Publications from 2019

@article{RN16711,

title = {A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk},

author = {R C Travis and A Perez-Cornago and P N Appleby and D Albanes and C E Joshu and P L Lutsey and A M Mondul and E A Platz and S J Weinstein and T M Layne and K J Helzlsouer and K Visvanathan and D Palli and P H Peeters and B Bueno-de-Mesquita and A Trichopoulou and M J Gunter and K K Tsilidis and M J Sanchez and A Olsen and H Brenner and B Schottker and L Perna and B Holleczek and P Knekt and H Rissanen and B B Yeap and L Flicker and O P Almeida and Y Y E Wong and J M Chan and E L Giovannucci and M J Stampfer and G Ursin and R E Gislefoss and T Bjorge and H E Meyer and R Blomhoff and S Tsugane and N Sawada and D R English and D W Eyles and A K Heath and E J Williamson and J Manjer and J Malm and M Almquist and L L Marchand and C A Haiman and L R Wilkens and J M Schenk and C M Tangen and A Black and M B Cook and W Y Huang and R G Ziegler and R M Martin and F C Hamdy and J L Donovan and D E Neal and M Touvier and S Hercberg and P Galan and M Deschasaux and T J Key and N E Allen},

doi = {10.1158/0008-5472.Can-18-2318},

issn = {0008-5472},

year  = {2019},

date = {2019-01-01},

journal = {Cancer Res},

volume = {79},

number = {1},

pages = {274-285},

abstract = {Previous prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-standardized vitamin D concentration were estimated using multivariable-adjusted conditional logistic regression. 25(OH)D concentration was positively associated with risk for total prostate cancer (multivariable-adjusted OR comparing highest vs. lowest study-specific fifth was 1.22; 95% confidence interval, 1.13-1.31; P trend \< 0.001). However, this association varied by disease aggressiveness (P heterogeneity = 0.014); higher circulating 25(OH)D was associated with a higher risk of nonaggressive disease (OR per 80 percentile increase = 1.24, 1.13-1.36) but not with aggressive disease (defined as stage 4, metastases, or prostate cancer death, 0.95, 0.78-1.15). 1,25(OH)2D concentration was not associated with risk for prostate cancer overall or by tumor characteristics. The absence of an association of vitamin D with aggressive disease does not support the hypothesis that vitamin D deficiency increases prostate cancer risk. Rather, the association of high circulating 25(OH)D concentration with a higher risk of nonaggressive prostate cancer may be influenced by detection bias. SIGNIFICANCE: This international collaboration comprises the largest prospective study on blood vitamin D and prostate cancer risk and shows no association with aggressive disease but some evidence of a higher risk of nonaggressive disease.},

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@article{RN16712,

title = {A Nationwide Study Comparing Knowledge and Beliefs about HPV among Female Students before and after HPV Vaccination},

author = {L P Wong and H Alias and I C Sam and G D Zimet},

doi = {10.1016/j.jpag.2018.10.010},

issn = {1083-3188},

year  = {2019},

date = {2019-01-01},

journal = {J Pediatr Adolesc Gynecol},

volume = {32},

number = {2},

pages = {158-164},

abstract = {STUDY OBJECTIVE: To assess the knowledge and beliefs regarding human papillomavirus (HPV) and the HPV vaccine among girls before and after vaccination in the Malaysian HPV Immunisation Programme. DESIGN: A nationwide longitudinal survey. SETTING: Thirty-two randomly selected schools from 13 states and 3 federal territories in Malaysia from February to March 2013, and October to November 2013. PARTICIPANTS: Form One female students (13 years old). INTERVENTIONS: None. MAIN OUTCOME MEASURES: Mean knowledge score of HPV infection. RESULTS: A total of 2644 students responded to the prevaccination survey, of whom 2005 (70%) completed the postvaccination survey. The mean knowledge score was 2.72 (SD +/- 2.20) of a maximum score of 10 in the prevaccination survey, which increased significantly to 3.33 (SD +/- 1.73) after the 3 doses of HPV vaccine (P = .001). Many answered incorrectly that, "Only girls can get HPV infection" (91.5%},

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@article{RN16622,

title = {A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study},

author = {N Papadimitriou and D Muller and P A Brandt and M Geybels and C J Patel and M J Gunter and D S Lopez and T J Key and A Perez-Cornago and P Ferrari and P Vineis and E Weiderpass and H Boeing and A Agudo and M J Sanchez and K Overvad and T Kuhn and R T Fortner and D Palli and I Drake and A Bjartell and C Santiuste and B H Bueno-de-Mesquita and V Krogh and A Tjonneland and D F Lauritzen and A B Gurrea and J R Quiros and P Stattin and A Trichopoulou and G Martimianaki and A Karakatsani and E Thysell and I Johansson and F Ricceri and R Tumino and N Larranaga and K T Khaw and E Riboli and I Tzoulaki and K K Tsilidis},

doi = {10.1007/s00394-019-02132-z},

issn = {1436-6207},

year  = {2019},

date = {2019-01-01},

journal = {Eur J Nutr},

abstract = {PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR \< 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). RESULTS: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. CONCLUSIONS: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.},

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@article{RN16802,

title = {A preliminary insight into the environmental awareness of community in the vicinity of batik manufacturing units in Kelantan, Malaysia},

author = {L Ramakreshnan and A Rajandra and N Aghamohammadi and C S Fong and S Nalatambi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068748591\&doi=10.1007%2fs10708-019-10046-w\&partnerID=40\&md5=dc8b2a4ff279343b235ca131e9000272},

doi = {10.1007/s10708-019-10046-w},

year  = {2019},

date = {2019-01-01},

journal = {GeoJournal},

abstract = {In response to a significant contribution of batik industries towards water pollution in Kelantan, this study sought to examine the environmental awareness of the community staying in the vicinity of batik manufacturing units in Kelantan. In this cross-sectional study, 160 participants were administered with interviewer-assisted questionnaire surveys between November 2013 and December 2013. Information pertaining to the participants’ awareness of the batik manufacturing process, nature and disposal of dyes as well as the associated environmental and health impacts due to improper wastewater discharges were recorded. Chi square and multivariate binary logistic regression model was deployed to determine the significance between the socio-demographic variables and the items assessed to explore their environmental awareness. Despite a limited awareness on the batik manufacturing process and chemical properties of dyes, more than half of the study participants were more likely to be aware of the dye disposal methods utilized by the manufacturing units as well as the environmental and health impacts of the wastewater discharges in their neighbourhood. Among the socio-demographic variables, having a formal education recorded a significant association with the nature of dye, dye disposal method, environmental and health impacts due to improper dye disposal. In a nutshell, this study contributed useful empirical insights on the current environmental awareness levels of the community near the batik manufacturing units in Kelantan to devise interventions for the cultivation of community-based surveillance. © 2019, Springer Nature B.V.},

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@article{RN16648,

title = {A qualitative examination of barriers and solutions to renal transplantation in Malaysia: Key-informants' perspective},

author = {P Gan Kim Soon and S K Lim and S Rampal and T T Su},

doi = {10.1371/journal.pone.0220411},

issn = {1932-6203},

year  = {2019},

date = {2019-01-01},

journal = {PLoS One},

volume = {14},

number = {8},

pages = {e0220411},

abstract = {INTRODUCTION: End-stage renal disease (ESRD) is increasing globally, and renal transplantation (RT) is the preferred renal replacement therapy to treat ESRD. Internationally, there are only a few countries with RT rates above 50 per million population (pmp), while most of the countries have RT rates between 30-40 pmp. The low- and middle-income countries (LMIC) makes up the majority for the RT rates below 20 pmp in which Malaysia belongs to despite its increasing ESRD rates. There is a need to explore the barriers to access RT with targeted solutions to improve the RT rates and service in LMIC. Thus, a qualitative study was undertaken in Malaysia to address this issue. METHOD: A qualitative methodological approach was performed between March-May 2018. Semi-structured interviews were used to explore current RT policy and service availability. Key-informants were identified from a detailed stakeholder analysis of RT system in Malaysia. Interviews were digitally audio-recorded, transcribed verbatim, coded with ATLAS.ti software and underwent thematic analysis thoroughly. RESULTS: Eight key-informants participated in the study. Barriers and related solutions were classified using the socio-ecological model (SEM). As reported, the barriers and solutions of RT in Malaysia are the results of a complex interplay of personal, cultural, and environmental factors. Key barriers are linked to public's attitude and perception towards RT and the unaccommodating practices in the healthcare fraternity for RT. Key-informants provided a systematic solution that shed light on how RT could be improved at each SEM level via effective communication, education and inter-agency collaboration. CONCLUSION: The SEM provided a framework to foster a better understanding of current practice, barriers, and solutions to RT in Malaysia. This study is the first to explore the barriers and related solutions to RT comprehensively as a whole. Implications of these findings could prompt a policy change for a better RT service delivery model not just for Malaysia but also for other LMIC. Further stakeholder engagement and evaluation of the systems are required to provide insight into best practices that will help to improve the RT rates and service in Malaysia.},

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@article{RN16776,

title = {A qualitative exploration on the awareness and knowledge of stakeholders towards Urban Heat Island phenomenon in Greater Kuala Lumpur: Critical insights for urban policy implications},

author = {L Ramakreshnan and N Aghamohammadi and C S Fong and A Ghaffarianhoseini and L P Wong and R M Noor and N R Hanif and W N Azriyati Wan Abd Aziz and N M Sulaiman and N Hassan},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062262912\&doi=10.1016%2fj.habitatint.2019.02.007\&partnerID=40\&md5=81ede28eb51ae1ccd593e1ef1a8d6c2b},

doi = {10.1016/j.habitatint.2019.02.007},

year  = {2019},

date = {2019-01-01},

journal = {Habitat International},

volume = {86},

pages = {28-37},

abstract = {Despite its notable role in the exacerbation of urban climate, Urban Heat Island (UHI) was poorly addressed, communicated and integrated into local urban policies of many developing countries. Such scenario often queried the level of UHI understanding amongst the key players who were involved in urban policy formulation. Hence, a qualitative study using Focus Group Discussions (FGD) was designed to investigate the awareness and knowledge level of stakeholders such as policy makers and practitioners in Greater Kuala Lumpur (GKL), an expanding socio-economic hub of a developing tropical country. The findings demonstrated a variable lack of awareness and knowledge about the concept of UHI, its status in GKL as well as organizational engagement in adaptation and mitigation initiatives among the study participants. Essentially, policy makers illustrated a facile awareness and knowledge towards UHI issues whereas practitioners displayed a more robust portfolio of factual understanding regarding the corresponding issues. In line with National Urbanization Policy's (NUP) aspiration to optimize urban developments that provide high quality of life, this study sheds some light on the exigency for UHI awareness creation and capacity building among the policy makers. This study also provides impactful prepositions for the articulation of necessary actions towards evidence-based urban policy formulation in future. © 2019},

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@article{RN16668,

title = {A Qualitative Study of HIV "Test-and-Treat" Experience Among Men Who Have Sex With Men in Malaysia},

author = {S H Lim and H Alias and J K W Kien and M Akbar and A Kamarulzaman and L P Wong},

doi = {10.1521/aeap.2019.31.3.193},

issn = {0899-9546},

year  = {2019},

date = {2019-01-01},

journal = {AIDS Educ Prev},

volume = {31},

number = {3},

pages = {193-205},

abstract = {This study aimed to examine the barriers and facilitators to HIV testing and treatment among Malaysian MSM. Between June 2014 and December 2015, in-depth interviews were conducted in 20 HIV-positive MSM recruited from a teaching hospital and NGO in Kuala Lumpur. Thematic analysis was used to identify, analyze, and report themes. Most participants investigated their HIV status after long period of sickness. Others sought testing upon partner's diagnosis and some were diagnosed via blood donation. Barriers to testing include personal (perceived good health, fear of positive result, denial); social and structural factors (stigmatization by health providers and family, lack of information about free HIV testing and long wait time). Barriers to treatment comprise personal factors (perceived HIV as incurable and treatment as complicated), social factors (HIV and homosexual stigma), and cost. Promoting benefits of regular testing and early treatment is needed to improve HIV care continuum among MSM in Malaysia.},

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@article{RN16682,

title = {A Stepwise Approach to a National Hepatitis C Screening Strategy in Malaysia to Meet the WHO 2030 Targets: Proposed Strategy, Coverage, and Costs},

author = {L Hiebert and R Hecht and S Soe-Lin and R Mohamed and F H Shabaruddin and S M Syed Mansor and M Dahlui and A Azzeri and S A McDonald},

doi = {10.1016/j.vhri.2018.12.005},

issn = {2212-1099},

year  = {2019},

date = {2019-01-01},

journal = {Value Health Reg Issues},

volume = {18},

pages = {112-120},

abstract = {BACKGROUND: In Malaysia, more than 330 000 individuals are estimated to be chronically infected with hepatitis C virus (HCV), but less than 2% have been treated to date. OBJECTIVES: To estimate the required coverage and costs of a national screening strategy to inform the launch of an HCV elimination program. METHODS: We designed an HCV screening strategy based on a "stepwise" approach. This approach relied on targeting of people who inject drugs in the early years, with delayed onset of widespread general population screening. Annual coverage requirements and associated costs were estimated to ensure that the World Health Organization elimination treatment targets were met. RESULTS: In total, 6 million individuals would have to be screened between 2018 and 2030. Targeting of people who inject drugs in the early years would limit annual screening coverage to less than 1 million individuals from 2018 to 2026. General population screening would have to be launched by 2026. Total costs were estimated at MYR 222 million ($58 million). Proportional to coverage targets, 60% of program costs would fall from 2026 to 2030. CONCLUSIONS: This exercise was one of the first attempts to conduct a detailed analysis of the required screening coverage and costs of a national HCV elimination strategy. These findings suggest that the stepwise approach could delay the onset of general population screening by more than 5 years after the program's launch. This delay would allow additional time to mobilize investments required for a successful general population screening program and also minimize program costs. This strategy prototype could inform the design of effective screening strategies in other countries.},

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@article{RN16645,

title = {A study to determine the educational objectives and outcomes for pre-registration Diploma nursing program: A modified Delphi},

author = {K Tan and M C Chong and L P Wong},

doi = {10.1016/j.nepr.2019.08.002},

issn = {1471-5953},

year  = {2019},

date = {2019-01-01},

journal = {Nurse Educ Pract},

volume = {39},

pages = {80-89},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16662,

title = {A systematic review of depression literacy: Knowledge, help-seeking and stigmatising attitudes among adolescents},

author = {S Singh and R A Zaki and N D N Farid},

doi = {10.1016/j.adolescence.2019.06.004},

issn = {0140-1971},

year  = {2019},

date = {2019-01-01},

journal = {J Adolesc},

volume = {74},

pages = {154-172},

abstract = {INTRODUCTION: Depression is a common mental health disorder and affects many adolescents worldwide. Depression literacy can improve mental health outcomes. The aim of this study was to collate and analyse the extant evidence on depression literacy among adolescents, with particular focus on tools used to examine depression literacy and the findings on components of depression literacy. METHODS: Nine electronic databases and 1 grey literature source were searched for studies published in English between January 2006 and December 2018 and involving adolescents aged 10-19 years. We included studies that reported on components of depression literacy such as knowledge, help-seeking and stigmatising attitudes. We excluded qualitative studies. Two independent reviewers verified that the studies met the inclusion criteria, assessed the quality of the studies and extracted their characteristics. The data were descriptively analysed and appraised using the Newcastle-Ottawa Scale (NOS), Cochrane Collaboration's tool and the Quality Assessment Tool for Quantitative Studies (QATSQ). RESULTS AND CONCLUSION: Fifty of the 14,626 references identified met the inclusion criteria. Depression literacy was most commonly (58%) assessed using tools that utilize a vignette-based methodology. A lack of uniformity in reporting of depression literacy was noted. Adolescents were poor at recognising depression, likely to seek help from informal sources and tended to attach stigma to depression. The implications of the findings are discussed and suggestions made for future research.},

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@article{RN16681,

title = {Acceptability of Women Self-Sampling versus Clinician-Collected Samples for HPV DNA Testing: A Systematic Review},

author = {K Morgan and M Azzani and S L Khaing and Y L Wong and T T Su},

doi = {10.1097/lgt.0000000000000476},

issn = {1089-2591},

year  = {2019},

date = {2019-01-01},

journal = {J Low Genit Tract Dis},

volume = {23},

number = {3},

pages = {193-199},

abstract = {OBJECTIVES: Female self-sampling for human papillomavirus (HPV) DNA testing is an alternative screening method that can potentially increase cervical cancer screening coverage. This review addresses the acceptability of HPV DNA testing using self-sampling compared with conventional clinician-collected sampling. Barriers to and others factors associated with acceptability of either method were also examined. METHODS: The following electronic resources were searched: Medline @EBSCOHOST(Medline), Embase, PubMed, and CINAHL databases. Manual searches were also conducted. The main outcome of interest was the acceptability of HPV DNA testing by self-sampling in comparison with clinician-collected sampling. RESULTS: In total, 23 articles were included in this systematic review. The majority (19 studies) were quantitative intervention studies and 4 studies were qualitative observational studies. Eleven studies reported a preference for self-sampling by women compared with clinician-collected sampling (64.7%-93%). The remaining studies found that women preferred clinician-collected sampling because mainly of respondents' lack of confidence in their ability to complete self-sampling correctly. In most articles reviewed, the studied associated factors, such as demographic factors (age, marital status, and ethnicity), socioeconomic factors (income, education level), reproductive factors (condom use, number of children, current use of contraception, and number of partners), and habits (smoking status) were not found to be significantly associated with preference. CONCLUSIONS: Both methods of sampling were found to be acceptable to women. Self-sampling is cost-effective and could increase the screening coverage among underscreened populations. However, more information about the quality, reliability, and accuracy of self-sampling is needed to increase women's confidence about using to this method.},

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@article{RN16663,

title = {Achieving cost-efficient management of drug supply via economic order quantity and minimum-maximum stock level},

author = {E K Dewi and M Dahlui and D Chalidyanto and T N Rochmah},

doi = {10.1080/14737167.2019.1633308},

issn = {1473-7167},

year  = {2019},

date = {2019-01-01},

journal = {Expert Rev Pharmacoecon Outcomes Res},

pages = {1-6},

abstract = {Background: A good drug inventory planning system is important for an efficient budgeting, procurement, and cost control of drugs. When stagnant drugs in the inventory are too much, wastage due to expired and spoiled drugs could occur. These will not only cause loss of income but could also jeopardize healthcare service delivery. Research design and methods: This study aimed to determine the most efficient and effective management of stagnant and shortage drugs by comparing three pharmacy logistic methods; the economic order quantity (EOQ), minimum-maximum stock level (MMSL), and the traditional consumption of drug inventory, at RA Basoeni Hospital, Mojokerto. Drug inventory was analyzed to calculate the opportunity loss, opportunity cost, and proportions of both stagnant and shortage drugs. Results: We found that EOQ and MMSL performed best for control of stagnant drugs and shortage drugs, respectively. Both methods had proved as effective pharmacy logistic planning. In addition, EOQ produced the lowest opportunity cost for stagnant drugs besides the lowest opportunity loss for shortage drugs. Conclusion: The study concluded that EOQ is the most effective and efficient method to manage stagnant and shortage drugs at hospital pharmacy.},

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@article{RN16768,

title = {Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer},

author = {N Walsh and H Zhang and P L Hyland and Q Yang and E Mocci and M Zhang and E J Childs and I Collins and Z Wang and A A Arslan and L Beane-Freeman and P M Bracci and P Brennan and F Canzian and E J Duell and S Gallinger and G G Giles and M Goggins and G E Goodman and P J Goodman and R J Hung and C Kooperberg and R C Kurtz and N Malats and L Lemarchand and R E Neale and S H Olson and G Scelo and X O Shu and S K Van Den Eeden and K Visvanathan and E White and W Zheng and D Albanes and G Andreotti and A Babic and W R Bamlet and S I Berndt and A Borgida and M C Boutron-Ruault and L Brais and B Bueno-De-Mesquita and J Buring and K G Chaffee and S Chanock and S Cleary and M Cotterchio and L Foretova and C Fuchs and J M M Gaziano and E Giovannucci and T Hackert and C Haiman and P Hartge and M Hasan and K J Helzlsouer and J Herman and I Holcatova and E A Holly and R Hoover and V Janout and E A Klein and D Laheru and I M Lee and L Lu and S Mannisto and R L Milne and A L Oberg and I Orlow and A V Patel and U Peters and M Porta and F X Real and N Rothman and H D Sesso and G Severi and D Silverman and O Strobel and M Sund and M D Thornquist and G S Tobias and J Wactawski-Wende and N Wareham and E Weiderpass and N Wentzensen and W Wheeler and H Yu and A Zeleniuch-Jacquotte and P Kraft and D Li and E J Jacobs and G M Petersen and B M Wolpin and H A Risch and L T Amundadottir and K Yu and A P Klein and R Z Stolzenberg-Solomon},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068554437\&doi=10.1093%2fjnci%2fdjy155\&partnerID=40\&md5=a302cf2127319a770a2ac68663096df3},

doi = {10.1093/jnci/djy155},

year  = {2019},

date = {2019-01-01},

journal = {Journal of the National Cancer Institute},

volume = {111},

number = {6},

pages = {557-567},

abstract = {Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes. Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. We performed expression quantitative trait loci (eQTL) analysis and functional annotation of the top SNPs in genes contributing to the top associated pathways and gene sets. All statistical tests were two-sided. Results: We identified 14 pathways and gene sets associated with PDAC at a false discovery rate of less than 0.05. After Bonferroni correction (P ≤ 1.3 × 10-5), the strongest associations were detected in five pathways and gene sets, including maturity-onset diabetes of the young, regulation of beta-cell development, role of epidermal growth factor (EGF) receptor transactivation by G protein-coupled receptors in cardiac hypertrophy pathways, and the Nikolsky breast cancer chr17q11-q21 amplicon and Pujana ATM Pearson correlation coefficient (PCC) network gene sets. We identified and validated rs876493 and three correlating SNPs (PGAP3) and rs3124737 (CASP7) from the Pujana ATM PCC gene set as eQTLs in two normal derived pancreas tissue datasets. Conclusion: Our agnostic pathway and gene set analysis integrated with functional annotation and eQTL analysis provides insight into genes and pathways that may be biologically relevant for risk of PDAC, including those not previously identified. © The Author(s) 2019.},

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@article{RN16696,

title = {An inverse association between the Mediterranean diet and bladder cancer risk: a pooled analysis of 13 cohort studies},

author = {W J A Witlox and F H M Osch and M Brinkman and S Jochems and M E Goossens and E Weiderpass and E White and P A Brandt and G G Giles and R L Milne and I Huybrechts and H O Adami and B Bueno-de-Mesquita and A Wesselius and M P Zeegers},

doi = {10.1007/s00394-019-01907-8},

issn = {1436-6207},

year  = {2019},

date = {2019-01-01},

journal = {Eur J Nutr},

abstract = {PURPOSE: The role of diet in bladder carcinogenesis has yet to be established. To date most studies have investigated dietary components individually, rather than as dietary patterns, which may provide stronger evidence for any influence of diet on bladder carcinogenesis. The Mediterranean diet has been associated with many health benefits, but few studies have investigated its association with bladder cancer risk. METHODS: We investigated the potential association between the Mediterranean diet score (MDS) and risk of developing bladder cancer by pooling 13 prospective cohort studies included in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study and applying a Cox regression analysis. RESULTS: Dietary data from 646,222 study participants, including 3639 incident bladder cancer cases, were analysed. We observed an inverse association between Mediterranean diet and bladder cancer risk (HRhigh 0.85 [95% CI 0.77, 0.93]). When stratifying the results on non-muscle-invasive or muscle-invasive disease or sex the association remained similar and the HR estimate was consistently below 1.00 both for medium and high adherence to the Mediterranean diet. A consistent association was observed when disregarding fat or alcohol intake. CONCLUSION: We found evidence that adherence to the Mediterranean diet was associated with reduced risk of developing bladder cancer, suggesting a positive effect of the diet as a whole and not just one component.},

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@article{RN16642,

title = {Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer},

author = {J Butt and M Jenab and M Pawlita and K Overvad and A Tjonneland and A Olsen and M C Boutron-Ruault and F Carbonnel and F R Mancini and R Kaaks and T Kuhn and H Boeing and A Trichopoulou and A Karakatsani and D Palli and V M Pala and R Tumino and C Sacerdote and S Panico and B Bueno-de-Mesquita and C H Gils and R C H Vermeulen and E Weiderpass and J R Quiros and E J Duell and M J Sanchez and M Dorronsoro and J M Huerta and E Ardanaz and B Van Guelpen and S Harlid and A Perez-Cornago and M J Gunter and N Murphy and H Freisling and D Aune and T Waterboer and D J Hughes},

doi = {10.1158/1055-9965.Epi-19-0313},

issn = {1055-9965},

year  = {2019},

date = {2019-01-01},

journal = {Cancer Epidemiol Biomarkers Prev},

volume = {28},

number = {9},

pages = {1552-1555},

abstract = {BACKGROUND: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are associated with colorectal cancer risk in prediagnostic serum samples in the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort. METHODS: We applied a multiplex serology assay to simultaneously measure antibody responses to 11 F. nucleatum antigens in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). RESULTS: We observed neither a statistically significant colorectal cancer risk association for antibodies to individual F. nucleatum proteins nor for combined positivity to any of the 11 proteins (OR, 0.81; 95% CI, 0.62-1.06). CONCLUSIONS: Antibody responses to F. nucleatum proteins in prediagnostic serum samples from a subset of colorectal cancer cases and matched controls within the EPIC study were not associated with colorectal cancer risk. IMPACT: Our findings in prospectively ascertained serum samples contradict the existing literature on the association of F. nucleatum with colorectal cancer risk. Future prospective studies, specifically detecting F. nucleatum in stool or tissue biopsies, are needed to complement our findings.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16665,

title = {Are Boys Ready for Human Papillomavirus Vaccine? A National Study of Boys in Malaysia},

author = {L P Wong and H Alias and Rnarm Yusoff and I C Sam and G D Zimet},

doi = {10.1097/olq.0000000000001024},

issn = {0148-5717},

year  = {2019},

date = {2019-01-01},

journal = {Sex Transm Dis},

volume = {46},

number = {9},

pages = {617-624},

abstract = {BACKGROUND: The aim of this study was to investigate factors associated with the willingness of boys to accept the human papillomavirus (HPV) vaccine. METHODS: A nationwide cross-sectional survey among Secondary One male students in Malaysia. RESULTS: Among 2823 respondents, knowledge about HPV infection and the HPV vaccine was extremely poor. The mean total knowledge score was only 3.17 (SD +/- 2.14), out of a possible score of 10. The majority of respondents were unaware that vaccinating boys can help protect girls against HPV infection (81.6%), and HPV is a sexually transmitted infection (70.1%). Many had the misconception that only females get HPV (78.9%). In multivariable analysis, the factors associated with the intention to receive the HPV vaccination were: agreeing boys need to be vaccinated against HPV infection (odds ratio [OR], 2.05; 95% confidence interval [CI], 1.57-2.68), perceiving their parents might allow them to get the HPV vaccine (OR, 1.66; 95% CI, 1.18-2.34), perceived susceptibility to HPV infection (OR, 1.63; 95% CI, 1.06-2.52), and attending a rural school (OR, 1.49; 95% CI, 1.14-1.95). CONCLUSIONS: Public health educational programs that are focused and tailored on parents consenting to HPV vaccination for boys at a young age can be useful in improving HPV vaccination rates among boys. There is also a pressing need to educate boys about the benefits of HPV vaccination in males and about HPV disease susceptibility to facilitate adoption of the HPV vaccine by young adults in the future.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16643,

title = {Association Between Soft Drink Consumption and Mortality in 10 European Countries},

author = {A Mullee and D Romaguera and J Pearson-Stuttard and V Viallon and M Stepien and H Freisling and G Fagherazzi and F R Mancini and M C Boutron-Ruault and T Kuhn and R Kaaks and H Boeing and K Aleksandrova and A Tjonneland and J Halkjaer and K Overvad and E Weiderpass and G Skeie and C L Parr and J R Quiros and A Agudo and M J Sanchez and P Amiano and L Cirera and E Ardanaz and K T Khaw and T Y N Tong and J A Schmidt and A Trichopoulou and G Martimianaki and A Karakatsani and D Palli and C Agnoli and R Tumino and C Sacerdote and S Panico and B Bueno-de-Mesquita and W M M Verschuren and J M A Boer and R Vermeulen and S Ramne and E Sonestedt and B Guelpen and P L Holgersson and K K Tsilidis and A K Heath and D Muller and E Riboli and M J Gunter and N Murphy},

doi = {10.1001/jamainternmed.2019.2478},

issn = {2168-6106},

year  = {2019},

date = {2019-01-01},

journal = {JAMA Intern Med},

abstract = {Importance: Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date. Objective: To examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality. Design, Setting, and Participants: This population-based cohort study involved participants (n = 451743 of the full cohort) in the European Prospective Investigation into Cancer and Nutrition (EPIC), an ongoing, large multinational cohort of people from 10 European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden, and the United Kingdom), with participants recruited between January 1, 1992, and December 31, 2000. Excluded participants were those who reported cancer, heart disease, stroke, or diabetes at baseline; those with implausible dietary intake data; and those with missing soft drink consumption or follow-up information. Data analyses were performed from February 1, 2018, to October 1, 2018. Exposure: Consumption of total, sugar-sweetened, and artificially sweetened soft drinks. Main Outcomes and Measures: Total mortality and cause-specific mortality. Hazard ratios (HRs) and 95% CIs were estimated using multivariable Cox proportional hazards regression models adjusted for other mortality risk factors. Results: In total, 521 330 individuals were enrolled. Of this total, 451743 (86.7%) were included in the study, with a mean (SD) age of 50.8 (9.8) years and with 321081 women (71.1%). During a mean (range) follow-up of 16.4 (11.1 in Greece to 19.2 in France) years, 41693 deaths occurred. Higher all-cause mortality was found among participants who consumed 2 or more glasses per day (vs consumers of \<1 glass per month) of total soft drinks (hazard ratio [HR], 1.17; 95% CI, 1.11-1.22; P \< .001), sugar-sweetened soft drinks (HR, 1.08; 95% CI, 1.01-1.16; P = .004), and artificially sweetened soft drinks (HR, 1.26; 95% CI, 1.16-1.35; P \< .001). Positive associations were also observed between artificially sweetened soft drinks and deaths from circulatory diseases (\>/=2 glasses per day vs \<1 glass per month; HR, 1.52; 95% CI, 1.30-1.78; P \< .001) and between sugar-sweetened soft drinks and deaths from digestive diseases (\>/=1 glass per day vs \<1 glass per month; HR, 1.59; 95% CI, 1.24-2.05; P \< .001). Conclusions and Relevance: This study found that consumption of total, sugar-sweetened, and artificially sweetened soft drinks was positively associated with all-cause deaths in this large European cohort; the results are supportive of public health campaigns aimed at limiting the consumption of soft drinks.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16676,

title = {Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status},

author = {V Fedirko and M Jenab and C Meplan and J S Jones and W Zhu and L Schomburg and A Siddiq and S Hybsier and K Overvad and A Tjonneland and H Omichessan and V Perduca and M C Boutron-Ruault and T Kuhn and V Katzke and K Aleksandrova and A Trichopoulou and A Karakatsani and A Kotanidou and R Tumino and S Panico and G Masala and C Agnoli and A Naccarati and B Bueno-de-Mesquita and R C H Vermeulen and E Weiderpass and G Skeie and T H Nost and L Lujan-Barroso and J R Quiros and J M Huerta and M Rodriguez-Barranco and A Barricarte and B Gylling and S Harlid and K E Bradbury and N Wareham and K T Khaw and M Gunter and N Murphy and H Freisling and K Tsilidis and D Aune and E Riboli and J E Hesketh and D J Hughes},

doi = {10.3390/nu11040935},

issn = {2072-6643},

year  = {2019},

date = {2019-01-01},

journal = {Nutrients},

volume = {11},

number = {4},

abstract = {Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P \< 0.1). SNPs in Wingless/Integrated (Wnt) and Transforming growth factor (TGF) beta-signaling genes (FRZB, SMAD3, SMAD7) from pathways affected by Se intake were also associated with CRC risk after multiple testing adjustments. Interactions with Se status (using existing serum Se and Selenoprotein P data) were tested at the SNP, gene, and pathway levels. Pathway analyses using the modified Adaptive Rank Truncated Product method suggested that genes and gene x Se status interactions in antioxidant, apoptosis, and TGF-beta signaling pathways may be associated with CRC risk. This study suggests that SNPs in the Se pathway alone or in combination with suboptimal Se status may contribute to CRC development.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16704,

title = {Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci},

author = {F R Schumacher and A A A Olama and S I Berndt and S Benlloch and M Ahmed and E J Saunders and T Dadaev and D Leongamornlert and E Anokian and C Cieza-Borrella and C Goh and M N Brook and X Sheng and L Fachal and J Dennis and J Tyrer and K Muir and A Lophatananon and V L Stevens and S M Gapstur and B D Carter and C M Tangen and P J Goodman and Jr. Thompson I. M. and J Batra and S Chambers and L Moya and J Clements and L Horvath and W Tilley and G P Risbridger and H Gronberg and M Aly and T Nordstrom and P Pharoah and N Pashayan and J Schleutker and T L J Tammela and C Sipeky and A Auvinen and D Albanes and S Weinstein and A Wolk and N Hakansson and C M L West and A M Dunning and N Burnet and L A Mucci and E Giovannucci and G L Andriole and O Cussenot and G Cancel-Tassin and S Koutros and L E Beane Freeman and K D Sorensen and T F Orntoft and M Borre and L Maehle and E M Grindedal and D E Neal and J L Donovan and F C Hamdy and R M Martin and R C Travis and T J Key and R J Hamilton and N E Fleshner and A Finelli and S A Ingles and M C Stern and B S Rosenstein and S L Kerns and H Ostrer and Y J Lu and H W Zhang and N Feng and X Mao and X Guo and G Wang and Z Sun and G G Giles and M C Southey and R J MacInnis and L M FitzGerald and A S Kibel and B F Drake and A Vega and A Gomez-Caamano and R Szulkin and M Eklund and M Kogevinas and J Llorca and G Castano-Vinyals and K L Penney and M Stampfer and J Y Park and T A Sellers and H Y Lin and J L Stanford and C Cybulski and others},

doi = {10.1038/s41588-018-0330-6},

issn = {1061-4036},

year  = {2019},

date = {2019-01-01},

journal = {Nat Genet},

volume = {51},

number = {2},

pages = {363},

abstract = {In the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16703,

title = {Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry},

author = {M Matejcic and E J Saunders and T Dadaev and M N Brook and K Wang and X Sheng and A A A Olama and F R Schumacher and S A Ingles and K Govindasami and S Benlloch and S I Berndt and D Albanes and S Koutros and K Muir and V L Stevens and S M Gapstur and C M Tangen and J Batra and J Clements and H Gronberg and N Pashayan and J Schleutker and A Wolk and C West and L Mucci and P Kraft and G Cancel-Tassin and K D Sorensen and L Maehle and E M Grindedal and S S Strom and D E Neal and F C Hamdy and J L Donovan and R C Travis and R J Hamilton and B Rosenstein and Y J Lu and G G Giles and A S Kibel and A Vega and J T Bensen and M Kogevinas and K L Penney and J Y Park and J L Stanford and C Cybulski and B G Nordestgaard and H Brenner and C Maier and J Kim and M R Teixeira and S L Neuhausen and K De Ruyck and A Razack and L F Newcomb and D Lessel and R Kaneva and N Usmani and F Claessens and P A Townsend and M Gago-Dominguez and M J Roobol and F Menegaux and K T Khaw and L A Cannon-Albright and H Pandha and S N Thibodeau and D J Schaid and F Wiklund and S J Chanock and D F Easton and R A Eeles and Z Kote-Jarai and D V Conti and C A Haiman},

doi = {10.1038/s41467-019-08293-z},

issn = {2041-1723},

year  = {2019},

date = {2019-01-01},

journal = {Nat Commun},

volume = {10},

number = {1},

pages = {382},

abstract = {The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16615,

title = {Biochar amendment improves alpine meadows growth and soil health in Tibetan plateau over a three year period},

author = {M K Rafiq and Y Bai and R Aziz and M T Rafiq and O Masek and R T Bachmann and S Joseph and M Shahbaz and A Qayyum and Z Shang and M Danaee and R Long},

doi = {10.1016/j.scitotenv.2019.135296},

issn = {0048-9697},

year  = {2019},

date = {2019-01-01},

journal = {Sci Total Environ},

pages = {135296},

abstract = {Previous biochar research has primarily focused on agricultural annual cropping systems with very little attention given to highly fragile, complex and diverse natural alpine grassland ecosystems. The present study investigated the effect of biochar on the growth of alpine meadows and soil health. This study was conducted in the Qinghai Tibetan Plateau over a three year period to investigate the effect of three rice husk biochar application rates alone and combination with high and low NPK fertilizer dosages on alpine meadow productivity, soil microbial diversity as well as pH, carbon and nitrogen content at 0-10 cm and 10-20 cm depth. At the end of the 3rd year soil samples were analysed and assessed by combined analysis of variance. The results showed that biochar application in combination with nitrogen (N), phosphorus (P) and potassium (K) fertilizer had a significant increase in fresh and dry biomass during the second and third year of the study as compared to control and alone biochar application (p \</= 0.05). Biochar alone and in combination with NPK fertilizer resulted in a significant increase in the soil pH and carbon contents of the soil. XPS results, the SEM imaging and EDS analysis of aged biochar demonstrated that the biochar has undergone complex changes over the 3 years as compared to fresh biochar. This research suggests that biochar has positive effect on alpine meadow growth and soil health and may be an effective tool for alpine meadow restoration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16725,

title = {Biodiesel Production from Waste Edible Oil with Heterogeneous Catalysts (Nanoclay-Based Nanocatalysts)},

author = {F Halek and N Aghamohammadi and F Mohamadi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069508497\&doi=10.1007%2fs13369-019-03986-5\&partnerID=40\&md5=4276c90f4e23424275ccb09a8cc2e5ff},

doi = {10.1007/s13369-019-03986-5},

year  = {2019},

date = {2019-01-01},

journal = {Arabian Journal for Science and Engineering},

volume = {44},

number = {12},

pages = {9919-9924},

abstract = {The various benefits of biofuels versus fossil fuels due to recent global challenges and issues are the best approach toward low-cost economic production of renewable energy. This study is trying to obtain economic catalysts with easy fabrication technology. The synthesized catalysts were obtained using calcium oxide/nanoclay catalysts by an initial ion-exchange reaction of calcium oxide and nanoclays (montmorillonite). These catalysts have been synthesized for the first time by being stirred for 5 h at a temperature of 80 °C, and the colloidal supernatant is obtained and kept in an ultrasonic bath for 20 min. The solution was filtered, washed several times, the residual mixture on filter paper was dried in the oven at 50 °C for few hours, and the powder was calcined for 8 h in a furnace at 600 °C. After identification and characterization, using XRD, BET, and SEM, the results approved the formation of a new nanostructure in synthesized catalysts, which were suitable to be used in biodiesel production from waste oils with high free fatty acids content. The results of this study indicate that the catalysts production process is not complicated, and methyl ester production rates in all biodiesel samples were more than 97% (97.1\textendash98.8%). © 2019, King Fahd University of Petroleum \& Minerals.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16653,

title = {Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition},

author = {S Christakoudi and A Kakourou and G Markozannes and I Tzoulaki and E Weiderpass and P Brennan and M Gunter and C C Dahm and K Overvad and A Olsen and A Tjonneland and M C Boutron-Ruault and A L Madika and G Severi and V Katzke and T Kuhn and M M Bergmann and H Boeing and A Karakatsani and G Martimianaki and P Thriskos and G Masala and S Sieri and S Panico and R Tumino and F Ricceri and A Agudo and D Redondo-Sanchez and S M Colorado-Yohar and O Mokoroa and O Melander and T Stocks and C Haggstrom and S Harlid and B Bueno-de-Mesquita and C H Gils and R C H Vermeulen and K T Khaw and N J Wareham and T Y N Tong and H Freisling and M Johansson and H Lennon and D Aune and E Riboli and D Trichopoulos and A Trichopoulou and K K Tsilidis},

doi = {10.1002/ijc.32576},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

abstract = {Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08-1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14-1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07-1.26) (SBP)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16742,

title = {Body shape, fear of falling, physical performance, and falls among individuals aged 55 years and above},

author = {S H Kioh and S Mat and S B Kamaruzzaman and F Ibrahim and M S Mokhtar and N N Hairi and R G Cumming and P K Myint and M P Tan and MELoR investigators},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069944669\&doi=10.1007%2fs41999-019-00220-1\&partnerID=40\&md5=736d6517c3638e9e335693905fa2d7df},

doi = {10.1007/s41999-019-00220-1},

year  = {2019},

date = {2019-01-01},

journal = {European Geriatric Medicine},

volume = {10},

number = {5},

pages = {801-808},

abstract = {Purpose: To evaluate the relationship between waist-to-hip ratio (WHR) and fall-related outcomes in community-dwelling individuals aged 55 and above. Methods: Cross-sectional data obtained from the first wave of the Malaysian Elders Longitudinal Research (MELoR) study were utilized for this study. Participants aged 55 years and over were recruited using simple random sampling from the electoral rolls of three local parliamentary constituencies. Socio-demographics, falls history and medical history were obtained through home-based computer-assisted interviews while anthropometric measurements, including WHR, and physical performance were obtained during hospital-based health checks. WHR was categorized into three arbitrary categories stratified by gender. Results: Data on both falls and WHR were available for 1335 participants, mean age ± standard deviation (SD) = 68.4 ± 7.1 years. Logistic regression analyses using dummy variables revealed that individuals within the higher WHR group were significantly more likely to report a history of fall in the preceding 12 months adjusted odds ratio (aOR) [95% confidence interval (CI)] = 1.78 (1.18\textendash2.67), fear of falling [aOR (95% CI) = 1.58 (1.08\textendash2.32)], impaired timed-up-and-go [2.14 (1.44\textendash3.17)] and reduced functional reach [1.68 (1.18\textendash2.38)] compared to those with lower WHR. A higher WHR remained independently associated with increased risk of falls compared to those with lower WHR after additional adjustment for fear of falling and functional performance. Conclusion: Our finding suggests WHR as an independent risk factor for higher risk of fall which may indicate body shape as a potentially modifiable risk factor for falls in adults in aged 55 years and over. © 2019, © 2019, European Geriatric Medicine Society.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16657,

title = {Breaking down the barriers: Understanding migrant workers' access to healthcare in Malaysia},

author = {T Loganathan and D Rui and C W Ng and N S Pocock},

doi = {10.1371/journal.pone.0218669},

issn = {1932-6203},

year  = {2019},

date = {2019-01-01},

journal = {PLoS One},

volume = {14},

number = {7},

pages = {e0218669},

abstract = {BACKGROUND: Malaysia is widely credited to have achieved universal health coverage for citizens. However, the accessibility of healthcare services to migrant workers is questionable. Recently, medical fees for foreigners at public facilities were substantially increased. Mandatory health insurance only covers public hospital admissions and excludes undocumented migrants. This study explores barriers to healthcare access faced by documented and undocumented migrant workers in Malaysia. METHODS: We use qualitative data from 17 in-depth interviews conducted with key informants from civil society organisations, trade unions, academia, medical professionals, as well as migrant workers and their representatives. We interviewed doctors working in public hospitals and private clinics frequented by migrants. Data were analysed using thematic analysis. RESULTS: We found that healthcare services in Malaysia are often inaccessible to migrant workers. Complex access barriers were identified, many beyond the control of the health sector. Major themes include affordability and financial constraints, the need for legal documents like valid passports and work permits, language barriers, discrimination and xenophobia, physical inaccessibility and employer-related barriers. Our study suggests that government mandated insurance for migrant workers is insufficient in view of the recent increase in medical fees. The perceived close working relationship between the ministries of health and immigration effectively excludes undocumented migrants from access to public healthcare facilities. Language barriers may affect the quality of care received by migrant workers, by inadvertently resulting in medical errors, while preventing them from giving truly informed consent. CONCLUSIONS: We propose instituting migrant-friendly health services at public facilities. We also suggest implementing a comprehensive health insurance to enable healthcare access and financial risk protection for all migrant workers. Non-health sector solutions include the formation of a multi-stakeholder migration management body towards a comprehensive national policy on labour migration which includes health.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16715,

title = {CA19-9 and apolipoprotein-A2 isoforms as detection markers for pancreatic cancer: a prospective evaluation},

author = {K Honda and V A Katzke and A Husing and S Okaya and H Shoji and K Onidani and A Olsen and A Tjonneland and K Overvad and E Weiderpass and P Vineis and D Muller and K Tsilidis and D Palli and V Pala and R Tumino and A Naccarati and S Panico and K Aleksandrova and H Boeing and H B Bueno-de-Mesquita and P H Peeters and A Trichopoulou and P Lagiou and K T Khaw and N Wareham and R C Travis and S Merino and E J Duell and M Rodriguez-Barranco and M D Chirlaque and A Barricarte and V Rebours and M C Boutron-Ruault and F Romana Mancini and P Brennan and G Scelo and J Manjer and M Sund and D Ohlund and F Canzian and R Kaaks},

doi = {10.1002/ijc.31900},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

volume = {144},

number = {8},

pages = {1877-1887},

abstract = {Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. Our study provides a first prospective evaluation of an ApoA2 isoform ("ApoA2-ATQ/AT"), alone and in combination with carbohydrate antigen 19-9 (CA19-9), as an early detection biomarker for pancreatic cancer. We performed ELISA measurements of CA19-9 and ApoA2-ATQ/AT in 156 patients with pancreatic cancer and 217 matched controls within the European EPIC cohort, using plasma samples collected up to 60 months prior to diagnosis. The detection discrimination statistics were calculated for risk scores by strata of lag-time. For CA19-9, in univariate marker analyses, C-statistics to distinguish future pancreatic cancer patients from cancer-free individuals were 0.80 for plasma taken \</=6 months before diagnosis, and 0.71 for \>6-18 months; for ApoA2-ATQ/AT, C-statistics were 0.62, and 0.65, respectively. Joint models based on ApoA2-ATQ/AT plus CA19-9 significantly improved discrimination within \>6-18 months (C = 0.74 vs. 0.71 for CA19-9 alone},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16617,

title = {Cardiometabolic Risk Factors and Physical Activity Patterns Maximizing Fitness and Minimizing Fatness Variation in Malaysian Adolescents: A Novel Application of Reduced Rank Regression},

author = {Z Toumpakari and R Jago and L D Howe and H A Majid and A Papadaki and S Mohammadi and M Y Jalaludin and M Dahlui and M N A Mohamed and T T Su and L Johnson},

doi = {10.3390/ijerph16234662},

issn = {1660-4601},

year  = {2019},

date = {2019-01-01},

journal = {Int J Environ Res Public Health},

volume = {16},

number = {23},

abstract = {Patterns of physical activity (PA) that optimize both fitness and fatness may better predict cardiometabolic health. Reduced rank regression (RRR) was applied to identify combinations of the type (e.g., football vs. skipping), location and timing of activity, explaining variation in cardiorespiratory fitness (CRF) and Body Mass Index (BMI). Multivariable regressions estimated longitudinal associations of PA pattern scores with cardiometabolic health in n = 579 adolescents aged 13-17 years from the Malaysian Health and Adolescent Longitudinal Research Team study. PA pattern scores in boys were associated with higher fitness (r = 0.3) and lower fatness (r = -0.3); however, in girls, pattern scores were only associated with higher fitness (r = 0.4) (fatness},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16744,

title = {Care Recipient Multimorbidity and Health Impacts on Informal Caregivers: A Systematic Review},

author = {A Amer Nordin and F Mohd Hairi and W Y Choo and N N Hairi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074799228\&doi=10.1093%2fgeront%2fgny072\&partnerID=40\&md5=be3ec5ca894a508227576ad6c624addc},

doi = {10.1093/geront/gny072},

year  = {2019},

date = {2019-01-01},

journal = {Gerontologist},

volume = {59},

number = {5},

pages = {e611-e628},

abstract = {Background and Objectives Caregiving outcomes have often been reported in terms of care recipients of single disease, rather than multiple health conditions. A systematic review was conducted to outline caregiving health outcomes and its association with care recipient multimorbidity for informal caregivers of older adults. Research Design and Methods A search strategy was applied in six databases and grey literature. Inclusion criteria were primary observational studies on informal caregiving for care recipients aged 60 years and above, in the English language. Informal caregivers were those not formally hired and multimorbidity referred to presence of at least two health conditions. From a total of 2,101 titles, 230 abstracts were screened, and 19 articles were included. Quality assessment was conducted with application of the Newcastle-Ottawa-Scale. Results Health-related and caregiving-related outcomes have been assessed for informal caregivers of older adults with multimorbidity. Caregiver subjective burden was most commonly evaluated and often reported to be low to moderate. In association with care recipient multimorbidity, caregiver burden, quality of life, and perceived difficulty in assisting the older adults were examined in 14 of the studies with mixed results. Studies were heterogeneous, with nonuniform definitions of informal caregivers and multimorbidity as well as measurement tools. Discussion and Implications This narrative review found that caring for older adults with multimorbidity impacts caregivers, although overall evidence is not conclusive. Despite caregiving-related outcomes being most commonly assessed among the caregivers, particularly subjective burden, findings suggest that it is worthwhile to examine other outcomes to enrich the evidence base. © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16699,

title = {Cause-specific mortality estimates for Malaysia in 2013: results from a national sample verification study using medical record review and verbal autopsy},

author = {A Omar and S S Ganapathy and M F M Anuar and Y Y Khoo and C Jeevananthan and S Maria Awaluddin and J L M Yn and C Rao},

doi = {10.1186/s12889-018-6384-7},

issn = {1471-2458},

year  = {2019},

date = {2019-01-01},

journal = {BMC Public Health},

volume = {19},

number = {1},

pages = {110},

abstract = {BACKGROUND: Mortality indicators are essential for monitoring population health. Although Malaysia has a functional death registration system, the quality of information on causes of death still needs improvement, since approximately 30% of deaths are classified to poorly defined causes. This study was conducted to verify registered causes in a sample of deaths in 2013 and utilise the findings to estimate cause-specific mortality indicators for Malaysia in 2013. METHODS: This is a cross-sectional study involving a nationally representative sample of 14,497 deaths distributed across 19 districts. Registered causes of deaths were verified using standard medical record review protocols for hospital deaths, and locally adapted international standard verbal autopsy procedures for deaths outside hospitals. The findings were used to measure the validity and reliability of the registration data, as well as to establish plausible cause-specific mortality fractions for hospital and non-hospital deaths, which were subsequently used as the basis for estimating national cause-specific mortality indicators. RESULTS: The overall response rate for the study was 67%. Verified causes of 5041 hospital deaths and 3724 deaths outside hospitals were used to derive national mortality estimates for 2013 by age, sex and cause. The study was able to reclassify most of the ill-defined deaths to a specific cause. The leading causes of deaths for males were Ischaemic Heart Disease (15.4%), Cerebrovascular diseases (13.7%), Chronic Obstructive Pulmonary Disease (8.5%) and Road Traffic Accident (8.0%). Among females, the leading causes were Cerebrovascular diseases (18.3%), Ischaemic Heart Disease (12.7%), Lower Respiratory Infections (11.5%) and Diabetes Mellitus (7.2%). CONCLUSIONS: Investigation of registered causes of death using verbal autopsy and medical record review yielded adequate information to enable estimation of cause-specific mortality indicators in Malaysia. Strengthening the national mortality statistics system must be made a priority as it is a core data source for policy and evaluation of the public health and healthcare sectors in Malaysia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16718,

title = {Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition},

author = {K E Bradbury and P N Appleby and S J Tipper and R C Travis and N E Allen and M Kvaskoff and K Overvad and A Tjonneland and J Halkjaer and I Cervenka and Y Mahamat-Saleh and F Bonnet and R Kaaks and R T Fortner and H Boeing and A Trichopoulou and C La Vecchia and A J Stratigos and D Palli and S Grioni and G Matullo and S Panico and R Tumino and P H Peeters and H B Bueno-de-Mesquita and R Ghiasvand and M B Veierod and E Weiderpass and C Bonet and E Molina and J M Huerta and N Larranaga and A Barricarte and S Merino and K Isaksson and T Stocks and I Ljuslinder and O Hemmingsson and N Wareham and K T Khaw and M J Gunter and S Rinaldi and K K Tsilidis and D Aune and E Riboli and T J Key},

doi = {10.1002/ijc.31854},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

volume = {144},

number = {5},

pages = {957-966},

abstract = {Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case-control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity\>/=0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16626,

title = {Circulating miR-3197 and miR-2116-5p as novel biomarkers for diabetic retinopathy},

author = {H Ji and Q Yi and L Chen and L Wong and Y Liu and G Xu and J Zhao and T Huang and B Li and Y Yang and W Li and L Han and S Duan},

doi = {10.1016/j.cca.2019.10.036},

issn = {0009-8981},

year  = {2019},

date = {2019-01-01},

journal = {Clin Chim Acta},

abstract = {Diabetic retinopathy (DR) is the leading cause of vision loss among older adults. The goal of this case-control study was to identify circulating miRNAs for the diagnosis of DR. The miRNeasy Serum/Plasma Kit was used to extract serum miRNAs. The muParaflo MicroRNA microarray was used to detect the expression levels of the miRNAs. The miRWalk algorithm was applied to predict the target genes of the miRNAs, which were further confirmed by the dual luciferase reporter gene system in HEK293T cells. A microarray was performed between 5 DR cases and 5 age-, sex-, body mass index-, and duration of diabetes-matched type 2 diabetic (T2DM) controls. The quantitative reverse transcription polymerase chain reaction technique was used to validate the differentially expressed circulating miRNAs in 45 DR cases and 45 well-matched controls. Receiver operating characteristic (ROC) curve analysis was used to evaluate the performance of the circulating miRNAs as diagnostic biomarkers for DR. Our microarray analysis screened out miR-2116-5p and miR-3197 as significantly up-regulated in DR cases compared with the controls. Furthermore, two miRNAs were validated in the 45 DR cases and 45 controls. The ROC analysis suggested that both miR-3197 and miR-2116-5p distinguished DR cases from controls. An additional dual-luciferase reporter gene assay confirmed that notch homolog 2 (NOTCH2) was the target gene of miR-2116-5p. Both miR-3197 and miR-2116-5p were identified as promising diagnostic biomarkers for DR. Future research is still needed to explore the molecular mechanisms of miR-3197 and miR-2116-5p in the pathogenesis of DR.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16620,

title = {Clinic and patient variation in intermediate clinical outcomes for type 2 diabetes: a multilevel analysis},

author = {Y M F Lim and S H Ang and N H Nasir and F Ismail and S A Ismail and S Sivasampu},

doi = {10.1186/s12875-019-1045-1},

issn = {1471-2296},

year  = {2019},

date = {2019-01-01},

journal = {BMC Fam Pract},

volume = {20},

number = {1},

pages = {158},

abstract = {BACKGROUND: Variation at different levels of diabetes care has not yet been quantified for low- and middle-income countries. Understanding this variation and its magnitude is important to guide policy makers in designing effective interventions. This study aims to quantify the variation in the control of glycated haemoglobin (HbA1c), systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) for type 2 diabetes (T2D) patients at the clinic and patient level and determine patient and clinic factors associated with control of these outcomes in T2D. METHODS: This is a cross-sectional study within the baseline data from the impact evaluation of the Enhanced Primary Health Care (EnPHC) intervention on 40 public clinics in Malaysia. Patients aged 30 and above, diagnosed with T2D, had a clinic visit for T2D between 01 Nov 2016 and 30 April 2017 and had at least one HbA1c, SBP and LDL-C measurement within 1 year from the date of visit were included for analysis. Multilevel linear regression adjusting for patient and clinic characteristics was used to quantify variation at the clinic and patient levels for each outcome. RESULTS: Variation in intermediate clinical outcomes in T2D lies predominantly (93% and above) at the patient level. The strongest predictors for poor disease control in T2D were the proxy measures for disease severity including duration of diabetes, presence of microvascular complications, being on insulin therapy and number of antihypertensives. Among the three outcomes, HbA1c and LDL-C results provide greatest opportunity for improvement. CONCLUSION: Clinic variation in HbA1c, SBP and LDL-C accounts for a small percentage from total variation. Findings from this study suggest that standardised interventions need to be applied across all clinics, with a focus on customizing therapy based on individual patient characteristics.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16792,

title = {Clinical text classification research trends: Systematic literature review and open issues},

author = {G Mujtaba and L Shuib and N Idris and W L Hoo and R G Raj and K Khowaja and K Shaikh and H F Nweke},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053829021\&doi=10.1016%2fj.eswa.2018.09.034\&partnerID=40\&md5=567d1483bd0c9be6999fcfae0f618f7e},

doi = {10.1016/j.eswa.2018.09.034},

year  = {2019},

date = {2019-01-01},

journal = {Expert Systems with Applications},

volume = {116},

pages = {494-520},

abstract = {The pervasive use of electronic health databases has increased the accessibility of free-text clinical reports for supplementary use. Several text classification approaches, such as supervised machine learning (SML) or rule-based approaches, have been utilized to obtain beneficial information from free-text clinical reports. In recent years, many researchers have worked in the clinical text classification field and published their results in academic journals. However, to the best of our knowledge, no comprehensive systematic literature review (SLR) has recapitulated the existing primary studies on clinical text classification in the last five years. Thus, the current study aims to present SLR of academic articles on clinical text classification published from January 2013 to January 2018. Accordingly, we intend to maximize the procedural decision analysis in six aspects, namely, types of clinical reports, data sets and their characteristics, pre-processing and sampling techniques, feature engineering, machine learning algorithms, and performance metrics. To achieve our objective, 72 primary studies from 8 bibliographic databases were systematically selected and rigorously reviewed from the perspective of the six aspects. This review identified nine types of clinical reports, four types of data sets (i.e., homogeneous\textendashhomogenous, homogenous\textendashheterogeneous, heterogeneous\textendashhomogenous, and heterogeneous\textendashheterogeneous), two sampling techniques (i.e., over-sampling and under-sampling), and nine pre-processing techniques. Moreover, this review determined bag of words, bag of phrases, and bag of concepts features when represented by either term frequency or term frequency with inverse document frequency, thereby showing improved classification results. SML-based or rule-based approaches were generally employed to classify the clinical reports. To measure the performance of these classification approaches, we used precision, recall, F-measure, accuracy, AUC, and specificity in binary class problems. In multi-class problems, we primarily used micro or macro-averaging precision, recall, or F-measure. Lastly, open research issues and challenges are presented for future scholars who are interested in clinical text classification. This SLR will definitely be a beneficial resource for researchers engaged in clinical text classification. © 2018 Elsevier Ltd},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16722,

title = {Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition},

author = {A Sen and N Papadimitriou and P Lagiou and A Perez-Cornago and R C Travis and T J Key and N Murphy and M Gunter and H Freisling and I Tzoulaki and D C Muller and A J Cross and D S Lopez and M Bergmann and H Boeing and C Bamia and A Kotanidou and A Karakatsani and A Tjonneland and C Kyro and M Outzen and M L Redondo and V Cayssials and M D Chirlaque and A Barricarte and M J Sanchez and N Larranaga and R Tumino and S Grioni and D Palli and S Caini and C Sacerdote and B Bueno-de-Mesquita and T Kuhn and R Kaaks and L M Nilsson and R Landberg and P Wallstrom and I Drake and B H Bech and K Overvad and D Aune and K T Khaw and E Riboli and D Trichopoulos and A Trichopoulou and K K Tsilidis},

doi = {10.1002/ijc.31634},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

volume = {144},

number = {2},

pages = {240-250},

abstract = {The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow-up. Data on coffee and tea consumption were collected through validated country-specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 vs. 12 mL/day) the HRs were 1.02 (95% CI, 0.94-1.09) and 0.98 (95% CI, 0.90-1.07) for risk of total prostate cancer and 0.97 (95% CI, 0.79-1.21) and 0.89 (95% CI, 0.70-1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16706,

title = {Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study},

author = {R Zamora-Ros and M A Alghamdi and V Cayssials and S Franceschi and M Almquist and J Hennings and M Sandstrom and K K Tsilidis and E Weiderpass and M C Boutron-Ruault and B Hammer Bech and K Overvad and A Tjonneland and K E N Petersen and F R Mancini and Y Mahamat-Saleh and F Bonnet and T Kuhn and R T Fortner and H Boeing and A Trichopoulou and C Bamia and G Martimianaki and G Masala and S Grioni and S Panico and R Tumino and F Fasanelli and G Skeie and T Braaten and C Lasheras and E Salamanca-Fernandez and P Amiano and M D Chirlaque and A Barricarte and J Manjer and P Wallstrom and H B Bueno-de-Mesquita and P H Peeters and K T Khaw and N J Wareham and J A Schmidt and D Aune and G Byrnes and A Scalbert and A Agudo and S Rinaldi},

doi = {10.1007/s00394-018-1874-z},

issn = {1436-6207},

year  = {2019},

date = {2019-01-01},

journal = {Eur J Nutr},

volume = {58},

number = {8},

pages = {3303-3312},

abstract = {PURPOSE: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. METHODS: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. RESULTS: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97-1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95-1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95-1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81-0.99), but this association was based on a sub-analysis with a small number of cancer cases. CONCLUSIONS: In this large prospective study, coffee and tea consumptions were not associated with TC risk.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16723,

title = {Consequences of Elder Abuse and Neglect: A Systematic Review of Observational Studies},

author = {R M Yunus and N N Hairi and W Y Choo},

doi = {10.1177/1524838017692798},

issn = {1524-8380},

year  = {2019},

date = {2019-01-01},

journal = {Trauma Violence Abuse},

volume = {20},

number = {2},

pages = {197-213},

abstract = {This article presents the results of a systematic review of the consequences of elder abuse and neglect (EAN). A systematic search was conducted in seven electronic databases and three sources of gray literature up to January 8, 2016, supplemented by scanning of citation lists in relevant articles and contact with field experts. All observational studies investigating elder abuse as a risk factor for adverse health outcomes, mortality, and health-care utilization were included. Of 517 articles initially captured, 19 articles met our inclusion criteria and were analyzed. Two reviewers independently performed abstract screening, full-texts appraisal, and quality assessment using the Newcastle-Ottawa Scale. Across 19 studies, methodological heterogeneity was a prominent feature; seven definitions of EAN and nine measurement tools for abuse were employed. Summary of results reveals a wide range of EAN outcomes, from premature mortality to increased health-care consumption and various forms of physical and psychological symptoms. Higher risks of mortality emerged as the most credible outcome, while the majority of morbidity outcomes originated from cross-sectional studies. Our findings suggest that there is an underrepresentation of older adults from non-Western populations and developing countries, and there is a need for more population-based prospective studies in middle- and low-income regions. Evidence gathered from this review is crucial in upgrading current practices, formulating policies, and shaping the future direction of research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16659,

title = {Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort},

author = {E K Aglago and I Huybrechts and N Murphy and C Casagrande and G Nicolas and T Pischon and V Fedirko and G Severi and M C Boutron-Ruault and A Fournier and V Katzke and T Kuhn and A Olsen and A Tjonneland and C C Dahm and K Overvad and C Lasheras and A Agudo and M J Sanchez and P Amiano and J M Huerta and E Ardanaz and A Perez-Cornago and A Trichopoulou and A Karakatsani and G Martimianaki and D Palli and V Pala and R Tumino and A Naccarati and S Panico and B Bueno-de-Mesquita and A May and J W G Derksen and S Hellstrand and B Ohlsson and M Wennberg and B Van Guelpen and G Skeie and M Brustad and E Weiderpass and A J Cross and H Ward and E Riboli and T Norat and V Chajes and M J Gunter},

doi = {10.1016/j.cgh.2019.06.031},

issn = {1542-3565},

year  = {2019},

date = {2019-01-01},

journal = {Clin Gastroenterol Hepatol},

abstract = {BACKGROUND \& AIMS: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. RESULTS: Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80-0.96; Ptrend = .005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82-0.98; Ptrend = .009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83-1.00; Ptrend = .016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78-0.95; Ptrend = .010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18-1.45; Ptrend \< .001). Plasma levels of phospholipid n-3 LC-PUFA was not associated with overall CRC risk, but an inverse trend was observed for proximal compared with distal colon cancer (Pheterogeneity = .026). CONCLUSIONS: In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16726,

title = {Correction to: The Prevalence and Associated Factors of Depression, Anxiety and Stress of First Year Undergraduate Students in a Public Higher Learning Institution in Malaysia (Journal of Child and Family Studies, (2019), 28, 12, (3545-3557), 10.1007/s10826-019-01537-y)},

author = {N S A Hamzah and N D N Farid and A Yahya and C Chin and T T Su and S R L Rampal and M Dahlui},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074041143\&doi=10.1007%2fs10826-019-01588-1\&partnerID=40\&md5=a5a3393fe73c8fcd3e73ae92c5039c66},

doi = {10.1007/s10826-019-01588-1},

year  = {2019},

date = {2019-01-01},

journal = {Journal of Child and Family Studies},

volume = {28},

number = {12},

pages = {3582},

abstract = {The original version of this article unfortunately contained mistakes. 1. On page 7, the heading should read as “Discussions”. 2. In Table 4, page 6 at Geographical location, anxiety section under the column heading “Total No (%)” the value 314 (36.0) should read as 314 (26.0) for the row Central Region. 3. On page 11, the first paragraph starting as “With regards limitations” should read as “With regards to limitations”. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16661,

title = {Cost of preterm birth during initial hospitalization: A care provider's perspective},

author = {H Zainal and M Dahlui and S A Soelar and T T Su},

doi = {10.1371/journal.pone.0211997},

issn = {1932-6203},

year  = {2019},

date = {2019-01-01},

journal = {PLoS One},

volume = {14},

number = {6},

pages = {e0211997},

abstract = {Preterm birth incidence has risen globally and remains a major cause of neonatal mortality despite improved survival. Demand and cost of initial hospitalization has also increased. This study assessed the cost of preterm birth during initial hospitalization from care provider perspective in neonatal intensive care units (NICU) of two hospitals in the state of Kedah, Malaysia. It utilized universal sampling and prospectively followed up preterm infants till discharge. Care provider cost was assessed using mixed method of top down approach and activity based costing. A total of 112 preterm infants were recruited from intensive care (93 infants) and minimal care (19 infants) units. Majority were from the moderate (23%) and late (36%) preterm groups followed by very preterm (32%) and extreme preterm (9%). Median cost per infant increased with level of care and degree of prematurity. Cost was dominated by overhead (fixed) costs for general (hospital), intermediate (clinical support services) and final (NICU) cost centers where it constituted at least three quarters of admission cost per infant while the remainder was consumables (variable) cost. Breakdown of overhead cost showed NICU specific overhead contributing at least two thirds of admission cost per infant. Personnel salary made up three quarters of NICU specific overhead. Laboratory investigation was the cost driver for consumables. Gender, birth weight and length of stay were significant factors and cost prediction was developed with these variables. This study demonstrated the inverse relation between resource utilization, cost and prematurity and identified personnel salary as the cost driver. Cost estimates and prediction provide in-depth understanding of provider cost and are applicable for further economic evaluations. Since gender is non-modifiable and reducing LOS alone is not effective, birth weight as a cost predictive factor in this study can be addressed through measures to prevent or delay preterm birth.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16678,

title = {Current issues facing the introduction of human papillomavirus vaccine in China and future prospects},

author = {L P Wong and L Han and H Li and J Zhao and Q Zhao and G D Zimet},

doi = {10.1080/21645515.2019.1611157},

issn = {2164-5515},

year  = {2019},

date = {2019-01-01},

journal = {Hum Vaccin Immunother},

volume = {15},

number = {7-8},

pages = {1533-1540},

abstract = {The introduction of human papillomavirus (HPV) vaccination in China aims to prevent HPV infection in all women. The issues that China might face include high cost of vaccines made in other countries, shortage in HPV vaccine supply, negative events attributed to vaccination (whether justified or not) that jeopardizes the general public's confidence in the HPV vaccine, cultural and literacy barriers, and sensitivity to receiving a vaccine for a sexually transmitted disease. Ensuring the effective delivery of the HPV vaccine in China, a country with vast economic, geographical, and cultural complexities, will require a commitment of significant resources. In light of the high price of imported vaccines, the availability of locally manufactured HPV vaccines would greatly facilitate the national HPV vaccination program. New evidence supporting the efficacy of a two-dose regime in younger adolescents would also be advantageous in terms of affordability and logistical simplicity of vaccine administration. Furthermore, it would potentially enhance the compliance and uptake, especially for hard to reach women in remote regions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16694,

title = {Dentition status among an ethnically diverse older urban Malaysian population},

author = {M A Amanat and J John and T M Pin and M Danaee and V Malhotra and S A Abbas and S B Kamaruzzaman},

doi = {10.1093/pubmed/fdz014},

issn = {1741-3842},

year  = {2019},

date = {2019-01-01},

journal = {J Public Health (Oxf)},

abstract = {BACKGROUND: Poor oral health affects not only dietary choices but overall well-being. This study explores the influence of lifestyle, socio-demographics and utilization of dental services on the dentition status of an older urban Malaysian population. METHODS: A total of 1210 participants 60 years and above, representing the three main ethnic groups were recruited from a larger cohort study. Weighted factors valued for comparison included socio demographics and health status. Knowledge of and attitude and behaviour towards personal oral health were also assessed. Dentition status, adapted from WHO oral health guidelines, was the dependent variable investigated. Data were analysed using descriptive chi square test and multivariate binary logistic regression. RESULTS: Overall, 1187 respondents completed the study. The dentition status and oral health related knowledge, attitude and behaviour varied between the three ethnic groups. The Chinese were significantly less likely to have \>/=13 missing teeth (OR = 0.698, 95% CI: 0.521-0.937) and \>/=1 decayed teeth (0.653; 0.519-0.932) compared to the Malays, while the Indians were significantly less likely than the Malays to have \>/=1 decayed teeth (0.695; 0.519-0.932) and \>/=2 filled teeth (0.781; 0.540-1.128). CONCLUSION: Ethnic differences in dentition outcome are related to oral health utilization highlighting the influence of cultural differences and the need for culturally sensitivity interventions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16695,

title = {Determinants of Diet and Physical Activity in Malaysian Adolescents: A Systematic Review},

author = {S Mohammadi and M Y Jalaludin and T T Su and M Dahlui and M N Azmi Mohamed and H Abdul Majid},

doi = {10.3390/ijerph16040603},

issn = {1660-4601},

year  = {2019},

date = {2019-01-01},

journal = {Int J Environ Res Public Health},

volume = {16},

number = {4},

abstract = {The increased prevalence of unhealthy eating habits and sedentary lifestyles among Malaysian adolescents has become a public health concern. The aim of this systematic review was to summarize evidence from observational studies related to diet and physical activity (PA) among Malaysian adolescents (13(-)18 years) and to recognize the associations between determinants of diet and PA and diet and PA behaviours. A systematic search for observational studies published from August 1990 through August 2017 was conducted via PubMed, Science Direct, Cochrane and Web of Science. A total of 18 studies met the inclusion criteria; these were independently extracted by two reviewers. Gender and ethnicity were the most commonly studied correlates of diet and PA; males were more physically active and they tended to have poorer diet quality and higher energy and macronutrient intakes in comparison to females; Malay adolescents had a lower diet quality and Chinese adolescents spent less time in PA compared to other ethnicities. However, the significance of these associations was often small or inconsistent. This review highlights the lack of longitudinal observational studies but summarizes the best available evidence for policymakers and public health practitioners to improve the diet and the level of PA in Malaysian adolescents.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16685,

title = {Determinants of Household Catastrophic Health Expenditure: A Systematic Review},

author = {M Azzani and A C Roslani and T T Su},

doi = {10.21315/mjms2019.26.1.3},

issn = {1394-195X (Print) 

1394-195x},

year  = {2019},

date = {2019-01-01},

journal = {Malays J Med Sci},

volume = {26},

number = {1},

pages = {15-43},

abstract = {The World Health Organization estimates that annually 150 million people experience severe (catastrophic) financial difficulties as a result of healthcare payments. Therefore, a systematic review was carried out to identify the determinants of household catastrophic health expenditure (CHE) in low-to high-income countries around the world. Both electronic and manual searches were conducted. The main outcome of interest was the determinants of CHE due to healthcare payments. Thirty eight studies met the inclusion criteria for review. The analysis revealed that household economic status, incidence of hospitalisation, presence of an elderly or disabled household member in the family, and presence of a family member with a chronic illness were the common significant factors associated with household CHE. The crucial finding of the current study is that socioeconomic inequality plays an important role in the incidence of CHE all over the world, where low-income households are at high risk of financial hardship from healthcare payments. This suggests that healthcare financing policies should be revised in order to narrow the gap in socioeconomic inequality and social safety nets should be implemented and strengthened for people who have a high need for health care.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16629,

title = {Determinants of shisha use among secondary school students in Sudan},

author = {M Othman and N Aghamohammadi and N D Nik Farid},

doi = {10.1186/s12889-019-7748-3},

issn = {1471-2458},

year  = {2019},

date = {2019-01-01},

journal = {BMC Public Health},

volume = {19},

number = {1},

pages = {1390},

abstract = {BACKGROUND: Shisha smoking has re-emerged in the Middle East in the last two decades and has spread rapidly in these communities. Information about shisha smoking in adolescents in Sudan is deficient. Hence, the aim of this study is to estimate the prevalence of shisha smoking among adolescents and determine the associated factors. METHODS: This study is a school based cross sectional study among secondary school students in Khartoum State - Sudan that targets both male and female students aged 14-17 years. A total of 3387 students from 29 public and private schools were selected by multi stage random sampling. The participants completed an anonymous self-administered questionnaire which was based on Arabic version of the Global Youth Tobacco Survey (GYTS). RESULTS: The response rate was 100% in schools and among participants, 57.3% were females and 51.6% were from public schools. The overall prevalence of those who had ever smoked shisha was 13.4%, and among male students the prevalence was 16.8%, while it was 10.9% in females. The associated factors were poor academic performance OR 2.90 CI 95% (1.21-6.94), friends smoking shisha OR 2.39 CI 95% (1.65-3.45), friends smoking cigarettes OR 2.76 CI 95% (1.90-4.01), peer pressure to smoke shisha OR 13.76 CI 95% (7.86-24.07) and unexpectedly restriction of selling shisha to minors OR 2.21 CI 95% (1.28-3.82). CONCLUSION: The prevalence of those who had ever smoked shisha is among the lowest in Middle East region; therefore, regular surveillance system is needed. A well-structured peer based comprehensive tobacco control programmes that are supported by strict and rigorous anti-tobacco regulations which control both commercial and social resources of tobacco are needed to contain this issue among adolescents.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16624,

title = {Development and Validation of an Evaluation Tool to Measure the Effectiveness of a Smoking Cessation Training among Healthcare Providers in Malaysia: The Providers' Smoking Cessation Training Evaluation (ProSCiTE)},

author = {S I Hasan and F Mohd Hairi and A S Amer Nordin and M Danaee},

doi = {10.3390/ijerph16214297},

issn = {1660-4601},

year  = {2019},

date = {2019-01-01},

journal = {Int J Environ Res Public Health},

volume = {16},

number = {21},

abstract = {Background: In line with Article 14 of the Framework Convention for Tobacco Control, we have witnessed vast developments in smoking cessation training for healthcare providers, offering help for smokers. However, there is no specific evaluation tool to monitor and evaluate the effectiveness of these programs for future enhancement and sustainability. Objective: To develop and validate a new tool for evaluating smoking cessation training programs for healthcare providers called the Providers' Smoking Cessation Training Evaluation (ProSCiTE). Methods: The 74-item ProSCiTE tool was developed based on a review of the literature and an expert panel review. The tool was validated in a sample of 403 healthcare providers using a cross-sectional study design from July to December 2016. Content validity was assessed by the Scale-Content Validity Index (S-CVI). The construct validity of the ProSCiTE was analyzed using exploratory factor analysis (EFA) to confirm psychometric properties. Internal consistency reliability was determined using Cronbach's alpha. Results: The content validity showed that the S-CVI ranged from 0.82 to 1.00 for consistency, representativeness, relevancy, and the clarity of each construct, resulting in 67 items for the questionnaire. The construct validity of the ProSCiTE (based on eigenvalues and factor loadings to confirm the four-factor structure (attitude, self-efficacy, behavior, and barriers) with 54.74% total variance) was acceptable (Kaiser-Mayer-Olkin = 0.923; Bartlett's test of sphericity was significant, p \< 0.001). The internal consistency reliability of the four-factor structure was very good, with Cronbach's alpha values at 0.89, 0.94, 0.95, and 0.90, respectively. Conclusions: This study showed that 67 items of the ProSCiTE demonstrated good content and construct validity, as well as a high internal consistency reliability for the measurement of knowledge, attitudes, self-efficacy, behavior, and barriers to smoking cessation interventions among healthcare providers. Therefore, the ProSCiTE is a valid and reliable research tool with which to evaluate the effectiveness of smoking cessation training programs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16714,

title = {Development of a Sexually Transmitted Disease Client-friendly Unit at a Primary Care Clinic in Malaysia: Lessons Learnt},

author = {S B Pannir Selvam and E M Khoo and S Y Chow and P F Wong and S S Mohsin and A Abdullah and W Y Choo},

doi = {10.1097/olq.0000000000000918},

issn = {0148-5717},

year  = {2019},

date = {2019-01-01},

journal = {Sex Transm Dis},

volume = {46},

number = {2},

pages = {143-145},

abstract = {Management of sexually transmitted diseases and human immunodeficiency virus is challenging due to the social stigma attached. We describe the development of a client-friendly sexually transmitted disease service in a primary care clinic in Malaysia with a special focus on key populations. Challenges and key lessons learnt from its development and implementation are discussed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16809,

title = {Diagnosing metabolic syndrome using genetically optimised Bayesian ARTMAP},

author = {H A Kakudi and C K Loo and F M Moy and N Masuyama and K Pasupa},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056546127\&doi=10.1109%2fACCESS.2018.2880224\&partnerID=40\&md5=236c2a1edae3550f2323218d7a6dda55},

doi = {10.1109/ACCESS.2018.2880224},

year  = {2019},

date = {2019-01-01},

journal = {IEEE Access},

volume = {7},

pages = {8437-8453},

abstract = {Metabolic Syndrome (MetS) constitutes of metabolic abnormalities that lead to non-communicable diseases, such as type II diabetes, cardiovascular diseases, and cancer. Early and accurate diagnosis of this abnormality is required to prevent its further progression to these diseases. This paper aims to diagnose the risk of MetS using a new non-clinical approach called 'genetically optimized Bayesian adaptive resonance theory mapping' (GOBAM). We evolve the Bayesian adaptive resonance theory mapping (BAM) by using genetic algorithm to optimize the parameters of BAM and its training input sequence. We use the GOBAM algorithm to classify individuals as either being at risk of MetS or not at risk of MetS with a related posterior probability, which ranges between 0 and 1. A data set of 11 237 Malaysians from the CLUSTer study stratified by age and gender into four subcategories was used to evaluate the proposed GOBAM algorithm. The comparative evaluation of our results suggested that the GOBAM performs significantly better than other classical adaptive resonance theory mapping models on the area under the receiver operating characteristic curves (AUC) and others criteria. Our algorithm gives an AUC of 86.42 %, 87.04 %, 91.08 %, and 89.24 % for the young female, middle aged female, young male, and middle-aged male subcategories, respectively. The proposed model can be used to support medical practitioners in accurate and early diagnosis of MetS. © 2013 IEEE.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16647,

title = {Diagnosis of severe dengue: Challenges, needs and opportunities},

author = {P F Wong and L P Wong and S AbuBakar},

doi = {10.1016/j.jiph.2019.07.012},

issn = {1876-0341},

year  = {2019},

date = {2019-01-01},

journal = {J Infect Public Health},

abstract = {BACKGROUND: Delayed diagnosis of dengue cases with increased risk for severe disease could lead to poor disease outcome. To date there is no specific laboratory diagnostic test for severe dengue. This qualitative study explored expert views regarding current issues in diagnosing severe dengue, rationale for severe dengue-specific diagnostics, future prospects and features of potential diagnostics for severe dengue. METHODS: In-depth individual interviews with thematic saturation were conducted between May and July 2018. The data was analyzed using thematic analysis. RESULTS: Based on expert opinion, diagnosis of severe dengue is challenging as it depends on astute clinical interpretation of non-dengue-specific clinical and laboratory findings. A specific test that detects impending manifestation of severe dengue could 1) overcome failure in identifying severe disease for referral or admission, 2) facilitate timely and appropriate management of plasma leakage and bleeding, 3) overcome the lack of clinical expertise and laboratory diagnosis in rural health settings. The most important feature of any diagnostics for severe dengue is the point-of-care (POC) format where it can be performed at or near the bedside. CONCLUSION: The development of diagnostics to detect impending severe dengue is warranted to reduce the morbidity and mortality rates of dengue infection and it should be prioritized.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16690,

title = {Dietary and physical activity patterns related to cardio-metabolic health among Malaysian adolescents: a systematic review},

author = {S Mohammadi and M Y Jalaludin and T T Su and M Dahlui and M N A Mohamed and H A Majid},

doi = {10.1186/s12889-019-6557-z},

issn = {1471-2458},

year  = {2019},

date = {2019-01-01},

journal = {BMC Public Health},

volume = {19},

number = {1},

pages = {251},

abstract = {BACKGROUND: A sedentary lifestyle and an unhealthy diet are major factors in the increasing prevalence of obesity among Malaysian adolescents. The purpose of this systematic review is to compile the evidence from observational and intervention studies among Malaysian adolescents to evaluate the associations between diet and physical activity (PA) as determinants of cardio-metabolic risk factors. METHODS: A systematic search of Medline via the PubMed, Science Direct, Cochrane Review and Web of Science databases was conducted for studies on the associations between diet and PA factors and cardio-metabolic risk factors among Malaysian adolescents aged 13-18 years that were published until 31 August 2017. The search results were independently screened and extracted by two reviewers. RESULTS: From over 2,410 references retrieved, 20 full texts articles were screened as potentially relevant. Seventeen (16 cross-sectional and one intervention) met the inclusion criteria for data extraction and analysis. All 17 studies were rated as poor quality and the majority had made insufficient adjustment for confounders. As regards the effect of diet and PA on cardio-metabolic health, the intakes of energy (n = 4) and macronutrients (n = 3) and meal frequency (n = 5) were the most commonly studied dietary factors, while the PA score and level were the most commonly studied PA factors. In addition, BMI and body weight were the most common cardio-metabolic health outcomes. The studies showed that obese and overweight adolescents consume significantly more energy and macronutrients. They are also more likely to skip their daily meals compared to their normal weight peers. In most studies, the direction of the PA effect on body weight was unclear. Some studies found that higher PA is associated with a lower risk of overweight and obesity. However, the associations are often small or inconsistent, with few studies controlling for confounding factors. CONCLUSIONS: This review identified a lack of evidence and well-conducted prospective studies on the effect of diet and PA on cardio-metabolic health of Malaysian adolescents.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16660,

title = {Dietary intake, physical activity and muscle strength among adolescents: the Malaysian Health and Adolescents Longitudinal Research Team (MyHeART) study},

author = {A K Ng and N N Hairi and M Y Jalaludin and H A Majid},

doi = {10.1136/bmjopen-2018-026275},

issn = {2044-6055},

year  = {2019},

date = {2019-01-01},

journal = {BMJ Open},

volume = {9},

number = {6},

pages = {e026275},

abstract = {OBJECTIVE: To examine the role of dietary intake and physical activity in muscle strength among adolescents. DESIGN: Cross-sectional analysis. SETTING: The Malaysian Health and Adolescents Longitudinal Research Team (MyHeART) study. PARTICIPANTS: Fifteen-year-old secondary school children who have given consent and who participated in the MyHeART study in 2014. PRIMARY OUTCOME MEASURE: Muscle strength was measured in relation to dietary intake (energy and macronutrients) and physical activity by using a hand grip dynamometer. RESULTS: Among the 1012 participants (395 male; 617 female), the hand grip strength of the males was higher than that of the females (27.08 kg vs 18.63 kg; p\<0.001). Also, males were more active (2.43vs2.12; p\<0.001) and consumed a higher amount of energy (2047 kcal vs 1738 kcal; p\<0.001), carbohydrate (280.71 g vs 229.31 g; p\<0.001) and protein (1.46 g/kg body weight (BW) vs 1.35 g/kg BW; p\<0.168). After controlling for ethnicity, place of residency and body mass index, there was a positive relationship between hand grip strength and the intake of energy (r=0.14; p=0.006), carbohydrate (r=0.153; p=0.002) and fat (r=0.124; p=0.014) and the physical activity score (r=0.170; p=0.001) and a negative relationship between hand grip strength and the intake of protein (r=-0.134; p=0.008), for males. However, this was not observed among females. CONCLUSIONS: Energy, carbohydrate and fat intakes and physical activity score were positively correlated with hand grip strength while protein intake was negatively correlated with hand grip strength in males but not in females.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16677,

title = {Dietary patterns in relation to lipid profiles among Iranian adults},

author = {F Zaribaf and N Mohammadifard and N Sarrafzadegan and G Karimi and A Gholampour and L Azadbakht},

doi = {10.15171/jcvtr.2019.04},

issn = {2008-5117 (Print) 

2008-5117},

year  = {2019},

date = {2019-01-01},

journal = {J Cardiovasc Thorac Res},

volume = {11},

number = {1},

pages = {19-27},

abstract = {Introduction: Lipid metabolism is one of the main concerns of cardiovascular disease and atherosclerosis. Little is known about the association between dietary patterns and dyslipidemia. Therefore, the present study aimed to determine such association among Iranian adults. Methods: This cross-sectional study was conducted on 1433 Iranian adults in Isfahan Healthy Heart Program (IHHP). Usual dietary intakes were assessed with the use of a 48 items food frequency questionnaire (FFQ). Factor analysis was used to identify dietary patterns. Three major dietary patterns were identified: western, semi healthy and healthy fat patterns. Results: After adjustment, subjects in the upper quartiles of western dietary pattern were more likely to have high total cholesterol concentrations than those in the first quartile (odds ratio [OR]: 2.07; 95% CI: 1.25-3.42). Individuals with greater adherence to western dietary pattern had greater odds of having high low-density lipoprotein-cholesterol (LDL-C) levels compared with those in the lowest quartiles (2.53; 1.45-4.40). Conclusion: Semi healthy dietary pattern was not associated with cardiovascular disease (CVD) risk factors. Same trend was observed for healthy fat dietary pattern. Significant association was found between western dietary pattern and dyslipidemia among Iranian adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16618,

title = {Dietary Practices and Meal Patterns among Overweight and Obese School Children in Malaysia: Baseline Data from a School-Based Intervention Study},

author = {R Selamat and J Raib and N A Abdul Aziz and N Zulkafly and A N Ismail and Mohamad W WNA and N I N Nasruddin and M Y Jalaludin and F Md Zain and Z Ishak and A Yahya and A H Mokhtar},

doi = {10.1080/03670244.2019.1694922},

issn = {0367-0244},

year  = {2019},

date = {2019-01-01},

journal = {Ecol Food Nutr},

pages = {1-16},

abstract = {This study aimed to determine dietary practices and meal patterns among Malaysian overweight and obese school children at baseline. This study was part of a school-based obesity intervention study, My Body is Fit and Fabulous at School (MyBFF@school). It involved 1045 primary and 1041 secondary overweight and obese school children from a randomly selected 23 out of 1196 primary and 15 out of 416 secondary government schools in central Peninsular Malaysia. The results showed a significantly higher of adequate intake (4-8 servings/day) of cereals and grains among primary (54.7%) than secondary school children (48.2%). About 28.2% of primary and 32.6% of secondary school children had consumed adequate fruit (2 servings/day), while a very low percentage of both primary (5.0%) and secondary (3.6%) school children consumed adequate vegetables (3 servings/day). As for the meal patterns, school children in both primary and secondary were not taking breakfast regularly (mean+/-SD for primary: 3.16 +/- 2.61 days/week vs secondary: 2.97 +/- 2.52 days/week). There was also a significantly higher mean frequency of primary school children brought plain water to school than the secondary school children. In conclusion, urgent actions to address improper dietary practices and meal patterns of overweight and obese school children in Malaysia are warranted.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16649,

title = {Dispensation of antiretroviral therapy and methadone maintenance therapy at the same facility in a low-barrier setting linked to optimal adherence to HIV treatment},

author = {N A Mohd Salleh and N Fairbairn and S Nolan and R Barrios and J Shoveller and L Richardson and M J Milloy},

doi = {10.1111/hiv.12777},

issn = {1464-2662},

year  = {2019},

date = {2019-01-01},

journal = {HIV Med},

volume = {20},

number = {9},

pages = {606-614},

abstract = {OBJECTIVES: We sought to examine the association between dispensation of methadone maintenance therapy (MMT) and antiretroviral therapy (ART) at the same facility, across multiple low-barrier dispensing outlets, and achieving optimal adherence to ART among people who use illicit drugs (PWUD). METHODS: We used data from the AIDS Care Cohort to Evaluate Exposure to Survival Services (ACCESS) study, a long-running study of a community-recruited cohort of HIV-positive PWUD, linked to comprehensive HIV clinical records in Vancouver, Canada, a setting of no-cost, universal access to HIV care. The longitudinal relationship between MMT-ART dispensation at the same facility and the odds of \>/= 95% ART adherence was analysed using multivariable generalized linear mixed-effects modelling. We conducted a further analysis using a marginal structural mode with inverse probability of treatment weights as a sensitivity analysis. RESULTS: This study included data on 1690 interviews of 345 ART- and MMT-exposed participants carried out between June 2012 and December 2017. In the final multivariable model, MMT-ART dispensation, compared with nondispensation at the same facility, was associated with greater odds of achieving \>/= 95% adherence [adjusted odds ratio (AOR) 1.56; 95% confidence interval (CI) 1.26-1.96]. A marginal structural model estimated a 1.48 (95% CI 1.15-1.80) greater odds of \>/= 95% adherence among participants who reported MMT-ART dispensation at the same facility compared with those who did not. CONCLUSIONS: The odds of achieving optimal adherence to ART were 56% higher during periods in which MMT and ART medications were dispensed at the same facility, in a low-barrier setting. Our findings highlight the need to consider a simpler integrated approach with medication dispensation at the same facility in low-threshold settings.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16717,

title = {Does abuse in late life worsen sleep quality? A two-year prospective cohort study among rural older adults},

author = {R M Yunus and N N Hairi and C Yuen and R Sooryanarayana and F Hairi and N Ismail and S Kandiben and T N Peng and Z M Ali and S N Ahmad and I A Razak and S Othman and D Peramalah and F H M Mydin and A Bulgiba},

doi = {10.1002/gps.4986},

issn = {0885-6230},

year  = {2019},

date = {2019-01-01},

journal = {Int J Geriatr Psychiatry},

volume = {34},

number = {1},

pages = {60-66},

abstract = {BACKGROUND: Elder abuse and neglect (EAN) is a growing public health problem, and numerous adverse health effects of abuse in late life have been documented. Little is known, however, about the impact of elder abuse on sleep quality. This study examines the longitudinal relationship between EAN and sleep quality. METHODS: This was a 2-year prospective cohort study involving 1927 older adults in a rural Malaysian district, Kuala Pilah. A multi-stage cluster sampling strategy was employed. After 2 years, 1189 respondents were re-assessed. EAN was determined using the modified Conflict Tactic Scale, while sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI). RESULTS: The prevalence of elder abuse was 8.1% (95% CI:6.9,9.3). Longitudinal analysis using generalized estimating equations showed that elder abuse contributed to higher PSQI scores (B:0.49, 95% CI:0.17,0.58). Sub-analyses demonstrated that psychological abuse and neglect had significant longitudinal relationships with increase of PSQI scores, while other subtypes did not. CONCLUSION: Abuse in late life, particularly psychological abuse and neglect, result in greater PSQI scores. Even though this may imply decline in sleep quality, our findings were not considered clinically significant as they did not exceed the clinical cut-off score of five. Nevertheless, sleep quality is an important determinant of health and a predictor of mortality among older adults; thus, understanding its relationship with abuse is useful to health care providers and policy-makers in improving health services and upgrading preventive measures.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16693,

title = {Does Body Mass Index and Height Influence the Incident Risk of Ischemic Stroke in Newly Diagnosed Type 2 Diabetes Subjects?},

author = {D Duan and H Li and J Xu and L Wong and G Xu and F Kong and S Li and Q Gong and X Zhang and J Zhao and L Zhang and G Xu and W Xing and L Han},

doi = {10.1155/2019/2591709},

year  = {2019},

date = {2019-01-01},

journal = {J Diabetes Res},

volume = {2019},

pages = {2591709},

abstract = {Objective: To estimate the incident risk of ischemic stroke (IS) in newly diagnosed type 2 diabetes (T2D) subjects according to different body mass index (BMI) and height categories. Methods: A total of 25,130 newly diagnosed T2D subjects were included in this study. All T2D subjects were enrolled consecutively from the Chronic Disease Surveillance System (CDSS) of Ningbo. Standardized incidence ratio (SIR) and its 95% confidence interval (95% CI) stratified by BMI categories and height quartiles were used to estimate the incident risk of IS in T2D subjects. Results: In total, 22,795 subjects completed the follow-up. Among them, 1268 newly diagnosed IS cases were identified, with 149,675 person-years. The SIRs of normal BMI (18.5-24.0 kg/m(2)), overweight (24.0-28.0 kg/m(2)), and obese (\>/=28.0 kg/m(2)) in overall subjects were 2.56 (95% CI 1.90-3.13), 2.13 (95% CI 1.90-3.13), and 1.87 (95% CI 1.29-2.43), respectively (P trend \< 0.01), comparing to the general population of Ningbo. For each 1 kg/m(2) increment in BMI, the SIR was 0.948 (95% CI 0.903-0.999). For height quartiles, the SIRs of male subjects in quartile 1 (\<160 cm), quartile 2 (161-165 cm), quartile 3 (165-170 cm), and quartile 4 (\>/=171 cm) were 2.27 (95% CI 1.99-2.56), 2.01 (95% CI 1.67-2.45), 1.37 (95% CI 1.05-1.68), and 0.91 (95% CI 0.40-1.32), respectively (P trend \< 0.01). While for female subjects, the SIRs in quartile 1 (\<155 cm), quartile 2 (156-160 cm), quartile 3 (161-165 cm), and quartile 4 (\>/=166 cm) were 3.57 (95% CI 3.11-3.49), 2.96 (95% CI 2.61-3.31), 1.94 (95% CI 1.51-2.36), and 1.71 (95% CI 0.95-2.47), respectively (P trend \< 0.01). Conclusion: Compared to the general population of Ningbo, T2D subjects had a higher incident risk of IS. Furthermore, the IS incident risk was not only higher in newly diagnosed T2D subjects with normal BMI but also lower in taller newly diagnosed T2D subjects.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16686,

title = {Effect of Blastocystis sp. in dengue patients-Increase in the treatment cost and exacerbation of symptoms},

author = {G Thergarajan and S Kumar and S Bhassu and Sfbs Omar and S Rampal},

doi = {10.1371/journal.pone.0211034},

issn = {1932-6203},

year  = {2019},

date = {2019-01-01},

journal = {PLoS One},

volume = {14},

number = {3},

pages = {e0211034},

abstract = {Increasing incidences of dengue have become a global health threat with major clinical manifestation including high fever and gastrointestinal symptoms. These symptoms were also expressed among Blastocystis sp. infected individuals, a parasite commonly seen in human stools. This parasite has been previously reported to replicate faster upon exposure to high temperature. The present study is a hospitalized-based cross-sectional study involved the collection of faecal sample from dengue patients. Stool examination was done by in vitro cultivation to isolate Blastocystis sp. Growth pattern of all the positive isolates were analyzed to identify the multiplication rate of Blastocystis sp. isolated from dengue patients. Distribution of Blastocystis sp. among dengue patients was 23.6%. Dengue patients who were positive for Blastocystis sp. infection denoted a significantly higher fever rate reaching 38.73 degrees C (p\<0.05) compared to the non-Blastocystis sp. infected patients (38.44 degrees C). It was also found that Blastocystis sp. infected patients complained of frequenting the toilet more than five times a day (p\<0.05) compared to those who were non-Blastocystis sp. infected. At the same time, the duration of hospitalization was significantly longer (p\<0.05) for Blastocystis sp. infected dengue patients compared to the non-Blastocystis sp. infected patients. Besides, Blastocystis sp. isolated from dengue patients (in vivo thermal stress) showed a higher growth rate compared to the non-dengue isolated which was exposed to high temperature (in vitro thermal stress). Our findings suggest that presence of Blastocystis sp. during dengue infection could trigger the increase of temperature which could be due to highly elevated pro inflammatory cytokines by both parasitic and virus infection. This could justify why the temperature in Blastocystis sp. infected dengue patients is higher compared to the non-Blastocystis sp. infected patients. Higher temperature could have triggered a greater parasite multiplication rate that contributed to the aggravation of the gastrointestinal symptoms.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16785,

title = {Effect of Blastocystis sp. In dengue patients\textemdashIncrease in the treatment cost and exacerbation of symptoms},

author = {G Thergarajan and S Kumar and S Bhassu and S F B S Omar and S Rampal},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063254279\&doi=10.1371%2fjournal.pone.0211034\&partnerID=40\&md5=a48004beadf8282779a894541a492363},

doi = {10.1371/journal.pone.0211034},

year  = {2019},

date = {2019-01-01},

journal = {PLoS ONE},

volume = {14},

number = {3},

abstract = {Increasing incidences of dengue have become a global health threat with major clinical manifestation including high fever and gastrointestinal symptoms. These symptoms were also expressed among Blastocystis sp. infected individuals, a parasite commonly seen in human stools. This parasite has been previously reported to replicate faster upon exposure to high temperature. The present study is a hospitalized-based cross-sectional study involved the collection of faecal sample from dengue patients. Stool examination was done by in vitro cultivation to isolate Blastocystis sp. Growth pattern of all the positive isolates were analyzed to identify the multiplication rate of Blastocystis sp. isolated from dengue patients. Distribution of Blastocystis sp. among dengue patients was 23.6%. Dengue patients who were positive for Blastocystis sp. infection denoted a significantly higher fever rate reaching 38.73C (p\<0.05) compared to the non-Blastocystis sp. infected patients (38.44C). It was also found that Blastocystis sp. infected patients complained of frequenting the toilet more than five times a day (p\<0.05) compared to those who were non-Blastocystis sp. infected. At the same time, the duration of hospitalization was significantly longer (p\<0.05) for Blastocystis sp. infected dengue patients compared to the non-Blastocystis sp. infected patients. Besides, Blastocystis sp. isolated from dengue patients (in vivo thermal stress) showed a higher growth rate compared to the non-dengue isolated which was exposed to high temperature (in vitro thermal stress). Our findings suggest that presence of Blastocystis sp. during dengue infection could trigger the increase of temperature which could be due to highly elevated pro inflammatory cytokines by both parasitic and virus infection. This could justify why the temperature in Blastocystis sp. infected dengue patients is higher compared to the non-Blastocystis sp. infected patients. Higher temperature could have triggered a greater parasite multiplication rate that contributed to the aggravation of the gastrointestinal symptoms. © 2019 Thergarajan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16798,

title = {Empirical study on temporal variations of canopy-level Urban Heat Island effect in the tropical city of Greater Kuala Lumpur},

author = {L Ramakreshnan and N Aghamohammadi and C S Fong and A Ghaffarianhoseini and L P Wong and N M Sulaiman},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056642789\&doi=10.1016%2fj.scs.2018.10.039\&partnerID=40\&md5=087997d806059c4a959aedef306c8ee2},

doi = {10.1016/j.scs.2018.10.039},

year  = {2019},

date = {2019-01-01},

journal = {Sustainable Cities and Society},

volume = {44},

pages = {748-762},

abstract = {A very few studies have evaluated and understood the temporal dynamics of UHI in many expanding tropical cities. Hence, this study investigated the temporal variations of canopy-level UHI in selected urban stations, namely Petaling Jaya (PJ) and Subang (SUB), of Greater Kuala Lumpur (GKL) using 2016’s hourly data set obtained from meteorological observatories. The association between meteorological factors and UHI Intensity (UHII) is evaluated using linear regression models and Pearson correlation analysis. The findings revealed positive thermal contrasts between urban and sub-urban stations with maximum UHII during dry, southwest monsoon season in PJ (June: 1.68 °C) and SUB (August: 1.29 °C) stations respectively. PJ station exhibited a distinct diurnal cycle with the maximum nocturnal UHII of 1.71 °C at about 8 p.m. after sunset under ideal meteorological conditions. The results also demonstrated that UHI events occurred more frequently at nights in urban stations in the magnitude range of 0\textendash2 °C. Cooling at all urban sites starts around 2\textendash3 p.m. with the highest rate of 0.73 °C/h and 0.96 °C/h in PJ and SUB stations. Meanwhile, relative humidity displayed a low positive correlation (r = 0.37, p ≥ 0.05) and a high negative correlation (r = −0.79, p \< 0.05) with UHII in PJ and SUB stations respectively. The influence of wind speed on UHII is weak (r = −0.44, p \< 0.05) in PJ station and strong (r = 0.83, p \< 0.05) in SUB station. Overall, this study can be regarded as one of the comprehensive observational investigations of canopy-level UHI in a tropical city that provide vital inputs to enrich the tropical urban climate literacy. © 2018 Elsevier Ltd},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16673,

title = {Ethnic differences in lifetime cumulative incidence of syncope: the Malaysian elders longitudinal research (MELoR) study},

author = {M P Tan and Y Y Ho and A V Chin and N Saedon and I Z Abidin and K H Chee and H M Khor and C H Goh and N N Hairi and S Othman and S B Kamaruzzaman},

doi = {10.1007/s10286-019-00610-2},

issn = {0959-9851},

year  = {2019},

date = {2019-01-01},

journal = {Clin Auton Res},

abstract = {PURPOSE: To determine the lifetime cumulative incidence of syncope, potential ethnic differences and factors associated with syncope using the Malaysian elders longitudinal research (MELoR) study first wave dataset. METHODS: The MELoR study recruited community-dwelling adults aged 55 years and over, selected through stratified random sampling from three parliamentary constituencies. The baseline data collected during the first wave was obtained through face-to-face interviews in participants' homes using computer-assisted questionnaires. During their baseline assessments, participants were asked whether they had ever experienced a blackout in their lifetime and if they had experienced a blackout in the preceding 12 months. RESULTS: Information on blackouts and ethnicity were available for 1530 participants. The weight-adjusted lifetime cumulative incidence of syncope for the overall population aged 55 years and above was 27.7%. The estimated lifetime cumulative incidence according to ethnic groups was 34.6% for Malays, 27.8% for Indians and 23.7% for Chinese. The estimated 12-month incidence of syncope was 6.1% overall, equating to 11.7% for Malays, 8.7 % for Indians and 2.3% for Chinese. Both Malay [odds ratio (OR) 1.46; 95% confidence interval (CI) 1.10-1.95 and OR 3.62, 95% CI 1.96-6.68] and Indian (OR 1.34; 95% CI 1.01-1.80 and OR 3.31, 1.78-6.15) ethnicities were independently associated with lifetime and 12-month cumulative incidence of syncope, respectively, together with falls, dizziness and myocardial infarction. CONCLUSION: Ethnic differences exist for lifetime cumulative incidence of syncope in community-dwelling individuals aged 55 years and over in an urban area in Southeast Asia. Future studies should now seek to determine potential genetic, cultural and lifestyle differences which may predispose to syncope.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16619,

title = {Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians},

author = {S Mat and M H Jaafar and C T Ng and S Sockalingam and J Raja and S B Kamaruzzaman and A V Chin and A A Abbas and C K Chan and N N Hairi and S Othman and R G Cumming and N P Tey and M P Tan},

doi = {10.1371/journal.pone.0225075},

issn = {1932-6203},

year  = {2019},

date = {2019-01-01},

journal = {PLoS One},

volume = {14},

number = {11},

pages = {e0225075},

abstract = {Knee pain is often underreported, underestimated and undertreated. This study was conducted to estimate the prevalence, burden and further identify socioeconomic factors influencing ethnic differences in knee pain and symptoms of OA among older adults aged 55 years and over in Greater Kuala Lumpur (the capital city of Malaysia). The sample for the Malaysian Elders Longitudinal Research (MELoR) was selected using stratified random sampling, by age and ethnicity from the electoral rolls of three parliamentary constituencies. Information on knee pain was available in 1226 participants, mean age (SD) 68.96 (1.57) years (409 Malay, 416 Chinese, 401 Indian). The crude and weighted prevalence of knee pain and self-reported knee OA symptoms were 33.3% and 30.8% respectively. There were significant ethnic differences in knee pain (crude prevalence: Malays 44.6%, Chinese 23.5% and Indians 31.9%, p\<0.001). The presence of two or more non-communicable diseases (NCD) attenuated the increased risk of knee pain among the ethnic Indians compared to the ethnic Chinese. The prevalence of knee pain remained significantly higher among the ethnic Malays after adjustment for confounders. While the prevalence of knee pain in our older population appears similar to that reported in other published studies in Asia, the higher prevalence among the ethnic Malays has not previously been reported. Further research to determine potential genetic susceptibility to knee pain among the ethnic Malays is recommended.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16640,

title = {Exogenous hormone use and cutaneous melanoma risk in women: The European Prospective Investigation into Cancer and Nutrition},

author = {I Cervenka and M Al Rahmoun and Y Mahamat-Saleh and A Fournier and M C Boutron-Ruault and G Severi and S Caini and D Palli and R Ghiasvand and M B Veierod and E Botteri and A Tjonneland and A Olsen and R T Fortner and R Kaaks and M B Schulze and S Panico and A Trichopoulou and C Dessinioti and K Niforou and S Sieri and R Tumino and C Sacerdote and B Bueno-de-Mesquita and T M Sandanger and S Colorado-Yohar and M J Sanchez and L Gil Majuelo and L Lujan-Barroso and E Ardanaz and S Merino and K Isaksson and S Butt and I Ljuslinder and M Jansson and R C Travis and K T Khaw and E Weiderpass and L Dossus and S Rinaldi and M Kvaskoff},

doi = {10.1002/ijc.32674},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

abstract = {Evidence suggests an influence of sex hormones on cutaneous melanoma risk, but epidemiologic findings are conflicting. We examined the associations between use of oral contraceptives (OCs) and menopausal hormone therapy (MHT) and melanoma risk in women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Information on exogenous hormone use at baseline was derived from country-specific self-administered questionnaires. We used Cox proportional hazards regression models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Over 1992-2015, 1,696 melanoma cases were identified among 334,483 women, whereof 770 cases among 134,758 postmenopausal women. There was a positive, borderline-significant association between OC use and melanoma risk (HR = 1.12, 95% CI = 1.00-1.26), with no detected heterogeneity across countries (phomogeneity = 0.42). This risk increased linearly with duration of use (ptrend = 0.01). Among postmenopausal women, ever use of MHT was associated with a nonsignificant increase in melanoma risk overall (HR = 1.14, 95% CI = 0.97-1.43), which was heterogeneous across countries (phomogeneity = 0.05). Our findings do not support a strong and direct association between exogenous hormone use and melanoma risk. In order to better understand these relations, further research should be performed using prospectively collected data including detailed information on types of hormone, and on sun exposure, which may act as an important confounder or effect modifier on these relations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16710,

title = {Exploring causality of the association between smoking and Parkinson's disease},

author = {V Gallo and P Vineis and M Cancellieri and P Chiodini and R A Barker and C Brayne and N Pearce and R Vermeulen and S Panico and B Bueno-de-Mesquita and N Vanacore and L Forsgren and S Ramat and E Ardanaz and L Arriola and J Peterson and O Hansson and D Gavrila and C Sacerdote and S Sieri and T Kuhn and V A Katzke and Y T Schouw and A Kyrozis and G Masala and A Mattiello and R Perneczky and L Middleton and R Saracci and E Riboli},

doi = {10.1093/ije/dyy230},

issn = {0300-5771},

year  = {2019},

date = {2019-01-01},

journal = {Int J Epidemiol},

volume = {48},

number = {3},

pages = {912-925},

abstract = {BACKGROUND: The aim of this paper is to investigate the causality of the inverse association between cigarette smoking and Parkinson's disease (PD). The main suggested alternatives include a delaying effect of smoking, reverse causality or an unmeasured confounding related to a low-risk-taking personality trait. METHODS: A total of 715 incident PD cases were ascertained in a cohort of 220 494 individuals from NeuroEPIC4PD, a prospective European population-based cohort study including 13 centres in eight countries. Smoking habits were recorded at recruitment. We analysed smoking status, duration, and intensity and exposure to passive smoking in relation to PD onset. RESULTS: Former smokers had a 20% decreased risk and current smokers a halved risk of developing PD compared with never smokers. Strong dose-response relationships with smoking intensity and duration were found. Hazard ratios (HRs) for smoking \<20 years were 0.84 [95% confidence interval (CI) 0.67-1.07], 20-29 years 0.73 (95% CI 0.56-0.96) and \>30 years 0.54 (95% CI 0.43-0.36) compared with never smokers. The proportional hazard assumption was verified, showing no change of risk over time, arguing against a delaying effect. Reverse causality was disproved by the consistency of dose-response relationships among former and current smokers. The inverse association between passive smoking and PD, HR 0.70 (95% CI 0.49-0.99) ruled out the effect of unmeasured confounding. CONCLUSIONS: These results are highly suggestive of a true causal link between smoking and PD, although it is not clear which is the chemical compound in cigarette smoking responsible for the biological effect.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16632,

title = {Factors associated with healthcare workers willingness to participate in disasters: a cross-sectional study in Sana'a, Yemen},

author = {W Al-Hunaishi and V C Hoe and K Chinna},

doi = {10.1136/bmjopen-2019-030547},

issn = {2044-6055},

year  = {2019},

date = {2019-01-01},

journal = {BMJ Open},

volume = {9},

number = {10},

pages = {e030547},

abstract = {OBJECTIVES: Willingness to participate in disasters is usually overlooked and not addressed in disaster preparedness training courses to ensure health service coverage. This will lead to issues during the disaster's response. This study, therefore, aims to assess healthcare workers willingness to participate in biological and natural disasters, and to identify its associated factors. DESIGN: This is a cross-sectional study using a self-administered questionnaire. The questionnaire was distributed to 1093 healthcare workers. The data were analysed using multiple logistic regression with significance level p\<0.05. Ethical clearance and consent of the participants were duly obtained. SETTING: In three public hospitals that provide tertiary-level healthcare in Sana'a City, Yemen. PARTICIPANTS: There were 692 nurses and doctors (response rate 63.3%) completed the questionnaires. RESULTS: Almost half of the participants 55.1% were nurses and 44.9% were doctors. The study found that self-efficacy was associated with willingness to participate in disaster response for any type of disasters (OR 1.319, 95% CI 1.197 to 1.453), natural disasters (OR 1.143, 95% CI 1.069 to 1.221) and influenza pandemic (OR 1.114, 95% CI 1.050 to 1.182). The results further show that willingness is associated with healthcare workers being young, male and having higher educational qualifications. CONCLUSION: Self-efficacy has been found to be an important factor associated with willingness. Improving self-efficacy through training in disaster preparedness may increase willingness of healthcare workers to participate in a disaster.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16687,

title = {Factors associated with online sexually transmissible infection information seeking among young people in Malaysia: an observational study},

author = {S M Mohamad Shakir and L P Wong and K L Abdullah and P Adam},

doi = {10.1071/sh17198},

issn = {1448-5028},

year  = {2019},

date = {2019-01-01},

journal = {Sex Health},

volume = {16},

number = {2},

pages = {158-171},

abstract = {Background The Internet is an important resource of information about sexually transmissible infections (STIs) among young people. Little is known of the facilitators of online STI information seeking. This study aimed to identify the factors associated with online STI information seeking among youth in Malaysia. METHODS: A cross-sectional online survey was conducted among Malaysian youth aged 18-25 years who were recruited through social media. RESULTS: Among 1530 respondents who completed the survey, 57.1% sought online STI information in the past 12 months mostly from general Internet websites, health websites, and Facebook. Respondents' overall STI knowledge was low. Young people who had higher STI knowledge (OR = 2.47, 95% CI = 1.87-3.25},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16613,

title = {Factors Determining the Increased Risk of Falls in Individuals With Knee Pain in the Malaysian Elders Longitudinal Research (MELoR) Study},

author = {S Mat and A H Razack and J Lim and S Y Khong and S B Kamaruzzaman and A V Chin and A A Abbas and N N Hairi and S Othman and M P Tan},

doi = {10.3389/fmed.2019.00277},

issn = {2296-858X (Print) 

2296-858x},

year  = {2019},

date = {2019-01-01},

journal = {Front Med (Lausanne)},

volume = {6},

pages = {277},

abstract = {Objectives: While the negative impact of falls in older persons has been recognized, the association between knee pains and falls remains inconclusive due to underreporting and undertreatment of knee pain. This study was conducted to evaluate the relationship between knee pain and knee pain severity with falls risk and to further determine factors which influence this potential relationship. Design: This was cross-sectional study from the Malaysian Elders Longitudinal Research (MELoR) study. Setting: Urban community dwellers in a middle-income South East Asian country. Participants: One thousand two hundred twelve of a representative sample of community dwelling older persons aged 55 years and older. Outcome measures: Falls in the preceding 12 months and knee pain were collected during a home-based computer-assisted interview. Physical and functional performance were measured using the Timed Up and Go test and the Katz and Lawton scales, respectively. Psychological status was determined using the Depression Anxiety and Stress Scale (DASS-21). Results: Of the 1,212 participants included in this analysis, knee pain was present in 402 (33.17%) individuals (124 (30.85%) mild, 210 (52.24%) moderate, 68 (16.92%) severe). The presence of knee pain was associated with increased risk of falls [odds Ratio, OR(95% confidence interval, CI): 1.81 (1.37-2.38)]. Severe knee pain was an independent predictor for falls after adjustment for functional impairment and psychological status. Mild, moderate, and severe knee pain had a specific indirect effect on falls through reducing functional impairment, which in turn increases their psychological concern. Conclusion: Future studies should explore this relationship prospectively and evaluate whether interventions which alleviate psychological concerns and improve function will reduce falls risk in those with mild to moderate knee pain.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16637,

title = {Factors influencing intention to obtain the HPV vaccine and acceptability of 2-, 4- and 9-valent HPV vaccines: A study of undergraduate female health sciences students in Fujian, China},

author = {Y Lin and Z Lin and F He and Z Hu and G D Zimet and H Alias and L P Wong},

doi = {10.1016/j.vaccine.2019.09.026},

issn = {0264-410x},

year  = {2019},

date = {2019-01-01},

journal = {Vaccine},

volume = {37},

number = {44},

pages = {6714-6723},

abstract = {BACKGROUND: Little research has been conducted on the intention to obtain HPV vaccine now that the vaccine is approved for use in China. Acceptance of the three HPV vaccines, which differ in valency and price, has never been investigated. METHODS: An online cross-sectional survey assessing female undergraduate students' intention to obtain the HPV vaccine and their acceptability of 2-, 4- and 9-valent HPV vaccines (2vHPV, 4vHPV, and 9vHPV, respectively). RESULTS: Of a total of 997 complete responses, 55.2% reported intent to obtain the HPV vaccine. Some of the significant factors exerting influence on intent to obtain HPV vaccination were high knowledge score (OR=1.469, 95% CI:1.087-1.987), perceived high risk of HPV infection (OR=1.466, 95%CI:1.017-2.114), perception of no serious side effects (OR=1.562, 95%CI:1.150-2.121), and mass media exposure to HPV vaccination information (OR=2.196, 95%CI: 1.625-2.966). Socioeconomic status indicators did not significantly influence intent to obtain the HPV vaccine. A higher proportion of respondents were willing to pay for 2vHPV (78.6%) and 4vHPV (68.0%) compared with 9vHPV (49.3%). Socioeconomic status indicators were the strongest correlates of acceptability for all the three vaccines. Exposure to mass media reporting about HPV vaccination is the factor which exerts the most influence on acceptance of 9vHPV after socioeconomic status indicators. CONCLUSIONS: It is important to improve knowledge and health beliefs, and to establish a mass media marketing strategy to promote HPV vaccination in order to enhance HPV vaccine uptake. Undergraduate female students should be provided with detailed information about the different valency vaccine choices to help them make informed decisions about immunization.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16655,

title = {Financial toxicity and its associations with health-related quality of life among urologic cancer patients in an upper middle-income country},

author = {C Y Ting and G C Teh and K L Yu and H Alias and H M Tan and L P Wong},

doi = {10.1007/s00520-019-04975-y},

issn = {0941-4355},

year  = {2019},

date = {2019-01-01},

journal = {Support Care Cancer},

abstract = {PURPOSE: This study examined the prevalence of financial toxicity (FT) and associated factors among urologic cancer patients. The association between FT and health-related quality of life (HRQoL) was also investigated. METHODS: A total of 429 respondents diagnosed with urologic cancers (prostate cancer, bladder and renal cancer) from Sarawak General Hospital and Subang Jaya Medical Centre in Malaysia were interviewed using a structured questionnaire. Objective and subjective FT were measured by catastrophic health expenditure (healthcare-cost-to-income ratio greater than 40%) and the Personal Financial Well-being Scale, respectively. HRQoL was measured with the Functional Assessment of Cancer Therapy - General 7 Items scale. RESULTS: Objective and subjective FT were experienced by 16.1 and 47.3% of the respondents, respectively. Respondents who sought treatment at a private hospital and had out-of-pocket health expenditures were more likely to experience objective FT, after adjustment for covariates. Respondents who were female and had a monthly household income less than MYR 5000 were more likely to experience average to high subjective FT. Greater objective FT (OR = 2.75, 95% CI 1.09-6.95) and subjective FT (OR = 4.68, 95% CI 2.63-8.30) were associated with poor HRQoL. CONCLUSIONS: The significant association between both objective and subjective FT and HRQoL highlights the importance of reducing FT among urologic cancer patients. Subjective FT was found to have a greater negative impact on HRQoL.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16623,

title = {From Evidence to Policy: Economic Evaluations of Healthcare in Malaysia - A Systematic Review},

author = {K N Ku Abd Rahim and H F Kamaruzaman and M Dahlui and S E Wan Puteh},

doi = {10.1016/j.vhri.2019.09.002},

issn = {2212-1099},

year  = {2019},

date = {2019-01-01},

journal = {Value Health Reg Issues},

volume = {21},

pages = {91-99},

abstract = {OBJECTIVE: To identify and describe the various economic evaluation studies in Malaysia and to determine the range of incremental cost-effectiveness ratios (ICERs) as reported in these studies. METHODS: A comprehensive search of the scientific electronic databases was conducted (Medline, EBM Reviews, Embase, and hand search) to identify all published economic evaluation studies related to Malaysian healthcare. Two researchers assessed the quality of selected studies using the Critical Appraisal Skills Programme (CASP) checklist and Quality of Health Economic Studies instrument. The assessment was also reviewed by expert members of the Technical Advisory Committee of Health Technology Economic Evaluations (TACHTEE). RESULTS: A total of 64 full-text articles were assessed for eligibility and included in this systematic review. Thirty studies were partial economic evaluations; the full economic evaluations included 17 cost-effectiveness analyses and 17 cost-utility analyses. From all the reported ICERs, the majority (68%) were categorized as highly cost-effective (ICER of less than 1 gross domestic product (GDP) per capita per quality-adjusted life-years or disability-adjusted life-years gained). CONCLUSION: This review identifies information gaps and loopholes in health economics research in Malaysia. Additionally, this study provides the information that the majority of published interventions in Malaysia fell within the cost-effectiveness threshold of 1 GDP per capita per quality-adjusted life-years or disability-adjusted life-years gained.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16705,

title = {Gallstones and incident colorectal cancer in a large pan-European cohort study},

author = {H A Ward and N Murphy and E Weiderpass and M F Leitzmann and E Aglago and M J Gunter and H Freisling and M Jenab and M C Boutron-Ruault and G Severi and F Carbonnel and T Kuhn and R Kaaks and H Boeing and A Tjonneland and A Olsen and K Overvad and S Merino and R Zamora-Ros and M Rodriguez-Barranco and M Dorronsoro and M D Chirlaque and A Barricarte and A Perez-Cornago and A Trichopoulou and C Bamia and P Lagiou and G Masala and S Grioni and R Tumino and C Sacerdote and A Mattiello and B Bueno-de-Mesquita and R Vermeulen and C Van Gils and H Nystrom and M Rutegard and D Aune and E Riboli and A J Cross},

doi = {10.1002/ijc.32090},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

volume = {145},

number = {6},

pages = {1510-1516},

abstract = {Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclear whether gallstones are a risk factor for CRC. We examined the association between history of gallstones and CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a prospective cohort of over half a million participants from ten European countries. History of gallstones was assessed at baseline using a self-reported questionnaire. The analytic cohort included 334,986 participants; a history of gallstones was reported by 3,917 men and 19,836 women, and incident CRC was diagnosed among 1,832 men and 2,178 women (mean follow-up: 13.6 years). Hazard ratios (HR) and 95% confidence intervals (CI) for the association between gallstones and CRC were estimated using Cox proportional hazards regression models, stratified by sex, study centre and age at recruitment. The models were adjusted for body mass index, diabetes, alcohol intake and physical activity. A positive, marginally significant association was detected between gallstones and CRC among women in multivariable analyses (HR = 1.14, 95%CI 0.99-1.31},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16713,

title = {Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study},

author = {D Campa and M Matarazzi and W Greenhalf and M Bijlsma and K U Saum and C Pasquali and H Laarhoven and A Szentesi and F Federici and P Vodicka and N Funel and R Pezzilli and H B Bueno-de-Mesquita and L Vodickova and D Basso and O Obazee and T Hackert and P Soucek and K Cuk and J Kaiser and C Sperti and M Lovecek and G Capurso and B Mohelnikova-Duchonova and K T Khaw and A K Konig and J Kupcinskas and R Kaaks and F Bambi and L Archibugi and A Mambrini and G M Cavestro and S Landi and P Hegyi and J R Izbicki and D Gioffreda and C F Zambon and F Tavano and R Talar-Wojnarowska and K Jamroziak and T J Key and G D Fave and O Strobel and L Jonaitis and A Andriulli and R T Lawlor and F Pirozzi and V Katzke and C Valsuani and Y K Vashist and H Brenner and F Canzian},

doi = {10.1002/ijc.31928},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

volume = {144},

number = {6},

pages = {1275-1283},

abstract = {Telomere deregulation is a hallmark of cancer. Telomere length measured in lymphocytes (LTL) has been shown to be a risk marker for several cancers. For pancreatic ductal adenocarcinoma (PDAC) consensus is lacking whether risk is associated with long or short telomeres. Mendelian randomization approaches have shown that a score built from SNPs associated with LTL could be used as a robust risk marker. We explored this approach in a large scale study within the PANcreatic Disease ReseArch (PANDoRA) consortium. We analyzed 10 SNPs (ZNF676-rs409627, TERT-rs2736100, CTC1-rs3027234, DHX35-rs6028466, PXK-rs6772228, NAF1-rs7675998, ZNF208-rs8105767, OBFC1-rs9420907, ACYP2-rs11125529 and TERC-rs10936599) alone and combined in a LTL genetic score ("teloscore", which explains 2.2% of the telomere variability) in relation to PDAC risk in 2,374 cases and 4,326 controls. We identified several associations with PDAC risk, among which the strongest were with the TERT-rs2736100 SNP (OR = 1.54; 95%CI 1.35-1.76; p = 1.54 x 10(-10) ) and a novel one with the NAF1-rs7675998 SNP (OR = 0.80; 95%CI 0.73-0.88; p = 1.87 x 10(-6)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16644,

title = {Gravid oviposition sticky trap and dengue non-structural 1 antigen test for early surveillance of dengue in multi-storey dwellings: study protocol of a cluster randomized controlled trial},

author = {J W K Liew and S Selvarajoo and W Tan and R Ahmad Zaki and I Vythilingam},

doi = {10.1186/s40249-019-0584-y},

issn = {2049-9957},

year  = {2019},

date = {2019-01-01},

journal = {Infect Dis Poverty},

volume = {8},

number = {1},

pages = {71},

abstract = {BACKGROUND: Dengue is a global disease, transmitted by the Aedes vectors. In 2018, there were 80 615 dengue cases with 147 deaths in Malaysia. Currently, the nationwide surveillance programs are dependent on Aedes larval surveys and notifications of lab-confirmed human infections. The existing, reactive programs appear to lack sensitivity and proactivity. More efficient dengue vector surveillance/control methods are needed. METHODS: A parallel, cluster, randomized controlled, interventional trial is being conducted for 18 months in Damansara Damai, Selangor, Malaysia, to determine the efficacy of using gravid oviposition sticky (GOS) trap and dengue non-structural 1 (NS1) antigen test for early surveillance of dengue among Aedes mosquitoes to reduce dengue outbreaks. Eight residential apartments were randomly assigned into intervention and control arms. GOS traps are set at the apartments to collect Aedes weekly, following which dengue NS1 antigen is detected in these mosquitoes. When a dengue-positive mosquito is detected, the community will be advised to execute vector search-and-destroy and protective measures. The primary outcome concerns the the percentage change in the (i) number of dengue cases and (ii) durations of dengue outbreaks. Whereas other outcome measures include the change in density threshold of Aedes and changes in dengue-related knowledge, attitude and practice among cluster inhabitants. DISCUSSION: This is a proactive and early dengue surveillance in the mosquito vector that does not rely on notification of dengue cases. Surveillance using the GOS traps should be able to efficiently provide sufficient coverage for multistorey dwellings where population per unit area is likely to be higher. Furthermore, trapping dengue-infected mosquitoes using the GOS trap, helps to halt the dengue transmission carried by the mosquito. It is envisaged that the results of this randomized controlled trial will provide a new proactive, cheap and targeted surveillance tool for the prevention and control of dengue outbreaks. TRIAL REGISTRATION: This is a parallel-cluster, randomized controlled, interventional trial, registered at ClinicalTrials.gov (ID: NCT03799237), on 8th January 2019 (retrospectively registered).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16621,

title = {Health facility use by dengue patients in the Klang Valley, Malaysia: a secondary analysis of dengue surveillance data},

author = {Y L Woon and C W Ng and R N Mudin and Z Suli},

doi = {10.5365/wpsar.2019.10.1.001},

issn = {2094-7321},

year  = {2019},

date = {2019-01-01},

journal = {Western Pac Surveill Response J},

volume = {10},

number = {2},

pages = {39-45},

abstract = {Background: Dengue patients in Malaysia have the choice to seek care from either public or private sector providers. This study aims to analyse the pattern of health facility use among dengue patients to provide input for the ongoing policy discussion regarding public-private integration. The focus of this study is in the Klang Valley, which has a high dengue burden as well as a high number of private facilities. Methods: This is a cross-sectional study using an available secondary data source - the Malaysian national dengue passive surveillance system, e-Dengue registry. A total of 61 455 serologically confirmed dengue cases from the Klang Valley, registered in year 2014, were included. We retrospectively examined the relationship between demographic factors and the choice of health-care sector by logistic regression. Results: The median age of the cohort was 26 (interquartile range: 17 to 37) years. More private facilities (54.4%) were used for inpatient care; more public facilities (68.2%) were used for outpatient care. The Chinese and urban populations showed significantly higher use of the private health-care sector with an adjusted odds ratio of 4.8 [95% confidence interval (CI): 4.6-5.1] and 2.3 (95% CI: 2.2-2.4), respectively. Conclusion: Both public and private health facilities bear significant responsibilities in delivering health-care services to dengue patients. The workload of both sectors should be included in future health policy planning by public agencies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16719,

title = {Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study},

author = {N Murphy and H A Ward and M Jenab and J A Rothwell and M C Boutron-Ruault and F Carbonnel and M Kvaskoff and R Kaaks and T Kuhn and H Boeing and K Aleksandrova and E Weiderpass and G Skeie and K B Borch and A Tjonneland and C Kyro and K Overvad and C C Dahm and P Jakszyn and M J Sanchez and L Gil and J M Huerta and A Barricarte and J R Quiros and K T Khaw and N Wareham and K E Bradbury and A Trichopoulou and C La Vecchia and A Karakatsani and D Palli and S Grioni and R Tumino and F Fasanelli and S Panico and B Bueno-de-Mesquita and P H Peeters and B Gylling and R Myte and K Jirstrom and J Berntsson and X Xue and E Riboli and A J Cross and M J Gunter},

doi = {10.1016/j.cgh.2018.07.030},

issn = {1542-3565},

year  = {2019},

date = {2019-01-01},

journal = {Clin Gastroenterol Hepatol},

volume = {17},

number = {7},

pages = {1323-1331.e6},

abstract = {BACKGROUND \& AIMS: Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most studies have been of insufficient size to identify heterogeneous associations with precision. METHODS: In the European Prospective Investigation into Cancer and Nutrition study, we used multivariable joint Cox proportional hazards models, which accounted for tumors at different anatomical sites (proximal colon, distal colon, and rectum) as competing risks, to examine the relationships between 14 established/suspected lifestyle, anthropometric, and reproductive/menstrual risk factors with colorectal cancer risk. Heterogeneity across sites was tested using Wald tests. RESULTS: After a median of 14.9 years of follow-up of 521,330 men and women, 6291 colorectal cancer cases occurred. Physical activity was related inversely to proximal colon and distal colon cancer, but not to rectal cancer (P heterogeneity = .03). Height was associated positively with proximal and distal colon cancer only, but not rectal cancer (P heterogeneity = .0001). For men, but not women, heterogeneous relationships were observed for body mass index (P heterogeneity = .008) and waist circumference (P heterogeneity = .03), with weaker positive associations found for rectal cancer, compared with proximal and distal colon cancer. Current smoking was associated with a greater risk of rectal and proximal colon cancer, but not distal colon cancer (P heterogeneity = .05). No heterogeneity by anatomical site was found for alcohol consumption, diabetes, nonsteroidal anti-inflammatory drug use, and reproductive/menstrual factors. CONCLUSIONS: The relationships between physical activity, anthropometry, and smoking with colorectal cancer risk differed by subsite, supporting the hypothesis that tumors in different anatomical regions may have distinct etiologies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16780,

title = {Holistic recommendations for future outdoor thermal comfort assessment in tropical Southeast Asia: A critical appraisal},

author = {C S Fong and N Aghamohammadi and L Ramakreshnan and N M Sulaiman and P Mohammadi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060740295\&doi=10.1016%2fj.scs.2019.101428\&partnerID=40\&md5=6691c35896d33d5b034fa76d4fc57164},

doi = {10.1016/j.scs.2019.101428},

year  = {2019},

date = {2019-01-01},

journal = {Sustainable Cities and Society},

volume = {46},

abstract = {Global climate change, rapid urbanization and population explosion in major cities of Southeast Asia (SEA) are negatively impacting the well-being and liveability of the public in terms of deteriorating outdoor thermal comfort (OTC) levels. However, the available scholarly studies on OTC in the tropical region are insufficient. There is great potential for OTC studies to be used as indicators to measure the sustainable liveability of contemporary cities. As such, there is an immense need for more studies to be conducted in the tropical regions. However, the assessment approaches undertaken in the last decades clearly indicate that there is a need for improvisation. By considering this, this paper provides an overview of published studies that evaluated thermal comfort conditions in the outdoor setting in the tropical context of SEA. Methodological discrepancies and shortcomings are highlighted and discussed to propose a holistic approach for future OTC studies in SEA. The implementation of the proposed holistic approach in the upcoming studies will be beneficial for the improved reliability and integration of findings from studies conducted in various outdoor settings and localities within SEA. © 2019 Elsevier Ltd},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16641,

title = {In-depth examination of issues surrounding the reasons for child marriage in Kelantan, Malaysia: a qualitative study},

author = {A Kohno and M Dahlui and N D Nik Farid and S H Ali and T Nakayama},

doi = {10.1136/bmjopen-2018-027377},

issn = {2044-6055},

year  = {2019},

date = {2019-01-01},

journal = {BMJ Open},

volume = {9},

number = {9},

pages = {e027377},

abstract = {OBJECTIVE: To examine individual, familial, community and societal issues surrounding the reasons for child marriage in Kelantan, Malaysia. DESIGN: Qualitative study by means of semistructured interviews with women and key informants, using social-ecological model as a conceptual framework. SETTING: Interviews were conducted in Kota Bharu district, Kelantan, a northeast state in Peninsular Malaysia. PARTICIPANTS: Eighteen women of reproductive age (18 to 44 years old) that experienced their first marriage below the age of 18, as well as five key informants, consisting of a government officer, a community leader, an officer from religious department and two mothers. The women were recruited from a reproductive health clinic. The key informants who had specialised knowledge related to child marriage were selectively chosen. RESULTS: Three themes emerged that aligned with the social-ecological model: immaturity in decision-making, family poverty and religious and cultural norms. CONCLUSIONS: The findings imply that sex education and awareness-building activities regarding the consequences of child marriage must be implemented to eradicate child marriage in Malaysia. Such implementation must be coordinated as a team-based approach involving experts in such fields as law, religion, psychology, social-welfare and public health. In order to increase the awareness of child marriage consequences, the target for awareness must extend not only to the adolescent girls and their families, but also to the community and society at large by clearly communicating the negative consequences of and addressing the drivers for child marriage.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16746,

title = {In-vitro cytotoxicity of Trigona itama honey against human lung adenocarcinoma epithelial cell line (A549)},

author = {S N M Salim and L Ramakreshnan and C S Fong and R A Wahab and M S B A Rasad},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070295604\&doi=10.1016%2fj.eujim.2019.100955\&partnerID=40\&md5=db642e53b8863f7f00bcea608559d374},

doi = {10.1016/j.eujim.2019.100955},

year  = {2019},

date = {2019-01-01},

journal = {European Journal of Integrative Medicine},

volume = {30},

abstract = {Introduction: Many efforts have been made to identify natural alternatives to reduce the side effects of cytotoxic drugs in cancer treatment. With this in mind, the current study aimed to investigate the cytotoxicity effects of one of the multifloral Malaysian honey, Kelulut honey (Trigona itama), as a potential natural anticancer agent in stimulating apoptosis and cell cycle arrest to a human lung adenocarcinoma epithelial cell line (A549). Methods: The cells were treated with various concentrations of T. itama honey for 24, 48 and 72 h. The cytotoxicity and cell viability were determined using trypan blue exclusion assay (TBEA) and flow cytometric analysis. Results: The moisture content in the analysed honey was 14.3 ± 0.8%, which was within the accepted international standard. The pH, electrical conductivity and proline content were 3.17 ± 0.02, 0.47 mS/cm - 0.55 mS/cm and 19.1 mg/kg 20.2 mg/kg respectively. The findings demonstrated a significant dose and time-dependent inhibitory effect of T. itama honey with the maximum cytotoxic effects observed at 72 h with 20% concentration of T. itama honey, indicating 100% growth inhibition. Meanwhile, IC50 of T. itama honey treatment for A549 cells was determined as 0.62% v/v. Moreover, T. itama honey had a promising cytotoxic effect and proven capable of inducing cell cycle arrest at G2/M phase at 72 h of exposure with IC50 concentration. Conclusion: This study provided prefatory evidence on T. itama honey's significant anticancer activity against human lung cancer cell lines. © 2019 Elsevier GmbH},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16669,

title = {Job Stress and Nurses Well-Being: Prayer and Age as Moderators},

author = {M Achour and I Binti Abdul Ghani Azmi and M Bin Isahak and M R Mohd Nor and M Y Z Mohd Yusoff},

doi = {10.1007/s10597-019-00410-y},

issn = {0010-3853},

year  = {2019},

date = {2019-01-01},

journal = {Community Ment Health J},

volume = {55},

number = {7},

pages = {1226-1235},

abstract = {There is increasing popularity among researchers, scholars, and policymakers concerning the efficacy of prayer as a coping strategy for job stress. This study examines the moderating effects of prayer and age on the relationship between job stress and nurses' well-being in UMMC. Three hundred (300) Muslim nursing staff working at the University of Malaya Medical Centre were sampled. Data were collected via questionnaires. The findings of this study show that the effect of job stress on well-being is significant for nurses and that prayer of nurses contributed to alleviating job stress and enhancing well-being. This study is limited to nurses in one public hospital in a developing country. Thus, it would be more interesting if the study could be extended to other public and private institutions in a Muslim country, and a comparison could be done between other religions as well.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16614,

title = {Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures},

author = {S C Lee and M S Tang and A V Easton and J C Devlin and L L Chua and I Cho and F M Moy and T F Khang and Y A L Lim and P Loke},

doi = {10.1371/journal.ppat.1008066},

issn = {1553-7366},

year  = {2019},

date = {2019-01-01},

journal = {PLoS Pathog},

volume = {15},

number = {12},

pages = {e1008066},

abstract = {Helminth infection and dietary intake can affect the intestinal microbiota, as well as the immune system. Here we analyzed the relationship between fecal microbiota and blood profiles of indigenous Malaysians, referred to locally as Orang Asli, in comparison to urban participants from the capital city of Malaysia, Kuala Lumpur. We found that helminth infections had a larger effect on gut microbial composition than did dietary intake or blood profiles. Trichuris trichiura infection intensity also had the strongest association with blood transcriptional profiles. By characterizing paired longitudinal samples collected before and after deworming treatment, we determined that changes in serum zinc and iron levels among the Orang Asli were driven by changes in helminth infection status, independent of dietary metal intake. Serum zinc and iron levels were associated with changes in the abundance of several microbial taxa. Hence, there is considerable interplay between helminths, micronutrients and the microbiota on the regulation of immune responses in humans.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16811,

title = {Lipid Fraction Derived From MRI In- and Opposed-Phase Sequence as a Novel Biomarker for Predicting Survival Outcome of Glioma},

author = {P Seow and V Narayanan and R J Romelean and J H D Wong and M T Win and H Chandran and K Chinna and K Rahmat and N Ramli},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066234369\&doi=10.1016%2fj.acra.2019.04.015\&partnerID=40\&md5=7453265cc3e8cd636829dff2113740d1},

doi = {10.1016/j.acra.2019.04.015},

year  = {2019},

date = {2019-01-01},

journal = {Academic Radiology},

abstract = {Rationale and Purpose: Our study evaluated the capability of magnetic resonance imaging in- and opposed-phase (IOP)derived lipid fraction as a novel prognostic biomarker of survival outcome in glioma. Materials and Methods: We analyzed 46 histologically proven glioma (WHO grades II\textendashIV)patients using standard 3T magnetic resonance imaging brain tumor protocol and IOP sequence. Lipid fraction was derived from the IOP sequence signal-loss ratio. The lipid fraction of solid nonenhancing region of glioma was analyzed, using a three-group analysis approach based on volume under surface of receiver-operating characteristics to stratify the prognostic factors into three groups of low, medium, and high lipid fraction. The survival outcome was evaluated, using Kaplan-Meier survival analysis and Cox regression model. Results: Significant differences were seen between the three groups (low, medium, and high lipid fraction groups)stratified by the optimal cut-off point for overall survival (OS)(p ≤ 0.01)and time to progression (p ≤ 0.01)for solid nonenhancing region. The group with high lipid fraction had five times higher risk of poor survival and earlier time to progression compared to the low lipid fraction group. The OS plot stratified by lipid fraction also had a strong correlation with OS plot stratified by WHO grade (R = 0.61, p \< 0.01), implying association to underlying histopathological changes. Conclusion: The lipid fraction of solid nonenhancing region showed potential for prognostication of glioma. This method will be a useful adjunct in imaging protocol for treatment stratification and as a prognostic tool in glioma patients. © 2019 The Association of University Radiologists},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16782,

title = {Low fermentable oligosaccharides, disaccharides, monosaccharides, and polypols diet and irritable bowel syndrome in Asia},

author = {Y Zhang and Z F Ma and H Zhang and B Pan and Y Li and H A Majid and Y Y Lee},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071703460\&doi=10.1002%2fjgh3.12125\&partnerID=40\&md5=4fd09f17177afb306c2b52db3af63a1c},

doi = {10.1002/jgh3.12125},

year  = {2019},

date = {2019-01-01},

journal = {JGH Open},

volume = {3},

number = {2},

pages = {173-178},

abstract = {Functional bowel disorders, including irritable bowel syndrome (IBS), are a chronic condition that can significantly reduce patients’ quality of life. Therefore, this paper will review the roles of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polypols (FODMAP) diet in treating IBS, particularly in an Asian setting. About 20% of the general population is diagnosed with IBS. However, there are limited effective medical therapies available for treating IBS. Therefore, IBS presents a major challenge to the health-care providers. Recently, there is an increasing interest in the use of a diet low in FODMAP for the treatment of IBS. A low FODMAP diet can decrease the delivery of readily fermentable substrates to the small intestine and colon, thereby improving functional gastrointestinal symptoms. © 2018 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley \& Sons Australia, Ltd.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16633,

title = {Mapping 123 million neonatal, infant and child deaths between 2000 and 2017},

author = {R Burstein and N J Henry and M L Collison and L B Marczak and A Sligar and S Watson and N Marquez and M Abbasalizad-Farhangi and M Abbasi and F Abd-Allah and A Abdoli and M Abdollahi and I Abdollahpour and R S Abdulkader and M R M Abrigo and D Acharya and O M Adebayo and V Adekanmbi and D Adham and M Afshari and M Aghaali and K Ahmadi and M Ahmadi and E Ahmadpour and R Ahmed and C G Akal and J O Akinyemi and F Alahdab and N Alam and G M Alamene and K A Alene and M Alijanzadeh and C Alinia and V Alipour and S M Aljunid and M J Almalki and H M Al-Mekhlafi and K Altirkawi and N Alvis-Guzman and A K Amegah and S Amini and A M L Amit and Z Anbari and S Androudi and M Anjomshoa and F Ansari and C A T Antonio and J Arabloo and Z Arefi and O Aremu and B Armoon and A Arora and A Artaman and A Asadi and M Asadi-Aliabadi and A Ashraf-Ganjouei and R Assadi and B Ataeinia and S R Atre and B P A Quintanilla and M A Ayanore and S Azari and E Babaee and A Babazadeh and A Badawi and S Bagheri and M Bagherzadeh and N Baheiraei and A Balouchi and A Barac and Q Bassat and B T Baune and M Bayati and N Bedi and E Beghi and M Behzadifar and M Behzadifar and Y B Belay and B Bell and M L Bell and D A Berbada and R S Bernstein and N V Bhattacharjee and S Bhattarai and Z A Bhutta and A Bijani and S Bohlouli and N J K Breitborde and G Britton and A J Browne and S B Nagaraja and R Busse and Z A Butt and J Car and R Cardenas and C A Castaneda-Orjuela and E Cerin and W F Chanie and P Chatterjee and D T Chu and others},

doi = {10.1038/s41586-019-1545-0},

issn = {0028-0836},

year  = {2019},

date = {2019-01-01},

journal = {Nature},

volume = {574},

number = {7778},

pages = {353-358},

abstract = {Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2-to end preventable child deaths by 2030-we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000-2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16830,

title = {Mapping disparities in education across low- and middle-income countries},

author = {N Graetz and L Woyczynski and K F Wilson and J B Hall and K H Abate and F Abd-Allah and O M Adebayo and V Adekanmbi and M Afshari and O Ajumobi and T Akinyemiju and F Alahdab and Z Al-Aly and J E A Rabanal and M Alijanzadeh and V Alipour and K Altirkawi and M Amiresmaili and N H Anber and C L Andrei and M Anjomshoa and C A T Antonio and J Arabloo and O Aremu and K K Aryal and M Asadi-Aliabadi and S Atique and M Ausloos and A Awasthi and B P A Quintanilla and S Azari and A Badawi and J A M Banoub and S L Barker-Collo and A Barnett and N Bedi and D A Bennett and N V Bhattacharjee and K Bhattacharyya and S Bhattarai and Z A Bhutta and A Bijani and B Bikbov and G Britton and R Burstein and Z A Butt and R C\'{a}rdenas and F Carvalho and C A Casta\~{n}eda-Orjuela and F Castro and E Cerin and J C Chang and M L Collison and C Cooper and M A Cork and F Daoud and R Das Gupta and N D Weaver and J W De Neve and K Deribe and B B Desalegn and A Deshpande and M Desta and M Dhimal and D Diaz and M T Dinberu and S Djalalinia and M Dubey and E Dubljanin and A R Dur\~{a}es and L Dwyer-Lindgren and L Earl and M E Kalan and Z El-Khatib and B Eshrati and M Faramarzi and M Fareed and A Faro and S M Fereshtehnejad and E Fernandes and I Filip and F Fischer and T Fukumoto and J A Garc\'{i}a and P S Gill and T K Gill and P N Gona and S V Gopalani and A Grada and Y Guo and R Gupta and V Gupta and A Haj-Mirzaian and A Haj-Mirzaian and R R Hamadeh and S Hamidi and M Hasan and H Y Hassen and D Hendrie and A Henok and others},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077152844\&doi=10.1038%2fs41586-019-1872-1\&partnerID=40\&md5=2c5e0d446b8799d41620564ec4ee2a6d},

doi = {10.1038/s41586-019-1872-1},

year  = {2019},

date = {2019-01-01},

journal = {Nature},

abstract = {Educational attainment is an important social determinant of maternal, newborn, and child health1\textendash3. As a tool for promoting gender equity, it has gained increasing traction in popular media, international aid strategies, and global agenda-setting4\textendash6. The global health agenda is increasingly focused on evidence of precision public health, which illustrates the subnational distribution of disease and illness7,8; however, an agenda focused on future equity must integrate comparable evidence on the distribution of social determinants of health9\textendash11. Here we expand on the available precision SDG evidence by estimating the subnational distribution of educational attainment, including the proportions of individuals who have completed key levels of schooling, across all low- and middle-income countries from 2000 to 2017. Previous analyses have focused on geographical disparities in average attainment across Africa or for specific countries, but\textemdashto our knowledge\textemdashno analysis has examined the subnational proportions of individuals who completed specific levels of education across all low- and middle-income countries12\textendash14. By geolocating subnational data for more than 184 million person-years across 528 data sources, we precisely identify inequalities across geography as well as within populations. © 2019, The Author(s).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16720,

title = {Maternal, prenatal and traditional practice factors associated with perinatal mortality in Yemen},

author = {A H Al-Shahethi and R A Zaki and A W A Al-Serouri and A Bulgiba},

doi = {10.1016/j.wombi.2018.06.016},

issn = {1871-5192},

year  = {2019},

date = {2019-01-01},

journal = {Women Birth},

volume = {32},

number = {2},

pages = {e204-e215},

abstract = {BACKGROUND: Perinatal mortality remains a major international problem responsible for nearly six million stillbirths and neonatal deaths. OBJECTIVES: To estimate the perinatal mortality rate in Sana'a, Yemen and to identify risk factors for perinatal deaths. METHODS: A community-based prospective cohort study was carried out between 2015 and 2016. Nine-hundred and eighty pregnant women were identified and followed up to 7 days following birth. A multi-stage cluster sampling was used to select participants from community households', residing in the five districts of the Sana'a City, Yemen. RESULTS: Total of 952 pregnant women were tracked up to 7 days after giving birth. The perinatal mortality rate, the stillbirth rate and the early neonatal mortality rate, were 89.3 per 1000, 46.2 per 1000 and 45.2 per 1000, respectively. In multivariable analysis older age (35+ years) of mothers at birth (Relative Risk=2.83), teenage mothers' age at first pregnancy (\<18 years) (Relative Risk=1.57), primipara mothers (Relative Risk=1.90), multi-nuclear family (Relative Risk=1.74), mud house (Relative Risk=2.02), mothers who underwent female genital mutilation (Relative Risk=2.92) and mothers who chewed khat (Relative Risk=1.60) were factors associated with increased risk of perinatal death, whereas a positive mother's tetanus vaccination status (Relative Risk=0.49) were significant protective factors against perinatal deaths. CONCLUSION: Rates of perinatal mortality were higher in Sana'a City compared to perinatal mortality at the national level estimated by World Health Organization. It is imperative there be sustainable interventions in order to improve the country's maternal and newborn health.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16707,

title = {Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort},

author = {M Gasull and J Pumarega and H Kiviranta and P Rantakokko and O Raaschou-Nielsen and I A Bergdahl and T M Sandanger and F Goni and L Cirera and C Donat-Vargas and J Alguacil and M Iglesias and A Tjonneland and K Overvad and F R Mancini and M C Boutron-Ruault and G Severi and T Johnson and T Kuhn and A Trichopoulou and A Karakatsani and E Peppa and D Palli and V Pala and R Tumino and A Naccarati and S Panico and M Verschuren and R Vermeulen and C Rylander and T H Nost and M Rodriguez-Barranco and A Molinuevo and M D Chirlaque and E Ardanaz and M Sund and T Key and W Ye and M Jenab and D Michaud and G Matullo and F Canzian and R Kaaks and A Nieters and U Nothlings and S Jeurnink and V Chajes and M Matejcic and M Gunter and D Aune and E Riboli and A Agudo and C A Gonzalez and E Weiderpass and B Bueno-de-Mesquita and E J Duell and P Vineis and M Porta},

doi = {10.1016/j.envres.2018.11.027},

issn = {0013-9351},

year  = {2019},

date = {2019-01-01},

journal = {Environ Res},

volume = {169},

pages = {417-433},

abstract = {BACKGROUND: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. OBJECTIVES: First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles. METHODS: Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models. RESULTS: There were differences among countries in subjects' characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last follow-up, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, country, and smoking. We detected and quantified 16 of the 22 POPs in more than 90% of individuals. All 22 POPs were detected in some participants, and the smallest number of POPs detected in one person was 15 (median, 19) with few differences by country. The highest concentrations were found for p,p'-DDE, PCBs 153 and 180 (median concentration: 3371, 1023, and 810 pg/mL, respectively). We assessed the possible occurrence of disease progression bias (DPB) in eight situations defined by lipid and POP measurements, on one hand, and by four factors: interval from blood draw to index date, tumour subsite, tumour stage, and grade of differentiation, on the other. In seven of the eight situations results supported the absence of DPB. CONCLUSIONS: The coexistence of differences across study centres in some design features and participant characteristics is of relevance to other multicentre studies. Relationships among subjects' characteristics and among such characteristics and design features may play important roles in the forthcoming analyses on the association between plasma concentrations of POPs and pancreatic cancer risk.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16658,

title = {Mindfulness-based stress reduction for psychological distress among nurses: A systematic review},

author = {S F Ghawadra and K L Abdullah and W Y Choo and C K Phang},

doi = {10.1111/jocn.14987},

issn = {0962-1067},

year  = {2019},

date = {2019-01-01},

journal = {J Clin Nurs},

volume = {28},

number = {21-22},

pages = {3747-3758},

abstract = {AIMS AND OBJECTIVES: To explore the studies that used interventions based on the Mindfulness-Based Stress Reduction (MBSR) for decreasing psychological distress among nurses. BACKGROUND: Because of the demanding nature of their work, nurses often have significantly high levels of stress, anxiety and depression. MBSR has been reported to be an effective intervention to decrease psychological distress. DESIGN: Systematic review. METHODS: The databases included were Science Direct, PubMed, EBSCO host, Springer Link and Web of Science from 2002 to 2018. Interventional studies published in English that used MBSR among nurses to reduce their psychological distress were retrieved for review. The PRISMA guideline was used in this systematic review. The included studies were assessed for quality using "The Quality Assessment Tool For Quantitative Studies (QATFQS)." RESULTS: Nine studies were found to be eligible and included in this review. Many benefits, including reduced stress, anxiety, depression, burnout and better job satisfaction, were reported in these studies. CONCLUSION: The adapted/brief versions of MBSR seem promising for reducing psychological distress in nurses. Future research should include randomised controlled trials with a larger sample size and follow-up studies. There should also be a focus on creative and effective ways of delivering MBSR to nurses. RELEVANCE TO CLINICAL PRACTICE: The results of this review are substantial for supporting the use of MBSR for nurses' psychological well-being.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16803,

title = {Nutritional status of post-acute stroke patients during rehabilitation phase in hospital},

author = {C C Weun and N Hasnan and L A Latif and H A Majid},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062292968\&doi=10.17576%2fjsm-2019-4801-15\&partnerID=40\&md5=3c884ade54c5b6fd03d00bcd5eef19f5},

doi = {10.17576/jsm-2019-4801-15},

year  = {2019},

date = {2019-01-01},

journal = {Sains Malaysiana},

volume = {48},

number = {1},

pages = {129-135},

abstract = {Malnutrition is highly prevalent among stroke patients during post-acute rehabilitation phase and may give a negative effect on rehabilitation and impair recovery. However, to date, there is no reported study in Malaysia investigating the nutritional status of stroke patients during rehabilitation phase. Thus, this paper aims to report the preliminary results of nutritional assessment for a randomized controlled trial at baseline. All participating patients were assessed for anthropometric measurements, nutritional status using validated Mini Nutrition Assessment (MNA), 24 h diet recall, and handgrip strength. Demographic data, biochemical profiles and functional outcomes (Modified Barthel Index Score, Motor Assessment Scale) were obtained from patients’ medical record. From a total of 45 post-acute stroke patients at baseline, 24.4% of them were malnourished during admission to rehabilitation ward and 66.7% of the patients were at risk of malnutrition. Mean dietary intake and protein intake of the patients were 1489 ± 297 kcal/day and 66.1 ± 17.2 g/ day, respectively. Mean handgrip strength for the patients was 17.9 ± 8.1 kg. Weight, body mass index, serum albumin, handgrip strength, Modified Barthel Index and Motor Assessment Scale score were positively correlated with MNA score (p\<0.05), but no correlation was found for the dietary intake (r=0.163},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16698,

title = {One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition},

author = {A Vrieling and H B Bueno-De-Mesquita and M M Ros and E Kampman and K K Aben and F L Buchner and E H Jansen and N Roswall and A Tjonneland and M C Boutron-Ruault and C Cadeau and J Chang-Claude and R Kaaks and S Weikert and H Boeing and A Trichopoulou and P Lagiou and D Trichopoulos and S Sieri and D Palli and S Panico and P H Peeters and E Weiderpass and G Skeie and P Jakszyn and M D Chirlaque and E Ardanaz and M J Sanchez and R Ehrnstrom and J Malm and B Ljungberg and K T Khaw and N J Wareham and P Brennan and M Johansson and E Riboli and L A Kiemeney},

doi = {10.1002/ijc.32165},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

volume = {145},

number = {9},

pages = {2349-2359},

abstract = {Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16628,

title = {Online STI information seeking behaviour and condom use intentions among young Facebook users in Malaysia},

author = {S M Mohamad Shakir and L P Wong and K Lim Abdullah and P Adam},

doi = {10.1093/heapro/daz108},

issn = {0957-4824},

year  = {2019},

date = {2019-01-01},

journal = {Health Promot Int},

abstract = {The Internet has opened pathways for youth to find sexual health information which was not easily available to them in the past. Studies have shown that seeking sexual health information online may potentially influence an individuals' decision-making to change their sexual health behaviours. However, there is a gap in research on the associations of seeking online sexually transmitted infection (STI) information with STI prevention among young people, particularly in Malaysia. This study investigated the associations of seeking STI information online with the intentions of condom use among young adult online users in Malaysia. A cross-sectional online survey was conducted among Malaysian youth aged 18-25 years old who were recruited through Facebook. In total, 1530 respondents completed the survey, identifying 874 respondents who had sought STI information online. The majority of respondents had intentions to use condoms as protection against STI. Respondents who sought online STI information were significantly more likely to have the intention to use condoms compared to respondents who did not seek online STI information (OR = 1.33, 95% CI = 1.01-1.76},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16630,

title = {Organisational antecedents of workplace victimisation: The role of organisational climate, culture, leadership, support, and justice in predicting junior doctors' exposure to bullying at work},

author = {E Z Samsudin and M Isahak and S Rampal and I Rosnah and M I Zakaria},

doi = {10.1002/hpm.2926},

issn = {0749-6753},

year  = {2019},

date = {2019-01-01},

journal = {Int J Health Plann Manage},

abstract = {Workplace bullying is a pervasive phenomenon among junior doctors that may negatively impact their training and abilities to deliver quality healthcare, yet evidence on the factors of bullying among them remains lacking. This study examined the role of organisational climate, culture, leadership, support, and justice in junior doctors' exposure to workplace bullying on the basis of the work environment hypothesis, which suggests that workplace psychosocial factors are the main antecedents of bullying at work. Multilevel analysis of a universal sample (n = 1074) of junior doctors working in the central zone of Malaysia, using mixed effects logistic regression, was conducted. Analysis indicates that junior doctors working in departments with neutral and positive organisational climate, moderate and high degree of clan culture, moderate and high degree of adhocracy culture, moderate degree of hierarchy culture, moderate degree of production and achievement-oriented leadership style, moderate and high degree of organisational support, moderate degree of procedural justice, moderate and high degree of interactional justice, and high degree of distributive justice have lower odds of bullying compared with their counterparts. The results present evidence that all aspects of the organisation influence junior doctors' exposure to bullying and should be considered when developing antibullying initiatives targeted at them.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16651,

title = {Outcome and Presentation of Heart Failure in Breast Cancer Patients; Findings from a Swedish register-based study},

author = {E Hedayati and A Papakonstantinou and S A M Gernaat and R Altena and J S Brand and J Alfredsson and N Bhoo-Pathy and J Herrmann and C Linde and U Dahlstrom and J Bergh and L Hubbert},

doi = {10.1093/ehjqcco/qcz039},

issn = {2058-1742},

year  = {2019},

date = {2019-01-01},

journal = {Eur Heart J Qual Care Clin Outcomes},

abstract = {AIMS: Heart failure (HF) patients diagnosed with breast cancer (BC) may have a higher risk of death, and different HF presentation and treatment than patients without BC. METHODS AND RESULTS: 14998 women with incident HF (iHF) or prevalent HF (pHF) enrolled in the Swedish HF Registry within and after one month since HF diagnosis, respectively, between 2008-2013. Patients were linked with the National Patient-, Cancer-, and Cause-of-Death Registry. 294 iHF and 338 pHF patients with BC were age-matched to 1470 iHF and 1690 pHF patients without BC. Comorbidity and treatment characteristics were compared using chi-squared tests for categories. Cox proportional hazard models assessed the hazard ratio (HR) and 95% confidence intervals (95%CI) of all-cause and cardiovascular mortality among HF patients with and without BC. In the pHF group, BC patients had less often myocardial infarction (47.6% vs. 55.1%, P \< 0.01) and received less often aspirin (11.8% vs. 16.2%},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16759,

title = {Pedometer-determined physical activity among primary schoolchildren in Kuala Lumpur},

author = {B S Wee and A Bulgiba and A T Ruzita and M N Ismail and B K Poh},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070371762\&doi=10.1177%2f2010105818823784\&partnerID=40\&md5=60ee195ff02935227443a7ec6a50cfb1},

doi = {10.1177/2010105818823784},

year  = {2019},

date = {2019-01-01},

journal = {Proceedings of Singapore Healthcare},

volume = {28},

number = {2},

pages = {115-123},

abstract = {Objective: The aim of this study was to objectively measure physical activity and its association with sociodemographic factors among Malaysian primary school-age children. Methods: A total of 111 primary school children in Kuala Lumpur were selected through random sampling. Activity pattern was determined using pedometers and differences by sex, ethnicity and body mass index categories were analysed. The relationship between pedometer-determined physical activity and sociodemographic factors were also studied. Results: Overall, boys attained significantly higher daily step counts than girls (9573 ± 4145 vs 7313 ± 2697). Significant difference in daily step counts between boys and girls were observed during weekdays (p\<0.01), weekends (p\<0.05) and total mean step counts (p\<0.01). Malay ethnicity showed higher daily step counts during weekdays than weekends (p\<0.05). Compared with boys, girls had higher odds (OR=5.58; 95% CI 1.12, 27.77) of not meeting the recommended daily step counts. Those who had low physical activity levels had higher odds (OR=15.75; 95% CI 1.78, 139.33) of not meeting recommended daily step counts than children who had moderate physical activity level. Conclusion: Boys were significantly more active than girls and physical activity was greater during weekdays than on weekends. The primary schoolchildren in Kuala Lumpur were sedentary, with minimum physical activity being observed. Differences in sexes and physical activity levels influenced pedometer step counts in children. © The Author(s) 2019.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16625,

title = {Perceptions on radioprotective garment usage and underlying reasons for non-adherence among medical radiation workers from public hospitals in a middle-income Asian setting: A qualitative exploration},

author = {S F Mohd Ridzwan and N Bhoo-Pathy and M Isahak and L H Wee},

doi = {10.1016/j.heliyon.2019.e02478},

issn = {2405-8440 (Print) 

2405-8440},

year  = {2019},

date = {2019-01-01},

journal = {Heliyon},

volume = {5},

number = {9},

pages = {e02478},

abstract = {Background: Radioprotective garments protect medical radiation workers from exposure to radiation at workplace. However, previous studies have found poor adherence to the use of radioprotective garments. Objectives: We explored the perceptions and practices related to the use of radioprotective garments among medical radiation workers in public hospitals, and sought to understand the reasons for non-adherence. Design and setting: A qualitative approach was applied by conducting face-to-face in-depth interviews with 18 medical radiation workers from three university hospitals using a semi-structured interview guide. Results: Five themes emerged with respect to perceptions on the use of radioprotective garments: (i) the dilemmas in practising radiation protection, (ii) indication of workers' credibility, (iii) physical appearance of radioprotective garments, (iv) practicality of radioprotective garment use, and (v) impact on workflow. Actual lack of radioprotective garment use was attributed to inadequate number of thyroid shield and other garments, radioprotective garments' unsightly appearance including being dirty and defective, impracticality of using radioprotective garments for some nuclear medicine procedures, disruption of workflow because of workers' limited movements, attitudes of workers, and organisational influences. Conclusion: Medical radiation workers demonstrated a definitive practice of using radioprotective aprons, but often neglected to use thyroid shields and other garments. Availability and hygiene are reported as the core issues, while unclear guidelines on practical use of radioprotective garments appear to lead to confusion among medical radiation workers. To the best of our knowledge, this is the first qualitative study of its kind from a middle-income Asian setting.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16721,

title = {Physical Activity and Health-Related Quality of Life Among Low-Income Adults in Metropolitan Kuala Lumpur},

author = {T T Su and M Azzani and A P Adewale and N Thangiah and R Zainol and H Majid},

doi = {10.2188/jea.JE20170183},

issn = {0917-5040},

year  = {2019},

date = {2019-01-01},

journal = {J Epidemiol},

volume = {29},

number = {2},

pages = {43-49},

abstract = {BACKGROUND: The aim of this research is to assess the level of physical activity (PA) in relation to different socio-economic factors and to examine the effect of the recommended level of PA on the domains of quality of life (QoL) among residents of low-income housing in the metropolitan area of Kuala Lumpur, Malaysia. METHODS: This was a cross-sectional study that included 680 respondents from community housing projects. Reported PA was assessed using the Global Physical Activity Questionnaire (GPAQ) short form version 2. The SF-12v2 was administered to assess the health-related QoL (HRQoL) among the study population. Respondents were grouped into "active" and "insufficient" groups according to reported weekly PA level. One-way analysis of variance, analysis of co-variance, and multiple linear regression were used in the analysis. RESULTS: Overall, 17.6% (95% CI, 14.3-20.9) of the respondents did not achieve the recommended levels of PA (\>/=600 metabolic equivalent [MET]-minutes week(-1)). Level of achieving recommended PA was higher among younger participants, females, members belonging to nuclear families, and in self-employed participants. The group that fulfilled recommended PA levels (active) has higher levels of QoL in all domains except physical functioning. CONCLUSIONS: Almost one out of five low-income urban residents were physically inactive. In addition, individuals who attained recommended PA levels had better scores on some domains of HRQOL than those who did not. Our findings call for tailor-made public health interventions to improve PA levels among the general population and particularly for low-income residents.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16650,

title = {Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort},

author = {R Zamora-Ros and V Cayssials and S Franceschi and C Kyro and E Weiderpass and J Hennings and M Sandstrom and A Tjonneland and A Olsen and K Overvad and M C Boutron-Ruault and T Truong and F R Mancini and V Katzke and T Kuhn and H Boeing and A Trichopoulou and A Karakatsani and G Martimianaki and D Palli and V Krogh and S Panico and R Tumino and C Sacerdote and C Lasheras and M Rodriguez-Barranco and P Amiano and S M Colorado-Yohar and E Ardanaz and M Almquist and U Ericson and H B Bueno-de-Mesquita and R Vermeulen and J A Schmidt and G Byrnes and A Scalbert and A Agudo and S Rinaldi},

doi = {10.1002/ijc.32589},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

abstract = {Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77-1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80-1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55-2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI \>/= 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16646,

title = {Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study},

author = {T Kuhn and M Stepien and M Lopez-Nogueroles and A D Machado and D Sookthai and T Johnson and M Roca and A Husing and S G Maldonado and A J Cross and N Murphy and H Freisling and S Rinaldi and A Scalbert and V Fedirco and G Severi and M C Boutron-Ruault and F R Mancini and S A Sowah and H Boeing and P Jakszyn and M J Sanchez and S Merino and S Colorado-Yohar and A Barricarte and K T Khaw and J A Schmidt and A Perez-Cornago and A Trichopoulou and A Karakatsani and P Thriskos and D Palli and C Agnoli and R Tumino and C Sacerdote and S Panico and B Bueno-de-Mesquita and C H Gils and A Heath and M J Gunter and E Riboli and A Lahoz and M Jenab and R Kaaks},

doi = {10.1093/jnci/djz166},

issn = {0027-8874},

year  = {2019},

date = {2019-01-01},

journal = {J Natl Cancer Inst},

abstract = {BACKGROUND: Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. METHODS: Associations between pre-diagnostic plasma levels of 17 primary, secondary and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations. RESULTS: Positive associations were observed between colon cancer risk and plasma levels of 7 conjugated bile acid metabolites, i.e. primary bile acids glycocholic acid (ORQuartile 4 vs. Quartile 1=2.22,95 % confidence interval[CI]=1.52, 3.26), taurocholic acid (OR = 1.78, 95%CI=1.23, 2.58), glycochenodeoxycholic acid (OR = 1.68, 95%CI=1.13, 2.48), taurochenodeoxycholic acid (OR = 1.62, 95%CI=1.11-2.36), and glycohyocholic acid (OR = 1.65, 95%CI=1.13, 2.40) as well as the secondary bile acids glycodeoxycholic acid (OR = 1.68, 95%CI=1.12, 2.54) and taurodeoxycholic acid (OR = 1.54, 95%CI=1.02, 2.31). By contrast, unconjugated bile acids and tertiary bile acids were not associated with risk. CONCLUSIONS: This prospective study showed that pre-diagnostic levels of certain conjugated primary and secondary bile acids were positively associated with risk of colon cancer. Our findings support experimental data to suggest that a high bile acid load is colon cancer promotive.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16631,

title = {Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition},

author = {N Kliemann and N Murphy and V Viallon and H Freisling and K K Tsilidis and S Rinaldi and F R Mancini and G Fagherazzi and M C Boutron-Ruault and H Boeing and M B Schulze and G Masala and V Krogh and C Sacerdote and M S Magistris and B Bueno-de-Mesquita and E Weiderpass and T Kuhn and R Kaaks and P Jakszyn and D Redondo-Sanchez and P Amiano and M D Chirlaque and A B Gurrea and U Ericson and I Drake and T H Nost and D Aune and A M May and A Tjonneland and C C Dahm and K Overvad and R Tumino and J R Quiros and A Trichopoulou and A Karakatsani and C La Vecchia and L M Nilsson and E Riboli and I Huybrechts and M J Gunter},

doi = {10.1002/ijc.32753},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

abstract = {Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD ]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD : 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD : 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD : 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD : 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD : 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD : 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16627,

title = {Predictors of low back pain among secondary school teachers in Malaysia: a longitudinal study},

author = {E N Zamri and V C W Hoe and F M Moy},

doi = {10.2486/indhealth.2019-0106},

issn = {0019-8366},

year  = {2019},

date = {2019-01-01},

journal = {Ind Health},

abstract = {Low back pain (LBP) is prevalent among workers both in developed and developing countries. School teachers represent a high proportion of working population in Malaysia. However, there is a lack of longitudinal study on predictors and course of LBP among teachers. Therefore, this study aimed to determine the predictors and course of LBP among secondary school teachers. Longitudinal data of 701 teachers in Selangor, Malaysia were collected from May 2015 to October 2016. Associations between predictors and LBP were analysed using logistic regression and reported as odds ratio (OR) and 95% confidence interval (CI). At 12-month of follow-up, 44% (95%CI: 40.6%, 48.0%) of the participants reported to have LBP. In the regression model that included all risk factors, only LBP at baseline (OR 10.43, 95%CI: 6.19, 17.58) was associated with LBP at 12-month follow-up. When LBP at baseline was removed from the model, anxiety symptom (OR 2.51, 95%CI: 1.19, 5.30) and lifting heavy weights (OR 4.16, 95%CI: 1.40, 12.30) were found to be significantly associated with LBP at 12-month follow-up. In conclusion, issues on anxiety and lifting heavy weights should be addressed to reduce the occurrence of LBP despite the presence of health condition itself (LBP at baseline).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16708,

title = {Prevalence and correlates of physical inactivity among older adults in Malaysia: Findings from the National Health and Morbidity Survey (NHMS) 2015},

author = {Y Y Chan and R Sooryanarayana and N Mohamad Kasim and K K Lim and S M Cheong and C C Kee and K H Lim and M A Omar and N A Ahmad and N N Mohd Hairi},

doi = {10.1016/j.archger.2018.11.012},

issn = {0167-4943},

year  = {2019},

date = {2019-01-01},

journal = {Arch Gerontol Geriatr},

volume = {81},

pages = {74-83},

abstract = {Malaysia has an increasingly aging population. Despite the substantial benefits of physical activity for healthy aging, older adults are considered the most physically inactive segment of the Malaysian population. The purpose of this study was to determine the prevalence of physical inactivity among older adults in Malaysia and its correlates. We analysed data on adults aged \>/=60 years (n = 3790) from the National Health and Morbidity Survey (NHMS) 2015, a cross-sectional, nationwide population-based survey covering information on socio-demographic characteristics, physical activity and other lifestyle-related variables, health conditions, and functional limitations. Individuals included in this study were classified as physically active or physically inactive. Logistic regression was used to determine factors associated with physical inactivity. The overall prevalence of physical inactivity among older adults aged \>/=60 years old was 48.8%. Physical inactivity was significantly more prevalent among females, older age groups, Indians, those being single/widowed/divorced, those with no formal education, those who reported high sedentary time (\>/=7 h/day), those with diabetes, anaemia, and functional limitations (p \< 0.001). In fully adjusted analyses, females, older age, high household income (\>/=MYR4000), inadequate fruits and vegetables consumption (\<5 servings/day), high sedentary time, having diabetes, and having mobility impairment were all associated with physical inactivity. Approximately half of the Malaysian older population are physically inactive. Identifying the correlates of physical inactivity among Malaysian older adults will help to develop public health policies and interventions that encourage active living among older people and promote healthy aging in Malaysia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16804,

title = {Prevalence and determinants of pathological internet use among undergraduate students in a public university in Malaysia},

author = {W T Tong and M A Islam and W Y Low and W Y Choo and A Abdullah},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065082132\&partnerID=40\&md5=157fcd29d36b626dad33c409f12b6323},

year  = {2019},

date = {2019-01-01},

journal = {Journal of Behavioral Science},

volume = {14},

number = {1},

pages = {63-83},

abstract = {Pathological Internet Use (PIU) affects one's physical and mental health, and university students are at risk as they are more likely to develop PIU. This study determines the prevalence of PIU and its associated factors among students in a public university in Malaysia. This cross-sectional study was conducted among 1023 undergraduate students in 2015. The questionnaire comprised of items from the Young's Diagnostic Questionnaire to assess PIU and items related to socio-demography, psychosocial, lifestyle and co-morbidities. Anonymous paper-based data collection method was adopted. Mean age of the respondents was 20.73 ± 1.49 years old. The prevalence of pathological Internet user was 28.9% mostly Chinese (31%), 22 years old and above (31.0%), in Year 1 (31.5%), and those who perceived themselves to be from family from higher socio-economic status (32.5%). The factors found statistically significant (p \< 0.05) with PIU were Internet use for three or more hours for recreational purpose (OR: 3.89; 95% CI:1.33 - 11.36), past week of Internet use for pornography purpose (OR: 2.52; 95% CI:1.07 - 5.93), having gambling problem (OR: 3.65; 95% CI:1.64 - 8.12), involvement in drug use in the past 12 months (OR: 6.81; 95% CI:1.42 - 32.77) and having moderate/severe depression (OR: 4.32; 95% CI:1.83 - 10.22). University authorities need to be aware of the prevalence so that interventions can be developed to prevent adverse outcomes. Interventions should focus on screening students for PIU, creating awareness on the negative effects of PIU and promoting healthy and active lifestyle and restricting students' access to harmful websites. © Behavioral Science Research Institute.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16656,

title = {Profiling of morphine and codeine in urine after the ingestion of curry containing poppy seed as an evidence for opiates defence in Malaysia},

author = {C Y Gan and Z Zainuddin and H Muhamad Noh and R Rahmat and F Mohd Akir and N H Mahad and N F Mohd Fazil and R Nasir and M Isahak and H A Samad},

doi = {10.1016/j.forsciint.2019.06.023},

issn = {0379-0738},

year  = {2019},

date = {2019-01-01},

journal = {Forensic Sci Int},

volume = {302},

pages = {109865},

abstract = {Consumption of curry containing poppy seeds has raised an issue concerning the opiate content in the urine that might exceed the cut-off value (300ng/mL). The main objective of this study was to examine the morphine and codeine contents in the urine of the consumers after partaking poppy seed-enriched curry in. The volunteers were asked to partake: (a) a single meal and their urines were collected within 24h, or (b) Two meals a day for three consecutive days and their urines were collected within 72h. Two different dosages were also tested in this study: (a) low dosage: 1g/100ml curry (containing 138mug of morphine and 66mug of codeine) and (b) high dosage: 5g/100ml curry (containing 690mug of morphine and 330mug of codeine). The subjects were randomised into the groups using the method of stratified randomization with age and gender groups as covariates. A total of 6 subjects was allocated for each group and placebos were used as control. Results showed that all subjects who consumed low dosage of poppy seeds either in single meal or multiple meals experiment were found negative. However, 1 out of 6high dosage subjects was confirmed positive at a period of 3-6h after the consumption of curry in the single meal study. This outlier maybe due to the lack of water consumption after consuming the curry, thus the low volume of urine was collected and the opiate was concentrated in the urine. On the other hand, 5 out of 6high dosage subjects in the multiple meals experiment were found positive. Majority of these subjects were found positive on the second and third day of the experiment after the second curry meal was consumed. The outlier (negative) in this group might be due to the high consumption of water throughout the experiment and the subject's urine volumes and frequency of urine collection were much higher compared to other subjects. From the result of this study, it can be concluded that partaking high dosages of poppy seed in curry could give a positive response (\>300ng/ml+uncertainty of measurement) in the urine, and the water consumption after partaking curry has significant influence for the opiate contents in the urine.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16684,

title = {Provider Costs of Treating Colorectal Cancer in Government Hospital of Malaysia},

author = {M Azzani and M Dahlui and W Z W Ishak and A C Roslani and T T Su},

doi = {10.21315/mjms2019.26.1.7},

issn = {1394-195X (Print) 

1394-195x},

year  = {2019},

date = {2019-01-01},

journal = {Malays J Med Sci},

volume = {26},

number = {1},

pages = {73-86},

abstract = {Background: The incidence of colorectal cancer (CRC) is rapidly rising in several Asian countries, including Malaysia, but there is little data on health care provider costs in this region. The aim of this study was to estimate the cost of CRC management from the perspective of the health care provider, based on standard operating procedures. Methods: A combination of top-down approach and activity-based costing was applied. The standard operating procedure (SOP) for CRC was developed for each stage according to national data and guidelines at the University of Malaya Medical Centre (UMMC). The unit cost was calculated and incorporated into the treatment pathway in order to obtain the total cost of managing a single CRC patient according to the stage of illness. The cost data were represented by means and standard deviation and the results were demonstrated by tabulation. All cost data are presented in Malaysian Ringgit (RM). The cost difference between early stage (Stage I) and late stage (Stage II-IV) was analysed using independent t-test. Results: The cost per patient increased with stage of CRC, from RM13,672 (USD4,410.30) for stage I, to RM27,972 (USD9,023.20) for Stage IV. The early stage had statistically significant lower cost compared to late stage t(2) = -4.729},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16654,

title = {Psychological distress and its association with job satisfaction among nurses in a teaching hospital},

author = {S F Ghawadra and K L Abdullah and W Y Choo and C K Phang},

doi = {10.1111/jocn.14993},

issn = {0962-1067},

year  = {2019},

date = {2019-01-01},

journal = {J Clin Nurs},

volume = {28},

number = {21-22},

pages = {4087-4097},

abstract = {AIM AND OBJECTIVES: To determine the prevalence of psychological distress and its association with job satisfaction among nurses in a teaching hospital in Malaysia. BACKGROUND: Nurses constitute the majority of health care workers, and, compared with other professions, nursing profession is highly stressful and, hence, a cause of anxiety and depression. This may affect nurses' job satisfaction. METHOD: Using self-administered questionnaires, Depression Anxiety and Stress Scale (DASS-21) and Job Satisfaction Scale for Nurses (JSS), a cross-sectional study of 932 nurses from the inpatient departments of a teaching hospital was conducted in December 2017. Descriptive analyses and multiple logistic regressions were used for the analysis. The STROBE guideline was used in this study. RESULTS: The overall prevalence of psychological distress was 41%. The prevalence of stress, anxiety and depression were 14.4%, 39.3% and 18.8%, respectively. It was found that single and widowed nurses had a higher level of stress, anxiety and depression compared with married nurses. In addition, nurses in the age of 26-30 years had a higher level of depression than nurses in other age groups. Also, nurses who worked in the paediatric departments had a higher level of depression compared with nurses in other departments. The majority of the nurses were satisfied with their job at 92.0%. Those nurses who were not satisfied were found to be significantly associated with a high level of stress and depression. CONCLUSION: This study revealed that the level of stress, anxiety and depression is high. Stress and depression were found to be associated with nurses' low job satisfaction. RELEVANCE TO CLINICAL PRACTICE: Stress and depression can affect nurses' job satisfaction, it is important for nursing managers to institute strategies to address this issue.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16691,

title = {Public perception and attitude towards dengue prevention activity and response to dengue early warning in Malaysia},

author = {R Zaki and S N Roffeei and Y L Hii and A Yahya and M Appannan and M A Said and N C Wan and N Aghamohammadi and N N Hairi and A Bulgiba and M Quam and J Rocklov},

doi = {10.1371/journal.pone.0212497},

issn = {1932-6203},

year  = {2019},

date = {2019-01-01},

journal = {PLoS One},

volume = {14},

number = {2},

pages = {e0212497},

abstract = {An early warning system for dengue is meant to predict outbreaks and prevent dengue cases by aiding timely decision making and deployment of interventions. However, only a system which is accepted and utilised by the public would be sustainable in the long run. This study aimed to explore the perception and attitude of the Malaysian public towards a dengue early warning system. The sample consisted of 847 individuals who were 18 years and above and living/working in the Petaling District, an area adjacent to Kuala Lumpur, Malaysia. A questionnaire consisting of personal information and three sub-measures of; i) perception, ii) attitude towards dengue early warning and iii) response towards early warning; was distributed to participants. We found that most of the respondents know about dengue fever (97.1%) and its association with climate factors (90.6%). Most of them wanted to help reduce the number of dengue cases in their area (91.5%). A small percentage of the respondents admitted that they were not willing to be involved in public activities, and 64% of them admitted that they did not check dengue situations or hotspots around their area regularly. Despite the high awareness on the relationship between climate and dengue, about 45% of respondents do not know or are not sure how this can be used to predict dengue. Respondents would like to know more about how climate data can be used to predict a dengue outbreak (92.7%). Providing more information on how climate can influence dengue cases would increase public acceptability and improve response towards climate-based warning system. The most preferred way of communicating early warning was through the television (66.4%). This study shows that the public in Petaling District considers it necessary to have a dengue warning system to be necessary, but more education is required.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16638,

title = {Randomised controlled clinical trial of a structured cognitive rehabilitation in patients with attention deficit following mild traumatic brain injury: study protocol},

author = {N Hamzah and V Narayanan and N Ramli and N A Mustapha and N A Mohammad Tahir and L K Tan and M Danaee and N A Muhamad and A Drummond and R Nair and S Y Goh and M Mazlan},

doi = {10.1136/bmjopen-2018-028711},

issn = {2044-6055},

year  = {2019},

date = {2019-01-01},

journal = {BMJ Open},

volume = {9},

number = {9},

pages = {e028711},

abstract = {OBJECTIVES: To measure the clinical, structural and functional changes of an individualised structured cognitive rehabilitation in mild traumatic brain injury (mTBI) population. SETTING: A single centre study, Malaysia. PARTICIPANTS: Adults aged between 18 and 60 years with mTBI as a result of road traffic accident, with no previous history of head trauma, minimum of 9 years education and abnormal cognition at 3 months will be included. The exclusion criteria include pre-existing chronic illness or neurological/psychiatric condition, long-term medication that affects cognitive/psychological status, clinical evidence of substance intoxication at the time of injury and major polytrauma. Based on multiple estimated calculations, the minimum intended sample size is 50 participants (Cohen's d effect size=0.35; alpha level of 0.05; 85% power to detect statistical significance; 40% attrition rate). INTERVENTIONS: Intervention group will receive individualised structured cognitive rehabilitation. Control group will receive the best patient-centred care for attention disorders. Therapy frequency for both groups will be 1 hour per week for 12 weeks. OUTCOME MEASURES: Primary: Neuropsychological Assessment Battery-Screening Module (S-NAB) scores. Secondary: Diffusion Tensor Imaging (DTI) parameters and Goal Attainment Scaling score (GAS). RESULTS: Results will include descriptive statistics of population demographics, CogniPlus cognitive program and metacognitive strategies. The effect of intervention will be the effect size of S-NAB scores and mean GAS T scores. DTI parameters will be compared between groups via repeated measure analysis. Correlation analysis of outcome measures will be calculated using Pearson's correlation coefficient. CONCLUSION: This is a complex clinical intervention with multiple outcome measures to provide a comprehensive evidence-based treatment model. ETHICS AND DISSEMINATION: The study protocol was approved by the Medical Research Ethics Committee UMMC (MREC ID NO: 2016928-4293). The findings of the trial will be disseminated through peer-reviewed journals and scientific conferences. TRIAL REGISTRATION NUMBER: NCT03237676.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16702,

title = {Religious Coping, Religiosity, Depression and Anxiety among Medical Students in a Multi-Religious Setting},

author = {B Francis and J S Gill and N Yit Han and C F Petrus and F L Azhar and Z Ahmad Sabki and M A Said and K Ong Hui and N Chong Guan and A H Sulaiman},

doi = {10.3390/ijerph16020259},

issn = {1660-4601},

year  = {2019},

date = {2019-01-01},

journal = {Int J Environ Res Public Health},

volume = {16},

number = {2},

abstract = {Medical students are vulnerable to depression and anxiety due to the nature of their academic life. This study aimed to determine the prevalence of depressive and anxiety symptoms among medical students and the association between religious coping, religiosity and socio-demographic factors with anxiety and depressive symptoms. A cross sectional design was used for this study. Scales used were the Malay version of the Duke Religious Index (DUREL-M), the Malay version of the Brief Religious Coping Scale (Brief RCOPE) and the Malay version Hospital and Anxiety Depression Scale (HADS-M). 622 students participated in this study. They scored moderately on the organized (mean: 3.51) and non-organized religious (mean: 3.85) subscales of the DUREL, but had high intrinsic religiosity (mean: 12.18). The prevalence of anxiety and depressive symptoms were 4.7% and 17.4% respectively, which is lower than local as well as international data. Islam, negative religious coping and the presence of depressive symptoms were significantly associated with anxiety symptoms. Only the presence of anxiety symptoms was significantly associated with depressive symptoms. Negative religious coping, rather than positive religious coping, has significant association with depressive and anxiety symptoms. Redirecting focus towards negative religious coping is imperative to boost mental health outcomes among medical students.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16709,

title = {Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition},

author = {L Costas and L Lujan-Barroso and Y Benavente and N E Allen and P Amiano and E Ardanaz and C Besson and H Boeing and B Bueno-de-Mesquita and I Cervenka and R T Fortner and A Fournier and M Gunter and S Harlid and J M Huerta and M Jerkeman and K Jirstrom and R Kaaks and A Karakatsani and K T Khaw and A Kotanidou and E Lund and G Masala and A Mattiello and B Melin and V Menendez and N Murphy and A Nieters and K Overvad and E Riboli and C Sacerdote and M J Sanchez and J A Schmidt and S Sieri and A Tjonneland and A Trichopoulou and R Tumino and R Vermeulen and E Weiderpass and S Sanjose and A Agudo and D Casabonne},

doi = {10.1093/aje/kwy259},

issn = {0002-9262},

year  = {2019},

date = {2019-01-01},

journal = {Am J Epidemiol},

volume = {188},

number = {2},

pages = {274-281},

abstract = {The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16701,

title = {Risk of all-cause and CHD mortality in women versus men with type 2 diabetes: a systematic review and meta-analysis},

author = {G Xu and D You and L Wong and D Duan and F Kong and X Zhang and J Zhao and W Xing and L Han and L Li},

doi = {10.1530/eje-18-0792},

issn = {0804-4643},

year  = {2019},

date = {2019-01-01},

journal = {Eur J Endocrinol},

volume = {180},

number = {4},

pages = {243-255},

abstract = {Objective: Previous studies have shown sex-specific differences in all-cause and CHD mortality in type 2 diabetes. We performed a systematic review and meta-analysis to provide a global picture of the estimated influence of type 2 diabetes on the risk of all-cause and CHD mortality in women vs men. Methods: We systematically searched PubMed, EMBASE and Web of Science for studies published from their starting dates to Aug 7, 2018. The sex-specific hazard ratios (HRs) and their pooled ratio (women vs men) of all-cause and CHD mortality associated with type 2 diabetes were obtained through an inverse variance-weighted random-effects meta-analysis. Subgroup analyses were used to explore the potential sources of heterogeneity. Results: The 35 analyzed prospective cohort studies included 2 314 292 individuals, among whom 254 038 all-cause deaths occurred. The pooled women vs men ratio of the HRs for all-cause and CHD mortality were 1.17 (95% CI: 1.12-1.23},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16771,

title = {Seroprevalence of borrelia burgdorferi among the indigenous people (Orang asli) of peninsular malaysia},

author = {C S Khor and H Hassan and N F Mohd-Rahim and J R Chandren and N Siti-Sarah and J Johari and L Shih-Keng and J Abd-Jamil and J J Khoo and L Hai-Yen and B L Pike and W L Ping and Y Ai-Lian Lim and S Abubakar},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070460372\&doi=10.3855%2fjidc.11001\&partnerID=40\&md5=76d3b515238ac4864d47f95a2f303e88},

doi = {10.3855/jidc.11001},

year  = {2019},

date = {2019-01-01},

journal = {Journal of Infection in Developing Countries},

volume = {13},

number = {5},

pages = {449-454},

abstract = {Introduction: Lyme disease has been well-described in the North America and European countries. However, information is still very limited in the developing countries including Malaysia. The Orang Asli (OA), the indigenous people of Peninsular Malaysia reside mostly in the forest and forest fringe areas abundant with the vector for Lyme disease. Here, we described the seroprevalence of Borellia burgdorferi (B. burgdorferi) among the OA and demographic variables that could be associated with seroprevalence. Methodology: A total of 16 OA villages distributed across 8 states in Peninsular Malaysia participated in this study. Sera obtained from 904 OA volunteers were screened for anti-B. burgdorferi IgG antibodies. ELISA results obtained and demographic information collected were analysed to identify possible variables associated with seroprevalence. Results: A total of 73 (8.1%) OA tested positive for anti-B. burgdorferi IgG antibodies. Among all the variables examined, village of residence (p = 0.045) was the only significant predictor for seropositivity. High (\> 10.0%) prevalence was associated with three OA villages. Those living in one particular village were 1.65 times more likely to be seropositive as compared to other OA villages. Age, gender, marital status, household size, level of education, monthly household income and occupation were not significant predictors for seropositivity. Conclusion: Results of the present study support earlier findings that B. burgdorferi infection among Malaysians is currently under-recognized. Further studies will be needed at these locations to confirm the presence of Lyme disease among these populations. © 2019 Khor et al.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16683,

title = {Significant factors influencing inadvertent hypothermia in pediatric anesthesia},

author = {L L Lai and M H See and S Rampal and K S Ng and L Chan},

doi = {10.1007/s10877-019-00259-2},

issn = {1387-1307},

year  = {2019},

date = {2019-01-01},

journal = {J Clin Monit Comput},

volume = {33},

number = {6},

pages = {1105-1112},

abstract = {Thermal imbalances are very common during surgery. Hypothermia exposes the patient to post-operative shivering, cardiac dysfunction, coagulopathy, bleeding, wound infection, delayed anesthesia recovery, prolonged hospital stay and increased hospitalization cost. There are many factors contributing to intraoperative hypothermia. This is a prospective cohort study conducted through observation and measurement of pediatric surgical patients' temperature. Convenience sampling methods were used in this study. Initial skin temperature and core temperature at 10 min, 30 min,1 h, 2 h, 3 h, 4 h, 5 h, 6 h and at the end of surgery were recorded. Body temperature was monitored from time of transfer to the operating table until recovery and discharge to the respective pediatric ward. The overall incidence of intraoperative hypothermia was still very high at about 46.6% even though active and passive temperature management were carried out during surgery. Patient's age, body weight, duration of surgery, type of surgery, intraoperative blood loss, type of anesthesia and operating room temperature were factors that contributed to intraoperative hypothermia. Hypothermia is common in surgery, especially in major and long duration surgery. Intraoperative hypothermia can be life threatening if it is not handled carefully. Various methods are used before, during and after surgery to maintain a patient's body temperature within the normothermia range. The use of an active warming device like the Bair Hugger(R) air-forced warming system seems to be a good method for reducing the risk of intraoperative hypothermia and effectively maintaining body temperature for all major and minor surgeries.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16652,

title = {Social support and depression among community dwelling older adults in Asia: a systematic review},

author = {T A M Tengku Mohd and R M Yunus and F Hairi and N N Hairi and W Y Choo},

doi = {10.1136/bmjopen-2018-026667},

issn = {2044-6055},

year  = {2019},

date = {2019-01-01},

journal = {BMJ Open},

volume = {9},

number = {7},

pages = {e026667},

abstract = {OBJECTIVES: This review aims to: (1) explore the social support measures in studies examining the association between social support and depression among community-dwelling older adults in Asia and (2) the evidence of association. DESIGN: A systematic review was conducted using electronic databases of CINAHL, PubMed, PsychINFO, Psychology and Behavioural Sciences Collection, SocINDEX and Web of Science for articles published until the 11th of January 2018. ELIGIBILITY CRITERIA: All observational studies investigating the association between social support and depression among community-dwelling older adults in Asia were included. PARTICIPANTS: Older adults aged 60 years and more who are living in the community. EXPOSURE MEASURES: Social support. OUTCOME MEASURES: Depression. RESULTS: We retrieved16 356 records and screened 66 full-text articles. Twenty-four observational studies were included in the review. They consisted of five cohort studies and 19 cross-sectional studies. Social support was found to be measured by multiple components, most commonly through a combination of structural and functional constructs. Perceived social support is more commonly measured compared with received social support. Good overall social support, having a spouse or partner, living with family, having a large social network, having more contact with family and friends, having emotional and instrumental support, good support from family and satisfaction with social support are associated with less depressive symptoms among community-dwelling older adults in Asia. CONCLUSIONS: There were 20 different social support measures and we applied a framework to allow for better comparability. Our findings emphasised the association between good social support and decrease depression among older adults. Compared with western populations, family support has a greater influence on depression among community-dwelling older adults in Asia. This indicates that the family institution needs to be incorporated into designed programmes and interventions when addressing depression in the Asian context. TRIAL : registration number : CRD42017074897.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16716,

title = {Socioeconomic Differences in Smoking and Cessation Across a Period of Rapid Economic Growth in an Upper-Middle-Income Country},

author = {J Mariapun and N N Hairi and C W Ng},

doi = {10.1093/ntr/nty203},

issn = {1462-2203},

year  = {2019},

date = {2019-01-01},

journal = {Nicotine Tob Res},

volume = {21},

number = {11},

pages = {1539-1546},

abstract = {INTRODUCTION: Higher smoking rates and lower cessation rates among the poor compared to the rich are evident in high-income countries. In low and middle-income countries (LMICs), many of which are in the early stages of tackling the tobacco epidemic, more knowledge is required of the socioeconomic inequalities in smoking. This is especially the case for upper-middle-income countries, where smoking prevalence is highest. This study examines trends in the socioeconomic gradient in smoking and cessation among adults across a period of rapid economic development in Malaysia, an LMIC with an upper-middle-income economy. METHODS: The socioeconomic trends in smoking were analyzed using data from cross-sectional National Health and Morbidity Surveys for the years 1996, 2006, and 2011. Household per capita income was used as a measure of socioeconomic position. As a measure of inequality, the concentration index that quantified the degree of socioeconomic inequality in a health outcome was computed. Smoking was assessed in current and former smokers. The study population was examined by gender, region, and age group. RESULTS: This study found a trend of an increasingly higher smoking prevalence among the poor and higher cessation rates among the rich. With the exception of younger women in Peninsular Malaysia, the socioeconomic gradient in current smoking is concentrated among the poor. For former smokers, especially men, distributions across the years were mostly concentrated among the rich. CONCLUSION: It is important to ensure that health policies, programs, and interventions consider the potential impact of the socioeconomic patterning in smoking on equity in health. IMPLICATIONS: Findings on the socioeconomic gradient in smoking and cessation from Malaysia across a period of rapid economic development will contribute to addressing the paucity of knowledge on the socioeconomic gradient of smoking and cessation in other progressing LMICs. This study provides evidence from an upper-middle-income country, of an increasing trend of smoking among the poor and an increasing trend of cessation rates among the rich, particularly for men. We found opposing trends for younger adult women in the more developed, Peninsular Malaysia. More rich young women were found to have taken up smoking compared to socioeconomically less advantaged young women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16666,

title = {Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study},

author = {L Cirera and J M Huerta and M D Chirlaque and K Overvad and M Lindstrom and S Regner and A Tjonneland and M C Boutron-Ruault and V Rebours and G Fagherazzi and V A Katzke and H Boeing and E Peppa and A Trichopoulou and E Valanou and D Palli and S Grioni and S Panico and R Tumino and F Ricceri and C Gils and R C H Vermeulen and G Skeie and T Braaten and E Weiderpass and S Merino and M J Sanchez and N Larranaga and E Ardanaz and M Sund and K T Khaw and T J Key and M Jenab and S Naudin and N Murphy and D Aune and H Ward and E Riboli and B Bueno-de-Mesquita and C Navarro and E J Duell},

doi = {10.1158/1055-9965.Epi-18-1153},

issn = {1055-9965},

year  = {2019},

date = {2019-01-01},

journal = {Cancer Epidemiol Biomarkers Prev},

volume = {28},

number = {6},

pages = {1089-1092},

abstract = {BACKGROUND: To analyze the potential effect of social inequality on pancreatic cancer risk in Western Europe, by reassessing the association within the European Prospective Investigation into Cancer and Nutrition (EPIC) Study, including a larger number of cases and an extended follow-up. METHODS: Data on highest education attained were gathered for 459,170 participants (70% women) from 10 European countries. A relative index of inequality (RII) based on adult education was calculated for comparability across countries and generations. Cox regression models were applied to estimate relative inequality in pancreatic cancer risk, stratifying by age, gender, and center, and adjusting for known pancreatic cancer risk factors. RESULTS: A total of 1,223 incident pancreatic cancer cases were included after a mean follow-up of 13.9 (+/-4.0) years. An inverse social trend was found in models adjusted for age, sex, and center for both sexes [HR of RII, 1.27; 95% confidence interval (CI), 1.02-1.59], which was also significant among women (HR, 1.42; 95% CI, 1.05-1.92). Further adjusting by smoking intensity, alcohol consumption, body mass index, prevalent diabetes, and physical activity led to an attenuation of the RII risk and loss of statistical significance. CONCLUSIONS: The present reanalysis does not sustain the existence of an independent social inequality influence on pancreatic cancer risk in Western European women and men, using an index based on adult education, the most relevant social indicator linked to individual lifestyles, in a context of very low pancreatic cancer survival from (quasi) universal public health systems. IMPACT: The results do not support an association between education and risk of pancreatic cancer.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16769,

title = {Techniques of monitoring blood glucose during pregnancy for women with pre-existing diabetes},

author = {L V Jones and A Ray and F M Moy and B S Buckley},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066832714\&doi=10.1002%2f14651858.CD009613.pub4\&partnerID=40\&md5=700f93979245780cff0ae7b6c2271f95},

doi = {10.1002/14651858.CD009613.pub4},

year  = {2019},

date = {2019-01-01},

journal = {Cochrane Database of Systematic Reviews},

volume = {2019},

number = {5},

abstract = {Background There are a number of ways of monitoring blood glucose in women with diabetes during pregnancy, with self-monitoring of blood glucose (SMBG) recommended as a key component of the management plan. No existing systematic reviews consider the benefits/ effectiveness of different techniques of blood glucose monitoring on maternal and infant outcomes among pregnant women with pre-existing diabetes. The effectiveness of the various monitoring techniques is unclear. This review is an update of a review that was first published in 2014 and subsequently updated in 2017. Objectives To compare techniques of blood glucose monitoring and their impact on maternal and infant outcomes among pregnant women with pre-existing diabetes. Search methods For this update, we searched Cochrane Pregnancy and Childbirth’s Trials Register, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (1 November 2018), and reference lists of retrieved studies. Selection criteria Randomised controlled trials (RCTs) and quasi-RCTs comparing techniques of blood glucose monitoring including SMBG, continuous glucose monitoring (CGM), automated telemedicine monitoring or clinic monitoring among pregnant women with pre-existing diabetes mellitus (type 1 or type 2). Trials investigating timing and frequency of monitoring were also eligible for inclusion. RCTs using a cluster-randomised design were eligible for inclusion but none were identified. Data collection and analysis Two review authors independently assessed study eligibility, extracted data and assessed the risk of bias of included studies. Data were checked for accuracy. The quality of the evidence was assessed using the GRADE approach. Main results This review update includes a total of 12 trials (863) women (792 women with type 1 diabetes and 152 women with type 2 diabetes). The trials took place in Europe, the USA and Canada. Three of the 12 included studies are at low risk of bias, eight studies are at moderate risk of bias, and one study is at high risk of bias. Four trials reported that they were provided with the continuous glucose monitors free of charge or at a reduced cost by the manufacturer. Continuous glucose monitoring (CGM) versus intermittent glucose monitoring, (four studies, 609 women) CGM may reduce hypertensive disorders of pregnancy (pre-eclampsia and pregnancy-induced hypertension) (risk ratio (RR) 0.58, 95% confidence interval (CI) 0.39 to 0.85; 2 studies, 384 women; low-quality evidence), although it should be noted that only two of the four relevant studies reported data for this composite outcome. Conversely, this did not translate into a clear reduction for pre-eclampsia (RR 0.65, 95% CI 0.39 to 1.08; 4 studies, 609 women, moderate-quality evidence). There was also no clear reduction in caesarean section (average RR 0.94, 95% CI 0.75 to 1.18; 3 studies, 427 women; I2 = 41%; moderate-quality evidence) or large-for-gestational age (average RR 0.84, 95% CI 0.57 to 1.26; 3 studies, 421 women; I2 = 70%; low-quality evidence) with CGM. There was not enough evidence to assess perinatal mortality (RR 0.82, 95% CI 0.05 to 12.61, 71 infants, 1 study; low-quality evidence), or mortality or morbidity composite (RR 0.80, 95% CI 0.61 to 1.06; 1 study, 200 women) as the evidence was based on single studies of low quality. CGM appears to reduce neonatal hypoglycaemia (RR 0.66, 95% CI 0.48 to 0.93; 3 studies, 428 infants). Neurosensory disability was not reported. Other methods of glucose monitoring For the following five comparisons, self-monitoring versus a different type of self-monitoring (two studies, 43 women); self-monitoring at home versus hospitalisation (one study, 100 women), pre-prandial versus post-prandial glucose monitoring (one study, 61 women), automated telemedicine monitoring versus conventional system (three studies, 84 women), and constant CGM versus intermittent CGM (one study, 25 women), it is uncertain whether any of the interventions has any impact on any of our GRADE outcomes (hypertensive disorders of pregnancy, caesarea section, large-for-gestational age) because the quality of the evidence was found to be very low. This was due to evidence largely being derived from single trials, with design limitations and limitations with imprecision (wide CIs, small sample sizes, and few events). There was not enough evidence to assess perinatal mortality and neonatal mortality and morbidity composite. Other important outcomes, such as neurosensory disability, were not reported in any of these comparisons. Authors’ conclusions Two new studies (406 women) have been incorporated to one of the comparisons for this update. Although the evidence suggests that CGM in comparison to intermittent glucose monitoring may reduce hypertensive disorders of pregnancy, this did not translate into a clear reduction for pre-eclampsia, and so this result should be viewed with caution. No differences were observed for other primary outcomes for this comparison. The evidence base for the effectiveness of other monitoring techniques analysed in the other five comparisons is weak and based on mainly single studies with very low-quality evidence. Additional evidence from large well-designed randomised trials is required to inform choices of other glucose monitoring techniques and to confirm the effectiveness of CGM. © 2019 The Cochrane Collaboration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16612,

title = {TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance},

author = {A K Nur Zati Iwani and M Y Jalaludin and R M Wan Mohd Zin and M Z Fuziah and J Y H Hong and Y Abqariyah and A H Mokhtar and W N Wan Mohamud},

doi = {10.1155/2019/8586167},

issn = {1687-8337 (Print) 

1687-8337},

year  = {2019},

date = {2019-01-01},

journal = {Int J Endocrinol},

volume = {2019},

pages = {8586167},

abstract = {Metabolic syndrome (MetS) is an important predictor of cardiovascular diseases in adulthood. This study aims to examine the clinical utility of triglyceride to high-density lipoprotein ratio (TG : HDL-C) in identifying cardiometabolic risk and insulin resistance (IR) among children with obesity, in comparison with MetS as defined by the International Diabetes Federation (IDF). Data of 232 children with obesity aged 10-16 years were obtained from our study, MyBFF@school study, conducted between January and December 2014. Children were divided into tertiles of TG : HDL-C ratio. The minimum value of the highest tertile was 1.11. Thus, elevated TG : HDL-C ratio was defined as TG : HDL-C \>/=1.11. Children with MetS were categorized based on the definition established by the IDF. Out of 232 children, 23 (9.9%) had MetS, out of which 5.6% were boys. Almost twofold of boys and girls had elevated TG : HDL-C ratio compared to MetS: 13.8% vs. 5.6% and 13.8% vs. 4.3%, respectively. Children with elevated TG : HDL-C ratio had lower fasting glucose compared to children with MetS (boys = 5.15 +/- 0.4 vs. 6.34 +/- 2.85 mmol/l},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16675,

title = {The Association of Breakfast Frequency and Cardiovascular Disease (CVD) Risk Factors among Adolescents in Malaysia},

author = {N Mustafa and H Abd Majid and Z Toumpakari and H A Carroll and M Yazid Jalaludin and N Al Sadat and L Johnson},

doi = {10.3390/nu11050973},

issn = {2072-6643},

year  = {2019},

date = {2019-01-01},

journal = {Nutrients},

volume = {11},

number = {5},

abstract = {Breakfast frequency is associated with cardiovascular disease (CVD) risk in Western populations, possibly via the types of food eaten or the timing of food consumption, but associations in Malaysian adolescents are unknown. While the timing of breakfast is similar, the type of food consumed at breakfast in Malaysia differs from Western diets, which allows novel insight into the mechanisms underlying breakfast-CVD risk associations. We investigated foods eaten for breakfast and associations between breakfast frequency and CVD risk factors in the Malaysian Health and Adolescents Longitudinal Research Team study (MyHeARTs). Breakfast (frequency of any food/drink reported as breakfast in 7-day diet history interviews) and CVD risk factors (body mass index (BMI), waist circumference, fasting blood glucose, triacylglycerol, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and systolic and diastolic blood pressure) were cross-sectionally associated using linear regression adjusting for potential confounders (n = 795, age 13 years). Twelve percent of adolescents never ate breakfast and 50% ate breakfast daily, containing mean (SD) 400 (+/-127) kilocalories. Commonly consumed breakfast foods were cereal-based dishes (primarily rice), confectionery (primarily sugar), hot/powdered drinks (primarily Milo), and high-fat milk (primarily sweetened condensed milk). After adjustment, each extra day of breakfast consumption per week was associated with a lower BMI (-0.34 kg/m(2), 95% confidence interval (CI) -0.02, -0.66), and serum total (-0.07 mmol/L 95% CI -0.02, -0.13) and LDL (-0.07 mmol/L 95% CI -0.02, -0.12) cholesterol concentrations. Eating daily breakfast in Malaysia was associated with slightly lower BMI and total and LDL cholesterol concentrations among adolescents. Longitudinal studies and randomized trials could further establish causality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16688,

title = {The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies},

author = {E L Watts and A Perez-Cornago and P N Appleby and D Albanes and E Ardanaz and A Black and H B Bueno-de-Mesquita and J M Chan and C Chen and S A P Chubb and M B Cook and M Deschasaux and J L Donovan and D R English and L Flicker and N D Freedman and P Galan and G G Giles and E L Giovannucci and M J Gunter and L A Habel and C Haggstrom and C Haiman and F C Hamdy and S Hercberg and J M Holly and J Huang and W Y Huang and M Johansson and R Kaaks and T Kubo and J A Lane and T M Layne and L Le Marchand and R M Martin and E J Metter and K Mikami and R L Milne and H A Morris and L A Mucci and D E Neal and M L Neuhouser and S E Oliver and K Overvad and K Ozasa and V Pala and C H Pernar and M Pollak and M A Rowlands and C A Schaefer and J M Schenk and P Stattin and A Tamakoshi and E Thysell and M Touvier and A Trichopoulou and K K Tsilidis and S K Van Den Eeden and S J Weinstein and L Wilkens and B B Yeap and T J Key and N E Allen and R C Travis},

doi = {10.1002/ijc.32276},

issn = {0020-7136},

year  = {2019},

date = {2019-01-01},

journal = {Int J Cancer},

volume = {145},

number = {12},

pages = {3244-3256},

abstract = {Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16700,

title = {The Effectiveness of a Voice Care Program Among Primary School Teachers in Northeastern Malaysia},

author = {E R Sundram and B Norsa'adah and H Mohamad and F M Moy and N R N Husain and M N Shafei},

doi = {10.5001/omj.2019.08},

issn = {1999-768X (Print) 

1999-768x},

year  = {2019},

date = {2019-01-01},

journal = {Oman Med J},

volume = {34},

number = {1},

pages = {49-55},

abstract = {Objectives: We sought to determine the effectiveness of a voice care program among primary school teachers in a northeastern district in Malaysia. Methods: We conducted a randomized community trial in eight primary schools in a northeastern district in Malaysia. The self-administered and validated Malay-Voice Handicap Index-10 (M-VHI-10) questionnaire was used to assess overall voice handicap scores pre-intervention and eight weeks post-intervention. Teachers with a score of five or more (n = 86) were randomized into intervention (n = 41) and control groups (n = 45). The intervention group received portable voice amplifiers and vocal hygiene instruction, which was delivered by lectures and a booklet. The control group was not prescribed any intervention. Results: The sociodemographic, lifestyle, and occupational characteristics of the teachers (except maximum number of students per class) were similar between both groups. The baseline M-VHI-10 scores between both groups were also comparable. After the intervention phase, there was a significant effect observed in the total M-VHI-10 scores (p = 0.021, F-stat (df): 5.33 (1,79)) between both groups after controlling for the maximum number of students per class. Conclusions: Our results support the use of voice amplification in adjunct with vocal hygiene instruction as a prevention and treatment modality to reduce voice handicap among teachers. Our study demonstrated encouraging evidence on the low-cost voice care program as well as the success of group and workplace-based approaches in the school setting.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16616,

title = {The Effectiveness of Educational Intervention in Improving Primary Health-Care Service Providers' Knowledge, Identification, and Management of Elder Abuse and Neglect: A Systematic Review},

author = {F H Mohd Mydin and C W Yuen and S Othman},

doi = {10.1177/1524838019889359},

issn = {1524-8380},

year  = {2019},

date = {2019-01-01},

journal = {Trauma Violence Abuse},

pages = {1524838019889359},

abstract = {Elder abuse and neglect (EAN) occurrence is expected to increase in many countries due to rapidly aging populations, yet it is still unrecognized and underreported. Gaps were identified in the knowledge and skills to intervene EAN among health-care service providers. It is still unclear whether educating health-care service providers on EAN improve the identification and management of EAN cases. A systematic review was conducted on the effectiveness of educational intervention designed to improve primary health-care service providers' (PHSPs) knowledge, attitude, and practice in managing EAN cases. We performed a comprehensive and systematic search for original studies in the following major electronic databases (ScienceDirect, PubMed, EMBASE, and CINAHL) and specialist registers (Cochrane Central Controlled Trials Register) with a set of search terms. Studies included were randomized controlled trials (RCTs) and observational studies on EAN education intervention that aimed to improve knowledge, attitude, and management skills of the PHSPs. There were no publication period restrictions until June 2018 and written in English. Overall, three RCTs and 10 observational studies were selected. These studies were grouped based on the type of the study, methodological quality (six moderate risk of bias and seven serious risk of bias), and the type of educational intervention (seven face-to-face educational intervention, two educational videos, two simulation-based training, and two online educational training). The education programs in the selected studies range from brief didactic to experiential learning. EAN educational intervention among primary care service providers potentially result in increasing awareness and knowledge on EAN. However, there is a lack of evidence on the changes of attitude and practice.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16801,

title = {The Incidence of Agenesis of Palmaris Longus Muscle Among Multiracial Medical Students of University Malaya, Malaysia},

author = {N M Kassim and I S Zulkafli and R M Zamin and M A Salim and M Danaee and S R M Zin},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075362630\&doi=10.1007%2fs12262-019-02026-8\&partnerID=40\&md5=114b24ae64f2d8e94c71dc3ac19a80de},

doi = {10.1007/s12262-019-02026-8},

year  = {2019},

date = {2019-01-01},

journal = {Indian Journal of Surgery},

abstract = {Palmaris longus (PL) is the most superficial flexor muscle of the wrist. Agenesis of this muscle does not result in disability but its presence plays a significant role in reconstructive plastic surgery as a donor tendon for grafting. The awareness of the incidence of PL occurrence in a population is therefore desirable. In the present study, 457 multiracial medical students (220 Malays, 198 Chinese and 39 Indians) of University of Malaya, Malaysia, ages between 18 to 22 years, were examined for the presence or absence of the PL tendon using Schaeffer’s test. This study demonstrated the overall difference in occurrence rate of PL among the multiracial students which indirectly represent its overall pattern in Malaysian population, as the students originate from various states of this country. The data collected were then analyzed using non-parametric test to determine pattern of occurrence and incidence of agenesis of this muscle with regard to ethnicity, laterality, and gender. The highest incidence of unilateral and bilateral PL agenesis was observed in Indian students despite being the smallest race among the three groups studied. This study contradicts with previous findings that concluded Malays to be the group with the highest incidence of unilateral PL agenesis. This contradiction therefore justifies the need to construct a larger cohort study, which covers more diverse ethnic groups in Malaysia including the indigenous groups in Sabah and Sarawak to obtain the true incidence rate of PL agenesis in Malaysia. © 2019, Association of Surgeons of India.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16689,

title = {The Maastricht FFQ: Development and validation of a comprehensive food frequency questionnaire for the Maastricht study},

author = {M C Dongen and N E G Wijckmans-Duysens and L J Biggelaar and M C Ocke and S Meijboom and H A Brants and J H Vries and E J Feskens and H B Bueno-de-Mesquita and A Geelen and C D Stehouwer and P C Dagnelie and S J Eussen},

doi = {10.1016/j.nut.2018.10.015},

issn = {0899-9007},

year  = {2019},

date = {2019-01-01},

journal = {Nutrition},

volume = {62},

pages = {39-46},

abstract = {OBJECTIVE: The aim of this study was to develop and validate a comprehensive food frequency questionnaire (FFQ) for The Maastricht Study, a population-based prospective cohort study in Maastricht, The Netherlands. METHODS: Item selection for the FFQ was based on explained variation and contribution to intake of energy and 24 nutrients. For validation, the FFQ was completed by 135 participants (25-70 y of age) of the Nutrition Questionnaires plus study. Per person, on average 2.8 (range 1-5) telephone-based 24-h dietary recalls (24HRs), two 24-h urinary samples, and one blood sample were available. Validity of 54 nutrients and 22 food groups was assessed by ranking agreement, correlation coefficients, attenuation factors, and ultimately deattenuated correlation coefficients (validity coefficients). RESULTS: Median correlation coefficients for energy and macronutrients, micronutrients, and food groups were 0.45, 0.36, and 0.38, respectively. Median deattenuated correlation coefficients were 0.53 for energy and macronutrients, 0.45 for micronutrients, and 0.64 for food groups, being \>0.50 for 18 of 22 macronutrients, 16 of 30 micronutrients and \>0.50 for 17 of 22 food groups. The FFQ underestimated protein and potassium intake compared with 24-h urinary nitrogen and potassium excretion by -18% and -2%, respectively. Correlation coefficients ranged from 0.50 and 0.55 for (fatty) fish intake and plasma eicosapentaenoic acid and docosahexaenoic acid, and from 0.26 to 0.42 between fruit and vegetable intake and plasma carotenoids. CONCLUSION: Overall, the validity of the 253-item Maastricht FFQ was satisfactory. The comprehensiveness of this FFQ make it well suited for use in The Maastricht Study and similar populations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16635,

title = {The mobile-phone-based iCO(TM) Smokerlyzer((R)): Comparison with the piCO(+) Smokerlyzer((R)) among smokers undergoing methadone-maintained therapy},

author = {H Y Wong and M Subramaniyan and C Bullen and A N Amer Siddiq and M Danaee and A Yee},

doi = {10.18332/tid/111355},

issn = {1617-9625},

year  = {2019},

date = {2019-01-01},

journal = {Tob Induc Dis},

volume = {17},

pages = {65},

abstract = {INTRODUCTION: The mobile-phone-based Bedfont iCO(TM) Smokerlyzer((R)) is of unknown validity and reproducibility compared to the widely-used piCO(+) Smokerlyzer((R)). We aimed to compare the validity and reproducibility of the iCO(TM) Smokerlyzer((R)) with the piCO(+) Smokerlyzer((R)) among patients reducing or quitting tobacco smoking. METHODS: Methadone-maintained therapy (MMT) users from three centers in Malaysia had their exhaled carbon monoxide (eCO) levels recorded via the piCO(+) and iCO(TM) Smokerlyzers((R)), their nicotine dependence assessed with the Malay version of the Fagerstrom Test for Nicotine Dependence (FTND-M), and daily tobacco intake measured via the Opiate Treatment Index (OTI) Tobacco Q-score. Pearson partial correlations were used to compare the eCO results of both devices, as well as the corresponding FTND-M scores. RESULTS: Among the 146 participants (mean age 47.9 years, 92.5% male, and 73.3% Malay ethnic group) most (55.5%) were moderate smokers (6-19 cigarettes/day). Mean eCO categories were significantly correlated between both devices (r=0.861, p\<0.001), and the first and second readings were significantly correlated for each device (r=0.94 for the piCO(+) Smokerlyzer((R)), p\<0.001; r=0.91 for the iCO(TM) Smokerlyzer((R)), p\<0.001). Exhaled CO correlated positively with FTND-M scores for both devices. The post hoc analysis revealed a significantly lower iCO(TM) Smokerlyzer((R)) reading of 0.82 (95% CI: 0.69-0.94, p\<0.001) compared to that of the piCO(+) Smokerlyzer((R)), and a significant intercept of -0.34 (95% CI: -0.61 - -0.07},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16806,

title = {The mobile-phone-based iCOTM Smokerlyzer®: Comparison with the piCO+ Smokerlyzer® among smokers undergoing methadone-maintained therapy},

author = {H Y Wong and M Subramaniyan and C Bullen and A N Amer Siddiq and M Danaee and A Yee},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076393878\&doi=10.18332%2ftid%2f111355\&partnerID=40\&md5=cf82b2b4c334c755a6f16c530711b2da},

doi = {10.18332/tid/111355},

year  = {2019},

date = {2019-01-01},

journal = {Tobacco Induced Diseases},

volume = {17},

number = {September},

abstract = {INTRODUCTION The mobile-phone-based Bedfont iCOTM Smokerlyzer® is of unknown validity and reproducibility compared to the widely-used piCO+ Smokerlyzer®. We aimed to compare the validity and reproducibility of the iCOTM Smokerlyzer® with the piCO+ Smokerlyzer® among patients reducing or quitting tobacco smoking. METHODS Methadone-maintained therapy (MMT) users from three centers in Malaysia had their exhaled carbon monoxide (eCO) levels recorded via the piCO+ and iCOTM Smokerlyzers®, their nicotine dependence assessed with the Malay version of the Fagerstr\"{o}m Test for Nicotine Dependence (FTND-M), and daily tobacco intake measured via the Opiate Treatment Index (OTI) Tobacco Q-score. Pearson partial correlations were used to compare the eCO results of both devices, as well as the corresponding FTND-M scores. RESULTS Among the 146 participants (mean age 47.9 years, 92.5% male, and 73.3% Malay ethnic group) most (55.5%) were moderate smokers (6-19 cigarettes/day). Mean eCO categories were significantly correlated between both devices (r=0.861, p\<0.001), and the first and second readings were significantly correlated for each device (r=0.94 for the piCO+ Smokerlyzer®, p\<0.001; r=0.91 for the iCOTM Smokerlyzer®, p\<0.001). Exhaled CO correlated positively with FTND-M scores for both devices. The post hoc analysis revealed a significantly lower iCOTM Smokerlyzer® reading of 0.82 (95% CI: 0.69-0.94, p\<0.001) compared to that of the piCO+ Smokerlyzer®, and a significant intercept of -0.34 (95% CI: -0.61 - -0.07},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16727,

title = {The Prevalence and Associated Factors of Depression, Anxiety and Stress of First Year Undergraduate Students in a Public Higher Learning Institution in Malaysia},

author = {N S Amir Hamzah and N D Nik Farid and A Yahya and C Chin and T T Su and S R L Rampal and M Dahlui},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073992634\&doi=10.1007%2fs10826-019-01537-y\&partnerID=40\&md5=0849c3fb627ef2e4807a7da1b35556fb},

doi = {10.1007/s10826-019-01537-y},

year  = {2019},

date = {2019-01-01},

journal = {Journal of Child and Family Studies},

volume = {28},

number = {12},

pages = {3545-3557},

abstract = {Objectives: While university life is characterized by the pursuit of greater educational opportunities and employment prospects, it can also be a trigger of mental health problems. This study aims to: (a) measure the prevalence of depression, anxiety, and stress among first-year undergraduate students in the University of Malaya, and; (b) determine the associated factors of depression, anxiety, and stress. Methods: This cross-sectional study consisted of two phases: survey administration and physical assessment. In the first phase, data were collected electronically using a mobile application during the orientation week. The Depression, Anxiety and Stress Scale-21 (DASS-21) questionnaire was employed to assess respondents’ mental health status. In the second phase, anthropometric measurements which included height, weight, waist circumference, and blood pressure were taken. Results: Of 1602 students, the prevalence of moderate to extremely severe depression was 21% (n = 341), anxiety 50% (n = 793), and stress 12% (n = 197). Findings showed that students who lived with non-family members were more likely to develop depression (OR: 1.846, 95% CI: 1.266\textendash2.693), anxiety (OR: 1.529, 95% CI: 1.024\textendash2.284), and stress (OR: 1.655, 95% CI: 1.110\textendash2.468). Those with previous medical history were more likely to have anxiety (OR: 1.697, 95% CI: 1.097\textendash2.626). Interestingly, students from the Southern region (OR: 0.667, 95% CI: 0.468\textendash0.950) and from Sabah and Sarawak (OR: 0.503, 95% CI: 0.281\textendash0.900) were less likely to report depression. Conclusions: Future intervention programs should follow the socio-ecological model while addressing university students’ mental health needs. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16670,

title = {The Prevalence of Smoking, Determinants and Chance of Psychological Problems among Smokers in an Urban Community Housing Project in Malaysia},

author = {R Abd Rashid and S Kanagasundram and M Danaee and H Abdul Majid and A H Sulaiman and M M Ahmad Zahari and C G Ng and B Francis and W A I Wan Husin and T T Su},

doi = {10.3390/ijerph16101762},

issn = {1660-4601},

year  = {2019},

date = {2019-01-01},

journal = {Int J Environ Res Public Health},

volume = {16},

number = {10},

abstract = {Objective: This study was conducted to assess the prevalence, pattern of smoking and sociodemographic factors among Kerinchi residents in Kuala Lumpur, as well as to identify the association between smoking, stress, anxiety and depression. Methods: This study was carried out at four community housing projects in the Lembah Pantai area in Kuala Lumpur. Data was collected between 3 February 2012, and 29 November 2012. Data collectors made house visits and used interviewer administered questionnaires containing questions on demographic data and smoking patterns. Depression anxiety stress scale (DASS) was used to assess psychological symptoms. Alcohol smoking and substance involvement screening tool (ASSIST) scale was used to assess nicotine use. Results: Data from 1989 individuals (833 households) showed the age of respondents ranged from 18 to 89 years and the mean age was 39.12 years. There were 316 smokers indicating the prevalence of smoking was 15.85%, with 35.5% among males and 1.8% among females. Further, 86.6% of smokers were Malay and 87% were Muslims. Divorce was associated with smoking. Unemployment and housewives were less associated with smoking. Depression and anxiety were significantly associated with smoking (OR = 1.347. 95% CI: 1.042-1.741) and (OR = 1.401. 95% CI: 1.095-1.793) respectively. Conclusion: Screening for depression and anxiety should be routinely performed in the primary care setting and in population-based health screening to intervene early in patients who smoke.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16672,

title = {The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition},

author = {K Smith Byrne and P N Appleby and T J Key and M V Holmes and G K Fensom and A Agudo and E Ardanaz and H Boeing and H B Bueno-de-Mesquita and M D Chirlaque and R Kaaks and N Larranaga and D Palli and A Perez-Cornago and J R Quiros and F Ricceri and M J Sanchez and G Tagliabue and K K Tsilidis and R Tumino and R T Fortner and P Ferrari and E Riboli and H Lilja and R C Travis},

doi = {10.1093/annonc/mdz121},

issn = {0923-7534},

year  = {2019},

date = {2019-01-01},

journal = {Ann Oncol},

volume = {30},

number = {6},

pages = {983-989},

abstract = {BACKGROUND: Microseminoprotein-beta (MSP), a protein secreted by the prostate epithelium, may have a protective role in the development of prostate cancer. The only previous prospective study found a 2% reduced prostate cancer risk per unit increase in MSP. This work investigates the association of MSP with prostate cancer risk using observational and Mendelian randomization (MR) methods. PATIENTS AND METHODS: A nested case-control study was conducted with the European Prospective Investigation into Cancer and Nutrition (EPIC) with 1871 cases and 1871 matched controls. Conditional logistic regression analysis was used to investigate the association of pre-diagnostic circulating MSP with risk of incident prostate cancer overall and by tumour subtype. EPIC-derived estimates were combined with published data to calculate an MR estimate using two-sample inverse-variance method. RESULTS: Plasma MSP concentrations were inversely associated with prostate cancer risk after adjusting for total prostate-specific antigen concentration [odds ratio (OR) highest versus lowest fourth of MSP = 0.65, 95% confidence interval (CI) 0.51-0.84},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16634,

title = {The systematic cultural adaptation of a UK public health cancer awareness raising programme for Malaysia: the Be Cancer Alert Campaign},

author = {D Schliemann and T T Su and D Paramasivam and S Somasundaram and N S B Ibrahim Tamin and M Dahlui and S Y Loh and M Donnelly},

doi = {10.1093/tbm/ibz134},

issn = {1613-9860},

year  = {2019},

date = {2019-01-01},

journal = {Transl Behav Med},

volume = {9},

number = {6},

pages = {1087-1099},

abstract = {Increasingly, policy and research attention is being directed toward improving global health in low- and middle-income countries. This study investigated the cultural adaptation of a UK-designed and developed evidence-based mass media campaign with the aim of improving colorectal cancer and breast cancer awareness in Malaysia. Guided by the heuristic framework of cultural adaptation, a multidisciplinary team adapted the UK Be Cancer Aware programme for implementation in the Malaysian context. The approach included five steps: (a) information gathering and needs assessment; (b) preliminary design; (c) preliminary testing; (d) refinement; and (e) final trial. Key findings from the information gathering stage related to the need to take into account differences in ethnicity, religion, and beliefs about cancer. Discussions with experts indicated that particular words were not acceptable in Malay culture and that specific aspects were "taboo" (e.g., showing pictures of breasts in relation to breast cancer on TV). Stage 3 of the analysis revealed that the presentation of cancer survivors rather than health professionals on programme materials was preferred by Malaysians and that there was a poor level of awareness about colorectal cancer. The results were used systematically to adapt two culturally suitable cancer awareness mass media campaigns for implementation in Malaysia. The developed materials were in line with government priorities and took into account the local health care system structure. The establishment of a partnership with key stakeholders (e.g., the Ministry of Health and the lead patient advocacy organization) and the application of a systematic approach to address cultural factors and resource constraints contribute to the successful implementation of public health programmes in global health settings.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16611,

title = {Transition of Care in Paediatric Surgery: Current practices and perspectives of paediatric surgeons in Malaysia},

author = {S K Tan and A Sanmugam and M Danaee and T M Ramanujam and M A Nallusamy and Z Zahari and T R Rao},

doi = {10.18295/squmj.2019.19.04.011},

issn = {2075-051x},

year  = {2019},

date = {2019-01-01},

journal = {Sultan Qaboos Univ Med J},

volume = {19},

number = {4},

pages = {e352-e358},

abstract = {Objectives: Transition of care (TOC) from paediatric to adult care is still at an early stage in Malaysia. This study aimed to explore current practices and perspectives regarding TOC among paediatric surgeons in Malaysia. Methods: This study was carried out between June and December 2017. All 48 paediatric surgeons currently working in Malaysia were invited to participate in a questionnaire-based survey to assess demographic characteristics and practices and perspectives regarding TOC. Results: A total of 38 paediatric surgeons participated in the survey (response rate: 79.2%). Overall, 97.4% did not have an organised TOC model in their institution, with most (65.8%) caring for paediatric patients with complex surgical conditions until adulthood. Although the majority (86.8%) felt that care should be transitioned to adult surgeons with appropriate credentials, most surgeons (84.2%) nevertheless preferred to be involved in the management of adolescent patients after transition. However, there was no consensus regarding the most suitable age to begin the transition. Years of experience as a paediatric surgeon and place of practice did not affect overall TOC practice scores (P \>0.050 each). The presence of adult comorbidities was considered the most common reason to initiate TOC (81.6%), while the lack of TOC guidelines was perceived to be the greatest barrier (84.2%). Conclusion: This study provides a better understanding of TOC from the point of view of paediatric surgeons in Malaysia. However, further studies involving other stakeholders (i.e. patients and adult surgeons) are needed to help formulate a suitable and successful TOC model in this setting.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16732,

title = {Two truncating variants in FANCC and breast cancer risk},

author = {T D\"{o}rk and P Peterlongo and A Mannermaa and M K Bolla and Q Wang and J Dennis and T Ahearn and I L Andrulis and H Anton-Culver and V Arndt and K J Aronson and A Augustinsson and L E B Freeman and M W Beckmann and A Beeghly-Fadiel and S Behrens and M Bermisheva and C Blomqvist and N V Bogdanova and S E Bojesen and H Brauch and H Brenner and B Burwinkel and F Canzian and T L Chan and J Chang-Claude and S J Chanock and J Y Choi and H Christiansen and C L Clarke and F J Couch and K Czene and M B Daly and I dos-Santos-Silva and M Dwek and D M Eccles and A B Ekici and M Eriksson and D G Evans and P A Fasching and J Figueroa and H Flyger and L Fritschi and M Gabrielson and M Gago-Dominguez and C Gao and S M Gapstur and M Garc\'{i}a-Closas and J A Garc\'{i}a-S\'{a}enz and M M Gaudet and G G Giles and M S Goldberg and D E Goldgar and P Gu\'{e}nel and L Haeberle and C A Haiman and N Hr{a}kansson and P Hall and U Hamann and M Hartman and J Hauke and A Hein and P Hillemanns and F B L Hogervorst and M J Hooning and J L Hopper and T Howell and D Huo and H Ito and M Iwasaki and A Jakubowska and W Janni and E M John and A Jung and R Kaaks and D Kang and P M Kapoor and E Khusnutdinova and S W Kim and C M Kitahara and S Koutros and P Kraft and V N Kristensen and A Kwong and D Lambrechts and L L Marchand and J Li and S Lindstr\"{o}m and M Linet and W Y Lo and J Long and A Lophatananon and J Lubi\'{n}ski and M Manoochehri and S Manoukian and S Margolin and E Martinez and K Matsuo and D Mavroudis and A Meindl and others},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071631153\&doi=10.1038%2fs41598-019-48804-y\&partnerID=40\&md5=984f789b353fa3508e4dedebb69a156f},

doi = {10.1038/s41598-019-48804-y},

year  = {2019},

date = {2019-01-01},

journal = {Scientific Reports},

volume = {9},

number = {1},

abstract = {Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk associations of others remain unknown. The gene for FA type C, FANCC, has been proposed as a breast cancer susceptibility gene based on epidemiological and sequencing studies. We used the Oncoarray project to genotype two truncating FANCC variants (p.R185X and p.R548X) in 64,760 breast cancer cases and 49,793 controls of European descent. FANCC mutations were observed in 25 cases (14 with p.R185X, 11 with p.R548X) and 26 controls (18 with p.R185X, 8 with p.R548X). There was no evidence of an association with the risk of breast cancer, neither overall (odds ratio 0.77, 95%CI 0.44\textendash1.33},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16799,

title = {Ultrasound-guided central venous vascular access\textemdashnovel needle navigation technology compared with conventional method: A randomized study},

author = {S C Chew and Z Y Beh and V R Hakumat Rai and M F Jamaluddin and C C Ng and K Chinna and M S Hasan},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066870068\&doi=10.1177%2f1129729819852057\&partnerID=40\&md5=fa4b58550379377b1f3207cb7c5a8b29},

doi = {10.1177/1129729819852057},

year  = {2019},

date = {2019-01-01},

journal = {Journal of Vascular Access},

abstract = {Purpose: Central venous catheter insertion is a common procedure in the intensive care setting. However, complications persist despite real-time ultrasound guidance. Recent innovation in needle navigation technology using guided positioning system enables the clinician to visualize the needle’s real-time position and trajectory as it approaches the target. We hypothesized that the guided positioning system would improve performance time in central venous catheter insertion. Methods: A prospective randomized study was conducted in a single-center adult intensive care unit. In total, 100 patients were randomized into two groups. These patients underwent internal jugular vein central venous catheter cannulation with ultrasound guidance (short-axis scan, out-of-plane needling approach) in which one group adopted conventional method, while the other group was aided with the guided positioning system. Outcomes were measured by procedural efficacy (success rate, number of attempts, time to successful cannulation), complications, level of operators’ experience, and their satisfaction. Results: All patients had successful cannulation on the first attempt except for one case in the conventional group. The median performance time for the guided positioning system method was longer (25.5 vs 15.5 s; p = 0.01). And 86% of the operators had more than 3-year experience in anesthesia. One post-insertion hematoma occurred in the conventional group. Only 88% of the operators using the guided positioning system method were satisfied compared to 100% in the conventional group. Conclusion: Ultrasound-guided central venous catheter insertion via internal jugular vein was a safe procedure in both conventional and guided positioning system methods. The guided positioning system did not confer additional benefit but was associated with slower performance time and lower satisfaction level among the experienced operators. © The Author(s) 2019.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16697,

title = {Using high frequency and low-intensity ultrasound to enhance activated sludge characteristics},

author = {P Mohammadi and N Karami and A A Zinatizadeh and F Falahi and N Aghamohammadi and A Almasi},

doi = {10.1016/j.ultsonch.2019.01.030},

issn = {1350-4177},

year  = {2019},

date = {2019-01-01},

journal = {Ultrason Sonochem},

volume = {54},

pages = {274-280},

abstract = {In this study, high-frequency ultrasound wave (1.8MHz) at low intensity was applied to improve activated sludge settleability at high MLSS concentration. The effect of irradiation intensity, sonication mode, MLSS concentration and sample volume on the physical characteristics of sludge in a pilot scale settling column were investigated for optimizing the conditions. The obtained results showed that high-frequency ultrasound decreased the height of sludge (44%) and effluent turbidity (82.2%) and increased sludge settling velocity about 3 times at high biomass concentration. Irradiation intensity of 0.4w/cm(2) and sonication mode with interval times of 10s showed the best results on the performance of the system at MLSS concentration of 8000mg/L with a sample volume of 3L.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN16636,

title = {Validity and Reliability of a Nutrition Screening Tool in Identifying Malnutrition Among Hospitalized Adult Patients},

author = {P C Tah and C C Kee and H A Majid},

doi = {10.1002/ncp.10416},

issn = {0884-5336},

year  = {2019},

date = {2019-01-01},

journal = {Nutr Clin Pract},

abstract = {BACKGROUND: Malnutrition among hospitalized patients is closely associated with various medical complications. This study aimed to determine the validity and reliability of a 3-Minute Nutrition Screening (3-MinNS) tool in identifying the risk of malnutrition among hospitalized patients that can be administered by healthcare professionals. METHODS: A cross-sectional study was conducted between January and December 2012. A total of 350 adult patients in a teaching hospital were screened for risk of malnutrition using 3-MinNS and Subjective Global Assessment (SGA). To assess interrater reliability, each patient was screened for risk of malnutrition using 3-MinNS by 2 different nurses on 2 different occasions within 24 hours after admission. To assess the validity of 3-MinNS, the level of risk of malnutrition identified by the nurses using 3-MinNS was compared with the risk of malnutrition as assessed by a dietitian using SGA within 48 hours after the patients' enrolment into the study. The sensitivity, specificity, and predictive values were calculated in detecting patients at risk of malnutrition. Interrater reliability was determined using kappa statistics. RESULTS: Using SGA, the estimated prevalence of moderate to severe malnutrition was 36.3% (127/350). There was 94% proportional agreement between 2 nurses using 3-MinNS, and interrater reliability was substantial (kappa = 0.79, P \< .001). The analysis showed that 3-MinNS had moderate sensitivity (61.4%-68.5%) but high specificity (95.1%). CONCLUSIONS: The 3-MinNS is a reliable and valid screening tool for use by healthcare professionals for identifying newly admitted medical and surgical patients who are at risk of malnutrition.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}