Metabolic syndrome and monotherapy antipsychotic treatment among schizophrenia patients in Malaysia.

Prev Med. 2013 Jan 18. pii: S0091-7435(13)00018-2. doi: 10.1016/j.ypmed.2013.01.005. [Epub ahead of print]

Author

Said MA, Hatim A, Habil MH, Zafidah W, Haslina MY, Badiah Y, Ramli MA, Ananjit S, Sapini Y, Shah M, Mahmud B, Bulgiba A, Hairi NN.

Institution

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Julius Centre University of Malaya, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; University of Malaya Centre of Addiction Sciences, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: mas_ayu@um.edu.my.

Abstract

OBJECTIVE: The objective of this study is to determine the prevalence of metabolic syndrome among schizophrenia patients receiving monotherapy antipsychotic in Malaysia.

METHOD: A cross-sectional study was conducted at multiple centres between June 2008 and September 2011. Two hundred and five patients who fulfilled the DSM IV-TR diagnostic criteria for schizophrenia and who had been on antipsychotic medication for at least one year, were screened for metabolic syndrome. Patients receiving a mood stabilizer were excluded from the study. Metabolic syndrome was defined by using the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Treatment Panel III (ATP III) modified for Asian waist circumference.

RESULTS: In the first-generation antipsychotic (FGA) group, the highest prevalence of metabolic syndrome was among patients treated with trifluoperazine and flupenthixol decanoate (66.7% each). For the second-generation antipsychotic (SGA) group, the highest prevalence of metabolic syndrome was among patients treated with clozapine (66.7%). The component with the highest prevalence in metabolic syndrome was waist circumference in both FGA and SGA groups except for aripiprazole in SGA.

CONCLUSION: The prevalence of metabolic syndrome in schizophrenia patients receiving monotherapy antipsychotic in Malaysia was very high. Intervention measures are urgently needed to combat these problems. Copyright 2013. Published by Elsevier Inc.


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