV-A71 epidemic periods and EV-A71 seroprevalence adjusting for age and climatic variables (temperature, rainfall, rain days and ultraviolet radiance). A 10% increase in absolute monthly EV-A71 seroprevalence was associated with a 45% higher odds of an epidemic (adjusted odds ratio, aOR1.45; 95% CI 1.24-1.69; P\<0.001). Every 10% decrease in seroprevalence between preceding and current months was associated with a 16% higher odds of an epidemic (aOR = 1.16; CI 1.01-1.34 P\<0.034). In summary, the 2-3 year cyclical pattern of EV-A71 epidemics in Malaysia is mainly due to the fall of population immunity accompanying the accumulation of susceptible children between epidemics. This study will impact the future planning, timing and target populations for vaccine programs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15676,

title = {Dengue in Malaysia: Factors Associated with Dengue Mortality from a National Registry},

author = {S M Liew and E M Khoo and B K Ho and Y K Lee and M Omar and V Ayadurai and F Mohamed Yusoff and Z Suli and R N Mudin and P P Goh and K Chinna},

doi = {10.1371/journal.pone.0157631},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {6},

pages = {e0157631},

abstract = {BACKGROUND: The increasing incidence and geographical distribution of dengue has had significant impact on global healthcare services and resources. This study aimed to determine the factors associated with dengue-related mortality in a cohort of Malaysian patients. METHODS: This was a retrospective cohort study of patients in the Malaysian National Dengue Registry of 2013. The outcome measure was dengue-related mortality. Associations between sociodemographic and clinical variables with the outcome were analysed using multivariate analysis. RESULTS: There were 43 347 cases of which 13081 were serologically confirmed. The mean age was 30.0 years (SD 15.7); 60.2% were male. The incidence of dengue increased towards the later part of the calendar year. There were 92 probable dengue mortalities, of which 41 were serologically confirmed. Multivariate analysis in those with positive serology showed that increasing age (OR 1.03; CI:1.01-1.05), persistent vomiting (OR 13.34; CI: 1.92-92.95), bleeding (OR 5.84; CI 2.17-15.70) and severe plasma leakage (OR 66.68; CI: 9.13-487.23) were associated with mortality. Factors associated with probable dengue mortality were increasing age (OR 1.04; CI:1.03-1.06), female gender (OR 1.53; CI:1.01-2.33), nausea and/or vomiting (OR 1.80; CI:1.17-2.77), bleeding (OR 3.01; CI:1.29-7.04), lethargy and/or restlessness (OR 5.97; CI:2.26-15.78), severe plasma leakage (OR 14.72; CI:1.54-140.70), and shock (OR 1805.37; CI:125.44-25982.98), in the overall study population. CONCLUSIONS: Older persons and those with persistent vomiting, bleeding or severe plasma leakage, which were associated with mortality, at notification should be monitored closely and referred early if indicated. Doctors and primary care practitioners need to detect patients with dengue early before they develop these severe signs and symptoms.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15669,

title = {Depression and Associated Factors in Patients with Type 2 Diabetes Mellitus},

author = {N A Hashim and S Ariaratnam and M R Salleh and M A Said and A H Sulaiman},

issn = {2078-9947},

year  = {2016},

date = {2016-01-01},

journal = {East Asian Arch Psychiatry},

volume = {26},

number = {2},

pages = {77-82},

abstract = {OBJECTIVES: To determine the prevalence of major depressive disorder and its association with socio-demographic and clinical factors in patients with type 2 diabetes mellitus. METHODS: This was a cross-sectional study of patients with type 2 diabetes mellitus who attended the hospital-based primary care clinics at the University Malaya Medical Centre, Kuala Lumpur, Malaysia. The patients were interviewed using the Mini-International Neuropsychiatric Interview to diagnose depression based on the DSM-IV criteria. The socio-demographic and clinical data were obtained by interviewing the patients and subsequently verified against their respective case notes. RESULTS: A total of 204 patients were recruited. The prevalence of major depressive disorder was 15.7%. Major depressive disorder was significantly associated with younger age of patients (mean +/- standard deviation, 57.8 +/- 15.1 years},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15693,

title = {Descriptive Epidemiology of Somatising Tendency: Findings from the CUPID Study},

author = {S Vargas-Prada and D Coggon and G Ntani and K Walker-Bone and K T Palmer and V E Felli and R Harari and L H Barrero and S A Felknor and D Gimeno and A Cattrell and M Bonzini and E Solidaki and E Merisalu and R R Habib and F Sadeghian and M M Kadir and S S Warnakulasuriya and K Matsudaira and B Nyantumbu and M R Sim and H Harcombe and K Cox and L M Sarquis and M H Marziale and F Harari and R Freire and N Harari and M V Monroy and L A Quintana and M Rojas and E C Harris and C Serra and J M Martinez and G Delclos and F G Benavides and M Carugno and M M Ferrario and A C Pesatori and L Chatzi and P Bitsios and M Kogevinas and K Oha and T Freimann and A Sadeghian and R J Peiris-John and N Sathiakumar and A R Wickremasinghe and N Yoshimura and H L Kelsall and V C Hoe and D M Urquhart and S Derrett and D McBride and P Herbison and A Gray and E J Vega},

doi = {10.1371/journal.pone.0153748},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {4},

pages = {e0153748},

abstract = {Somatising tendency, defined as a predisposition to worry about common somatic symptoms, is importantly associated with various aspects of health and health-related behaviour, including musculoskeletal pain and associated disability. To explore its epidemiological characteristics, and how it can be specified most efficiently, we analysed data from an international longitudinal study. A baseline questionnaire, which included questions from the Brief Symptom Inventory about seven common symptoms, was completed by 12,072 participants aged 20-59 from 46 occupational groups in 18 countries (response rate 70%). The seven symptoms were all mutually associated (odds ratios for pairwise associations 3.4 to 9.3), and each contributed to a measure of somatising tendency that exhibited an exposure-response relationship both with multi-site pain (prevalence rate ratios up to six), and also with sickness absence for non-musculoskeletal reasons. In most participants, the level of somatising tendency was little changed when reassessed after a mean interval of 14 months (75% having a change of 0 or 1 in their symptom count), although the specific symptoms reported at follow-up often differed from those at baseline. Somatising tendency was more common in women than men, especially at older ages, and varied markedly across the 46 occupational groups studied, with higher rates in South and Central America. It was weakly associated with smoking, but not with level of education. Our study supports the use of questions from the Brief Symptom Inventory as a method for measuring somatising tendency, and suggests that in adults of working age, it is a fairly stable trait.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15632,

title = {Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents},

author = {J C Ling and M N Mohamed and M Y Jalaludin and S Rampal and N L Zaharan and Z Mohamed},

doi = {10.1038/srep36270},

issn = {2045-2322},

year  = {2016},

date = {2016-01-01},

journal = {Sci Rep},

volume = {6},

pages = {36270},

abstract = {Hyperinsulinaemia is the earliest subclinical metabolic abnormality, which precedes insulin resistance in obese children. An investigation was conducted on the potential predictors of fasting insulin and insulin resistance among overweight/obese adolescents in a developing Asian country. A total of 173 overweight/obese (BMI \> 85(th) percentile) multi-ethnic Malaysian adolescents aged 13 were recruited from 23 randomly selected schools in this cross-sectional study. Waist circumference (WC), body fat percentage (BF%), physical fitness score (PFS), fasting glucose and fasting insulin were measured. Insulin resistance was calculated using homeostasis model assessment of insulin resistance (HOMA-IR). Adjusted stepwise multiple regression analysis was performed to predict fasting insulin and HOMA-IR. Covariates included pubertal stage, socioeconomic status, nutritional and physical activity scores. One-third of our adolescents were insulin resistant, with girls having significantly higher fasting insulin and HOMA-IR than boys. Gender, pubertal stage, BMI, WC and BF% had significant, positive moderate correlations with fasting insulin and HOMA-IR while PFS was inversely correlated (p \< 0.05). Fasting insulin was primarily predicted by gender-girls (Beta = 0.305, p \< 0.0001), higher BMI (Beta = -0.254},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15705,

title = {Dialysis Malnutrition and Malnutrition Inflammation Scores: screening tools for prediction of dialysis-related protein-energy wasting in Malaysia},

author = {G S Harvinder and W C Swee and T Karupaiah and S Sahathevan and K Chinna and G Ahmad and S Bavanandan and B L Goh},

doi = {10.6133/apjcn.2016.25.1.01},

issn = {0964-7058 (Print) 

0964-7058},

year  = {2016},

date = {2016-01-01},

journal = {Asia Pac J Clin Nutr},

volume = {25},

number = {1},

pages = {26-33},

abstract = {BACKGROUND AND OBJECTIVES: Malnutrition is highly prevalent in Malaysian dialysis patients and there is a need for a valid screening tool for early identification and management. This cross-sectional study aims to examine the sensitivity of the Dialysis Malnutrition Score (DMS) and Malnutrition Inflammation Score (MIS) tools in predicting protein-energy wasting (PEW) among Malaysian dialysis patients. METHODS AND STUDY DESIGN: A total of 155 haemodialysis (HD) and 90 peritoneal dialysis (PD) patients were screened for risk of malnutrition using DMS and MIS and comparisons were made with established guidelines by International Society of Renal Nutrition and Metabolism (ISRNM) for PEW. RESULTS: MIS cut-off score of \>=5 indicated presence of malnutrition in all patients. A total of 59% of HD and 83% of PD patients had PEW by ISRNM criteria. Based on DMS, 73% of HD and 71% of PD patients exhibited moderate malnutrition, whilst using MIS, 88% and 90%, respectively were malnourished. DMS and MIS correlated significantly in HD (r2=0.552, p\<0.001) and PD (r2=0.466, p\<0.001) patients. DMS and MIS had higher sensitivity values in PD (81% and 82%, respectively) compared to HD (59% and 60%, respectively) patients. CONCLUSIONS: The MIS cut-off scores for malnutrition classification were established (score \>=5) for use amongst Malaysian dialysis patients. Both DMS and MIS are valid tools to be used for nutrition screening of dialysis patients especially those undergoing peritoneal dialysis. The DMS may be a more practical and simpler tool to be utilized in the Malaysian dialysis settings as it does not require laboratory markers.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15688,

title = {Dietary Intake among Adolescents in a Middle-Income Country: An Outcome from the Malaysian Health and Adolescents Longitudinal Research Team Study (the MyHeARTs Study)},

author = {H Abdul Majid and L Ramli and S P Ying and T T Su and M Y Jalaludin and N A Abdul Mohsein},

doi = {10.1371/journal.pone.0155447},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {5},

pages = {e0155447},

abstract = {Optimal nutrition is essential for healthy growth during adolescence. This study aims to investigate the baseline nutritional intake of Malaysian adolescents by gender, body mass index, and places of residence, both urban and rural. A cohort study was conducted consisting of 794 adolescents (aged 13-years) attending 15 public secondary schools from the Central (Kuala Lumpur and Selangor) and Northern (Perak) Regions of Peninsular Malaysia. Qualified dietitians conducted a 7-day historical assessment of habitual food intakes. Facilitated by flipcharts and household measurement tools, detailed information on portion sizes and meal contents were recorded. Nutritionist Pro Diet Analysis software was also used to analyze the dietary records.The mean age of the adolescents was 12.86 +/- 0.33 y; the mean energy intake was 1659.0 +/- 329.6 kcal/d. Males had significantly (P \< .001) higher energy intake than females (1774.0 +/- 369.8 vs 1595.2 +/- 320.6 kcal/d); adolescents in rural schools consumed more energy and cholesterol (P \< .001) compared to adolescents in urban schools (1706.1 +/- 377.7 kcal/d and 244.1 +/- 100.2 mg/d, respectively). Obese adolescents in rural schools consumed more energy and sugar (1987.6 +/- 374.0 kcal/d and 48.9 +/- 23.0 g/d) (p-value \<0.001).The dietary intake of normal weight versus obese adolescents differs by the location of their school. Thus, the implementation of a structured and tailored intervention is recommended to help minimize this nutritional inequality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15726,

title = {Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study},

author = {A Racine and F Carbonnel and S S Chan and A R Hart and H B Bueno-de-Mesquita and B Oldenburg and F D Schaik and A Tjonneland and A Olsen and C C Dahm and T Key and R Luben and K T Khaw and E Riboli and O Grip and S Lindgren and G Hallmans and P Karling and F Clavel-Chapelon and M M Bergman and H Boeing and R Kaaks and V A Katzke and D Palli and G Masala and P Jantchou and M C Boutron-Ruault},

doi = {10.1097/mib.0000000000000638},

issn = {1078-0998},

year  = {2016},

date = {2016-01-01},

journal = {Inflamm Bowel Dis},

volume = {22},

number = {2},

pages = {345-54},

abstract = {BACKGROUND: Specific nutrients or foods have been inconsistently associated with ulcerative colitis (UC) or Crohn's disease (CD) risks. Thus, we investigated associations between diet as a whole, as dietary patterns, and UC and CD risks. METHODS: Within the prospective EPIC (European Prospective Investigation into Cancer) study, we set up a nested matched case-control study among 366,351 participants with inflammatory bowel disease data, including 256 incident cases of UC and 117 of CD, and 4 matched controls per case. Dietary intake was recorded at baseline from validated food frequency questionnaires. Incidence rate ratios of developing UC and CD were calculated for quintiles of the Mediterranean diet score and a posteriori dietary patterns produced by factor analysis. RESULTS: No dietary pattern was associated with either UC or CD risks. However, when excluding cases occurring within the first 2 years after dietary assessment, there was a positive association between a "high sugar and soft drinks" pattern and UC risk (incidence rate ratios for the fifth versus first quintile, 1.68 [1.00-2.82]; Ptrend = 0.02). When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes. CONCLUSIONS: A diet imbalance with high consumption of sugar and soft drinks and low consumption of vegetables was associated with UC risk. Further studies are needed to investigate whether microbiota alterations or other mechanisms mediate this association.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15777,

title = {Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study},

author = {R Zamora-Ros and V Knaze and J A Rothwell and B Hemon and A Moskal and K Overvad and A Tjonneland and C Kyro and G Fagherazzi and M C Boutron-Ruault and M Touillaud and V Katzke and T Kuhn and H Boeing and J Forster and A Trichopoulou and E Valanou and E Peppa and D Palli and C Agnoli and F Ricceri and R Tumino and M S Magistris and P H Peeters and H B Bueno-de-Mesquita and D Engeset and G Skeie and A Hjartaker and V Menendez and A Agudo and E Molina-Montes and J M Huerta and A Barricarte and P Amiano and E Sonestedt and L M Nilsson and R Landberg and T J Key and K T Khaw and N J Wareham and Y Lu and N Slimani and I Romieu and E Riboli and A Scalbert},

doi = {10.1007/s00394-015-0950-x},

issn = {1436-6207},

year  = {2016},

date = {2016-01-01},

journal = {Eur J Nutr},

volume = {55},

number = {4},

pages = {1359-75},

abstract = {BACKGROUND/OBJECTIVES: Polyphenols are plant secondary metabolites with a large variability in their chemical structure and dietary occurrence that have been associated with some protective effects against several chronic diseases. To date, limited data exist on intake of polyphenols in populations. The current cross-sectional analysis aimed at estimating dietary intakes of all currently known individual polyphenols and total intake per class and subclass, and to identify their main food sources in the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Dietary data at baseline were collected using a standardized 24-h dietary recall software administered to 36,037 adult subjects. Dietary data were linked with Phenol-Explorer, a database with data on 502 individual polyphenols in 452 foods and data on polyphenol losses due to cooking and food processing. RESULTS: Mean total polyphenol intake was the highest in Aarhus-Denmark (1786 mg/day in men and 1626 mg/day in women) and the lowest in Greece (744 mg/day in men and 584 mg/day in women). When dividing the subjects into three regions, the highest intake of total polyphenols was observed in the UK health-conscious group, followed by non-Mediterranean (non-MED) and MED countries. The main polyphenol contributors were phenolic acids (52.5-56.9 %), except in men from MED countries and in the UK health-conscious group where they were flavonoids (49.1-61.7 %). Coffee, tea, and fruits were the most important food sources of total polyphenols. A total of 437 different individual polyphenols were consumed, including 94 consumed at a level \>1 mg/day. The most abundant ones were the caffeoylquinic acids and the proanthocyanidin oligomers and polymers. CONCLUSION: This study describes the large number of dietary individual polyphenols consumed and the high variability of their intakes between European populations, particularly between MED and non-MED countries.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15659,

title = {Different patterns of pfcrt and pfmdr1 polymorphism in Plasmodium falciparum isolates from Tehama region, Yemen},

author = {W M Atroosh and H M Al-Mekhlafi and A Al-Jasari and H Sady and S S Dawaki and F N Elyana and M A Al-Areeqi and N A Nasr and A M Abdulsalam and L R Subramaniam and M Azzani and I Ithoi and Y L Lau and J Surin},

doi = {10.7717/peerj.2191},

issn = {2167-8359 (Print)},

year  = {2016},

date = {2016-01-01},

journal = {PeerJ},

volume = {4},

pages = {e2191},

abstract = {Introduction. Despite the efforts of the malaria control programme, malaria morbidity is still a common health problem in Yemen, with 60% of the population at risk. Plasmodium falciparum is responsible for 99% of malaria cases. The emergence in Yemen of parasite resistance to chloroquine (CQ) prompted the adoption of artemisinin combination therapy (ACT) in 2009, which involves the use of artesunate plus sulphadoxine-pyrimethamine (AS + SP). However, CQ was retained as the drug of choice for vivax malaria. To assess the impact of the change in the malaria treatment policy five years after its introduction, the present study investigated the mutations in the CQ resistance transporter (pfcrt) and multidrug resistance 1 (pfmdr1) genes. Method. A molecular investigation of 10 codons of pfcrt (72-76, 220, 271, 326, 356, and 371) and five codons of pfmdr1 (86, 184, 1034, 1042, and 1246) was conducted on P. falciparum isolates from districts with the highest malaria endemicity in the Hodeidah and Al-Mahwit governorates in Tehama region, Yemen. A total of 86 positive cases of falciparum monoinfection were investigated for the presence of mutations related to CQ and other antimalarials using a PCR-RFLP assay. Results. There was a wide prevalence of pfcrt gene mutations with the pfcrt 76T CQ resistance marker being predominant (97.7%). The prevalence of other pfcrt mutations varied from high (75E: 88%) to moderate (74I: 79.1%, 220S: 69.8%, 271E and 371I: 53.5%) or low (326S: 36%, 72S: 10.5%). Mutated pfcrt 72-76 amino acids haplotypes were highly prevalent (98.8%). Among these, the CVIET classic, old-world African/Southeast Asian haplotype was the most predominant, and was mostly found in the isolates from the Khamis Bani Saad district of Al-Mahwit (93.1%) and the AdDahi district of Hodeidah (88.9%). However, it was only found in 26.3% of the isolates from the Bajil district of Hodeidah. Surprisingly, the SVMNT new-world South American haplotype was exclusively detected in 9.3% of the isolates from the Bajil district of Hodeidah. Mutations at Y184F of pfmdr1 were found in all isolates (100%) from all districts. The mutation for codons 1034C and 86Y were found only in the isolates from the AdDahi and Khamis Bani Saad districts. Overall, the AdDahi and Khamis Bani Saad districts were similar in terms of carrying most of the mutations in the pfcrt and pfmdr1 genes, while there was a lower prevalence of mutation in the isolates from the Bajil district. Conclusion. The high prevalence of mutations in pfcrt 5 years after the official cessation of CQ use against P. falciparum suggests that there is sustained CQ pressure on P. falciparum isolates in the study area. Moreover, the low prevalence of mutations in the pfmdr1 gene could be a good indicator of the high susceptibility of P. falciparum isolates to antimalarials other than CQ. A new strategy to ensure the complete nationwide withdrawal of CQ from the private drug market is recommended.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15725,

title = {Effectiveness of progressive muscle relaxation therapy as a worksite health promotion program in the automobile assembly line},

author = {B M Sundram and M Dahlui and K Chinna},

doi = {10.2486/indhealth.2014-0091},

issn = {0019-8366},

year  = {2016},

date = {2016-01-01},

journal = {Ind Health},

volume = {54},

number = {3},

pages = {204-14},

abstract = {The aim of this study was to examine the effectiveness of Progressive Muscle Relaxation (PMR) as part of a Worksite Health Promotion Program on self-perceived stress, anxiety and depression among male automotive assembly-line workers through a quasi-experimental trial. Two assembly plants were chosen with one receiving PMR therapy and the other Pamphlets. Intention-to-treat analysis was conducted to test the effectiveness of the relaxation therapy. Stress, Depression and Anxiety levels were measured using the shortened DASS-21 questionnaire. Data were analyzed using Chi-square, Independent sample t test and Repeated-measures analysis of variance to test the significance of the effects of intervention (time * group) for the measures of Stress, Depression and Anxiety. Significant favourable intervention effects on stress were found in the PMR group (Effect size=0.6) as compared to the Pamphlet group (Effect size=0.2). There was a significant group *time interaction effect (p\<0.001) on Stress levels. Depression and Anxiety levels were minimal at baseline in both the groups with mild or no reduction in levels. The improvement in stress levels showed the potential of PMR therapy as a coping strategy at the workplace. Further research in this field is necessary to examine the beneficial effects of coping strategies in the workplace.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15624,

title = {Effects of a Community-Based Healthy Lifestyle Intervention Program (Co-HELP) among Adults with Prediabetes in a Developing Country: A Quasi-Experimental Study},

author = {N Ibrahim and F Ming Moy and I A Awalludin and Z Mohd Ali and I S Ismail},

doi = {10.1371/journal.pone.0167123},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {12},

pages = {e0167123},

abstract = {BACKGROUND: The prevalence of type 2 diabetes among Malaysian adults has increased by more than two folds over the past two decades. Strategies to collaborate with the existing community partners may become a promising channel for wide-scale dissemination of diabetes prevention in the country. The objectives of this study were to determine the effects of community-based lifestyle interventions delivered to adults with prediabetes and their health-related quality of life as compared to the usual care group. METHODS: This was a quasi-experimental study conducted in two sub-urban communities in Seremban, Malaysia. A total of 268 participants with prediabetes aged between 18 to 65 years old were assigned to either the community-based lifestyle intervention (Co-HELP) (n = 122) or the usual care (n = 146) groups. The Co-HELP program was delivered in partnership with the existing community volunteers to incorporate diet, physical activity, and behaviour modification strategies. Participants in the Co-HELP group received twelve group-based sessions and two individual counselling to reinforce behavioural change. Participants in the usual care group received standard health education from primary health providers in the clinic setting. Primary outcomes were fasting blood glucose, 2-hour plasma glucose, and HbA1C. Secondary outcomes included weight, BMI, waist circumference, total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, systolic and diastolic blood pressure, physical activity, diet, and health-related quality of life (HRQOL). RESULTS: An intention-to-treat analysis of between-groups at 12-month (mean difference, 95% CI) revealed that the Co-HELP participants' mean fasting plasma glucose reduced by -0.40 mmol/l (-0.51 to -0.28, p\<0.001), 2-hour post glucose by -0.58 mmol/l (-0.91 to -0.24, p\<0.001), HbA1C by -0.24% (-0.34 to -0.15, p\<0.001), diastolic blood pressure by -2.63 mmHg (-3.79 to -1.48, p\<0.01), and waist circumference by -2.44 cm (-4.75 to -0.12, p\<0.05) whereas HDL cholesterol increased by 0.12 mmol/l (0.05 to 0.13, p\<0.01), compared to the usual care group. Significant improvements were also found in HRQOL for both physical component (PCS) by 6.51 points (5.21 to 7.80, p\<0.001) and mental component (MCS) by 7.79 points (6.44 to 9.14, p\<0.001). Greater proportion of participants from the Co-HELP group met the clinical recommended target of 5% or more weight loss from the initial weight (24.6% vs 3.4%, p\<0.001) and physical activity of \>600 METS/min/wk (60.7% vs 32.2%, p\<0.001) compared to the usual care group. CONCLUSIONS: This study provides evidence that a culturally adapted diabetes prevention program can be implemented in the community setting, with reduction of several diabetes risk factors and improvement of HRQOL. Collaboration with existing community partners demonstrated a promising channel for the wide-scale dissemination of diabetes prevention at the community level. Further studies are required to determine whether similar outcomes could be achieved in communities with different socioeconomic backgrounds and geographical areas. TRIAL REGISTRATION: IRCT201104106163N1.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15684,

title = {Elder mistreatment in a community dwelling population: the Malaysian Elder Mistreatment Project (MAESTRO) cohort study protocol},

author = {W Y Choo and N N Hairi and R Sooryanarayana and R M Yunus and F M Hairi and N Ismail and S Kandiben and Z Mohd Ali and S N Ahmad and I Abdul Razak and S Othman and M P Tan and F H Mydin and D Peramalah and P Brownell and A Bulgiba},

doi = {10.1136/bmjopen-2016-011057},

issn = {2044-6055},

year  = {2016},

date = {2016-01-01},

journal = {BMJ Open},

volume = {6},

number = {5},

pages = {e011057},

abstract = {INTRODUCTION: Despite being now recognised as a global health concern, there is still an inadequate amount of research into elder mistreatment, especially in low and middle-income regions. The purpose of this paper is to report on the design and methodology of a population-based cohort study on elder mistreatment among the older Malaysian population. The study aims at gathering data and evidence to estimate the prevalence and incidence of elder mistreatment, identify its individual, familial and social determinants, and quantify its health consequences. METHODS AND ANALYSIS: This is a community-based prospective cohort study using randomly selected households from the national census. A multistage sampling method was employed to obtain a total of 2496 older adults living in the rural Kuala Pilah district. The study is divided into two phases: cross-sectional study (baseline), and a longitudinal follow-up study at the third and fifth years. Elder mistreatment was measured using instrument derived from the previous literature and modified Conflict Tactic Scales. Outcomes of elder mistreatment include mortality, physical function, mental health, quality of life and health utilisation. Logistic regression models are used to examine the relationship between risk factors and abuse estimates. Cox proportional hazard regression will be used to estimate risk of mortality associated with abuse. Associated annual rate of hospitalisation and health visit frequency, and reporting of abuse, will be estimated using Poisson regression. ETHICS AND DISSEMINATION: The study has been approved by the Medical Ethics Committee of the University of Malaya Medical Center (MEC Ref 902.2) and the Malaysian National Medical Research Register (NMRR-12-1444-11726). Written consent was obtained from all respondents prior to baseline assessment and subsequent follow-up. Findings will be disseminated to local stakeholders via forums with community leaders, and health and social welfare departments, and published in appropriate scientific journals and presented at conferences.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15766,

title = {Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study},

author = {R Zamora-Ros and S Rinaldi and K K Tsilidis and E Weiderpass and M C Boutron-Ruault and A L Rostgaard-Hansen and A Tjonneland and F Clavel-Chapelon and S Mesrine and V A Katzke and T Kuhn and J Forster and H Boeing and A Trichopoulou and P Lagiou and E Klinaki and G Masala and S Sieri and F Ricceri and R Tumino and A Mattiello and P H Peeters and H B Bueno-de-Mesquita and D Engeset and G Skeie and M Arguelles and A Agudo and M J Sanchez and M D Chirlaque and A Barricarte and S Chamosa and M Almquist and A Tosovic and J Hennings and M Sandstrom and J A Schmidt and K T Khaw and N J Wareham and A J Cross and N Slimani and G Byrnes and I Romieu and E Riboli and S Franceschi},

doi = {10.1002/ijc.29693},

issn = {0020-7136},

year  = {2016},

date = {2016-01-01},

journal = {Int J Cancer},

volume = {138},

number = {1},

pages = {65-73},

abstract = {Incidence rates of differentiated thyroid carcinoma (TC) have increased in many countries. Adiposity and dietary risk factors may play a role, but little is known on the influence of energy intake and macronutrient composition. The aim of this study was to investigate the associations between TC and the intake of energy, macronutrients, glycemic index (GI) and glycemic load in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,274 middle-age participants (70.2% women) from ten European countries. Dietary data were collected using country-specific validated dietary questionnaires. Total carbohydrates, proteins, fats, saturated, monounsaturated and polyunsaturated fats (PUFA), starch, sugar, and fiber were computed as g/1,000 kcal. Multivariable Cox regression was used to calculate multivariable adjusted hazard ratios (HR) and 95% confidence interval (CI) by intake quartile (Q). After a mean follow-up time of 11 years, differentiated TC was diagnosed in 556 participants (90% women). Overall, we found significant associations only with total energy (HRQ4 vs .Q1 , 1.29; 95% CI, 1.00-1.68) and PUFA intakes (HRQ4 vs .Q1 , 0.74; 95% CI, 0.57-0.95). However, the associations with starch and sugar intake and GI were significantly heterogeneous across body mass index (BMI) groups, i.e., positive associations with starch and GI were found in participants with a BMI \>/= 25 and with sugar intake in those with BMI \< 25. Moreover, inverse associations with starch and GI were observed in subjects with BMI \< 25. In conclusion, our results suggest that high total energy and low PUFA intakes may increase the risk of differentiated TC. Positive associations with starch intake and GI in participants with BMI \>/= 25 suggest that those persons may have a greater insulin response to high starch intake and GI than lean people.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15627,

title = {Ethnic differences in the prevalence of knee pain among adults of a community in a cross-sectional study},

author = {Y C Chia and H C Beh and C J Ng and C L Teng and N S Hanafi and W Y Choo and S M Ching},

doi = {10.1136/bmjopen-2016-011925},

issn = {2044-6055},

year  = {2016},

date = {2016-01-01},

journal = {BMJ Open},

volume = {6},

number = {12},

pages = {e011925},

abstract = {OBJECTIVE: To determine the prevalence of knee pain among 3 major ethnic groups in Malaysia. By identifying high-risk groups, preventive measures can be targeted at these populations. DESIGN AND SETTING: A cross-sectional survey was carried out in rural and urban areas in a state in Malaysia. Secondary schools were randomly selected and used as sampling units. PARTICIPANTS: Adults aged \>/=18 years old were invited to answer a self-administered questionnaire on pain experienced over the previous 6 months. Out of 9300 questionnaires distributed, 5206 were returned and 150 participants who did not fall into the 3 ethnic groups were excluded, yielding a total of 5056 questionnaires for analysis. 58.2% (n=2926) were women. 50% (n=2512) were Malays, 41.4% (n=2079) were Chinese and 8.6% (n=434) were Indians. RESULTS: 21.1% (n=1069) had knee pain during the previous 6 months. More Indians (31.8%) experienced knee pain compared with Malays (24.3%) and Chinese (15%) (p\<0.001). The odds of Indian women reporting knee pain was twofold higher compared with Malay women. There was a rising trend in the prevalence of knee pain with increasing age (p\<0.001). The association between age and knee pain appeared to be stronger in women than men. 68.1% of Indians used analgesia for knee pain while 75.4% of Malays and 52.1% of Chinese did so (p\<0.001). The most common analgesic used for knee pain across all groups was topical medicated oil (43.7%). CONCLUSIONS: The prevalence of knee pain in adults was more common in Indian women and older women age groups and Chinese men had the lowest prevalence of knee pain. Further studies should investigate the reasons for these differences.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15661,

title = {Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case-Control Study},

author = {J L Opstelten and R M J Beelen and M Leenders and G Hoek and B Brunekreef and F D M Schaik and P D Siersema and K T Eriksen and O Raaschou-Nielsen and A Tjonneland and K Overvad and M C Boutron-Ruault and F Carbonnel and K Hoogh and T J Key and R Luben and S S M Chan and A R Hart and H B Bueno-de-Mesquita and B Oldenburg},

doi = {10.1007/s10620-016-4249-4},

issn = {0163-2116},

year  = {2016},

date = {2016-01-01},

journal = {Dig Dis Sci},

volume = {61},

number = {10},

pages = {2963-2971},

abstract = {BACKGROUND: Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). AIM: We investigated the association between air pollution exposure and IBD. METHODS: The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn's disease (CD) (n = 38) and ulcerative colitis (UC) (n = 104) and controls (n = 568) from Denmark, France, the Netherlands, and the UK, matched for center, gender, age, and date of recruitment. Air pollution data were obtained from the European Study of Cohorts for Air Pollution Effects. Residential exposure was assessed with land-use regression models for particulate matter with diameters of \<10 mum (PM10), \<2.5 mum (PM2.5), and between 2.5 and 10 mum (PMcoarse), soot (PM2.5 absorbance), nitrogen oxides, and two traffic indicators. Conditional logistic regression analyses were performed to calculate odds ratios (ORs) with 95 % confidence intervals (CIs). RESULTS: Although air pollution was not significantly associated with CD or UC separately, the associations were mostly similar. Individuals with IBD were less likely to have higher exposure levels of PM2.5 and PM10, with ORs of 0.24 (95 % CI 0.07-0.81) per 5 mug/m(3) and 0.25 (95 % CI 0.08-0.78) per 10 mug/m(3), respectively. There was an inverse but nonsignificant association for PMcoarse. A higher nearby traffic load was positively associated with IBD [OR 1.60 (95 % CI 1.04-2.46) per 4,000,000 motor vehicles x m per day]. Other air pollutants were positively but not significantly associated with IBD. CONCLUSION: Exposure to air pollution was not found to be consistently associated with IBD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15683,

title = {Exposure to Famine at a Young Age and Unhealthy Lifestyle Behavior Later in Life},

author = {H P Fransen and P H Peeters and J W Beulens and J M Boer and G A Wit and N C Onland-Moret and Y T Schouw and H B Bueno-de-Mesquita and J Hoekstra and S G Elias and A M May},

doi = {10.1371/journal.pone.0156609},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {5},

pages = {e0156609},

abstract = {BACKGROUND: A healthy diet is important for normal growth and development. Exposure to undernutrition during important developmental periods such as childhood and adolescence can have effects later in life. Inhabitants of the west of the Netherlands were exposed to severe undernutrition during the famine in the last winter of the second World War (1944-1945). OBJECTIVE: We investigated if exposure of women to the Dutch famine during childhood and adolescence was associated with an unhealthy lifestyle later in life. DESIGN: We studied 7,525 women from the Prospect-EPIC cohort, recruited in 1993-97 and aged 0-18 years during the Dutch famine. An individual famine score was calculated based on self-reported information about experience of hunger and weight loss. We investigated the association between famine exposure in early life and four lifestyle factors in adulthood: smoking, alcohol consumption, physical activity level and a Mediterranean-style diet. RESULTS: Of the 7,525 included women, 46% were unexposed, 38% moderately exposed and 16% severely exposed to the Dutch famine. Moderately and severely exposed women were more often former or current smokers compared to women that did not suffer from the famine: adjusted prevalence ratio 1.10 (95% CI: 1.05; 1.14) and 1.18 (1.12; 1.25), respectively. They also smoked more pack years than unexposed women. Severely exposed women were more often physically inactive than unexposed women, adjusted prevalence ratio 1.32 (1.06; 1.64). Results did not differ between exposure age categories (0-9 and 10-17 years). We found no associations of famine exposure with alcohol consumption and no dose-dependent relations with diet. CONCLUSIONS: Exposure to famine early in female life may be associated with higher prevalence of smoking and physical inactivity later in life, but not with unhealthy diet and alcohol consumption.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15703,

title = {Factors affecting Japanese retirees' healthcare service utilisation in Malaysia: a qualitative study},

author = {A Kohno and N D Nik Farid and G Musa and N Abdul Aziz and T Nakayama and M Dahlui},

doi = {10.1136/bmjopen-2015-010668},

issn = {2044-6055},

year  = {2016},

date = {2016-01-01},

journal = {BMJ Open},

volume = {6},

number = {3},

pages = {e010668},

abstract = {OBJECTIVE: While living overseas in another culture, retirees need to adapt to a new environment but often this causes difficulties, particularly among those elderly who require healthcare services. This study examines factors affecting healthcare service utilisation among Japanese retirees in Malaysia. DESIGN: We conducted 6 focus group discussions with Japanese retirees and interviewed 8 relevant medical services providers in-depth. Guided by the Andersen Healthcare Utilisation Model, we managed and analysed the data, using QSR NVivo 10 software and the directed content analysis method. SETTING: We interviewed participants at Japan Clubs and their offices. PARTICIPANTS: 30 Japanese retirees who live in Kuala Lumpur and Ipoh, and 8 medical services providers. RESULTS: We identified health beliefs, medical symptoms and health insurance as the 3 most important themes, respectively, representing the 3 dimensions within the Andersen Healthcare Utilisation Model. Additionally, language barriers, voluntary health repatriation to Japan and psychological support were unique themes that influence healthcare service utilisation among Japanese retirees. CONCLUSIONS: The healthcare service utilisation among Japanese retirees in Malaysia could be partially explained by the Andersen Healthcare Utilisation Model, together with some factors that were unique findings to this study. Healthcare service utilisation among Japanese retirees in Malaysia could be improved by alleviating negative health beliefs through awareness programmes for Japanese retirees about the healthcare systems and cultural aspects of medical care in Malaysia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15637,

title = {Factors affecting the employability in people with epilepsy},

author = {M C Wo and K S Lim and W Y Choo and C T Tan},

doi = {10.1016/j.eplepsyres.2016.10.003},

issn = {0920-1211},

year  = {2016},

date = {2016-01-01},

journal = {Epilepsy Res},

volume = {128},

pages = {6-11},

abstract = {PURPOSE: People with epilepsy (PWE) are negatively prejudiced in their ability to work. This study aimed to examine demographic, clinical and psychological factors associated with employability in PWE. METHODS: This study recruited epilepsy patients from a neurology clinic in Malaysia. Employability was measured using employment ratio, with a ratio \>/=90% (ER90) classified as high employability. Basic demographic data such as age, gender, marital status, religion, education level and household income was collected. Clinical measures consisted of age of seizure onset, seizure frequency, type of epilepsy, aura, polytherapy, nocturnal seizures and seizure control. Psychological measures included Work Self-Determination Index (WSDI), Rosenberg Self-Esteem Scale (SES), and Multidimensional Scale of Perceived Social Support (MSPSS). RESULTS: Of 146 PWE, 64.4% had high employability. The participants were predominantly female (52%), Chinese (50.7%), single (50%), having tertiary education (55.5%) and focal epilepsy (72.6%). Clinically, only type of epilepsy was significantly correlated to employability of PWE. Employability of PWE was associated with ability to work (indicated by education level, work performance affected by seizures, ability to travel independently and ability to cope with stress at work) and family overprotection. The high employability group was found to have lower self-perceived stigma (ESS), higher self-determined motivation (WSDI), self-esteem (SES) and perceived social support (MSPSS), than the low employability group. Logistic regression analysis showed that tertiary education level (AOR 3.42, CI: 1.46-8.00), higher self-determination (WSDI, AOR 1.09, CI: 1.012-1.17), lower family overprotection (AOR 0.76, CI: 0.61-0.95), and generalised epilepsy (AOR 4.17, CI: 1.37-12.70) were significant predictors for higher employability in PWE. CONCLUSION: Ability to work (education level), clinical factor (type of epilepsy) and psychological factor (self-determined motivation and family overprotection) were important factors affecting employability in PWE.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15674,

title = {Factors Associated with Tick Bite Preventive Practices among Farmworkers in Malaysia},

author = {M Ghane Kisomi and L P Wong and S T Tay and A Bulgiba and K Zandi and K L Kho and F X Koh and B L Ong and T Jaafar and Q N Hassan Nizam},

doi = {10.1371/journal.pone.0157987},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {6},

pages = {e0157987},

abstract = {BACKGROUND: Farmworkers are at high-risk for tick bites, which potentially transmit various tick-borne diseases. Previous studies show that personal prevention against tick bites is key, and certain factors namely, knowledge, experience of tick bites, and health beliefs influence compliance with tick bites preventive behaviour. This study aimed to assess these factors and their associations with tick bite preventive practices among Malaysian farmworkers. METHODS: A total of eight cattle, goat and sheep farms in six states in Peninsular Malaysia participated in a cross-sectional survey between August and October 2013. RESULTS: A total of 151 (72.2%) out of 209 farmworkers answered the questionnaire. More than half of the farmworkers (n = 91) reported an experience of tick bites. Farms with monthly acaricide treatment had significantly (P\<0.05) a low report of tick bites. Tick bite exposure rates did not differ significantly among field workers and administrative workers. The mean total knowledge score of ticks for the overall farmworkers was 13.6 (SD+/-3.2) from 20. The mean total tick bite preventive practices score for all farmworkers was 8.3 (SD+/-3.1) from 15. Fixed effect model showed the effects of four factors on tick bite prevention: (1) farms, (2) job categories (administrative workers vs. field workers), (3) perceived severity of tick bites, and (4) perceived barriers to tick bite prevention. CONCLUSIONS: A high proportion of farmworkers, including administrative workers, reported an experience of tick bites. The effectiveness of monthly acaricide treatment was declared by low reports of tick bites on these farms. Tick bite preventive practices were insufficient, particularly in certain farms and for administrative workers. Our findings emphasise the need to have education programmes for all farmworkers and targeting farms with low prevention practices. Education and health programmes should increase the perception of the risk of tick bites and remove perceived barriers of tick bite prevention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15673,

title = {Faster onset time of supraclavicular brachial plexus block using local anesthetic diluted with dextrose},

author = {H J Lim and M S Hasan and K Chinna},

doi = {10.1016/j.bjane.2014.11.012},

year  = {2016},

date = {2016-01-01},

journal = {Braz J Anesthesiol},

volume = {66},

number = {4},

pages = {341-5},

abstract = {BACKGROUND AND OBJECTIVES: A high sodium concentration is known to antagonize local anesthetics when infiltrated around neural tissue. Thus, we hypothesized that the onset time for sensory and motor blockade, in supraclavicular brachial plexus block using ropivacaine diluted with dextrose would be shorter than with saline. METHODS: Patients scheduled for upper limb surgery were randomized to receive ultrasound guided supraclavicular brachial plexus block with 0.5% ropivacaine. Evaluation of sensory and motor blockade was performed every 5min for 60min. Patients were followed-up on postoperative day 1, and between days 7 and 10 for the presence of any complications. Twenty-five patients in each group were analyzed. RESULTS: Mean time for onset of analgesia for the dextrose group was 37.6+/-12.9min while the mean time for the saline group was 45.2+/-13.9min with a p-value of 0.05. The effect size was 0.567, which was moderate to large. No major complications were observed. CONCLUSION: We conclude that there was a decrease in onset time of analgesia when dextrose was used as a diluent instead of saline for ultrasound guided supraclavicular block.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15681,

title = {Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome},

author = {M J Machiela and W Zhou and E Karlins and J N Sampson and N D Freedman and Q Yang and B Hicks and C Dagnall and C Hautman and K B Jacobs and C C Abnet and M C Aldrich and C Amos and L T Amundadottir and A A Arslan and L E Beane-Freeman and S I Berndt and A Black and W J Blot and C H Bock and P M Bracci and L A Brinton and H B Bueno-de-Mesquita and L Burdett and J E Buring and M A Butler and F Canzian and T Carreon and K G Chaffee and I S Chang and N Chatterjee and C Chen and C Chen and K Chen and C C Chung and L S Cook and M Crous Bou and M Cullen and F G Davis and I De Vivo and T Ding and J Doherty and E J Duell and C G Epstein and J H Fan and J D Figueroa and J F Fraumeni and C M Friedenreich and C S Fuchs and S Gallinger and Y T Gao and S M Gapstur and M Garcia-Closas and M M Gaudet and J M Gaziano and G G Giles and E M Gillanders and E L Giovannucci and L Goldin and A M Goldstein and C A Haiman and G Hallmans and S E Hankinson and C C Harris and R Henriksson and E A Holly and Y C Hong and R N Hoover and C A Hsiung and N Hu and W Hu and D J Hunter and A Hutchinson and M Jenab and C Johansen and K T Khaw and H N Kim and Y H Kim and Y T Kim and A P Klein and R Klein and W P Koh and L N Kolonel and C Kooperberg and P Kraft and V Krogh and R C Kurtz and A LaCroix and Q Lan and M T Landi and L L Marchand and D Li and X Liang and L M Liao and D Lin and J Liu and J Lissowska and L Lu and A M Magliocco and N Malats and others},

doi = {10.1038/ncomms11843},

issn = {2041-1723},

year  = {2016},

date = {2016-01-01},

journal = {Nat Commun},

volume = {7},

pages = {11843},

abstract = {To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events \>2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15685,

title = {Financial burden of colorectal cancer treatment among patients and their families in a middle-income country},

author = {M Azzani and A C Roslani and T T Su},

doi = {10.1007/s00520-016-3283-2},

issn = {0941-4355},

year  = {2016},

date = {2016-01-01},

journal = {Support Care Cancer},

volume = {24},

number = {10},

pages = {4423-32},

abstract = {BACKGROUND: In Malaysia, the healthcare system consists of a government-run universal healthcare system and a co-existing private healthcare system. However, with high and ever rising healthcare spending on cancer management, cancer patients and their families are likely to become vulnerable to a healthcare-related financial burden. Moreover, they may have to reduce their working hours and lose income. To better understand this issue, this study aims to assess the financial burden of colorectal cancer patients and their families in the first year following diagnosis. METHODS: Data on patient costs were collected prospectively in the first year following diagnosis by using a self-administered questionnaire and telephone interviews at three time points for all four stages of colorectal cancer. The patient cost data consisted of direct out-of-pocket payments for medical-related expenses such as hospital stays, tests and treatment and for non-medical items such as travel and food associated with hospital visits. In addition, indirect cost data related to the loss of productivity of the patient and caregiver(s) was assessed. The patient's perceived level of financial difficulty and types of coping strategy were also explored. RESULT: The total 1-year patient cost (both direct and indirect) increased with the stage of colorectal cancer: RM 6544.5 (USD 2045.1) for stage I, RM 7790.1 (USD 2434.4) for stage II, RM 8799.1 (USD 2749.7) for stage III and RM 8638.2 (USD 2699.4) for stage IV. The majority of patients perceived paying for their healthcare as somewhat difficult. The most frequently used financial coping strategy was a combination of current income and savings. CONCLUSION: Despite the high subsidisation in public hospitals, the management of colorectal cancer imposes a substantial financial burden on patients and their families. Moreover, the majority of patients and their families perceive healthcare payments as difficult. Therefore, it is recommended that policy- and decision-makers should further consider some financial protection strategies and support for cancer treatment because cancer is a very costly and chronic disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15735,

title = {Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci},

author = {L Kachuri and C I Amos and J D McKay and M Johansson and P Vineis and H B Bueno-de-Mesquita and M C Boutron-Ruault and M Johansson and J R Quiros and S Sieri and R C Travis and E Weiderpass and L Le Marchand and B E Henderson and L Wilkens and G E Goodman and C Chen and J A Doherty and D C Christiani and Y Wei and L Su and S Tworoger and X Zhang and P Kraft and D Zaridze and J K Field and M W Marcus and M P A Davies and R Hyde and N E Caporaso and M T Landi and G Severi and G G Giles and G Liu and J R McLaughlin and Y Li and X Xiao and G Fehringer and X Zong and R E Denroche and P C Zuzarte and J D McPherson and P Brennan and R J Hung},

doi = {10.1093/carcin/bgv165},

issn = {0143-3334},

year  = {2016},

date = {2016-01-01},

journal = {Carcinogenesis},

volume = {37},

number = {1},

pages = {96-105},

abstract = {Chromosome 5p15.33 has been identified as a lung cancer susceptibility locus, however the underlying causal mechanisms were not fully elucidated. Previous fine-mapping studies of this locus have relied on imputation or investigated a small number of known, common variants. This study represents a significant advance over previous research by investigating a large number of novel, rare variants, as well as their underlying mechanisms through telomere length. Variants for this fine-mapping study were identified through a targeted deep sequencing (average depth of coverage greater than 4000x) of 576 individuals. Subsequently, 4652 SNPs, including 1108 novel SNPs, were genotyped in 5164 cases and 5716 controls of European ancestry. After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15690,

title = {Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort},

author = {E Molina-Montes and M J Sanchez and R Zamora-Ros and H B Bueno-de-Mesquita and P A Wark and M Obon-Santacana and T Kuhn and V Katzke and R C Travis and W Ye and M Sund and A Naccarati and A Mattiello and V Krogh and C Martorana and G Masala and P Amiano and J M Huerta and A Barricarte and J R Quiros and E Weiderpass and L Angell Asli and G Skeie and U Ericson and E Sonestedt and P H Peeters and I Romieu and A Scalbert and K Overvad and M Clemens and H Boeing and A Trichopoulou and E Peppa and P Vidalis and K T Khaw and N Wareham and A Olsen and A Tjonneland and M C Boutroun-Rualt and F Clavel-Chapelon and A J Cross and Y Lu and E Riboli and E J Duell},

doi = {10.1002/ijc.30190},

issn = {0020-7136},

year  = {2016},

date = {2016-01-01},

journal = {Int J Cancer},

volume = {139},

number = {7},

pages = {1480-92},

abstract = {Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95-1.11 and 1.02; 95% CI: 0.89-1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91-1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15658,

title = {Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk},

author = {D Campa and M Pastore and M Gentiluomo and R Talar-Wojnarowska and J Kupcinskas and E Malecka-Panas and J P Neoptolemos and W Niesen and P Vodicka and G Delle Fave and H B Bueno-de-Mesquita and M Gazouli and P Pacetti and M Di Leo and H Ito and H Kluter and P Soucek and V Corbo and K Yamao and S Hosono and R Kaaks and Y Vashist and D Gioffreda and O Strobel and Y Shimizu and F Dijk and A Andriulli and A Ivanauskas and P Bugert and F Tavano and L Vodickova and C F Zambon and M Lovecek and S Landi and T J Key and U Boggi and R Pezzilli and K Jamroziak and B Mohelnikova-Duchonova and A Mambrini and F Bambi and O Busch and V Pazienza and R Valente and G E Theodoropoulos and T Hackert and G Capurso and G M Cavestro and C Pasquali and D Basso and C Sperti and K Matsuo and M Buchler and K T Khaw and J Izbicki and E Costello and V Katzke and C Michalski and A Stepien and C Rizzato and F Canzian},

doi = {10.18632/oncotarget.10935},

issn = {1949-2553},

year  = {2016},

date = {2016-01-01},

journal = {Oncotarget},

volume = {7},

number = {35},

pages = {57011-57020},

abstract = {The CDKN2A (p16) gene plays a key role in pancreatic cancer etiology. It is one of the most commonly somatically mutated genes in pancreatic cancer, rare germline mutations have been found to be associated with increased risk of developing familiar pancreatic cancer and CDKN2A promoter hyper-methylation has been suggested to play a critical role both in pancreatic cancer onset and prognosis. In addition several unrelated SNPs in the 9p21.3 region, that includes the CDNK2A, CDNK2B and the CDNK2B-AS1 genes, are associated with the development of cancer in various organs. However, association between the common genetic variability in this region and pancreatic cancer risk is not clearly understood. We sought to fill this gap in a case-control study genotyping 13 single nucleotide polymorphisms (SNPs) in 2,857 pancreatic ductal adenocarcinoma (PDAC) patients and 6,111 controls in the context of the Pancreatic Disease Research (PANDoRA) consortium. We found that the A allele of the rs3217992 SNP was associated with an increased pancreatic cancer risk (ORhet=1.14, 95% CI 1.01-1.27},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15743,

title = {Gambling Risk Amongst Adolescents: Evidence from a School-Based Survey in the Malaysian Setting},

author = {P S Sheela and W Y Choo and L Y Goh and C P Tan},

doi = {10.1007/s10899-015-9577-3},

issn = {1050-5350},

year  = {2016},

date = {2016-01-01},

journal = {J Gambl Stud},

volume = {32},

number = {2},

pages = {643-59},

abstract = {There has been emerging evidence regarding gambling experiences of young people in Asia recently, but to date, none in Malaysia. This study aimed to estimate the prevalence of gambling, and to identify individual, familial and high-risk behaviours factors among Malaysian adolescents. A cross-sectional study was conducted over 4 months at randomly selected secondary schools in Seremban in Negeri Sembilan state. A total of 2265 self-administered, anonymous questionnaires were distributed to the students. The students completed the questionnaire consisting of sociodemographic and family background, gambling behaviours, high risk behaviours and mental health questions. Approximately 29.6 % (95 % CI 27.7-31.5) of respondents reported participating in some forms of gambling activities in the previous 12 months. Among these, 3.6 % (95 % CI 2.8-4.3) of them were problem gamblers. Parental gambling was the strongest correlate with adolescent gambling behaviour. Signification association was found between gambling behaviour and gender (being males), but interestingly, not with ethnicity. Adolescents who reported engaging in high risk behaviours (such as smoking, alcohol consumption, involvement in physical fights, illegal vehicular racing) were also more likely to gamble. Gambling is not an uncommon phenomenon amongst Malaysian adolescents. Public awareness campaign, health education to targeted groups, revision of existing laws, and screening at primary care level should be implemented to address the issue of gambling among adolescents. This study also highlights the need to examine the national scope of the problem in Malaysia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15635,

title = {Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer},

author = {C Lesseur and B Diergaarde and A F Olshan and V Wunsch-Filho and A R Ness and G Liu and M Lacko and J Eluf-Neto and S Franceschi and P Lagiou and G J Macfarlane and L Richiardi and S Boccia and J Polesel and K Kjaerheim and D Zaridze and M Johansson and A M Menezes and M P Curado and M Robinson and W Ahrens and C Canova and A Znaor and X Castellsague and D I Conway and I Holcatova and D Mates and M Vilensky and C M Healy and N Szeszenia-Dabrowska and E Fabianova and J Lissowska and J R Grandis and M C Weissler and E H Tajara and F D Nunes and M B Carvalho and S Thomas and R J Hung and W H Peters and R Herrero and G Cadoni and H B Bueno-de-Mesquita and A Steffen and A Agudo and O Shangina and X Xiao and V Gaborieau and A Chabrier and D Anantharaman and P Boffetta and C I Amos and J D McKay and P Brennan},

doi = {10.1038/ng.3685},

issn = {1061-4036},

year  = {2016},

date = {2016-01-01},

journal = {Nat Genet},

volume = {48},

number = {12},

pages = {1544-1550},

abstract = {We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P \< 5 x 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15666,

title = {Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types},

author = {S P Kar and J Beesley and A Amin Al Olama and K Michailidou and J Tyrer and Z Kote-Jarai and K Lawrenson and S Lindstrom and S J Ramus and D J Thompson and A S Kibel and A Dansonka-Mieszkowska and A Michael and A K Dieffenbach and A Gentry-Maharaj and A S Whittemore and A Wolk and A Monteiro and A Peixoto and A Kierzek and A Cox and A Rudolph and A Gonzalez-Neira and A H Wu and A Lindblom and A Swerdlow and A Ziogas and A B Ekici and B Burwinkel and B Y Karlan and B G Nordestgaard and C Blomqvist and C Phelan and C McLean and C L Pearce and C Vachon and C Cybulski and C Slavov and C Stegmaier and C Maier and C B Ambrosone and C K Hogdall and C C Teerlink and D Kang and D C Tessier and D J Schaid and D O Stram and D W Cramer and D E Neal and D Eccles and D Flesch-Janys and D R Edwards and D Wokozorczyk and D A Levine and D Yannoukakos and E J Sawyer and E V Bandera and E M Poole and E L Goode and E Khusnutdinova and E Hogdall and F Song and F Bruinsma and F Heitz and F Modugno and F C Hamdy and F Wiklund and G G Giles and H Olsson and H Wildiers and H U Ulmer and H Pandha and H A Risch and H Darabi and H B Salvesen and H Nevanlinna and H Gronberg and H Brenner and H Brauch and H Anton-Culver and H Song and H Y Lim and I McNeish and I Campbell and I Vergote and J Gronwald and J Lubinski and J L Stanford and J Benitez and J A Doherty and J B Permuth and J Chang-Claude and J L Donovan and J Dennis and J M Schildkraut and J Schleutker and J L Hopper and J Kupryjanczyk and J Y Park and J Figueroa and others},

doi = {10.1158/2159-8290.Cd-15-1227},

issn = {2159-8274},

year  = {2016},

date = {2016-01-01},

journal = {Cancer Discov},

volume = {6},

number = {9},

pages = {1052-67},

abstract = {UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P \< 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P \< 10(-5) in the three-cancer meta-analysis. SIGNIFICANCE: We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. Cancer Discov; 6(9); 1052-67. (c)2016 AACR.This article is highlighted in the In This Issue feature, p. 932.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15671,

title = {Health-care providers' perceptions, attitudes towards and recommendation practice of cervical cancer screening},

author = {N A Hweissa and J N Lim and T T Su},

doi = {10.1111/ecc.12537},

issn = {0961-5423},

year  = {2016},

date = {2016-01-01},

journal = {Eur J Cancer Care (Engl)},

volume = {25},

number = {5},

pages = {864-70},

abstract = {In Libya, cervical cancer is ranked third as the most frequent cancer among women with early diagnosis being shown to reduce morbidity and mortality. Health-care providers can influence women's screening behaviours, and their lack of recommendations for screening can be one of the barriers that affect women's participation in screening programmes. This study aims to assess the health-care provider's perception around cervical cancer screening. In-depth, face-to-face interviews were conducted with 16 health-care providers, from both public and private sectors in Az-Zawiya city, Libya, between February and July of 2014. The interviews were recorded and transcribed, then analysed using thematic analysis. Our findings suggest that health-care providers did not provide sufficient information regarding cervical cancer screening for women who attend health-care facilities. The results highlight the role played by health-care professionals in motivating women to attend cervical cancer screening programs, and the need for health education of health-care providers to offer a precious advice regarding the screening. On the other hand, health-care providers highlighted that implementation of reminding system of cervical cancer screening will support them to improve screening attendance. In addition, health-care providers stressed the necessity for educational and awareness campaigns of cervical cancer screening among Libyan women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15723,

title = {Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry},

author = {J D Figueroa and C D Middlebrooks and A R Banday and Y Ye and M Garcia-Closas and N Chatterjee and S Koutros and L A Kiemeney and T Rafnar and T Bishop and H Furberg and G Matullo and K Golka and M Gago-Dominguez and J A Taylor and T Fletcher and A Siddiq and V K Cortessis and C Kooperberg and O Cussenot and S Benhamou and J Prescott and S Porru and C P Dinney and N Malats and D Baris and M P Purdue and E J Jacobs and D Albanes and Z Wang and C C Chung and S H Vermeulen and K K Aben and T E Galesloot and G Thorleifsson and P Sulem and K Stefansson and A E Kiltie and M Harland and M Teo and K Offit and J Vijai and D Bajorin and R Kopp and G Fiorito and S Guarrera and C Sacerdote and S Selinski and J G Hengstler and H Gerullis and D Ovsiannikov and M Blaszkewicz and J E Castelao and M Calaza and M E Martinez and P Cordeiro and Z Xu and V Panduri and R Kumar and E Gurzau and K Koppova and H B Bueno-De-Mesquita and B Ljungberg and F Clavel-Chapelon and E Weiderpass and V Krogh and M Dorronsoro and R C Travis and A Tjonneland and P Brennan and J Chang-Claude and E Riboli and D Conti and M C Stern and M C Pike and D Van Den Berg and J M Yuan and C Hohensee and R P Jeppson and G Cancel-Tassin and M Roupret and E Comperat and C Turman and I De Vivo and E Giovannucci and D J Hunter and P Kraft and S Lindstrom and A Carta and S Pavanello and C Arici and G Mastrangelo and A M Kamat and L Zhang and Y Gong and X Pu and A Hutchinson and L Burdett and W A Wheeler and M R Karagas and others},

doi = {10.1093/hmg/ddv492},

issn = {0964-6906},

year  = {2016},

date = {2016-01-01},

journal = {Hum Mol Genet},

volume = {25},

number = {6},

pages = {1203-14},

abstract = {Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising single-nucleotide polymorphisms (SNPs) that had not achieved genome-wide significance in 6911 cases and 11 814 controls (rs6104690, rs4510656, rs5003154 and rs4907479, P \< 1 x 10(-6)), using additional data from existing GWAS datasets and targeted genotyping for studies that did not have GWAS data. In a combined analysis, which included data on up to 15 058 cases and 286 270 controls, two SNPs achieved genome-wide statistical significance: rs6104690 in a gene desert at 20p12.2 (P = 2.19 x 10(-11)) and rs4907479 within the MCF2L gene at 13q34 (P = 3.3 x 10(-10)). Imputation and fine-mapping analyses were performed in these two regions for a subset of 5551 bladder cancer cases and 10 242 controls. Analyses at the 13q34 region suggest a single signal marked by rs4907479. In contrast, we detected two signals in the 20p12.2 region-the first signal is marked by rs6104690, and the second signal is marked by two moderately correlated SNPs (r(2) = 0.53), rs6108803 and the previously reported rs62185668. The second 20p12.2 signal is more strongly associated with the risk of muscle-invasive (T2-T4 stage) compared with non-muscle-invasive (Ta, T1 stage) bladder cancer (case-case P \</= 0.02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15713,

title = {Impact of a Workplace Health Promotion Program on Employees' Blood Pressure in a Public University},

author = {J Y Eng and F M Moy and A Bulgiba},

doi = {10.1371/journal.pone.0148307},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {2},

pages = {e0148307},

abstract = {INTRODUCTION: Workplace health promotion is important in the prevention of non-communicable diseases among employees. Previous workplace health programs have shown benefits such as lowered disease prevalence, reduced medical costs and improved productivity. This study aims to evaluate the impact of a 6-year workplace health promotion program on employees' blood pressure in a public university. METHODS: In this prospective cohort study, we included 1,365 employees enrolled in the university's workplace health promotion program, a program conducted since 2008 and using data from the 2008-2013 follow-up period. Participants were permanent employees aged 35 years and above, with at least one follow up measurements and no change in antihypertensive medication during the study period. Baseline socio-demographic information was collected using a questionnaire while anthropometry measurements and resting blood pressure were collected during annual health screening. Changes in blood pressure over time were analyzed using a linear mixed model. RESULTS: The systolic blood pressure in the hypertension subgroup decreased 2.36 mmHg per year (p\<0.0001). There was also significant improvement in systolic blood pressure among the participants who were at risk of hypertension (-0.75 mmHg, p\<0.001). The diastolic blood pressure among the hypertensive and at risk subgroups improved 1.76 mmHg/year (p\<0.001) and 0.56 mmHg/year (p\<0.001), respectively. However, there was no change in both systolic and diastolic blood pressure among participants in the healthy subgroup over the 6-year period. CONCLUSION: This study shows that continuing participation in workplace health promotion program has the potential to improve blood pressure levels among employees.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15667,

title = {International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics},

author = {M E Goossens and F Isa and M Brinkman and D Mak and R Reulen and A Wesselius and S Benhamou and C Bosetti and B Bueno-de-Mesquita and A Carta and M F Allam and K Golka and E J Grant and X Jiang and K C Johnson and M R Karagas and E Kellen and C La Vecchia and C M Lu and J Marshall and K Moysich and H Pohlabeln and S Porru and G Steineck and M C Stern and L Tang and J A Taylor and P Brandt and P J Villeneuve and K Wakai and E Weiderpass and E White and A Wolk and Z F Zhang and F Buntinx and M P Zeegers},

doi = {10.1186/s13690-016-0140-1},

issn = {0778-7367 (Print) 

0778-7367},

year  = {2016},

date = {2016-01-01},

journal = {Arch Public Health},

volume = {74},

pages = {30},

abstract = {BACKGROUND: In 2012, more than 400,000 urinary bladder cancer cases occurred worldwide, making it the 7(th) most common type of cancer. Although many previous studies focused on the relationship between diet and bladder cancer, the evidence related to specific food items or nutrients that could be involved in the development of bladder cancer remains inconclusive. Dietary components can either be, or be activated into, potential carcinogens through metabolism, or act to prevent carcinogen damage. METHODS/DESIGN: The BLadder cancer, Epidemiology and Nutritional Determinants (BLEND) study was set up with the purpose of collecting individual patient data from observational studies on diet and bladder cancer. In total, data from 11,261 bladder cancer cases and 675,532 non-cases from 18 case-control and 6 cohort studies from all over the world were included with the aim to investigate the association between individual food items, nutrients and dietary patterns and risk of developing bladder cancer. DISCUSSION: The substantial number of cases included in this study will enable us to provide evidence with large statistical power, for dietary recommendations on the prevention of bladder cancer.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15853,

title = {Intervention to improve intensive care nurses' knowledge of sedation assessment and management},

author = {V Ramoo and K L Abdullah and P S Tan and L P Wong and P Y Chua},

doi = {10.1111/nicc.12105},

issn = {1362-1017},

year  = {2016},

date = {2016-01-01},

journal = {Nurs Crit Care},

volume = {21},

number = {5},

pages = {287-94},

abstract = {BACKGROUND: Sedation management is an integral component of critical care practice. It requires the greatest attention of critical care practitioners because it carries significant risks to patients. Therefore, it is imperative that nurses are aware of potential adverse consequences of sedation therapy and current sedation practice recommendations. AIMS AND OBJECTIVES: To evaluate the impact of an educational intervention on nurses' knowledge of sedation assessment and management. DESIGNS AND METHODS: A quasi-experimental design with a pre- and post-test method was used. The educational intervention included theoretical sessions on assessing and managing sedation and hands-on sedation assessment practice using the Richmond Agitation Sedation Scale. Its effect was measured using self-administered questionnaire, completed at the baseline level and 3 months following the intervention. RESULTS: Participants were 68 registered nurses from an intensive care unit of a teaching hospital in Malaysia. Significant increases in overall mean knowledge scores were observed from pre- to post-intervention phases (mean of 79.00 versus 102.00, p \< 0.001). Nurses with fewer than 5 years of work experience, less than 26 years old, and with a only basic nursing education had significantly greater level of knowledge improvement at the post-intervention phase compared to other colleagues, with mean differences of 24.64 (p = 0.001), 23.81 (p = 0.027) and 27.25 (p = 0.0001), respectively. A repeated-measures analysis of variance revealed a statistically significant effect of educational intervention on knowledge score after controlling for age, years of work and level of nursing education (p = 0.0001, etap (2) = 0.431). CONCLUSION: An educational intervention consisting of theoretical sessions and hands-on sedation assessment practice was found effective in improving nurses' knowledge and understanding of sedation management. RELEVANCE TO CLINICAL PRACTICE: This study highlighted the importance of continuing education to increase nurses' understanding of intensive care practices, which is vital for improving the quality of patient care.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15568,

title = {Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts},

author = {M Pedersen and M Stafoggia and G Weinmayr and Z J Andersen and C Galassi and J Sommar and B Forsberg and D Olsson and B Oftedal and N H Krog and G Aamodt and A Pyko and G Pershagen and M Korek and U De Faire and N L Pedersen and C G Ostenson and L Fratiglioni and M Sorensen and K T Eriksen and A Tjonneland and P H Peeters and B Bueno-de-Mesquita and R Vermeulen and M Eeftens and M Plusquin and T J Key and A Jaensch and G Nagel and H Concin and M Wang and M Y Tsai and S Grioni and A Marcon and V Krogh and F Ricceri and C Sacerdote and A Ranzi and G Cesaroni and F Forastiere and I Tamayo and P Amiano and M Dorronsoro and L T Stayner and M Kogevinas and M J Nieuwenhuijsen and R Sokhi and K Hoogh and R Beelen and P Vineis and B Brunekreef and G Hoek and O Raaschou-Nielsen},

doi = {10.1016/j.euf.2016.11.008},

issn = {2405-4569},

year  = {2016},

date = {2016-01-01},

journal = {Eur Urol Focus},

abstract = {BACKGROUND: Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population. OBJECTIVE: To evaluate the association between long-term exposure to ambient air pollution and BC incidence. DESIGN, SETTING, AND PARTICIPANTS: We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N=303431; mean follow-up 14.1 yr). We estimated exposure to nitrogen oxides (NO2 and NOx), particulate matter (PM) with diameter \<10mum (PM10), \<2.5mum (PM2.5), between 2.5 and 10mum (PM2.5-10), PM2.5absorbance (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardized land-use regression models from the European Study of Cohorts for Air Pollution Effects project. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence. RESULTS AND LIMITATIONS: During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-mug/m(3) increase in NO2 and 5-mug/m(3) increase in PM2.5 were 0.98 (95% confidence interval [CI] 0.89-1.08) and 0.86 (95% CI 0.63-1.18), respectively. Limitations include the lack of information about lifetime exposure. CONCLUSIONS: There was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC. PATIENT SUMMARY: We assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. We found no association between the levels of outdoor air pollution at place of residence and bladder cancer risk.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15691,

title = {Issues in healthcare services in Malaysia as experienced by Japanese retirees},

author = {A Kohno and G Musa and N D Nik Farid and N Abdul Aziz and T Nakayama and M Dahlui},

doi = {10.1186/s12913-016-1417-3},

issn = {1472-6963},

year  = {2016},

date = {2016-01-01},

journal = {BMC Health Serv Res},

volume = {16},

pages = {167},

abstract = {BACKGROUND: Worldwide, international retirement migration is growing in its popularity and Japanese retirees choose Malaysia as their most preferred destination. This study examines the pertinent issues related to healthcare services as experienced by Japanese retirees in this country. METHODS AND RESULTS: From January to March 2015, we conducted focus group discussions with 30 Japanese retirees who live in Kuala Lumpur and Ipoh. Guided by the social-ecological model, we discovered seven pertinent themes: 'language barriers','healthcare decisions', 'medical check-ups','healthcare insurance', 'nursing and palliative care', 'trust and distrust of healthcare services', and 'word-of-mouth information'. DISCUSSION: We identified seven pertinent issues related to healthcare services among Japanese retirees in Malaysia, of which four are especially important. These issues are explained as integrated themes within the social-ecological model. Language barriers prohibit them from having difficulty accessing to healthcare in Malaysia, but lack of will to improve their language skills exist among them. For that reason, they rely heavily on word-of-mouth information when seeking for healthcare. As a consequence, some develop feelings of trust and distrust of healthcare services. In addition, we have identified the needs for provide nursing and palliative care among Japanese retirees in Malaysia. CONCLUSION: Based on the magnitude of the discussion, we concluded that there are four crucial healthcare issues among Japanese retirees; 'language barriers', 'trust and distrust of healthcare services', 'word-of-mouth information' and 'nursing and palliative care'. We propose that further dialogue by healthcare stakeholders should be carried out to improve further the healthcare service provisions for Japanese retirees in Malaysia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15854,

title = {Job satisfaction of Malaysian registered nurses: a qualitative study},

author = {N Atefi and K L Abdullah and L P Wong},

doi = {10.1111/nicc.12100},

issn = {1362-1017},

year  = {2016},

date = {2016-01-01},

journal = {Nurs Crit Care},

volume = {21},

number = {1},

pages = {8-17},

abstract = {BACKGROUND: Job satisfaction is an important factor in health care settings. Strong empirical evidence supports a causal relationship between job satisfaction, patient safety and quality of care. However, there have not been any studies exploring the job satisfaction of Malaysian nurses. AIM: The main purpose of this qualitative descriptive study was to explore the factors related to feelings of job satisfaction as well as job dissatisfaction experienced by registered nurses in Malaysia. METHOD: A convenient sample of 46 Malaysian nurses recruited from a large hospital (number of beds = 895) participated in the study. A total of seven focus group discussions were conducted with nurses from surgical, medical and critical care wards. A semi-structured interview guide was used to facilitate the interviews, which were audio-recorded, transcribed verbatim and checked. The transcripts were used as data and were analysed using a thematic approach. FINDING: The study identified three main themes that influenced job satisfaction: (1) nurses' personal values and beliefs; (2) work environment factors and (3) motivation factors. Concerning the nurses' personal values and beliefs, the ability to help people made the nurses felt honoured and happy, which indirectly contributed to job satisfaction. For work environment factors, team cohesion, benefit and reward, working conditions play an important role in the nurses' job satisfaction. Motivation factors, namely, professional development and clinical autonomy contributed to job satisfaction. CONCLUSION: It is important for nurse leaders to provide more rewards, comfortable work environments and to understand issues that affect nurses' job satisfaction. RELEVANCE TO CLINICAL PRACTICE: Our findings highlight the importance of factors that can improve nurses' job satisfaction. The study provides basic information for hospital administrators in planning effective and efficient policies to improve nursing job satisfaction in order to increase the quality of patient care and decrease nursing turnover.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15642,

title = {Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study},

author = {A Moskal and H Freisling and G Byrnes and N Assi and M T Fahey and M Jenab and P Ferrari and A Tjonneland and K E Petersen and C C Dahm and C P Hansen and A Affret and M C Boutron-Ruault and C Cadeau and T Kuhn and V Katzke and K Iqbal and H Boeing and A Trichopoulou and C Bamia and A Naska and G Masala and M S Magistris and S Sieri and R Tumino and C Sacerdote and P H Peeters and B H Bueno-de-Mesquita and D Engeset and I Licaj and G Skeie and E Ardanaz and G Buckland and J M Castano and J R Quiros and P Amiano and E Molina-Portillo and A Winkvist and R Myte and U Ericson and E Sonestedt and A Perez-Cornago and N Wareham and K T Khaw and I Huybrechts and K K Tsilidis and H Ward and M J Gunter and N Slimani},

doi = {10.1038/bjc.2016.334},

issn = {0007-0920},

year  = {2016},

date = {2016-01-01},

journal = {Br J Cancer},

volume = {115},

number = {11},

pages = {1430-1440},

abstract = {BACKGROUND: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. METHODS: Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors. RESULTS: During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk. CONCLUSIONS: Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15759,

title = {Main nutrient patterns are associated with prospective weight change in adults from 10 European countries},

author = {H Freisling and P T Pisa and P Ferrari and G Byrnes and A Moskal and C C Dahm and A C Vergnaud and M C Boutron-Ruault and G Fagherazzi and C Cadeau and T Kuhn and J Neamat-Allah and B Buijsse and H Boeing and J Halkjaer and A Tjonneland and C P Hansen and J R Quiros and N Travier and E Molina-Montes and P Amiano and J M Huerta and A Barricarte and K T Khaw and N Wareham and T J Key and D Romaguera and Y Lu and C M Lassale and A Naska and P Orfanos and A Trichopoulou and G Masala and V Pala and F Berrino and R Tumino and F Ricceri and M S Magistris and H B Bueno-de-Mesquita and M C Ocke and E Sonestedt and U Ericson and M Johansson and G Skeie and E Weiderpass and T Braaten and P H Peeters and N Slimani},

doi = {10.1007/s00394-015-1023-x},

issn = {1436-6207},

year  = {2016},

date = {2016-01-01},

journal = {Eur J Nutr},

volume = {55},

number = {6},

pages = {2093-104},

abstract = {PURPOSE: Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults. METHODS: This study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders. RESULTS: Mean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. CONCLUSIONS: We identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15630,

title = {Meat and haem iron intake in relation to glioma in the European Prospective Investigation into Cancer and Nutrition study},

author = {H A Ward and A Gayle and P Jakszyn and M Merritt and B Melin and H Freisling and E Weiderpass and A Tjonneland and A Olsen and C C Dahm and K Overvad and V Katzke and T Kuhn and H Boeing and A Trichopoulou and P Lagiou and A Kyrozis and D Palli and V Krogh and R Tumino and F Ricceri and A Mattiello and B Bueno-de-Mesquita and P H Peeters and J R Quiros and A Agudo and M Rodriguez-Barranco and N Larranaga and J M Huerta and A Barricarte and E Sonestedt and I Drake and M Sandstrom and R C Travis and P Ferrari and E Riboli and A J Cross},

doi = {10.1097/cej.0000000000000331},

issn = {0959-8278},

year  = {2016},

date = {2016-01-01},

journal = {Eur J Cancer Prev},

abstract = {Diets high in red or processed meat have been associated positively with some cancers, and several possible underlying mechanisms have been proposed, including iron-related pathways. However, the role of meat intake in adult glioma risk has yielded conflicting findings because of small sample sizes and heterogeneous tumour classifications. The aim of this study was to examine red meat, processed meat and iron intake in relation to glioma risk in the European Prospective Investigation into Cancer and Nutrition study. In this prospective cohort study, 408 751 individuals from nine European countries completed demographic and dietary questionnaires at recruitment. Multivariable Cox proportional hazards models were used to examine intake of red meat, processed meat, total dietary iron and haem iron in relation to incident glioma. During an average follow-up of 14.1 years, 688 incident glioma cases were diagnosed. There was no evidence that any of the meat variables (red, processed meat or subtypes of meat) or iron (total or haem) were associated with glioma; results were unchanged when the first 2 years of follow-up were excluded. This study suggests that there is no association between meat or iron intake and adult glioma. This is the largest prospective analysis of meat and iron in relation to glioma and as such provides a substantial contribution to a limited and inconsistent literature.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15644,

title = {Menstrual and Reproductive Factors, Hormone Use, and Risk of Pancreatic Cancer: Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4)},

author = {L Lujan-Barroso and W Zhang and S H Olson and Y T Gao and H Yu and P A Baghurst and P M Bracci and H B Bueno-de-Mesquita and L Foretova and S Gallinger and I Holcatova and V Janout and B T Ji and R C Kurtz and C La Vecchia and P Lagiou and D Li and A B Miller and D Serraino and W Zatonski and H A Risch and E J Duell},

doi = {10.1097/mpa.0000000000000635},

issn = {0885-3177},

year  = {2016},

date = {2016-01-01},

journal = {Pancreas},

volume = {45},

number = {10},

pages = {1401-1410},

abstract = {OBJECTIVES: We aimed to evaluate the relation between menstrual and reproductive factors, exogenous hormones, and risk of pancreatic cancer (PC). METHODS: Eleven case-control studies within the International Pancreatic Cancer Case-control Consortium took part in the present study, including in total 2838 case and 4748 control women. Pooled estimates of odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using a 2-step logistic regression model and adjusting for relevant covariates. RESULTS: An inverse OR was observed in women who reported having had hysterectomy (ORyesvs.no, 0.78; 95% CI, 0.67-0.91), remaining significant in postmenopausal women and never-smoking women, adjusted for potential PC confounders. A mutually adjusted model with the joint effect for hormone replacement therapy (HRT) and hysterectomy showed significant inverse associations with PC in women who reported having had hysterectomy with HRT use (OR, 0.64; 95% CI, 0.48-0.84). CONCLUSIONS: Our large pooled analysis suggests that women who have had a hysterectomy may have reduced risk of PC. However, we cannot rule out that the reduced risk could be due to factors or indications for having had a hysterectomy. Further investigation of risk according to HRT use and reason for hysterectomy may be necessary.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15689,

title = {Metabolically Healthy Obesity and the Development of Nonalcoholic Fatty Liver Disease},

author = {Y Chang and H S Jung and J Cho and Y Zhang and K E Yun and M Lazo and R Pastor-Barriuso and J Ahn and C W Kim and S Rampal and M Cainzos-Achirica and D Zhao and E C Chung and H Shin and E Guallar and S Ryu},

doi = {10.1038/ajg.2016.178},

issn = {0002-9270},

year  = {2016},

date = {2016-01-01},

journal = {Am J Gastroenterol},

volume = {111},

number = {8},

pages = {1133-40},

abstract = {OBJECTIVES: The risk of nonalcoholic fatty liver disease (NAFLD) among obese individuals without obesity-related metabolic abnormalities, a condition referred to as metabolically healthy obese (MHO), is largely unexplored. Therefore, we examined the association between body mass index (BMI) categories and the development of NAFLD in a large cohort of metabolically healthy men and women. METHODS: A cohort study was conducted in 77,425 men and women free of NAFLD and metabolic abnormalities at baseline, who were followed-up annually or biennially for an average of 4.5 years. Being metabolically healthy was defined as not having any metabolic syndrome component and having a homeostasis model assessment of insulin resistance \<2.5. The presence of fatty liver was determined using ultrasound. RESULTS: During 348,193.5 person-years of follow-up, 10,340 participants developed NAFLD (incidence rate, 29.7 per 1,000 person-years). The multivariable adjusted hazard ratios (95% confidence intervals) for incident NAFLD comparing overweight and obese with normal-weight participants were 2.15 (2.06-2.26) and 3.55 (3.37-3.74), respectively. In detailed dose-response analyses, increasing baseline BMI showed a strong and approximately linear relationship with the incidence of NAFLD, with no threshold at no risk. This association was present in both men and women, although it was stronger in women (P for interaction \<0.001), and it was evident in all clinically relevant subgroups evaluated, including participants with low inflammation status. CONCLUSIONS: In a large cohort of strictly defined metabolically healthy men and women, overweight and obesity were strongly and progressively associated with an increased incidence of NAFLD, suggesting that the obese phenotype per se, regardless of metabolic abnormalities, can increase the risk of NAFLD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15662,

title = {Missed Opportunities for Loco-Regional Treatment of Elderly Women with Breast Cancer},

author = {N Bhoo-Pathy and N Balakrishnan and M H See and N A Taib and C H Yip},

doi = {10.1007/s00268-016-3658-z},

issn = {0364-2313},

year  = {2016},

date = {2016-01-01},

journal = {World J Surg},

volume = {40},

number = {12},

pages = {2913-2921},

abstract = {BACKGROUND: Factors associated with surgery, adjuvant radiotherapy, and chemotherapy and whether there were missed opportunities for treatment in elderly patients were determined in an Asian setting. METHODS: All 5616 patients, diagnosed with breast cancer in University Malaya Medical Centre from 1999 to 2013 were included. In 945 elderly patients (aged 65 years and above), multivariable logistic regression was performed to identify factors associated with treatment, following adjustment for age, ethnicity, tumor, and other treatment characteristics. The impact of lack of treatment on survival of the elderly was assessed while accounting for comorbidities. RESULTS: One in five elderly patients had comorbidities. Compared to younger patients, the elderly had more favorable tumor characteristics, and received less loco-regional treatment and chemotherapy. Within stage I-IIIa elderly breast cancer patients, 10 % did not receive any surgery. These patients were older, more likely to be Malays, have comorbidities, and bigger tumors. In elderlies with indications for adjuvant radiotherapy, no irradiation (30 %) was associated with increasing age, comorbidity, and the absence of systemic therapy. Hormone therapy was optimal, but only 35 % of elderly women with ER negative tumors received chemotherapy. Compared to elderly women who received adequate treatment, those not receiving surgery (adjusted hazard ratio: 2.30, 95 %CI: 1.10-4.79), or radiotherapy (adjusted hazard ratio: 1.56, 95 %CI: 1.10-2.19), were associated with higher mortality. Less than 25 % of the survival discrepancy between elderly women receiving loco-regional treatment and no treatment were attributed to excess comorbidities in untreated patients. CONCLUSION: While the presence of comorbidities significantly influenced loco-regional treatment decisions in the elderly, it was only able to explain the lower survival rates in untreated patients up to a certain extent, suggesting missed opportunities for treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15665,

title = {Missense Mutation of Brain Derived Neurotrophic Factor (BDNF) Alters Neurocognitive Performance in Patients with Mild Traumatic Brain Injury: A Longitudinal Study},

author = {V Narayanan and V Veeramuthu and A Ahmad-Annuar and N Ramli and V Waran and K Chinna and M W Bondi and L Delano-Wood and D Ganesan},

doi = {10.1371/journal.pone.0158838},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {7},

pages = {e0158838},

abstract = {The predictability of neurocognitive outcomes in patients with traumatic brain injury is not straightforward. The extent and nature of recovery in patients with mild traumatic brain injury (mTBI) are usually heterogeneous and not substantially explained by the commonly known demographic and injury-related prognostic factors despite having sustained similar injuries or injury severity. Hence, this study evaluated the effects and association of the Brain Derived Neurotrophic Factor (BDNF) missense mutations in relation to neurocognitive performance among patients with mTBI. 48 patients with mTBI were prospectively recruited and MRI scans of the brain were performed within an average 10.1 (SD 4.2) hours post trauma with assessment of their neuropsychological performance post full Glasgow Coma Scale (GCS) recovery. Neurocognitive assessments were repeated again at 6 months follow-up. The paired t-test, Cohen's d effect size and repeated measure ANOVA were performed to delineate statistically significant differences between the groups [wildtype G allele (Val homozygotes) vs. minor A allele (Met carriers)] and their neuropsychological performance across the time point (T1 = baseline/ admission vs. T2 = 6th month follow-up). Minor A allele carriers in this study generally performed more poorly on neuropsychological testing in comparison wildtype G allele group at both time points. Significant mean differences were observed among the wildtype group in the domains of memory (M = -11.44},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15679,

title = {Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study},

author = {D C Muller and N Murphy and M Johansson and P Ferrari and K K Tsilidis and M C Boutron-Ruault and F Clavel and L Dartois and K Li and R Kaaks and C Weikert and M Bergmann and H Boeing and A Tjonneland and K Overvad and M L Redondo and A Agudo and E Molina-Portillo and J M Altzibar and L Cirera and E Ardanaz and K T Khaw and N J Wareham and T J Key and R C Travis and C Bamia and P Orfanos and A Trichopoulou and D Palli and V Pala and R Tumino and P Vineis and S Panico and H B Bueno-de-Mesquita and W M Verschuren and E A Struijk and P H Peeters and G Engstrom and O Melander and M Sund and E Weiderpass and G Skeie and E Lund and T Norat and M Gunter and E Riboli and P Brennan},

doi = {10.1186/s12916-016-0630-6},

issn = {1741-7015},

year  = {2016},

date = {2016-01-01},

journal = {BMC Med},

volume = {14},

pages = {87},

abstract = {BACKGROUND: Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death. METHODS: We analysed data from 264,906 European adults from the EPIC prospective cohort study, aged between 40 and 70 years at the time of recruitment. Flexible parametric survival models were used to model risk of death conditional on risk factors, and survival functions and attributable fractions (AF) for deaths prior to age 70 years were calculated based on the fitted models. RESULTS: We identified 11,930 deaths which occurred before the age of 70. The AF for premature mortality for smoking was 31 % (95 % confidence interval (CI), 31-32 %) and 14 % (95 % CI, 12-16 %) for poor diet. Important contributions were also observed for overweight and obesity measured by waist-hip ratio (10 %; 95 % CI, 8-12 %) and high blood pressure (9 %; 95 % CI, 7-11 %). AFs for physical inactivity and excessive alcohol intake were 7 % and 4 %, respectively. Collectively, the AF for all six risk factors was 57 % (95 % CI, 55-59 %), being 35 % (95 % CI, 32-37 %) among never smokers and 74 % (95 % CI, 73-75 %) among current smokers. CONCLUSIONS: While smoking remains the predominant risk factor for premature death in Europe, poor diet, overweight and obesity, hypertension, physical inactivity, and excessive alcohol consumption also contribute substantially. Any attempt to minimise premature deaths will ultimately require all six factors to be addressed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15655,

title = {Nationwide study of factors associated with public's willingness to use home self-test kit for dengue fever in Malaysia},

author = {L P Wong and N Atefi and S AbuBakar},

doi = {10.1186/s12889-016-3409-y},

issn = {1471-2458},

year  = {2016},

date = {2016-01-01},

journal = {BMC Public Health},

volume = {16},

pages = {780},

abstract = {BACKGROUND: As there is no specific treatment for dengue, early detection and access to proper treatment may lower dengue fatality. Therefore, having new techniques for the early detection of dengue fever, such as the use of dengue test kit, is vitally important. The aims of the study were: 1) identify factors associated with acceptance of a home self-test kit for dengue fever if the dengue test is available to the public and 2) find out the characteristics of the test kits that influence the use of the dengue test kit. METHODS: A national telephone survey was carried out with 2,512 individuals of the Malaysian public aged 18-60 years old. Individuals were contacted by random digit dialling covering the whole of Malaysia from February 2012 to June 2013. RESULTS: From 2,512 participants, 6.1 % reported to have heard of the availability of the dengue home test kit and of these, 44.8 % expressed their intention to use the test kit if it was available. Multivariate logistic regressions indicated that participants with primary (OR: 0.65; 95 % CI: 0.43-0.89; p = 0.02, vs. tertiary educational level) and secondary educational levels (OR: 0.73; 95 % CI: 0.57-0.90; p = 0.01, vs. tertiary educational level) were less likely than participants with a tertiary educational level to use a home self-testing dengue kit for dengue if the kit was available. Participants with lower perceived barriers to dengue prevention (level of barriers 0-5) were less likely (OR: 0.67, 95 % CI: 0.53-0.85, p \< 0.001, vs. higher perceived barriers) to use a home self-testing dengue kit for dengue if the kit was available compared to those with higher perceived barriers to dengue prevention (level of barriers 6-10). Participants with a lower total dengue fever knowledge score (range 0-22) were also less likely to use a home self-testing dengue kit for dengue if the kit was available (OR: 0.75; 95 % CI: 0.61-0.91},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15648,

title = {Nationwide Survey of Knowledge and Health Beliefs regarding Human Papillomavirus among HPV-Vaccinated Female Students in Malaysia},

author = {L P Wong and R N Raja Muhammad Yusoff and Z Edib and I C Sam and G D Zimet},

doi = {10.1371/journal.pone.0163156},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {9},

pages = {e0163156},

abstract = {The National HPV Immunization Programme, which offers free human papillomavirus (HPV) vaccines to teenaged female students, was launched in Malaysia in 2010. HPV vaccination paired with adequate knowledge about HPV infection provides the best protection against cervical cancer. To identify the level of knowledge and the health beliefs towards HPV and the HPV vaccine among HPV-vaccinated female students in Malaysia. A nationwide cross-sectional survey among 14 years old female students who had received three doses of the HPV vaccine was conducted in 32 randomly selected schools from 13 states and 3 federal territories in Malaysia between February 2013 and April 2013. Among 2482 respondents, knowledge about HPV infection and the HPV vaccine was extremely poor. The mean total knowledge score was only 3.56 (SD +/- 1.76), out of a possible score of 10. The majority of respondents were unaware that vaccinating boys with HPV can help protect girls against HPV infection (91.6%), HPV cannot be cured (81.6%) and that HPV is a sexually transmitted infection (70.3%). Most of the respondents had the misconception that only females get HPV (95.1%), and that the HPV vaccine eliminates the need for Pap smear tests (68.3%). Most respondents (91.6%) believed that they would not get an HPV infection. Almost half of the respondents (42.9%) held the misconception that HPV infection could not lead to serious illness. Findings revealed poor knowledge about both HPV and the HPV vaccine, low perceived susceptibility to HPV infection and misinformation about HPV infection among HPV-vaccinated girls. Therefore, it is essential to increase the knowledge and awareness of health risks regarding HPV infection among teenaged girls who have received the HPV vaccine.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15732,

title = {Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study},

author = {M A Merritt and I Tzoulaki and P A Brandt and L J Schouten and K K Tsilidis and E Weiderpass and C J Patel and A Tjonneland and L Hansen and K Overvad and M His and L Dartois and M C Boutron-Ruault and R T Fortner and R Kaaks and K Aleksandrova and H Boeing and A Trichopoulou and P Lagiou and C Bamia and D Palli and V Krogh and R Tumino and F Ricceri and A Mattiello and H B Bueno-de-Mesquita and N C Onland-Moret and P H Peeters and G Skeie and M Jareid and J R Quiros and M Obon-Santacana and M J Sanchez and S Chamosa and J M Huerta and A Barricarte and J A Dias and E Sonestedt and A Idahl and E Lundin and N J Wareham and K T Khaw and R C Travis and P Ferrari and E Riboli and M J Gunter},

doi = {10.3945/ajcn.115.118588},

issn = {0002-9165},

year  = {2016},

date = {2016-01-01},

journal = {Am J Clin Nutr},

volume = {103},

number = {1},

pages = {161-7},

abstract = {BACKGROUND: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk. OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort. DESIGN: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs. RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41). CONCLUSION: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15677,

title = {Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States},

author = {M Arnold and H Freisling and R Stolzenberg-Solomon and F Kee and M G O'Doherty and J M Ordonez-Mena and T Wilsgaard and A M May and H B Bueno-de-Mesquita and A Tjonneland and P Orfanos and A Trichopoulou and P Boffetta and F Bray and M Jenab and I Soerjomataram},

doi = {10.1007/s10654-016-0169-z},

issn = {0393-2990},

year  = {2016},

date = {2016-01-01},

journal = {Eur J Epidemiol},

volume = {31},

number = {9},

pages = {893-904},

abstract = {Recent studies have shown that cancer risk related to overweight and obesity is mediated by time and might be better approximated by using life years lived with excess weight. In this study we aimed to assess the impact of overweight duration and intensity in older adults on the risk of developing different forms of cancer. Study participants from seven European and one US cohort study with two or more weight assessments during follow-up were included (n = 329,576). Trajectories of body mass index (BMI) across ages were estimated using a quadratic growth model; overweight duration (BMI \>/= 25) and cumulative weighted overweight years were calculated. In multivariate Cox models and random effects analyses, a longer duration of overweight was significantly associated with the incidence of obesity-related cancer [overall hazard ratio (HR) per 10-year increment: 1.36; 95 % CI 1.12-1.60], but also increased the risk of postmenopausal breast and colorectal cancer. Additionally accounting for the degree of overweight further increased the risk of obesity-related cancer. Risks associated with a longer overweight duration were higher in men than in women and were attenuated by smoking. For postmenopausal breast cancer, increased risks were confined to women who never used hormone therapy. Overall, 8.4 % of all obesity-related cancers could be attributed to overweight at any age. These findings provide further insights into the role of overweight duration in the etiology of cancer and indicate that weight control is relevant at all ages. This knowledge is vital for the development of effective and targeted cancer prevention strategies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15845,

title = {Pain experience and satisfaction with postoperative pain control among surgical patients},

author = {P Subramanian and S Ramasamy and K H Ng and K Chinna and R Rosli},

doi = {10.1111/ijn.12363},

issn = {1322-7114},

year  = {2016},

date = {2016-01-01},

journal = {Int J Nurs Pract},

volume = {22},

number = {3},

pages = {232-8},

abstract = {Alleviating acute pain and providing pain relief are central to caring for surgical patients as pain can lead to many adverse medical consequences. This study aimed to explore patients' experience of pain and satisfaction with postoperative pain control. A cross-sectional survey was carried out among 107 respondents who had undergone abdominal surgery in the surgical ward of an urban hospital using the Revised American Pain Society's Patient Outcome and Satisfaction Survey Questionnaires (APS-POQ-R). Data were analysed using descriptive statistics and chi-square test. Chi-square test showed significant association between race (P = 0.038), education level (P \</= 0.001), previous operation status (P = 0.032) and operation status (P \</= 0.001). Further analysis on nominal regression, association between dissatisfaction with factors of operation status (46.09 (95% CI 7.456, 284.947)) and previous operation status (13.38 (95% CI 1.39, 128.74)) was found to be significant. Moderate to high levels of pain intensity in the last 24 h after surgery, as well as moderate to high rates of pain-related interference with care activities were most reported. Pain still remains an issue among surgical patients, and effective pain management and health education are needed to manage pain more effectively after surgery.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15731,

title = {Particulate matter air pollution components and risk for lung cancer},

author = {O Raaschou-Nielsen and R Beelen and M Wang and G Hoek and Z J Andersen and B Hoffmann and M Stafoggia and E Samoli and G Weinmayr and K Dimakopoulou and M Nieuwenhuijsen and W W Xun and P Fischer and K T Eriksen and M Sorensen and A Tjonneland and F Ricceri and K Hoogh and T Key and M Eeftens and P H Peeters and H B Bueno-de-Mesquita and K Meliefste and B Oftedal and P E Schwarze and P Nafstad and C Galassi and E Migliore and A Ranzi and G Cesaroni and C Badaloni and F Forastiere and J Penell and U De Faire and M Korek and N Pedersen and C G Ostenson and G Pershagen and L Fratiglioni and H Concin and G Nagel and A Jaensch and A Ineichen and A Naccarati and M Katsoulis and A Trichpoulou and M Keuken and A Jedynska and I M Kooter and J Kukkonen and B Brunekreef and R S Sokhi and K Katsouyanni and P Vineis},

doi = {10.1016/j.envint.2015.11.007},

issn = {0160-4120},

year  = {2016},

date = {2016-01-01},

journal = {Environ Int},

volume = {87},

pages = {66-73},

abstract = {BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence. METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis. RESULTS: The 245,782 cohort members contributed 3,229,220 person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5 ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20 ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200 ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2 ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100 ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S. CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15660,

title = {Physical activity, body composition and lipids changes in adolescents: analysis from the MyHeART Study},

author = {H A Majid and M Amiri and N Mohd Azmi and T T Su and M Y Jalaludin and N Al-Sadat},

doi = {10.1038/srep30544},

issn = {2045-2322},

year  = {2016},

date = {2016-01-01},

journal = {Sci Rep},

volume = {6},

pages = {30544},

abstract = {Insufficient physical activity and growing obesity levels among Malaysian adolescents are becoming a public health concern. Our study is to identify the trends of self-reported physical activity (PA) levels, blood lipid profiles, and body composition (BC) indices from a cohort of 820 adolescents. The self-reported PA was assessed using a validated Malay version of the PA Questionnaire for Older Children (PAQ-C). Fasting blood samples were collected to investigate their lipid profiles. Height, weight, waist and hip circumferences as well as body fat percentage were measured. The baseline and the first follow-up were conducted in 2012 and 2014, respectively. A downward trend in the PA level was seen in all categories with a significant reduction among all rural adolescents (P = 0.013) and more specifically, PA among girls residing in rural areas dropped significantly (P = 0.006). Either a significant reduction in high-density lipoprotein (HDL) or a significant increment in BC indices (i.e., body mass index [BMI], waist circumference [WC], hip circumference, and body fat percentage [BF %]) were seen in this group. Female adolescents experienced more body fat increment with the reduction of physical activity. If not intervened early, adolescents from rural areas may increase their risk of developing cardiovascular diseases earlier.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15716,

title = {Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort},

author = {M F Bakker and P H Peeters and V M Klaasen and H B Bueno-de-Mesquita and E H Jansen and M M Ros and N Travier and A Olsen and A Tjonneland and K Overvad and S Rinaldi and I Romieu and P Brennan and M C Boutron-Ruault and F Perquier and C Cadeau and H Boeing and K Aleksandrova and R Kaaks and T Kuhn and A Trichopoulou and P Lagiou and D Trichopoulos and P Vineis and V Krogh and S Panico and G Masala and R Tumino and E Weiderpass and G Skeie and E Lund and J R Quiros and E Ardanaz and C Navarro and P Amiano and M J Sanchez and G Buckland and U Ericson and E Sonestedt and M Johansson and M Sund and R C Travis and T J Key and K T Khaw and N Wareham and E Riboli and C H Gils},

doi = {10.3945/ajcn.114.101659},

issn = {0002-9165},

year  = {2016},

date = {2016-01-01},

journal = {Am J Clin Nutr},

volume = {103},

number = {2},

pages = {454-64},

abstract = {BACKGROUND: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity. OBJECTIVE: This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer. DESIGN: In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for alpha-carotene, beta-carotene, lycopene, lutein, zeaxanthin, beta-cryptoxanthin, retinol, alpha-tocopherol, gamma-tocopherol, and vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided. RESULTS: In quintile 5 compared with quintile 1, alpha-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and beta-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER- breast tumors. The other analytes were not statistically associated with ER- breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER- and ER+ tumors was statistically significant only for beta-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution). CONCLUSION: Our results indicate that higher concentrations of plasma beta-carotene and alpha-carotene are associated with lower breast cancer risk of ER- tumors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15795,

title = {Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium},

author = {J M Ordonez-Mena and B Schottker and V Fedirko and M Jenab and A Olsen and J Halkjaer and E Kampman and L Groot and E Jansen and H B Bueno-de-Mesquita and P H Peeters and G Siganos and T Wilsgaard and L Perna and B Holleczek and U Pettersson-Kymmer and P Orfanos and A Trichopoulou and P Boffetta and H Brenner},

doi = {10.1007/s10654-015-0040-7},

issn = {0393-2990},

year  = {2016},

date = {2016-01-01},

journal = {Eur J Epidemiol},

volume = {31},

number = {3},

pages = {311-23},

abstract = {The associations of circulating 25-hydroxyvitamin D [25(OH)D] concentrations with total and site-specific cancer incidence have been examined in several epidemiological studies with overall inconclusive findings. Very little is known about the association of vitamin D with cancer incidence in older populations. We assessed the association of pre-diagnostic serum 25(OH)D levels with incidence of all cancers combined and incidence of lung, colorectal, breast, prostate and lymphoid malignancies among older adults. Pre-diagnostic 25(OH)D concentrations and cancer incidence were available in total for 15,486 older adults (mean age 63, range 50-84 years) participating in two cohort studies: ESTHER (Germany) and TROMSO (Norway); and a subset of previously published nested-case control data from a another cohort study: EPIC-Elderly (Greece, Denmark, Netherlands, Spain and Sweden) from the CHANCES consortium on health and aging. Cox proportional hazards or logistic regression were used to derive multivariable adjusted hazard and odds ratios, respectively, and their 95% confidence intervals across 25(OH)D categories. Meta-analyses with random effects models were used to pool study-specific risk estimates. Overall, lower 25(OH)D concentrations were not significantly associated with increased incidence of most of the cancers assessed. However, there was some evidence of increased breast cancer and decreased lymphoma risk with higher 25(OH)D concentrations. Our meta-analyses with individual participant data from three large European population-based cohort studies provide at best limited support for the hypothesis that vitamin D may have a major role in cancer development and prevention among European older adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15589,

title = {Prevalence of falls among community-dwelling elderly and its associated factors: A cross-sectional study in Perak, Malaysia},

author = {U Y Yeong and S Y Tan and J F Yap and W Y Choo},

issn = {1985-207X (Print) 

1985-2274},

year  = {2016},

date = {2016-01-01},

journal = {Malays Fam Physician},

volume = {11},

number = {1},

pages = {7-14},

abstract = {INTRODUCTION: Fall is a major cause of injuries and can increase the risk of early mortality among elderly. The objective of this study was to determine the prevalence of falls among community-dwelling elderly in rural Malaysia and its associated factors. METHODS: Data were obtained from a cross-sectional survey in five randomly selected districts in the state of Perak, Malaysia. A total of 250 households were randomly selected. A total of 811 individuals aged 60 years or more were recruited and interviewed using a structured questionnaire. Information about socio-demographic, history of falls in the past 1 year, medical history, drug history and physical activity level were enquired. RESULTS: The prevalence of falls in the past 1 year among community-dwelling elderly was reported to be 4.07%. Indigenous elderly (Adjusted odd ratio},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15719,

title = {Prospective association of liver function biomarkers with development of hepatobiliary cancers},

author = {M Stepien and V Fedirko and T Duarte-Salles and P Ferrari and H Freisling and E Trepo and A Trichopoulou and C Bamia and E Weiderpass and A Olsen and A Tjonneland and K Overvad and M C Boutron-Ruault and G Fagherazzi and A Racine and T Kuhn and R Kaaks and K Aleksandrova and H Boeing and P Lagiou and V Benetou and D Trichopoulos and D Palli and S Grioni and R Tumino and A Naccarati and S Panico and H B Bueno-de-Mesquita and P H Peeters and E Lund and J R Quiros and O C Napoles and M J Sanchez and M Dorronsoro and J M Huerta and E Ardanaz and B Ohlsson and K Sjoberg and M Werner and H Nystrom and K T Khaw and T J Key and M Gunter and A Cross and E Riboli and I Romieu and M Jenab},

doi = {10.1016/j.canep.2016.01.002},

issn = {1877-7821},

year  = {2016},

date = {2016-01-01},

journal = {Cancer Epidemiol},

volume = {40},

pages = {179-87},

abstract = {INTRODUCTION: Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. METHODS: A nested-case control study was conducted within the prospective EPIC cohort (\>520,000 participants, 10 European countries). After a mean 7.5 mean years of follow-up, 121 hepatocellular carcinoma (HCC), 34 intrahepatic bile duct (IHBC) and 131 gallbladder and biliary tract (GBTC) cases were identified and matched to 2 controls each. Circulating biomarkers were measured in serum taken at recruitment into the cohort, prior to cancer diagnosis. Multivariable adjusted conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI). RESULTS: In multivariable models, 1SD increase of each log-transformed biomarker was positively associated with HCC risk (OR(GGT)=4.23, 95%CI:2.72-6.59; OR(ALP)=3.43, 95%CI:2.31-5.10;OR(AST)=3.00, 95%CI:2.04-4.42; OR(ALT)=2.69, 95%CI:1.89-3.84; OR(Bilirubin)=2.25, 95%CI:1.58-3.20). Each liver enzyme (OR(GGT)=4.98; 95%CI:1.75-14.17; OR(AST)=3.10, 95%CI:1.04-9.30; OR(ALT)=2.86, 95%CI:1.26-6.48, OR(ALP)=2.31, 95%CI:1.10-4.86) but not bilirubin (OR(Bilirubin)=1.46,95%CI:0.85-2.51) showed a significant association with IHBC. Only ALP was significantly associated with GBTC risk (OR(ALP)=1.59, 95%CI:1.20-2.09). CONCLUSION: This study shows positive associations between circulating liver biomarkers in sera collected prior to cancer diagnoses and the risks of developing HCC or IHBC, but not GBTC.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15698,

title = {Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium},

author = {J M Ordonez-Mena and B Schottker and U Mons and M Jenab and H Freisling and B Bueno-de-Mesquita and M G O'Doherty and A Scott and F Kee and B H Stricker and A Hofman and C E Keyser and R Ruiter and S Soderberg and P Jousilahti and K Kuulasmaa and N D Freedman and T Wilsgaard and L C Groot and E Kampman and N Hakansson and N Orsini and A Wolk and L M Nilsson and A Tjonneland and A Pajak and S Malyutina and R Kubinova and A Tamosiunas and M Bobak and M Katsoulis and P Orfanos and P Boffetta and A Trichopoulou and H Brenner},

doi = {10.1186/s12916-016-0607-5},

issn = {1741-7015},

year  = {2016},

date = {2016-01-01},

journal = {BMC Med},

volume = {14},

pages = {62},

abstract = {BACKGROUND: Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking intensity, and duration) with total and site-specific (lung, breast, colorectal, prostate, gastric, head and neck, and pancreatic) cancer incidence and mortality. METHODS: This is a meta-analysis of 19 population-based prospective cohort studies with individual participant data for 897,021 European and American adults. For each cohort we calculated hazard ratios (HRs) for the association of smoking exposure with cancer outcomes using Cox regression adjusted for a common set of the most important potential confounding variables. RAPs (in years) were calculated as the ratio of the logarithms of the HRs for a given smoking exposure variable and age. Meta-analyses were employed to summarize cohort-specific HRs and RAPs. RESULTS: Overall, 140,205 subjects had a first incident cancer, and 53,164 died from cancer, during an average follow-up of 12 years. Current smoking advanced the overall risk of developing and dying from cancer by eight and ten years, respectively, compared with never smokers. The greatest advancements in cancer risk and mortality were seen for lung cancer and the least for breast cancer. Smoking cessation was statistically significantly associated with delays in the risk of cancer development and mortality compared with continued smoking. CONCLUSIONS: This investigation shows that smoking, even among older adults, considerably advances, and cessation delays, the risk of developing and dying from cancer. These findings may be helpful in more effectively communicating the harmful effects of smoking and the beneficial effect of smoking cessation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15638,

title = {Reasons for Using Electronic Cigarettes and Intentions to Quit Among Electronic Cigarette Users in Malaysia},

author = {L P Wong and S M Mohamad Shakir and H Alias and N Aghamohammadi and V C Hoe},

doi = {10.1007/s10900-016-0196-4},

issn = {0094-5145},

year  = {2016},

date = {2016-01-01},

journal = {J Community Health},

volume = {41},

number = {6},

pages = {1101-1109},

abstract = {The rapidly increasing uptake of e-cigarettes in Malaysia as of late demands a study to identify factors leading to its increased popularity and user intentions to quit smoking e-cigarettes. A convenience sample of e-cigarette smokers visiting e-cigarette retail shops in Selangor and Kuala Lumpur was recruited. The majority of e-cigarette smokers were youth in colleges or universities (39 %), and young professionals and managers (36 %). The main reasons for using e-cigarettes were to help the user quit tobacco cigarettes (88 %), the perception that e-cigarettes are not as intrusive as tobacco cigarettes (85 %) and can be used in public areas (70 %), the perception that e-cigarettes are healthier than tobacco cigarettes (85 %), and its relatively lower cost compared to tobacco cigarettes (65 %). A total of 65.3 % of respondents expressed intentions to quit e-cigarettes. In a multivariate analysis, the respondents who earned monthly income of RM1000 or less were significantly more likely to intend to quit smoking e-cigarettes [OR 1.551; 95 % CI 1.022-2.355; p = 0.015] compared to the respondents who earned a monthly income of more than RM2000. The respondents who disagreed with the statement 'Smoking e-cigs is relatively cheaper compared to tobacco cigarettes' were significantly more likely to intend to quit smoking e-cigarettes [OR 1.548; 95 % CI 1.045-2.293; p = 0.027] compared to respondents who did not agree. e-cigarette preventive interventions should target areas related to the identified main reasons for using e-cigarettes, namely as an aid for quitting tobacco cigarettes, the perception that e-cigarettes are not as intrusive as tobacco cigarettes and can be used in public areas, the idea that e-cigarettes are healthier than tobacco cigarettes, and its relatively lower cost compared to tobacco cigarettes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15707,

title = {Research on Climate and Dengue in Malaysia: A Systematic Review},

author = {Y L Hii and R A Zaki and N Aghamohammadi and J Rocklov},

doi = {10.1007/s40572-016-0078-z},

issn = {2196-5412},

year  = {2016},

date = {2016-01-01},

journal = {Curr Environ Health Rep},

volume = {3},

number = {1},

pages = {81-90},

abstract = {BACKGROUND \& OBJECTIVES: Dengue is a climate-sensitive infectious disease. Climate-based dengue early warning may be a simple, low-cost, and effective tool for enhancing surveillance and control. Scientific studies on climate and dengue in local context form the basis for advancing the development of a climate-based early warning system. This study aims to review the current status of scientific studies in climate and dengue and the prospect or challenges of such research on a climate-based dengue early warning system in a dengue-endemic country, taking Malaysia as a case study. METHOD: We reviewed the relationship between climate and dengue derived from statistical modeling, laboratory tests, and field studies. We searched electronic databases including PubMed, Scopus, EBSCO (MEDLINE), Web of Science, and the World Health Organization publications, and assessed climate factors and their influence on dengue cases, mosquitoes, and virus and recent development in the field of climate and dengue. RESULTS \& DISCUSSION: Few studies in Malaysia have emphasized the relationship between climate and dengue. Climatic factors such as temperature, rainfall, and humidity are associated with dengue; however, these relationships were not consistent. Climate change projections for Malaysia show a mounting risk for dengue in the future. Scientific studies on climate and dengue enhance dengue surveillance in the long run. CONCLUSION: It is essential for institutions in Malaysia to promote research on climate and vector-borne diseases to advance the development of climate-based early warning systems. Together, effective strategies that improve existing research capacity, maximize the use of limited resources, and promote local-international partnership are crucial for sustaining research on climate and health.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15717,

title = {Risk factors for low birth weight in Nigeria: evidence from the 2013 Nigeria Demographic and Health Survey},

author = {M Dahlui and N Azahar and O M Oche and N A Aziz},

doi = {10.3402/gha.v9.28822},

issn = {1654-9880},

year  = {2016},

date = {2016-01-01},

journal = {Glob Health Action},

volume = {9},

pages = {28822},

abstract = {BACKGROUND: Low birth weight (LBW) continues to be the primary cause of infant morbidity and mortality. OBJECTIVE: This study was undertaken to identify the predictors of LBW in Nigeria. DESIGN: The data for this study was extracted from the 2013 Nigeria Demographic and Health Survey conducted by the National Population Commission. Several questionnaires were used in the survey, some covering questions on pregnancy characteristics. The inclusion criteria include mothers who gave birth to a child 5 years before the interview and aged 15-49 years who were either permanent residents or visitors present in the household on the night before the survey conducted. The birth weight of the infants was recorded from written records from the hospital cards or the mothers' recall. RESULTS: The prevalence of LBW in this study was 7.3%. Multiple logistic regression analysis showed an adjusted significant odds ratio for mothers from North West region (aOR 10.67; 95% CI [5.83-19.5]), twin pregnancy (aOR 5.11; 95% CI [3.11-8.39]), primiparous mother (aOR 2.08; 95% CI [1.15-3.77]), maternal weight of less than 70 kg (aOR 1.92; 95% CI [1.32-2.78]), and manual paternal employment (aOR 1.91; 95% CI [1.08-3.37]). CONCLUSIONS: The risk factors for LBW identified in this study are modifiable. In order to reduce this menace in Nigeria, holistic approaches such as health education, maternal nutrition, improvement in socio-economic indices, and increasing the quality and quantity of the antenatal care services are of paramount importance.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15694,

title = {Role of Individual, Family, and Peers in Sexual Initiation Among Late Adolescents Attending Institutions of Higher Learning in Malaysia},

author = {S Abdul Samad and N N Hairi and M Ismail},

doi = {10.1177/1010539516645158},

issn = {1010-5395},

year  = {2016},

date = {2016-01-01},

journal = {Asia Pac J Public Health},

volume = {28},

number = {4},

pages = {313-24},

abstract = {This cross-sectional study aimed to determine the prevalence and the factors associated with sexual initiation among the late adolescents in 6 institutions of higher learning in Malaysia. A total of 1572 students completed self-administered questionnaires between April and September 2013. Hierarchical multivariate logistic regression analyses stratified by gender were employed to identify the correlates of sexual initiation. The analyses were further adjusted by sampling weights. The overall prevalence of sexual initiation was 9.8% (95% confidence interval [CI] = 8.3-11.6), 18.1% (95% CI = 15.1-21.5) among males, and 4.1% (95% CI = 2.9-5.9) among females. The risk factors identified in this study supported the influence of the individual, family, and peer factors in the social-ecological model on adolescents' behaviors. The findings suggest the need for risk-reduction strategies aimed at the individual, family, and peer levels as well as the importance of gender-specific focus in assuring better outcomes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15634,

title = {Rotavirus vaccines contribute towards universal health coverage in a mixed public-private healthcare system},

author = {T Loganathan and M Jit and R Hutubessy and C W Ng and W S Lee and S Verguet},

doi = {10.1111/tmi.12766},

issn = {1360-2276},

year  = {2016},

date = {2016-01-01},

journal = {Trop Med Int Health},

volume = {21},

number = {11},

pages = {1458-1467},

abstract = {OBJECTIVES: To evaluate rotavirus vaccination in Malaysia from the household's perspective. The extended cost-effectiveness analysis (ECEA) framework quantifies the broader value of universal vaccination starting with non-health benefits such as financial risk protection and equity. These dimensions better enable decision-makers to evaluate policy on the public finance of health programmes. METHODS: The incidence, health service utilisation and household expenditure related to rotavirus gastroenteritis according to national income quintiles were obtained from local data sources. Multiple birth cohorts were distributed into income quintiles and followed from birth over the first five years of life in a multicohort, static model. RESULTS: We found that the rich pay more out of pocket (OOP) than the poor, as the rich use more expensive private care. OOP payments among the poorest although small are high as a proportion of household income. Rotavirus vaccination results in substantial reduction in rotavirus episodes and expenditure and provides financial risk protection to all income groups. Poverty reduction benefits are concentrated amongst the poorest two income quintiles. CONCLUSION: We propose that universal vaccination complements health financing reforms in strengthening Universal Health Coverage (UHC). ECEA provides an important tool to understand the implications of vaccination for UHC, beyond traditional considerations of economic efficiency.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15668,

title = {Selenium and Prostate Cancer: Analysis of Individual Participant Data From Fifteen Prospective Studies},

author = {N E Allen and R C Travis and P N Appleby and D Albanes and M J Barnett and A Black and H B Bueno-de-Mesquita and M Deschasaux and P Galan and G E Goodman and P J Goodman and M J Gunter and M Heliovaara and K J Helzlsouer and B E Henderson and S Hercberg and P Knekt and L N Kolonel and C Lasheras and J Linseisen and E J Metter and M L Neuhouser and A Olsen and V Pala and E A Platz and H Rissanen and M E Reid and J M Schenk and M J Stampfer and P Stattin and C M Tangen and M Touvier and A Trichopoulou and P A Brandt and T J Key},

doi = {10.1093/jnci/djw153},

issn = {0027-8874},

year  = {2016},

date = {2016-01-01},

journal = {J Natl Cancer Inst},

volume = {108},

number = {11},

abstract = {BACKGROUND: Some observational studies suggest that a higher selenium status is associated with a lower risk of prostate cancer but have been generally too small to provide precise estimates of associations, particularly by disease stage and grade. METHODS: Collaborating investigators from 15 prospective studies provided individual-participant records (from predominantly men of white European ancestry) on blood or toenail selenium concentrations and prostate cancer risk. Odds ratios of prostate cancer by selenium concentration were estimated using multivariable-adjusted conditional logistic regression. All statistical tests were two-sided. RESULTS: Blood selenium was not associated with the risk of total prostate cancer (multivariable-adjusted odds ratio [OR] per 80 percentile increase = 1.01, 95% confidence interval [CI] = 0.83 to 1.23, based on 4527 case patients and 6021 control subjects). However, there was heterogeneity by disease aggressiveness (ie, advanced stage and/or prostate cancer death},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15714,

title = {Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort},

author = {S Y Kong and H Q Tran and A T Gewirtz and G McKeown-Eyssen and V Fedirko and I Romieu and A Tjonneland and A Olsen and K Overvad and M C Boutron-Ruault and N Bastide and A Affret and T Kuhn and R Kaaks and H Boeing and K Aleksandrova and A Trichopoulou and M Kritikou and E Vasilopoulou and D Palli and V Krogh and A Mattiello and R Tumino and A Naccarati and H B Bueno-de-Mesquita and P H Peeters and E Weiderpass and J R Quiros and N Sala and M J Sanchez and J M Castano and A Barricarte and M Dorronsoro and M Werner and N J Wareham and K T Khaw and K E Bradbury and H Freisling and F Stavropoulou and P Ferrari and M J Gunter and A J Cross and E Riboli and W R Bruce and M Jenab},

doi = {10.1158/1055-9965.Epi-15-0798},

issn = {1055-9965},

year  = {2016},

date = {2016-01-01},

journal = {Cancer Epidemiol Biomarkers Prev},

volume = {25},

number = {2},

pages = {291-301},

abstract = {BACKGROUND: Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the gut barrier. The objective of this study, nested within a prospective cohort, was to examine associations between circulating LPS and flagellin serum antibody levels and colorectal cancer risk. METHODS: A total of 1,065 incident colorectal cancer cases (colon},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15663,

title = {Shisha Smoking Practices, Use Reasons, Attitudes, Health Effects and Intentions to Quit among Shisha Smokers in Malaysia},

author = {L P Wong and H Alias and N Aghamohammadi and S Aghazadeh and V C Hoe},

doi = {10.3390/ijerph13070726},

issn = {1660-4601},

year  = {2016},

date = {2016-01-01},

journal = {Int J Environ Res Public Health},

volume = {13},

number = {7},

abstract = {Despite its popularity, shisha smoking practices, reasons for its use, attitudes, detrimental health effects and intention to quit among shisha users in Malaysia have never been investigated. A total of 503 shisha users responded to a cross-sectional study conducted between July 2015 and March 2016. The majority of users were young people aged 21-30; a small minority were underage. The reasons for shisha use were its growing popularity as a favourite pastime activity and the perception of shisha use as cool and trendy. Just over half (57.3%) agree that shisha use exposes the smoker to large amounts of smoke and the majority were unsure about the health risks of shisha smoking compared to tobacco smoking. The three most common detrimental health effects reported by the study respondents were dry throat, headache and nausea. Regular shisha users have significantly higher detrimental health effects compared to no-regular shisha users. Shisha users with a duration of smoking of 6-12 months (odds ratio (OR) 3.212; 95% confidence interval (CI) 1.651-6.248) and 6 months and below (OR 2.601; 95% CI 1.475-4.584) were significantly more likely to have a higher proportion who intend quitting smoking than shisha users of more than 12 months duration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15678,

title = {Sugar-sweetened carbonated beverage consumption and coronary artery calcification in asymptomatic men and women},

author = {S Chun and Y Choi and Y Chang and J Cho and Y Zhang and S Rampal and D Zhao and J Ahn and B S Suh and R Pastor-Barriuso and J A Lima and E C Chung and H Shin and E Guallar and S Ryu},

doi = {10.1016/j.ahj.2016.03.018},

issn = {0002-8703},

year  = {2016},

date = {2016-01-01},

journal = {Am Heart J},

volume = {177},

pages = {17-24},

abstract = {BACKGROUND: Sugar-sweetened carbonated beverage consumption has been linked to obesity, metabolic syndrome, type 2 diabetes, and clinically manifest coronary heart disease, but its association with subclinical coronary heart disease remains unclear. We investigated the relationship between sugar-sweetened carbonated beverage consumption and coronary artery calcium (CAC) in a large study of asymptomatic men and women. METHODS: This was a cross-sectional study of 22,210 adult men and women who underwent a comprehensive health screening examination between 2011 and 2013 (median age 40 years). Sugar-sweetened carbonated beverage consumption was assessed using a validated food frequency questionnaire, and CAC was measured by cardiac computed tomography. Multivariable-adjusted CAC score ratios and 95% CIs were estimated from robust Tobit regression models for the natural logarithm (CAC score +1). RESULTS: The prevalence of detectable CAC (CAC score \>0) was 11.7% (n = 2,604). After adjustment for age; sex; center; year of screening examination; education level; physical activity; smoking; alcohol intake; family history of cardiovascular disease; history of hypertension; history of hypercholesterolemia; and intake of total energy, fruits, vegetables, and red and processed meats, only the highest category of sugar-sweetened carbonated beverage consumption was associated with an increased CAC score compared with the lowest consumption category. The multivariable-adjusted CAC ratio comparing participants who consumed \>/=5 sugar-sweetened carbonated beverages per week with nondrinkers was 1.70 (95% CI, 1.03-2.81). This association did not differ by clinical subgroup, including participants at low cardiovascular risk. CONCLUSION: Our findings suggest that high levels of sugar-sweetened carbonated beverage consumption are associated with a higher prevalence and degree of CAC in asymptomatic adults without a history of cardiovascular disease, cancer, or diabetes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15656,

title = {Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)},

author = {E M Navarrete-Munoz and P A Wark and D Romaguera and N Bhoo-Pathy and D Michaud and E Molina-Montes and A Tjonneland and A Olsen and K Overvad and M C Boutron-Ruault and F Clavel-Chapelon and G Fagherazzi and V A Katzke and T Kuhn and A Steffen and A Trichopoulou and E Klinaki and E M Papatesta and G Masala and V Krogh and R Tumino and A Naccarati and A Mattiello and P H Peeters and C Rylander and C L Parr and G Skeie and E Weiderpass and J R Quiros and E J Duell and M Dorronsoro and J M Huerta and E Ardanaz and N Wareham and K T Khaw and R C Travis and T Key and M Stepien and H Freisling and E Riboli and H B Bueno-de-Mesquita},

doi = {10.3945/ajcn.116.130963},

issn = {0002-9165},

year  = {2016},

date = {2016-01-01},

journal = {Am J Clin Nutr},

volume = {104},

number = {3},

pages = {760-8},

abstract = {BACKGROUND: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well. OBJECTIVE: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk. DESIGN: The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baseline were included, and 865 exocrine pancreatic cancers were diagnosed after a median follow-up of 11.60 y (IQR: 10.10-12.60 y). Sweet-beverage consumption was assessed with the use of validated dietary questionnaires at baseline. HRs and 95% CIs were obtained with the use of multivariable Cox regression models that were stratified by age, sex, and center and adjusted for educational level, physical activity, smoking status, and alcohol consumption. Associations with total soft-drink consumption were adjusted for juice and nectar consumption and vice versa. RESULTS: Total soft-drink consumption (HR per 100 g/d: 1.03; 95% CI: 0.99, 1.07), sugar-sweetened soft-drink consumption (HR per 100 g/d: 1.02; 95% CI: 0.97, 1.08), and artificially sweetened soft-drink consumption (HR per 100 g/d: 1.04; 95% CI: 0.98, 1.10) were not associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake. CONCLUSIONS: Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15649,

title = {Ten-year survival in women with primary stage IV breast cancer},

author = {L G Eng and S Dawood and V Sopik and B Haaland and P S Tan and N Bhoo-Pathy and E Warner and J Iqbal and S A Narod and R Dent},

doi = {10.1007/s10549-016-3974-x},

issn = {0167-6806},

year  = {2016},

date = {2016-01-01},

journal = {Breast Cancer Res Treat},

volume = {160},

number = {1},

pages = {145-152},

abstract = {PURPOSE: To evaluate breast cancer-specific survival at 10 years in patients who present with primary stage IV breast cancer, and to determine whether survival varies with age of diagnosis. METHODS: We retrieved the records of 25,323 women diagnosed with primary stage IV breast cancer in the surveillance, epidemiology, and end results 18 registries database from 1990 to 2012. For each case, we extracted information on age at diagnosis, tumour size, nodal status, oestrogen receptor status, progesterone receptor status, ethnicity, cause of death and date of death. The Cox proportional hazards model was used to estimate the unadjusted and adjusted hazard ratio (HR) of death due to stage IV breast cancer, according to age group. RESULTS: Among 25,323 women with stage IV breast cancer, 2542 (10.0 %) were diagnosed at age 40 or below, 5562 (22.0 %) were diagnosed between ages 41 and 50 and 17,219 (68.0 %) were diagnosed between ages 51 and 70. After a mean follow-up of 2.2 years, 16,387 (64.7 %) women died of breast cancer (median survival 2.3 years). The ten-year actuarial breast cancer-specific survival rate was 15.7 % for women ages 40 and below, 14.9 % for women ages 41-50 and 11.7 % for women ages 51 to 70 (p \< 0.0001). In an adjusted analysis, the risk of death from breast cancer at 10 years was significantly lower for women ages 40 and below (HR 0.78; 95 % CI 0.74-0.82; p \< 0.0001) and for women ages 41-50 (HR 0.82; 95 % CI 0.79-0.85; p \< 0.0001), compared to women ages 51-70. CONCLUSIONS: Approximately 13 % of women with primary stage IV breast cancer survive 10 years after diagnosis. Women diagnosed with stage IV breast cancer before age 50 have better survival at 10 years compared to older women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15763,

title = {Test-retest reliability of HeartQoL and its comparability to the MacNew heart disease health-related quality of life questionnaire},

author = {W L Lee and K Chinna and A Bulgiba and K L Abdullah and I Z Abidin and S Hofer},

doi = {10.1007/s11136-015-1097-1},

issn = {0962-9343},

year  = {2016},

date = {2016-01-01},

journal = {Qual Life Res},

volume = {25},

number = {2},

pages = {351-7},

abstract = {OBJECTIVES: Heart Quality of Life (HeartQoL) is a new "hybrid" developed from the MacNew and two condition-specific questionnaires measuring health-related quality of life (HRQoL) in patients with ischemic heart disease (IHD). This study investigates test-retest reliability of HeartQoL (English version) according to international criteria (e.g., COSMIN, GRRAS). Findings on HeartQoL are compared to the published data on MacNew in view that both serve as the core IHD-specific HRQoL instrument. METHODS: Out of 105 patients with IHD, 76 completed self-administration of HeartQoL at the clinic followed by at home within a 2-week interval. In retest, patients responded using non-interview methods (phone messaging, email, fax, and post). Phone interviewing was reserved for non-respondents to reminder. RESULTS: Reliability of HeartQoL was good (intraclass correlation coefficients = 0.78-0.82), was supported in the Bland-Altman plot, and was comparable to five studies on MacNew of similar retest interval (MacNew-English = 0.70-0.75; translated MacNew = 0.72-0.91). Applicability of its standard error of measurement (0.20-0.25) and smallest detectable change (0.55-0.70) will depend on availability of normative data in future. CONCLUSION: The reliability of HeartQoL is comparable to its parent instrument, the MacNew. The HeartQoL is a potentially reliable core IHD-specific HRQoL instrument in measuring group change.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15643,

title = {The development and validation of the advance care planning questionnaire in Malaysia},

author = {P S Lai and S Mohd Mudri and K Chinna and S Othman},

doi = {10.1186/s12910-016-0147-8},

issn = {1472-6939},

year  = {2016},

date = {2016-01-01},

journal = {BMC Med Ethics},

volume = {17},

number = {1},

pages = {61},

abstract = {BACKGROUND: Advance care planning is a voluntary process whereby individual preferences, values and beliefs are used to aid a person in planning for end-of-life care. Currently, there is no local instrument to assess an individual's awareness and attitude towards advance care planning. This study aimed to develop an Advance Care Planning Questionnaire and to determine its validity and reliability among older people in Malaysia. METHODS: The Advance Care Planning Questionnaire was developed based on literature review. Face and content validity was verified by an expert panel, and piloted among 15 participants. Our study was conducted from October 2013 to February 2014, at an urban primary care clinic in Malaysia. Included were those aged \>50 years, who could understand English. A retest was conducted 2 weeks after the first administration. RESULTS: Participants from the pilot study did not encounter any problems in answering the Advance Care Planning Questionnaire. Hence, no further modifications were made. Flesch reading ease was 71. The final version of the Advance Care Planning Questionnaire consists of 66 items: 30 items were measured on a nominal scale, whilst 36 items were measured on a Likert-like scale; of which we were only able to validate 22 items, as the remaining 14 items were descriptive in nature. A total of 245 eligible participants were approached; of which 230 agreed to participate (response rate = 93.9 %). Factor analysis on the 22 items measured on a Likert-scale revealed four domains: "feelings regarding advance care planning", "justifications for advance care planning", "justifications for not having advance care planning: fate and religion", and "justifications for not having advance care planning: avoid thinking about death". The Cronbach's alpha values for items each domain ranged from 0.637-0.915. In test-retest, kappa values ranged from 0.738-0.947. CONCLUSIONS: The final Advance Care Planning Questionnaire consisted of 63 items and 4 domains. It was found to be a valid and reliable instrument to assess the awareness and attitude of older people in Malaysia towards advance care planning.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15617,

title = {The Effectiveness of a Wireless Modular Bed Absence Sensor Device for Fall Prevention among Older Inpatients},

author = {K Subermaniam and R Welfred and P Subramanian and K Chinna and F Ibrahim and M S Mohktar and M P Tan},

doi = {10.3389/fpubh.2016.00292},

issn = {2296-2565 (Print) 

2296-2565},

year  = {2016},

date = {2016-01-01},

journal = {Front Public Health},

volume = {4},

pages = {292},

abstract = {BACKGROUND: Falls and fall-related injuries are increasingly serious issues among elderly inpatients due to population aging. The bed-exit alarm has only previously been evaluated in a handful of studies with mixed results. Therefore, we evaluated the effectiveness of a modular bed absence sensor device (M-BAS) in detecting bed exits among older inpatients in a middle income nation in East Asia. METHODS: Patients aged \>/=65 years on an acute geriatric ward who were able to mobilize with or without walking aids and physical assistance were recruited to the study. The total number of alarms and the numbers of true and false alarms were recorded by ward nurses. The M-BAS device is placed across the mattress of all consenting participants. Nurses' workload was assessed using the National Aeronautics and Space Administration-Task Load Index (NASA-TLX) score, while nurses' perceptions were surveyed. RESULTS: The sensitivity of the M-BAS was 100% with a positive predictive value of 68% and a nuisance alarm rate of 31%. There was a significant reduction in total NASA-TLX workload score (mean difference = 14.34 +/- 13.96 SD, p \< 0.001) at the end of the intervention period. 83% of the nurses found the device useful for falls prevention, 97% found it user friendly, and 87% would use it in future. CONCLUSION: The M-BAS was able to accurately detect bed absence episodes among geriatric inpatients and alert nurses accordingly. The use of the device significantly reduced the total workload score, while the acceptability of the device was high among our nurses. A larger, cluster randomized study to measure actual falls outcome associated with the use of the device is now indicated.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15702,

title = {The Hidden Health and Economic Burden of Rotavirus Gastroenteritis in Malaysia: An Estimation Using Multiple Data Sources},

author = {T Loganathan and C W Ng and W S Lee and M Jit},

doi = {10.1097/inf.0000000000001129},

issn = {0891-3668},

year  = {2016},

date = {2016-01-01},

journal = {Pediatr Infect Dis J},

volume = {35},

number = {6},

pages = {601-6},

abstract = {BACKGROUND: Rotavirus gastroenteritis (RVGE) results in substantial mortality and morbidity worldwide. However, an accurate estimation of the health and economic burden of RVGE in Malaysia covering public, private and home treatment is lacking. METHODS: Data from multiple sources were used to estimate diarrheal mortality and morbidity according to health service utilization. The proportion of this burden attributable to rotavirus was estimated from a community-based study and a meta-analysis we conducted of primary hospital-based studies. Rotavirus incidence was determined by multiplying acute gastroenteritis incidence with estimates of the proportion of gastroenteritis attributable to rotavirus. The economic burden of rotavirus disease was estimated from the health systems and societal perspective. RESULTS: Annually, rotavirus results in 27 deaths, 31,000 hospitalizations, 41,000 outpatient visits and 145,000 episodes of home-treated gastroenteritis in Malaysia. We estimate an annual rotavirus incidence of 1 death per 100,000 children and 12 hospitalizations, 16 outpatient clinic visits and 57 home-treated episodes per 1000 children under-5 years. Annually, RVGE is estimated to cost US$ 34 million to the healthcare provider and US$ 50 million to society. Productivity loss contributes almost a third of costs to society. Publicly, privately and home-treated episodes consist of 52%, 27% and 21%, respectively, of the total societal costs. CONCLUSIONS: RVGE represents a considerable health and economic burden in Malaysia. Much of the burden lies in privately or home-treated episodes and is poorly captured in previous studies. This study provides vital information for future evaluation of cost-effectiveness, which are necessary for policy-making regarding universal vaccination.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15715,

title = {The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort},

author = {E Roura and N Travier and T Waterboer and S Sanjose and F X Bosch and M Pawlita and V Pala and E Weiderpass and N Margall and J Dillner and I T Gram and A Tjonneland and C Munk and D Palli and K T Khaw and K Overvad and F Clavel-Chapelon and S Mesrine and A Fournier and R T Fortner and J Ose and A Steffen and A Trichopoulou and P Lagiou and P Orfanos and G Masala and R Tumino and C Sacerdote and S Polidoro and A Mattiello and E Lund and P H Peeters and H B Bueno-de-Mesquita and J R Quiros and M J Sanchez and C Navarro and A Barricarte and N Larranaga and J Ekstrom and D Lindquist and A Idahl and R C Travis and M A Merritt and M J Gunter and S Rinaldi and M Tommasino and S Franceschi and E Riboli and X Castellsague},

doi = {10.1371/journal.pone.0147029},

issn = {1932-6203},

year  = {2016},

date = {2016-01-01},

journal = {PLoS One},

volume = {11},

number = {1},

pages = {e0147029},

abstract = {BACKGROUND: In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). METHODS AND FINDINGS: We followed a cohort of 308,036 women recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. At enrollment, participants completed a questionnaire and provided serum. After a 9-year median follow-up, 261 ICC and 804 CIN3/CIS cases were reported. In a nested case-control study, the sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11,16,18,31,33,35,45,52,58, and antibodies against Chlamydia trachomatis and Human herpesvirus 2. Multivariate analyses were performed to estimate hazard ratios (HR), odds ratios (OR) and corresponding 95% confidence intervals (CI). The cohort analysis showed that number of full-term pregnancies was positively associated with CIN3/CIS risk (p-trend = 0.03). Duration of oral contraceptives use was associated with a significantly increased risk of both CIN3/CIS and ICC (HR = 1.6 and HR = 1.8 respectively for \>/= 15 years versus never use). Ever use of menopausal hormone therapy was associated with a reduced risk of ICC (HR = 0.5, 95%CI: 0.4-0.8). A non-significant reduced risk of ICC with ever use of intrauterine devices (IUD) was found in the nested case-control analysis (OR = 0.6). Analyses restricted to all cases and HPV seropositive controls yielded similar results, revealing a significant inverse association with IUD for combined CIN3/CIS and ICC (OR = 0.7). CONCLUSIONS: Even though HPV is the necessary cause of CC, our results suggest that several hormonal factors are risk factors for cervical carcinogenesis. Adherence to current cervical cancer screening guidelines should minimize the increased risk of CC associated with these hormonal risk factors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15626,

title = {The Self-Regulation Model of Illness: Comparison between Zika and Dengue and Its Application to Predict Mosquito Prevention Behaviours in Malaysia, a Dengue-Endemic Country},

author = {L P Wong and H Alias and N Aghamohammadi and I C Sam and S AbuBakar},

doi = {10.3390/ijerph13121210},

issn = {1660-4601},

year  = {2016},

date = {2016-01-01},

journal = {Int J Environ Res Public Health},

volume = {13},

number = {12},

abstract = {Perceptions about illnesses may influence self-care and preventive health behaviours. Illness perceptions of the Zika virus (ZIKV) infection were investigated under the framework of the Self-Regulation Model of Illness. Illness perception differences between ZIKV and dengue fever were also examined. Lastly, associations between illness perceptions of ZIKV with mosquito prevention practices were studied. Samples were drawn from landline telephone numbers using computer-assisted telephone interviewing in Malaysia. A total of 567 respondents completed the survey between February 2015 and May 2016. The median and interquartile range (IQR) for the total six dimensions of illness perceptions score was higher for dengue (23.0 (IQR 17.0-28.0)) than ZIKV (20.0 (IRQ 11.0-28.0)), p \< 0.001. Respondents who planned to have children (OR 1.670, 95% CI 1.035-2.694 vs. no intention to have children) and had friends or acquaintances who died of dengue (OR 2.372, 95% CI 1.300-4.327 vs. no friends who died of dengue) were more likely to have a higher total score for six illness perceptions for ZIKV compared to dengue. Multivariate analysis indicated that the best predictors for mosquito control practices after the ZIKV outbreak was declared a Public Health Emergency of International Concern, in descending order, were causes, control, timeline, and consequences dimensions of illness perception. Understanding the context in which a person perceives ZIKV may contribute to developing interventions that influence prevention behaviours.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15686,

title = {The value of adjuvant radiotherapy on survival and recurrence in triple-negative breast cancer: A systematic review and meta-analysis of 5507 patients},

author = {M A O'Rorke and L J Murray and J S Brand and N Bhoo-Pathy},

doi = {10.1016/j.ctrv.2016.05.001},

issn = {0305-7372},

year  = {2016},

date = {2016-01-01},

journal = {Cancer Treat Rev},

volume = {47},

pages = {12-21},

abstract = {BACKGROUND: The value of adjuvant radiotherapy in triple negative breast cancer (TNBC) remains unclear. A systematic review and meta-analysis was conducted in TNBC patients to assess survival and recurrence outcomes associated with radiotherapy following either breast conserving therapy (BCT) or post-mastectomy radiotherapy (PMRT). METHODS: Four electronic databases were searched from January 2000 to November 2015 (PubMed, MEDLINE, EMBASE and Web of Science). Studies investigating overall survival and/or recurrence in TNBC patients according to radiotherapy administration were included. A random effects meta-analysis was conducted using mastectomy only patients as the reference. RESULTS: Twelve studies were included. The pooled hazard ratio (HR) for locoregional recurrence comparing BCT and PMRT to mastectomy only was 0.61 (95% confidence interval [CI] 0.41-0.90) and 0.62 (95% CI 0.44-0.86), respectively. Adjuvant radiotherapy was not significantly associated with distant recurrence. The pooled HR for overall survival comparing BCT and PMRT to mastectomy only was 0.57 (95% CI 0.36-0.88) and HR 1.12 (95% CI 0.75, 1.69). Comparing PMRT to mastectomy only, tests for interaction were not significant for stage (p=0.98) or age at diagnosis (p=0.85). However, overall survival was improved in patients with late-stage disease (T3-4, N2-3) pooled HR 0.53 (95% CI 0.32-0.86), and women \<40years, pooled HR 0.30 (95% CI 0.11-0.82). CONCLUSIONS: Adjuvant radiotherapy was associated with a significantly lower risk of locoregional recurrence in TNBC patients, irrespective of the type of surgery. While radiotherapy was not consistently associated with an overall survival gain, benefits may be obtained in women with late-stage disease and younger patients.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15651,

title = {Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21},

author = {M Zhang and Z Wang and O Obazee and J Jia and E J Childs and J Hoskins and G Figlioli and E Mocci and I Collins and C C Chung and C Hautman and A A Arslan and L Beane-Freeman and P M Bracci and J Buring and E J Duell and S Gallinger and G G Giles and G E Goodman and P J Goodman and A Kamineni and L N Kolonel and M H Kulke and N Malats and S H Olson and H D Sesso and K Visvanathan and E White and W Zheng and C C Abnet and D Albanes and G Andreotti and L Brais and H B Bueno-de-Mesquita and D Basso and S I Berndt and M C Boutron-Ruault and M F Bijlsma and H Brenner and L Burdette and D Campa and N E Caporaso and G Capurso and G M Cavestro and M Cotterchio and E Costello and J Elena and U Boggi and J M Gaziano and M Gazouli and E L Giovannucci and M Goggins and M Gross and C A Haiman and M Hassan and K J Helzlsouer and N Hu and D J Hunter and E Iskierka-Jazdzewska and M Jenab and R Kaaks and T J Key and K T Khaw and E A Klein and M Kogevinas and V Krogh and J Kupcinskas and R C Kurtz and M T Landi and S Landi and L Le Marchand and A Mambrini and S Mannisto and R L Milne and R E Neale and A L Oberg and S Panico and A V Patel and P H Peeters and U Peters and R Pezzilli and M Porta and M Purdue and J R Quiros and E Riboli and N Rothman and A Scarpa and G Scelo and X O Shu and D T Silverman and P Soucek and O Strobel and M Sund and E Malecka-Panas and P R Taylor and F Tavano and R C Travis and M Thornquist and A Tjonneland and G S Tobias and others},

doi = {10.18632/oncotarget.11041},

issn = {1949-2553},

year  = {2016},

date = {2016-01-01},

journal = {Oncotarget},

volume = {7},

number = {41},

pages = {66328-66343},

abstract = {Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15710,

title = {Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study},

author = {S Ambatipudi and C Cuenin and H Hernandez-Vargas and A Ghantous and F Le Calvez-Kelm and R Kaaks and M Barrdahl and H Boeing and K Aleksandrova and A Trichopoulou and P Lagiou and A Naska and D Palli and V Krogh and S Polidoro and R Tumino and S Panico and B Bueno-de-Mesquita and P H Peeters and J R Quiros and C Navarro and E Ardanaz and M Dorronsoro and T Key and P Vineis and N Murphy and E Riboli and I Romieu and Z Herceg},

doi = {10.2217/epi-2016-0001},

issn = {1750-192x},

year  = {2016},

date = {2016-01-01},

journal = {Epigenomics},

volume = {8},

number = {5},

pages = {599-618},

abstract = {AIM: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. MATERIALS \& METHODS: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort. RESULTS: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation. CONCLUSION: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15692,

title = {Understanding of elder abuse and neglect among health care professionals in Malaysia: An exploratory survey},

author = {A Ahmed and W Y Choo and S Othman and N N Hairi and F M Hairi and F H Mohd Mydin and S N Illiani Jaafar},

doi = {10.1080/08946566.2016.1185985},

issn = {0894-6566},

year  = {2016},

date = {2016-01-01},

journal = {J Elder Abuse Negl},

volume = {28},

number = {3},

pages = {163-77},

abstract = {Elder abuse and neglect (EAN) is a hidden public health challenge for Malaysia. This cross-sectional survey studied the awareness of EAN among 148 doctors and nurses from two neighboring states in Malaysia using a self-administered questionnaire exploring their knowledge, perceptions, practices, and experience concerning EAN. Both doctors and nurses demonstrated poor understanding of signs of EAN and exhibited misperceptions on reporting requirements. Both groups perceived EAN as a national burden and reporting it as their responsibility; but most felt they had not been trained to diagnose it. Many were unsure of procedures and whether their own intervention could be effective. Only four (nurses) of 41 participants who suspected abuse during the past year reported the cases. Targeted education and uniform protocols are mandatory to ensure best practice with regards to EAN. Further research is crucial to extend this inquiry into the broader health care workforce.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15641,

title = {Validation of the CancerMath prognostic tool for breast cancer in Southeast Asia},

author = {H Miao and M Hartman and H M Verkooijen and N A Taib and H S Wong and S Subramaniam and C H Yip and E Y Tan and P Chan and S C Lee and N Bhoo-Pathy},

doi = {10.1186/s12885-016-2841-9},

issn = {1471-2407},

year  = {2016},

date = {2016-01-01},

journal = {BMC Cancer},

volume = {16},

number = {1},

pages = {820},

abstract = {BACKGROUND: CancerMath is a set of web-based prognostic tools which predict nodal status and survival up to 15 years after diagnosis of breast cancer. This study validated its performance in a Southeast Asian setting. METHODS: Using Singapore Malaysia Hospital-Based Breast Cancer Registry, clinical information was retrieved from 7064 stage I to III breast cancer patients who were diagnosed between 1990 and 2011 and underwent surgery. Predicted and observed probabilities of positive nodes and survival were compared for each subgroup. Calibration was assessed by plotting observed value against predicted value for each decile of the predicted value. Discrimination was evaluated by area under a receiver operating characteristic curve (AUC) with 95 % confidence interval (CI). RESULTS: The median predicted probability of positive lymph nodes is 40.6 % which was lower than the observed 43.6 % (95 % CI, 42.5 %-44.8 %). The calibration plot showed underestimation for most of the groups. The AUC was 0.71 (95 % CI, 0.70-0.72). Cancermath predicted and observed overall survival probabilities were 87.3 % vs 83.4 % at 5 years after diagnosis and 75.3 % vs 70.4 % at 10 years after diagnosis. The difference was smaller for patients from Singapore, patients diagnosed more recently and patients with favorable tumor characteristics. Calibration plot also illustrated overprediction of survival for patients with poor prognosis. The AUC for 5-year and 10-year overall survival was 0.77 (95 % CI: 0.75-0.79) and 0.74 (95 % CI: 0.71-0.76). CONCLUSIONS: The discrimination and calibration of CancerMath were modest. The results suggest that clinical application of CancerMath should be limited to patients with better prognostic profile.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15733,

title = {Vegetable and fruit consumption and the risk of hormone receptor-defined breast cancer in the EPIC cohort},

author = {M J Emaus and P H Peeters and M F Bakker and K Overvad and A Tjonneland and A Olsen and I Romieu and P Ferrari and L Dossus and M C Boutron-Ruault and L Baglietto and R T Fortner and R Kaaks and H Boeing and A Trichopoulou and P Lagiou and D Trichopoulos and G Masala and V Pala and S Panico and R Tumino and S Polidoro and G Skeie and E Lund and E Weiderpass and J R Quiros and N Travier and M J Sanchez and M D Chirlaque and E Ardanaz and M Dorronsoro and A Winkvist and M Wennberg and H B Bueno-de-Mesquita and K T Khaw and R C Travis and T J Key and D Aune and M Gunter and E Riboli and C H Gils},

doi = {10.3945/ajcn.114.101436},

issn = {0002-9165},

year  = {2016},

date = {2016-01-01},

journal = {Am J Clin Nutr},

volume = {103},

number = {1},

pages = {168-77},

abstract = {BACKGROUND: The recent literature indicates that a high vegetable intake and not a high fruit intake could be associated with decreased steroid hormone receptor-negative breast cancer risk. OBJECTIVE: This study aimed to investigate the association between vegetable and fruit intake and steroid hormone receptor-defined breast cancer risk. DESIGN: A total of 335,054 female participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were included in this study (mean +/- SD age: 50.8 +/- 9.8 y). Vegetable and fruit intake was measured by country-specific questionnaires filled out at recruitment between 1992 and 2000 with the use of standardized procedures. Cox proportional hazards models were stratified by age at recruitment and study center and were adjusted for breast cancer risk factors. RESULTS: After a median follow-up of 11.5 y (IQR: 10.1-12.3 y), 10,197 incident invasive breast cancers were diagnosed [3479 estrogen and progesterone receptor positive (ER+PR+); 1021 ER and PR negative (ER-PR-)]. Compared with the lowest quintile, the highest quintile of vegetable intake was associated with a lower risk of overall breast cancer (HRquintile 5-quintile 1: 0.87; 95% CI: 0.80, 0.94). Although the inverse association was most apparent for ER-PR- breast cancer (ER-PR-: HRquintile 5-quintile 1: 0.74; 95% CI: 0.57, 0.96; P-trend = 0.03; ER+PR+: HRquintile 5-quintile 1: 0.91; 95% CI: 0.79, 1.05; P-trend = 0.14), the test for heterogeneity by hormone receptor status was not significant (P-heterogeneity = 0.09). Fruit intake was not significantly associated with total and hormone receptor-defined breast cancer risk. CONCLUSION: This study supports evidence that a high vegetable intake is associated with lower (mainly hormone receptor-negative) breast cancer risk.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15718,

title = {Victimization After Meeting With Online Acquaintances: A Cross-Sectional Survey of Adolescents in Malaysia},

author = {M J Marret and W Y Choo},

doi = {10.1177/0886260515625502},

issn = {0886-2605},

year  = {2016},

date = {2016-01-01},

journal = {J Interpers Violence},

abstract = {This study aimed to determine contact and privacy risks encountered by Malaysian adolescents with access to the Internet and mobile phones and factors associated with face-to-face meetings with online acquaintances as well as to estimate the prevalence of subsequent victimization. Secondary school students from randomly selected public schools in Selangor and Kuala Lumpur responded to an anonymous self-administered questionnaire (78% response rate). Out of 3,349 Internet or mobile phone users, 51% had been invited to meet offline with an online-meeting acquaintance and 30% complied. Of the 1,005 respondents who went to offline meetings, 55% had meetings with more than six people. Male gender, Malay ethnicity, online access at an Internet cafe, viewing pornography on the Internet, the absence of parental restrictions on visiting certain website and chat rooms, not being explicitly forbidden to meet strangers encountered online, and disclosure of personal information were significantly associated with increased odds of face-to-face meetings with online acquaintances. Verbal, physical, or sexual assaults were reported by 5.5% of the 1,005 including 13 males and five females who reported forced sexual intercourse. Similarities as well as differences in factors associated with risk-taking behavior compared with adolescents in Western countries have important implications on policy and intervention.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15639,

title = {Vitamin D and Calcium Intakes, Physical Activity, and Calcaneus BMC among School-Going 13-Year Old Malaysian Adolescents},

author = {A A Suriawati and H A Majid and N Al-Sadat and M N Mohamed and M Y Jalaludin},

doi = {10.3390/nu8100666},

issn = {2072-6643},

year  = {2016},

date = {2016-01-01},

journal = {Nutrients},

volume = {8},

number = {10},

abstract = {BACKGROUND: Dietary calcium and vitamin D are essential for bone development. Apart from diet, physical activity may potentially improve and sustain bone health. OBJECTIVE: To investigate the relationship between the dietary intake of calcium and vitamin D, physical activity, and bone mineral content (BMC) in 13-year-old Malaysian adolescents. DESIGN: Cross-sectional. SETTING: Selected public secondary schools from the central and northern regions of Peninsular Malaysia. PARTICIPANTS: The subjects were from the Malaysian Health and Adolescents Longitudinal Research Team Cohort study (MyHeARTs). METHODS: The data included seven-day diet histories, anthropometric measurements, and the BMC of calcaneal bone using a portable broadband ultrasound bone densitometer. Nutritionist Pro software was used to calculate the dietary calcium and vitamin D intakes from the diet histories, based on the Nutrient Composition of Malaysian Food Database guidance for the dietary calcium intake and the Singapore Energy and Nutrient Composition of Food Database for vitamin D intake. RESULTS: A total of 289 adolescents (65.7% females) were recruited. The average dietary intakes of calcium and vitamin D were 377 +/- 12 mg/day and 2.51 +/- 0.12 microg/day, respectively, with the majority of subjects failing to meet the Recommended Nutrient Intake (RNI) of Malaysia for dietary calcium and vitamin D. All the subjects had a normal Z-score for the BMC (-2.00 or higher) with a mean of 0.55 +/- 0.01. From the statistical analysis of the factors contributing to BMC, it was found that for those subjects with a higher intake of vitamin D, a higher combination of the intake of vitamin D and calcium resulted in significantly higher BMC quartiles. The regression analysis showed that the BMC might have been influenced by the vitamin D intake. CONCLUSIONS: A combination of the intake of vitamin D and calcium is positively associated with the BMC.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15653,

title = {Vitamin D deficiency in Malaysian adolescents aged 13 years: findings from the Malaysian Health and Adolescents Longitudinal Research Team study (MyHeARTs)},

author = {N Al-Sadat and H A Majid and P Y Sim and T T Su and M Dahlui and M F Abu Bakar and N Dzaki and S Norbaya and L Murray and M M Cantwell and M Y Jalaludin},

doi = {10.1136/bmjopen-2015-010689},

issn = {2044-6055},

year  = {2016},

date = {2016-01-01},

journal = {BMJ Open},

volume = {6},

number = {8},

pages = {e010689},

abstract = {OBJECTIVE: To determine the prevalence of vitamin D deficiency (\<37.5 nmol/L) among young adolescents in Malaysia and its association with demographic characteristics, anthropometric measures and physical activity. DESIGN: This is a cross-sectional study among Form 1 (year 7) students from 15 schools selected using a stratified random sampling design. Information regarding sociodemographic characteristics, clinical data and environmental factors was collected and blood samples were taken for total vitamin D. Descriptive and multivariable logistic regression was performed on the data. SETTING: National secondary schools in Peninsular Malaysia. PARTICIPANTS: 1361 students (mean age 12.9+/-0.3 years) (61.4% girls) completed the consent forms and participated in this study. Students with a chronic health condition and/or who could not understand the questionnaires due to lack of literacy were excluded. MAIN OUTCOME MEASURES: Vitamin D status was determined through measurement of sera 25-hydroxyvitamin D (25(OH)D). Body mass index (BMI) was classified according to International Obesity Task Force (IOTF) criteria. Self-reported physical activity levels were assessed using the validated Malay version of the Physical Activity Questionnaire for Older Children (PAQ-C). RESULTS: Deficiency in vitamin D was seen in 78.9% of the participants. The deficiency was significantly higher in girls (92.6%, p\<0.001), Indian adolescents (88.6%, p\<0.001) and urban-living adolescents (88.8%, p\<0.001). Females (OR=8.98; 95% CI 6.48 to 12.45), adolescents with wider waist circumference (OR=2.64; 95% CI 1.65 to 4.25) and in urban areas had higher risks (OR=3.57; 95% CI 2.54 to 5.02) of being vitamin D deficient. CONCLUSIONS: The study shows a high prevalence of vitamin D deficiency among young adolescents. Main risk factors are gender, ethnicity, place of residence and obesity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15706,

title = {Vitamin D level and its association with adiposity among multi-ethnic adults in Kuala Lumpur, Malaysia: a cross sectional study},

author = {I S Shafinaz and F M Moy},

doi = {10.1186/s12889-016-2924-1},

issn = {1471-2458},

year  = {2016},

date = {2016-01-01},

journal = {BMC Public Health},

volume = {16},

pages = {232},

abstract = {BACKGROUND: Vitamin D deficiency is highly prevalent in both temperate as well as tropical countries. Obesity is one of the factors contributing to vitamin D deficiency. As our country has a high prevalence of overweight and obesity, we aimed to study serum 25-hydroxyvitamin D (25(OH)D) level and its association with adiposity using various adiposity indicators; and to study other risk factors that affect serum 25(OH)D level among multi-ethnic adults in Kuala Lumpur, Malaysia. METHODS: This was a cross sectional study conducted with a multistage sampling. All permanent teachers working in government secondary schools in Kuala Lumpur were invited for the study. The data collection included serum 25(OH)D, Parathyroid Hormone (PTH), body fat percentage, waist circumference, body mass index (BMI) and blood pressure. Demographic characteristics, sun avoidance, sun exposure and physical activity were enquired from the participants using a self-administered questionnaire. The data was analyzed using a complex sample analysis. RESULTS: A total of 858 participants were recruited. Majority of them were Malays, females and had tertiary education. The overall prevalence of vitamin D deficiency (\<20 ng/ml) was 67.4 %. Indian participants (80.9 %) had the highest proportion of vitamin D deficiency, followed by Malays (75.6 %), others (44.9 %) and Chinese (25.1 %). There was a significant negative association between serum 25(OH)D level with BMI (beta = -0.23) and body fat percentage (beta = -0.14). In the multivariate linear regression analysis, Malays, Indians and females (p \< 0.001); higher BMI and larger waist circumference (p \< 0.05) were significantly associated with lower serum 25(OH)D level. The full model explained 32.8 % of the variation between participants in the serum 25(OH)D level. The two most influential factors affecting serum 25(OH)D level were ethnicity and gender. CONCLUSIONS: The prevalence of vitamin D deficiency among our participants was high. Adiposity was associated with serum 25(OH)D level. Skin pigmentation and gender based behaviours were more dominant in contributing to serum 25(OH)D level. Health education should be targeted in weight management, gender based behaviours on sun exposure, as skin pigmentation is non-modifiable.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN15682,

title = {Work Ability and Its Related Factors Among Workers in Small and Medium Enterprises: Comparison Among Four ASEAN Countries},

author = {O Kaewboonchoo and M Isahak and I Susilowati and T N Phuong and I Morioka and K Harncharoen and W Y Low and P Ratanasiripong},

doi = {10.1177/1010539516651957},

issn = {1010-5395},

year  = {2016},

date = {2016-01-01},

journal = {Asia Pac J Public Health},

volume = {28},

number = {5},

pages = {438-49},

abstract = {Work ability is related to many factors that might influence one's capacity to work. This study aimed to examine the work ability and its related factors among small and medium enterprises (SME) workers in 4 Association of Southeast Asian Nations (ASEAN) countries. The participants in this study included 2098 workers from food and textile industries in Indonesia, Malaysia, Thailand, and Vietnam. A cross-sectional survey of anonymous self-administrated questionnaire was designed to collect information on sociodemographic factors, work environment and ergonomic condition, musculoskeletal disorders, and work ability. Bivariate correlation coefficient and multiple linear regression analyses were used to predict the work ability. Results of this study confirm that work ability in 4 ASEAN countries was similar to that in European countries, and that the sociodemographic factors, work environment and ergonomic condition, and musculoskeletal disorder (MSD) were associated with work ability. These factors are important for considering occupational health and safety policy to promote work ability in food, textile, and other SME workers.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}